-
1
-
-
0024387816
-
Thienothiopyran-2-sulfonamides: Novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma
-
Baldwin JJ, Ponticello GS, Anderson PS, Christy ME, Murcko MA, Randall WC, Schwam H, Sugrue MF, Springer JP, Gautheron P, Grove J, Mallorga P, Viader MP, McKeever BM, Navia MA. 1989. Thienothiopyran-2-sulfonamides: Novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma. J Med Chem 32:2510-2513.
-
(1989)
J Med Chem
, vol.32
, pp. 2510-2513
-
-
Baldwin, J.J.1
Ponticello, G.S.2
Anderson, P.S.3
Christy, M.E.4
Murcko, M.A.5
Randall, W.C.6
Schwam, H.7
Sugrue, M.F.8
Springer, J.P.9
Gautheron, P.10
Grove, J.11
Mallorga, P.12
Viader, M.P.13
McKeever, B.M.14
Navia, M.A.15
-
2
-
-
0002898371
-
Decrease in intraocular pressure in man by a carbonic anhydrase inhibitor, Diamox
-
Becker B. 1954. Decrease in intraocular pressure in man by a carbonic anhydrase inhibitor, Diamox. Am J Ophth 37:13-15.
-
(1954)
Am J Ophth
, vol.37
, pp. 13-15
-
-
Becker, B.1
-
3
-
-
0029025445
-
Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants
-
Boriack PA, Christianson DW, Kingery-Wood J, Whitesides GM. 1995. Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J Med Chem 38:2286-2291.
-
(1995)
J Med Chem
, vol.38
, pp. 2286-2291
-
-
Boriack, P.A.1
Christianson, D.W.2
Kingery-Wood, J.3
Whitesides, G.M.4
-
4
-
-
0023140814
-
Crystallographic R factor refinement by molecular dynamics
-
Brünger AT, Kuriyan J, Karplus M. 1987. Crystallographic R factor refinement by molecular dynamics. Science 235:458-460.
-
(1987)
Science
, vol.235
, pp. 458-460
-
-
Brünger, A.T.1
Kuriyan, J.2
Karplus, M.3
-
5
-
-
0028022705
-
Mapping protein-peptide affinity: Binding of peptidylsulfonamide inhibitors to human carbonic anhydrase II
-
Bunn AMC, Alexander RS, Christianson DW. 1994. Mapping protein-peptide affinity: Binding of peptidylsulfonamide inhibitors to human carbonic anhydrase II. J Am Chem Soc 116:5063-5068.
-
(1994)
J Am Chem Soc
, vol.116
, pp. 5063-5068
-
-
Bunn, A.M.C.1
Alexander, R.S.2
Christianson, D.W.3
-
6
-
-
0024260626
-
Weakly polar interactions in proteins
-
Burley SK, Petsko GA. 1988. Weakly polar interactions in proteins. Adv Protein Chem 39:125-189.
-
(1988)
Adv Protein Chem
, vol.39
, pp. 125-189
-
-
Burley, S.K.1
Petsko, G.A.2
-
7
-
-
0014217558
-
Combination of bovine carbonic anhydrase with a fluorescent sulfonamide
-
Chen RF, Kernohan JC. 1967. Combination of bovine carbonic anhydrase with a fluorescent sulfonamide. J Biol Chem 242:5813-5823.
-
(1967)
J Biol Chem
, vol.242
, pp. 5813-5823
-
-
Chen, R.F.1
Kernohan, J.C.2
-
8
-
-
0000726701
-
Carbonic anhydrase: Evolution of the zinc binding site by nature and by design
-
Christianson DW, Fierke CA. 1996. Carbonic anhydrase: Evolution of the zinc binding site by nature and by design. Acc Chem Res 29:331-339.
-
(1996)
Acc Chem Res
, vol.29
, pp. 331-339
-
-
Christianson, D.W.1
Fierke, C.A.2
-
9
-
-
0028103275
-
-
Collaborative Computational Project, Number 4
-
CCP4. 1994. Collaborative Computational Project, Number 4. Acta Crystallogr D 50:760-763.
-
(1994)
Acta Crystallogr D
, vol.50
, pp. 760-763
-
-
-
10
-
-
0001795569
-
The formation of the intraocular fluid
-
Friedenwald JS. 1949. The formation of the intraocular fluid. Am J Ophth 32:9-27.
-
(1949)
Am J Ophth
, vol.32
, pp. 9-27
-
-
Friedenwald, J.S.1
-
11
-
-
0028297112
-
Application of the three-dimensional structures of protein target molecules in structure-based drug design
-
Greer J, Erickson JW, Baldwin JJ, Varney MD. 1994. Application of the three-dimensional structures of protein target molecules in structure-based drug design. J Med Chem 37:1035-1054.
-
(1994)
J Med Chem
, vol.37
, pp. 1035-1054
-
-
Greer, J.1
Erickson, J.W.2
Baldwin, J.J.3
Varney, M.D.4
-
12
-
-
0026463503
-
Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes
-
Håkansson K, Carlsson M, Svensson LA, Liljas A. 1992. Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes. J Mol Biol 227:1192-1204.
-
(1992)
J Mol Biol
, vol.227
, pp. 1192-1204
-
-
Håkansson, K.1
Carlsson, M.2
Svensson, L.A.3
Liljas, A.4
-
13
-
-
0028111626
-
The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide
-
Håkansson K, Liljas A. 1994. The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide. FEBS Lett 350:319-322.
-
(1994)
FEBS Lett
, vol.350
, pp. 319-322
-
-
Håkansson, K.1
Liljas, A.2
-
14
-
-
0027936228
-
Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors
-
Jain A, Whitesides GM, Alexander RS, Christianson DW. 1994. Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors. J Med Chem 37:2100-2105.
-
(1994)
J Med Chem
, vol.37
, pp. 2100-2105
-
-
Jain, A.1
Whitesides, G.M.2
Alexander, R.S.3
Christianson, D.W.4
-
15
-
-
0001147656
-
Comparative chemistry of aqueous humor in posterior and anterior chambers of rabbit eye
-
Kinsey VE. 1953. Comparative chemistry of aqueous humor in posterior and anterior chambers of rabbit eye. Arch Ophth 50:401-417.
-
(1953)
Arch Ophth
, vol.50
, pp. 401-417
-
-
Kinsey, V.E.1
-
17
-
-
0001176531
-
Sulphanilamide as a specific inhibitor of carbonic anhydrase
-
Mann T, Keilin D. 1940. Sulphanilamide as a specific inhibitor of carbonic anhydrase. Nature 146:164-165.
-
(1940)
Nature
, vol.146
, pp. 164-165
-
-
Mann, T.1
Keilin, D.2
-
18
-
-
0023224380
-
Carbonic anhydrase: General perspectives and advances in glaucoma research
-
Maren TH. 1987. Carbonic anhydrase: General perspectives and advances in glaucoma research. Drug Dev Res 10:255-276.
-
(1987)
Drug Dev Res
, vol.10
, pp. 255-276
-
-
Maren, T.H.1
-
19
-
-
0009593678
-
Unexpected pH-dependent conformation of His64, the proton shuttle of carbonic anhydrase II
-
Nair SK, Christianson DW. 1991. Unexpected pH-dependent conformation of His64, the proton shuttle of carbonic anhydrase II. J Am Chem Soc 113:9455-9458.
-
(1991)
J Am Chem Soc
, vol.113
, pp. 9455-9458
-
-
Nair, S.K.1
Christianson, D.W.2
-
20
-
-
0023240172
-
Thienothiopyran-2-sulfonamides: A novel class of water-soluble carbonic anhydrase inhibitors
-
Ponticello GS, Freedman MB, Habecker CN, Lyle PA, Schwam H, Varga SL, Christy ME, Randall WC, Baldwin JJ. 1987. Thienothiopyran-2-sulfonamides: A novel class of water-soluble carbonic anhydrase inhibitors. J Med Chem 30:591-597.
-
(1987)
J Med Chem
, vol.30
, pp. 591-597
-
-
Ponticello, G.S.1
Freedman, M.B.2
Habecker, C.N.3
Lyle, P.A.4
Schwam, H.5
Varga, S.L.6
Christy, M.E.7
Randall, W.C.8
Baldwin, J.J.9
-
21
-
-
0025848454
-
New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides
-
Prugh JD, Hartman GD, Mallorga PJ, McKeever BM, Michelson SR, Murcko MA, Schwam H, Smith RL, Sondey JM, Springer JP, Sugrue MF. 1991. New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides. J Med Chem 34:1805-1818.
-
(1991)
J Med Chem
, vol.34
, pp. 1805-1818
-
-
Prugh, J.D.1
Hartman, G.D.2
Mallorga, P.J.3
McKeever, B.M.4
Michelson, S.R.5
Murcko, M.A.6
Schwam, H.7
Smith, R.L.8
Sondey, J.M.9
Springer, J.P.10
Sugrue, M.F.11
-
22
-
-
33845278732
-
The catalytic mechanism for carbonic anhydrase: Implications of a rate-limiting protolysis of water
-
Silverman DN, Lindskog S. 1988. The catalytic mechanism for carbonic anhydrase: Implications of a rate-limiting protolysis of water. Acc Chem Res 21:30-36.
-
(1988)
Acc Chem Res
, vol.21
, pp. 30-36
-
-
Silverman, D.N.1
Lindskog, S.2
-
23
-
-
0028053256
-
Positions of His64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors
-
Smith GM, Alexander RS, Christianson DW, McKeever BM, Ponticello GS, Springer JP, Randall WC, Baldwin JJ, Habecker CN. 1994. Positions of His64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors. Protein Sci 3:118-125.
-
(1994)
Protein Sci
, vol.3
, pp. 118-125
-
-
Smith, G.M.1
Alexander, R.S.2
Christianson, D.W.3
McKeever, B.M.4
Ponticello, G.S.5
Springer, J.P.6
Randall, W.C.7
Baldwin, J.J.8
Habecker, C.N.9
-
24
-
-
0031887344
-
Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: Molecular basis of isozyme-drug discrimination
-
Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW. 1998. Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: Molecular basis of isozyme-drug discrimination. Protein Sci 7:556-563.
-
(1998)
Protein Sci
, vol.7
, pp. 556-563
-
-
Stams, T.1
Chen, Y.2
Boriack-Sjodin, P.A.3
Hurt, J.D.4
Liao, J.5
May, J.A.6
Dean, T.7
Laipis, P.8
Silverman, D.N.9
Christianson, D.W.10
-
25
-
-
0024421430
-
Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant
-
Tu CK, Silverman DN, Forsman C, Jonsson BH, Lindskog S. 1989. Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant. Biochemistry 28:7913-7918.
-
(1989)
Biochemistry
, vol.28
, pp. 7913-7918
-
-
Tu, C.K.1
Silverman, D.N.2
Forsman, C.3
Jonsson, B.H.4
Lindskog, S.5
-
26
-
-
0025637061
-
Refined structure of the acetazolamide complex of human carbonic anhydrase II at 1.9 Å
-
Vidgren J, Liljas A, Walker NPC. 1990. Refined structure of the acetazolamide complex of human carbonic anhydrase II at 1.9 Å. Int J Biol Macromol 12:342-344.
-
(1990)
Int J Biol Macromol
, vol.12
, pp. 342-344
-
-
Vidgren, J.1
Liljas, A.2
Walker, N.P.C.3
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