Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF): Potential role in asthma

Journal of Clinical Investigation

Volumn 101, Issue 12, 1998, Pages 2869-2874

  Rossi, Adriano G ^a   Haslett, Christopher ^a   Hirani, Nikhil ^a   Greening, Andrew P ^b   Rahman, Irfan ^a   Metz, Christine N ^c   Bucala, Richard ^c   Donnelly, Seamas C ^a,d  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c PICOWER INST FOR MEDICAL RESEARCH   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Granulocyte; Inflammation; Lung; Protein kinase C; Protein synthesis

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CYCLOHEXIMIDE; MACROPHAGE MIGRATION INHIBITION FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ARTICLE; ASTHMA; CONTROLLED STUDY; EOSINOPHIL; GRANULOCYTE; HUMAN; HUMAN CELL; INFLAMMATION; LUNG LAVAGE; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0032525889     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1524     Document Type: Article

References (28)

1. Donnelly, S.C., and R. Bucala. 1997. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Mol. Med. Today. 3:502-507.
2. George, M., and J.H. Vaughn. 1962. In vitro cell migration as a model for delayed hypersensitivity. Proc. Soc. Exp. Biol. Med. 111:514-521.
3. Bloom, B.R., and B. Bennett. 1996. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science. 153:80-82.
4. David, J. 1966. Delayed hypersensitivity in vitro: its mediation by cell free substances formed by lymphoid cell-antigen interaction. Proc. Natl. Acad. Sci. USA. 56:72-77.
5. Calandra, T., J. Bernhagen, R.A. Mitchell, and R. Bucala. 1994. The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J. Exp. Med. 179:1895-1902.
6. Bernhagen, J., M. Bacher, T. Calandra, C.N. Metz, S. Doty, T. Donnelly, and R. Bucala. 1996. An essential role for macrophage migration inhibitory factor (MIF) in the tuberculin delayed-type hypersensitivity reaction. J. Exp .Med. 183:277-282.
7. Bacher, M., C.N. Metz, T. Calandra, K. Mayer, J. Chesney, M. Lohoff, D. Gemsa, T. Donnelly, and R. Bucala. 1996. An essential regulatory role for macrophage migration inhibitory factor in T-cell activation. Proc. Natl. Acad. Sci. USA. 93:7849-7854.
8. Calandra, T., J. Bernhagen, C.N. Metz, L.A. Spiegel, M. Bacher, T. Donnelly, A. Cerami, and R. Bucala. 1995. MIF as a glucocorticoid-induced modulator of cytokine production. Nature. 377:68-71.
9. Donnelly, S.C., C. Haslett, P.T. Reid, I.S. Grant, W.A.H. Wallace, C.N. Metz, L.J. Bruce, and R. Bucala. 1997. Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat. Med. 3:320-323.
10. Bernhagen, J., T. Calandra, R.A. Mitchell, S.B. Martin, K.I. Tracey, W. Voelter, K.R. Manogue, A. Cerami, and R. Bucala. 1993. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature. 365:756-759.
11. Nishino, T., J. Bernhagen, H. Shiiki, T. Calandra, K. Dohi, and R. Bucala. 1995. Localization of macrophage migration inhibitory factor (MIF) to secretory granules within the corticotrophic and thyrotrophic cells of the pituitary gland. Mol. Med. 1:781-788.
12. Stern, M., L. Meagher, J. Savill, and C. Haslett. 1992. Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. J. Immunol. 148:3543-3549.
13. Meagher, L.C., J.M. Cousin, J.R. Seckl, and C. Haslett. 1996. Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J. Immunol. 156:4422-4428.
14. Bernhagen, J., R.A. Mitchell, T. Calandra, W. Voelter, A. Cerami, and R. Bucala. 1994. Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). Biochemistry. 33:14144-14155.
15. Greening, A.P., P. Nunn, N. Dobson, M. Rudolf, and A.D.M. Rees. 1985. Pulmonary sarcoidosis: alterations in bronchoalveolar lymphocytes and T cell subsets. Thorax. 40:278-283.
16. Thomas, L.H., and J.A. Warner. 1996. The eosinophil and its role in asthma. Gen. Pharmacol. 27:543-597.
17. Kay, A.B., L. Barata, Q. Meng, S.R. Durham, and S. Ying. 1997. Eosinophils and eosinophil-associated cytokines in allergic inflammation. Int. Arch. Allergy Immunol. 113:196-199.
18. Martin, L.B., H. Kita, K.M. Leiferman, and G.J. Gleich. 1996. Eosinophils in allergy: role in disease, degranulation, and cytokines. Int. Arch. Allergy Immunol. 109:207-215.
19. Texeira, M.M., T.J. Williams, and P.G. Hellewell. 1995. Mechanisms and pharmacological manipulation of eosinophil accumulation in vivo. Trends Pharmacol. Sci. 16:418-423.
20. Wooley, K.L., P.G. Gibson, K. Carty, A.J. Wilson, S.H. Twaddell, and M.J. Wooley. 1996. Eosinophil apoptosis and the resolution of airway inflammation. Am. J. Respir. Crit. Care Med. 154:237-243.
21. Schleimer, R.P., and B.S. Bochner. 1994. The effects of glucocorticoids on human eosinophils. J. Allergy Clin. Immunol. 94:1202-1213.
22. Schleimer, R.P. 1993. An overview of glucocorticoid anti-inflammatory actions. Eur. J. Clin. Pharmacol. 45(Suppl. 1):S3-S7.
23. Teran, L.M., M.G. Campos, B.T. Begishvilli, J.M. Schroder, R. Djukanovic, J.K. Shute, M.K. Church, S.T. Holgate, and D.E. Davies. 1997. Identification of neutrophil chemotactic factors in bronchoalveolar lavage fluid of asthmatics. Clin. Exp. Allergy. 27:396-405.
24. Lee, J.J., M.P. McGarry, S.C. Farmer, K.L. Denzler, K. A. Larson, P.E. Carrigan, I.E. Brenneise, M.A. Horton, A. Haczku, E.W. Gelfand, et al. 1997. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J. Exp. Med. 185:2143-2156.
25. Lan, H.Y., W. Mu, N. Yang, A. Meinhardt, D.J. Nikolic-Paterson, Y.Y. Ng, M. Bacher, R.C. Atkins, and R. Bucala. 1996. De novo renal expression of macrophage migration inhibitory factor during the development of rat crescenteric glomerulonephritis. Am. J. Pathol. 149:1119-1127.
26. Lan, B.H., M. Bacher, N. Yang, W. Mu, D.J. Nikolic-Paterson, C. Metz, A. Meinhardt, R. Bucala, and R.C. Atkins. 1997. The pathogenic role of macrophage migration inhibitory factor in immunologically induced kidney disease in the rat. J. Exp. Med. 185:1455-1465.
27. Barnes, P.J., and I.M. Adcock. 1995. Steroid resistance in asthma. Q. J. Med. 88:455-468.
28. Barnes, P.J., A.P. Greening, and G.K. Crompton. 1995. Glucocorticoid resistance in asthma. Am. J. Respir. Crit. Care Med. 152:S125-S142.