Adrenomedullin functions as an important tumor survival factor in human carcinogenesis

Microscopy Research and Technique

Volumn 57, Issue 2, 2002, Pages 110-119

  Cuttitta, Frank ^a   Pío, Rubén ^b   Garayoa, Mercedes ^b   Zudaire, Enrique ^a   Julián, Miguel ^c   Elsasser, Ted H ^c   Montuenga, Luis M ^b   Martínez, Alfredo ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF NAVARRA   (Spain)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Angiogenesis; Apoptosis; Cancer; Growth factor; Hypoxia

Indexed keywords

CANCER CELLS; CELL PROLIFERATION; DISEASES; PATHOLOGY; PEPTIDES; TUMORS;

ANGIOGENESIS; CANCER; CANCER CELLS; GROWTH FACTOR; HUMAN CARCINOGENESIS; HYPOXIA; PLURIPOTENT; REGULATORY PEPTIDE; SURVIVAL FACTOR; TUMOUR CELLS;

CELL DEATH;

ADRENOMEDULLIN; GROWTH FACTOR;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER SURVIVAL; CARCINOGENESIS; CELL DEATH; HORMONE ACTION; HUMAN; HYPOXIA; OUTCOMES RESEARCH; OXYGEN TENSION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR; TUMOR GROWTH;

EID: 0037090715     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.10059     Document Type: Article

References (89)

1. An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral respiratory tract and gut microflora
2. Inflammation and cancer: Back to Virchow?
3. Binding of myc protein to canonical and noncanonical DNA sequences
4. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
5. Elevated plasma levels of human adrenomedullin in cardiovascular, respiratory, hepatic and renal disorders
6. Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes
7. Inflammatory cells and cancer: Think different!
8. The role of adrenomedullin as a growth regulatory peptide in the normal and malignant setting
9. Increased urinary adrenomedullin excretion in children with urinary tract infection
10. Effect of adrenomedullin on renal hemodynamics and function in dogs
11. High levels of circulating adrenomedullin in severe illness: Correlation with C-reactive protein and evidence against the adrenal medulla as site of origin
12. Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack
13. Hypoxia-inducible facrtor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: A possible promotion mechanism of carcinogenesis
14. Expression of the hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density
15. The hallmarks of cancer
16. Expression of the adrenomedullin gene in epithelial ovarian cancer
17. Increased circulation adrenomedullin, a novel vasodilatory peptide, in sepsis
18. Tissue hypoxygenation activates the adrenomedullin system in vivo
19. Regulation of hypoxia-inducible factor 1α is mediated by an 02-dependent degradation domain vial the ubiquitin-proteasome pathway
20. Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats
21. Regulation of adrenomedullin production in rat endothelial cells
22. Adrenomedullin in experimental congestive heart failure: Cardiorenal activation
23. Exceptional resistance of human H2 glioblastoma cells to complement-mediated killing by expression and utilization of factor H and factor H-like protein 1
24. Adrenomedullin inhibits the secretion of cytokine-induced neurtophil chemoattractant, a member of the interleukin-8 family, from rat alveolar macrophages
25. Adrenomedullin, a newly discovered hypotensive peptide, is a potent bronchodilator
26. Identification of an orphan receptor gene as a type 1 calcitonin gene-related peptide receptor
27. Cloning and expression of cDNA encoding a rat adrenomedullin receptor
28. Adrenomedullin has mitogenic effects on human oral keratinocytes: Involvement of cyclic AMP
29. Plasma adrenomedullin concentration in patients with heart failure
30. Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells
31. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
32. The von Hippel-Lindau tumor suppressor gene
33. Production of adrenomedullin in macrophage cell lines and peritoneal macrophage
34. Adrenomedullin production is correlated with differentiation in human leukemia cell lines and peripheral blooc monocytes
35. Coordinated up-regulation by hypoxia of adrenomedullin and one of its putative recepotrs (RDC-1) in cells of the rat blood-brain barrier
36. Circulating adrenomedullin is increased in patients with corticotropin-dependent Cushing's syndrome due to pituitary adenoma
37. Adrenoemdullin in nonmammalian vertebrates pancreas: An immunocytochemical study
38. Expression of adrenomedullin in normal lung and in pulmonary tumors
39. Adrenomedullin-like immunoreactivity in the nervous system of the starfish Marthasterias glacialis
40. Regulation of insulin secretion and blood glucose metabolism by adrenomedullin
41. Central action of adrenomedullin to inhibit gastric emptying in rats
42. Expression of adrenomedullin and its receptor in normal and malignant human skin: A potential pluripotent role in the integument
43. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
44. Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor
45. Role of c-fos in hypoxia-induced AP-1 cis-element activity and tyrosine hydrolyase gene expression
46. Adrenomedullin binds with high affinity, elevates cyclic AMP, and stimulates c-fos mRNA in C6 glioma cells
47. The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat
48. Hypoxia-induced adrenomedullin production in kidney
49. Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells
50. Induction of adrenomedullin by hypoxia in cultured human coronary artery endothelial cells
51. Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes
52. Cardiac production and secretion of adrenomedullin are increased in heart failure
53. Adrenomedullin induces endothelium-dependent vasorelaxation via the phophatidylinositol 3-kinase/Akt-dependent pathway in rat aorta
54. Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds
55. Adrenomedullin inhibits hypoxic death by upregulation of Bcl-2 in endometrial cancer cells: A possible promotion mechanism for tumour growth
56. Hypoxic induction of adrenomedullin in cultured human umbilical vein endothelial cells
57. Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory protein factors H and I
58. Cardiovascular actions of adrenomedullin in conscious sheep
59. Complement factor H is a serum binding protein for adrenomedullin, and the resulting complex modulates the bioactivity of both partners
60. Exercise-induced increase in circulating adrenomedullin is related to mean blood pressure in heart transplant recipients
61. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung
62. Expression of adrenomedullin and peptide amidation activity in human prostate cancer and human prostate cancer cell lines
63. A novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release
64. Adrenomedullin in human brain, adrenal glands and tumor tissue of pheochromocytoma, ganglioneuroblastoma and neuroblastoma
65. Adrenomedullin stimulates DNA synthesis of rat adrenal zona glomerulosa cells through activated of the mitogen-activated protein kinase-dependent cascade
66. Induction of Max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis
67. Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells
68. Endotoxin markedly elevates plasma concentration of gene transcript of adrenomedullin in rat
69. Production and secretion of adrenomedullin from vascular smooth muscle cells: Augmented production by tumor necrosis factor-α
70. Interleukin-1, tumor necrosis factor and lipopolysaccharide activity stimulates production of adrenomedullin in vascular smooth muscle cells
71. Production and secretion of adrenomedullin from glial cell tumors and its effects on cAMP production
72. Plasma adrenomedullin in various diseases and exercise-induced change in adrenomedullin in healthy subjects
73. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
74. Adrenomedullin: A player at high altitude?
75. Increased Expression of adrenomedullin mRNA in the tissue of intraocular and orbital tumors
76. Induction of adrenomedullin by hypoxia in cultured retinal pigment epithelial cells
77. Adrenomedullin increases intracellular Ca2+ and inositol 1,4,5-trisphosphate in human oligodendroglial cell line KG-1C
78. Antimicrobial activity of adrenomedullin and its gene related peptides
79. Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage
80. Oxygen(es) and the hypoxia-inducible factor-1
81. Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells
82. Induction of adrenomedullin mRNA and protein by lipopolysaccharide and paclitaxel (taxol) in murine macrophage
83. Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms and partial cDNA sequence of a precursor
84. Adrenomedullin activity in chronically hypoxic rat lungs
85. PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by an non estrogenic mechanism in the human endometrium
86. Overexpression of hypoxia-inducible factor-1α in common human cancers and their metastases
87. Adrenomedullin and calcitonin gene-related peptide interact with the same receptor in cultured human neuroblastoma SK-N-MC cells