Adrenomedullin activity in chronically hypoxic rat lungs

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 2 40-2, 1996, Pages

  Zhao, Lan ^a   Brown, Lesley A ^a   Owji, Ali A ^a   Nunez, Derek J R ^a   Smith, David M ^a   Ghatei, Mohammad A ^a   Bloom, Stephen R ^a   Wilkins, Martin R ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

calcitonin gene related peptide; messenger ribonucleic acid; receptor

Indexed keywords

ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOXIA; ISOLATED LUNG; LUNG ARTERY PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; RAT; TISSUE DISTRIBUTION; VASODILATATION;

EID: 0029781225     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.2.h622     Document Type: Article

References (33)

1. Adnot, S., B. Raffestin, S. Eddahibi, P. Braquet, and P. Chabrier. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest. 87: 155-162, 1991.
2. Barnes, P. J., and S. F. Liu. Regulation of pulmonary vascular tone. Pharmacol. Rev. 47: 87-131, 1995.
3. Bhogal, R., D. M. Smith, P. Purkiss, and S. R. Bloom. Molecular identification of binding sites for calcitonin gene-related peptide (CGRP) and islet amyloid polypeptide (IAPP) in mammalian lung: species variation and binding of truncated CGRP and IAPP. Endocrinology 133: 2351-2361, 1993.
4. Brown, L. A., D. J. R. Nunez, and M. R. Wilkins. Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat. J. Clin. Invest. 92: 2702-2712, 1993.
5. Chomczynski, P., and N. Saachi. Single step method of RNA isolation by acid guanidium isothiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
6. DeWitt, B. J., D. Y. Cheng, G. N. Caminiti, B. D. Nossaman, D. H. Coy, W. A. Murphy, and P. J. Kadowitz. Comparison of responses to adrenomedullm and calcitonin gene-related peptide in the pulmonary vascular bed of the cat. Eur. J. Pharmacol. 257: 303-306, 1994.
7. Ebara, T., K. Miura, M. Okumura, T. Matsuura, S. Kim, T. Yukimura, and H. Iwao. Effect of adrenomedullin on renal hemodynamics and functions in dogs. Eur. J. Pharmacol. 263: 69-73, 1994.
8. Elhawary, A. M., J. Poon, and C. C. Y. Pang. Effects of calcitonin gene-related peptide receptor antagonists on renal actions of adrenomedullin. Br. J. Pharmacol. 115: 1133-1140, 1995.
9. Elton, T. S., S. Oparil, G. R. Taylor, P. H. Hicks, R. Yang, H. Jin, and Y. F. Chen. Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R1260-R1264, 1992.
10. Entzeroth, M., H. N. Doods, H. A. Wieland, and W. Wienen. Adrenomedullin mediates vasodilation via CGRP1 receptors. Life Sci. 56: 19-25, 1995.
11. Fort, P., L. Marty, M. Piechaczyk, S. E. Sabrouty, C. Dani, P. Jeanteur, and J. M. Blanchard. Various rat tissues express only one major mRNA species from the glutaraldehyde-3-phosphate dehydrogenase mutagenic family. Nucleic Acids Res 13: 1431-1442, 1985.
12. Fracker, P. J., and J. C. Speck. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3α, 6α-diphenylglycoluril. Biochem. Biophys. Res. Commun. 80: 849-857, 1978.
13. Gardiner, S. M., P. A. Kemp, J. E. March, and T. Bennett. Regional haemodynamic effects of human and rat adrenomedullin in conscious rats. Br. J. Pharmacol. 114: 584-091, 1995.
14. Imai, T., Y. Hirata, M. Iwashina, and F. Marumo. Hormonal regulation of rat adrenomedullin gene in vasculature. Endocrinology 136: 1544-1548, 1995.
15. Ishimitsu, T., T. Nishikimi, Y. Saito, K. Kitamura, T. Eto, K. Kangawa, H. Matsuo, T. Omae, and H. Matsuoka. Plasma levels of adrenomedullin, a newly identified hypotensive peptide in patients with hypertension and renal failure. J. Clin. Invest. 94: 2158-2161, 1994.
16. Ishiyama, Y., K. Kitamura, Y. Ichiki, S. Nakamura, O. Kida, K. Kangawa, and T. Eto. Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats. Eur. J. Pharmacol. 241: 271-273, 1993.
17. Kanazawa, H., N. Kurihara, K. Hirata, S. Kudoh, T. Kawaguchi, and T. Takeda. Adrenomedullin, a newly discovered hypotensive peptide is a potent bronchodilator. Biochem. Biophys. Res Commun. 205: 251-254, 1995.
18. Kitamura, K., Y. Ichiki, M. Tanaka, M. Kawamoto, J. Emura, S. Sakakibara, K. Kangawa, H. Matsuo, and T. Eto. Immunoreactive adrenomedullin in human plasma. FEBS Lett. 341: 288-290, 1994.
19. Kitamura, K., K. Kangawa, and M. Kawamoto. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun. 192: 553-560, 1993.
20. Kitamura, K., J. Sakata, K. Kangawa, M. Kojima, H. Matsuo, and T. Eto. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem. Biophys. Res. Commun. 194: 720-725, 1993.
21. Lippton, H., J. Chang, Q. Hao, W. Summer, and A. L. Lyman. Adrenomedullin dilates the pulmonary vascular bed in vivo. J. Appl. Physiol. 76: 2154-2156, 1994.
22. Mak, J. C., and P. J. Barnes. Autoradiographic localization of calcitonin gene-related-peptide (CGRP) binding sites in human and guinea pig lung. Peptides Tarryt. 9: 957-963, 1988.
23. Nishikimi, T., K. Kitamura, Y. Saito, K. Shimada, T. Ishimitsu, K. Takamiya, H. Matsuo, T. Eto, M. Omae, and H. Matsuoka. Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects. Hypertension Dallas 24: 600-604, 1994.
24. Nossaman, B. D., C. J. Feng, D. Y. Cheng, B. J. DeWitt, D. H. Coy, W. A. Murphy, and P. J. Kadowitz. Comparative effects of adrenomedullin, an adrenomedullin analog and CGRP in the pulmonary vascular bed of the cat and rat. Life Sci. 56: 63-66, 1995.
25. Nuki, C., H. Kawasaki, K. Kitamura, M. Takenaga, K. Kangawa, T. Eto, and A. Wada. Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochem. Biophys. Res. Commun. 196: 245-251, 1993.
26. Nunez, D. J. R., A. P. Davenport, and M. J. Brown. Atrial natriuretic factor mRNA and binding sites in the adrenal gland. Biochem. J. 271: 555-558, 1990.
27. Owji, A. A., D. M. Smith, H. A. Coppock, D. G. A. Morgan, R. Bhogal, M. A. Ghatei, and S. R. Bloom. An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat. Endocrinology 136: 2127-2134, 1995.
28. Rabinovitch, M., W. Gamble, A. S. Nadas, O. S. Miettinen, and L. Reid. Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am. J. Physiol. 236 (Heart Circ. Physiol. 5): H818-H827, 1979.
29. Roncalli, M., D. R. Springall, M. Maggioni, A. Moradoghli-Haftvani, R. J. D. Winter, L. Zhao, G. Coggi, and J. M. Polak. Early changes in the calcitonin gene-related peptide (CGRP) content of pulmonary endocrine cells concomitant with vascular remodeling in the hypoxic rat. Am. J. Respir Cell Mol. Biol. 9: 467-474, 1993.
30. Sakata, J., T. Shimokubo, K. Kitamura, S. Nakamura, K. Kangawa, H. Matsuo, and T. Eto. Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem. Biophys. Res. Commun. 195: 921-927, 1993.
31. Sugo, S., N. Minamino, H. Shoji, K. Kangawa, K. Kitamura, T. Eto, and H. Matsuo. Interleukin-1. tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 207: 25-32, 1995.
32. Zhao, L., D. E. Crawley, J. M. B. Hughes, T. W. Evans, and R. J. D. Winter. Endothelium-derived relaxing factor activity in rat lung during hypoxic pulmonary vascular remodeling. J. Appl. Physiol. 74: 1061-1064, 1993.
33. Zhao, L., R. J. D. Winter, T. Krauz, and J. M. B. Hughes. Effects of continuous infusion of atrial natriuretic peptide on the pulmonary hypertension induced by chronic hypoxia in rats. Clin. Sci. Lond. 81: 379-385, 1991.