Expression of the hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density

Clinical Cancer Research

Volumn 6, Issue 7, 2000, Pages 2808-2814

  Hague, Stephen ^a,b   Zhang, Lyna ^a,b   Oehler, Martin K ^a,b   Manek, Sanjiv ^c   MacKenzie, Ian Z ^a   Bicknell, Roy ^b   Rees, Margaret C P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; ANGIOGENESIS INHIBITOR; ANGIOGENIC FACTOR; FIBROBLAST GROWTH FACTOR;

ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOMETRIUM; FEMALE; GENE EXPRESSION; HUMAN; HYPOXIA; MAJOR CLINICAL STUDY; MYOMETRIUM; PRIORITY JOURNAL; TUMOR VASCULARIZATION; UTERUS MYOMA;

ADRENOMEDULLIN; ADULT; BIOLOGICAL MARKERS; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FEMALE; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; HUMANS; LEIOMYOMA; LYMPHOKINES; MENSTRUAL CYCLE; MICROCIRCULATION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDES; RETROSPECTIVE STUDIES; THYMIDINE PHOSPHORYLASE; UTERINE NEOPLASMS; UTERUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033928332     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Andersen, J. Growth factors and cytokines in uterine leiomyomas. Semin. Reprod. Endocrinol., 14: 269-282, 1996.
2. Vollenhoven, B. J., and Healy, D. L. Pathophysiology and medical treatment of uterine fibroids. In: I. T. Cameron, I. S. Fraser, and S. K. Smith (eds.), Clinical Disorders of the Endometrium and Menstrual Cycle, pp. 207-218. Oxford: Oxford University Press, 1998.
3. Kawaguchi, K., Fuji, S., Konishi, I., Iwai, T., Nanbu, Y., Nonogaki, H., Ishikawa, Y., and Mori, T. Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki 67 in leiomyoma and myometrium during the menstrual cycle and pregnancy. Virchows Arch. Pathol. Anat. Histopathol., 419: 309-315, 1991.
4. Brandon, D. D., Bethea, C. L., Strawn, E. Y., Novy, M. J., Burry, K. A., Harrington, M. S., Erickson, T. E., Warner, C., Keenan, E. J., and Clinton, G. M. Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas. Am. J. Obstet. Gynecol., 169: 78-85, 1993.
5. Vollenhoven, B. J., Pearce, P., Herington, A. C., and Healy, D. L. Steroid receptor binding and messenger RNA expression in fibroids from untreated and gonadotrophin releasing hormone agonist pretreated women. Clin. Endocrinol., 40: 537-544, 1994.
6. Viville, B., Charnock-Jones, D. S., Sharkey, A. M., Wetzka, B., and Smith, S. K. Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium. Hum. Reprod., 12: 815-822, 1997.
7. Zhang, L., Rees, M. C. P., and Bicknell, R. The isolation and long term culture of normal human endometrial epithelium and stroma: expression of mRNAs for angiogenic polypeptides basally and on oestrogen challenge. J. Cell Sci., 108: 323-331, 1995.
8. Dou, Q., Zhao, Y., Tarnuzzer, R. W., Rong, H., Williams, R. S., Schultz, G. S., and Chegini, N. Suppression of transforming growth factor β (TGF β) and TGF β receptor messenger ribonucleic acid and protein expression in leiomyomata in women receiving gonadotrophin-releasing hormone agonist therapy. J. Clin. Endocrinol. Metab., 81: 3222-3230, 1996.
9. Harrison-Woolrych, M. L., Charnock-Jones, D. S., and Smith, S. K. Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction. J. Clin. Endocrinol. Metab., 78: 1179-1184, 1994.
10. Harrison-Woolrych, M. L., Sharkey, A. M., Charnock-Jones, D. S., and Smith, S. K. Localization and quantification of vascular endothelial growth factor messenger ribonucleic acid in human myometrium and leiomyomata. J. Clin. Endocrinol. Metab., 80: 1853-1858, 1995.
11. Mangrulkar, R. S., Ono, M., Ishikawa, M., Takashima, S., Klagbrun, M., and Nowark, R. A. Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium. Biol. Reprod., 53: 636-646, 1995.
12. Sourla, A., and Koutsileris, M. Purification and partial sequencing of the major mitogene for human uterine smooth muscle-like cells in leiomyoma extracts. J. Clin. Investig., 96: 751-758, 1995.
13. Vollenhoven, B. J., Pearce, P., Herington, A. C., and Healy, D. L. Messenger ribonucleic acid expression of the insulin-like growth factors and their binding proteins in uterine fibroids and myometrium. J. Clin. Endocrinol. Metab., 76: 1106-1110, 1993.
14. Vollenhoven, B. J., Herington, A. C., and Healy, D. L. Epidermal growth factor and transforming growth factor β in uterine fibroids and myometrium. Gynaecol. Obstet. Investig., 40: 120-124, 1995.
15. Rauk, P. N., Surti, U., Roberts, J. M., and Michalopoulos, G. Mitogenic effect of basic fibroblast growth factor and estradiol on cultured human myometrial and leiomyoma cells. Am. J. Obstet. Gynecol., 173: 571-577, 1995.
16. Hata, K., Hata, T., Iida, K., and Miyazaki, K. Expression of thymidine phosphorylase in uterine sarcoma and uterine leiomyoma: association with microvessel density and Doppler blood flow analysis. Ultrasound Obstet. Gynecol., 10: 54-58, 1997.
17. Zhang, L., Rees, M. C. P., Mackenzie, I. Z., and Bicknell, R. Regulation of the expression of the angiogenic enzyme PD-ECGF/ thymidine phosphorylase in endometrial isolates by ovarian steroids and cytokines. Endocrinology, 138: 4921-4930, 1997.
18. Zhao, Y., Hague, S., Manek, S., Zhang, L., Bicknell, R., and Rees, M. C. P. PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non-oestrogenic mechanism in human endometrium. Oncogene, 16: 409-415, 1998.
19. Michishita, M., Minegishi, T., Abe, K., Kangawa, K., Kojima, M., and Ibuki, Y. Expression of adrenomedullin in the endometrium of the human uterus. Obstet. Gynecol., 93: 66-70, 1999.
20. Kitamura, K., Kangawa, K., Kawamoto, M., Ichiki, Y., Nakamura, S., Matsuo, H., and Eto, T. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun., 192: 553-560, 1993.
21. Wells, M. Female genital tract. In: J. C. Underwood (ed.), General and Systemic Pathology, pp. 551-584. Edinburgh: Churchill Livingston, 1996.
22. Zhang, L., Scott, P. A. E., Turley, H., Leek, R. D., Lewis, C. E., Gatter, K. C., Harris, A. L., MacKenzie, I. Z., Rees, M. C., and Bicknell, R. Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections: expression of VEGF in human endometrium. J. Pathol., 185: 402-408, 1998.
23. Fox, S. B., Leek, R. D., Weekes, M. P., Whitehouse, R. M., Gatter, K. C., and Harris, A. L. Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count and computer image analysis. J. Pathol., 177: 277-283, 1995.
24. Nagata, D., Hirata, Y., Suzuki, E., Kakoki, M., Hayakawa, H., Goto, A., Ishimitsu, T., Minamino, N., Ono, Y., Kangawa, K., Matsuo, H., and Omata, M. Hypoxia-induced adrenomedullin production in the kidney. Kidney Int., 55: 1259-1267, 1999.
25. Shweiki, D., Itin, A., Neufeld, G., Gitay-Goren, H., and Keshet, E. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J. Clin. Investig., 91: 2235-2243, 1993.
26. Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., and Semenza, G. L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol., 16: 4604-4613, 1996.
27. Cormier-Regard, S., Nguyen, S. V., and Claycomb, W. C. Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J. Biol. Chem., 273: 17787-17792, 1998.
28. Miller, M. J., Martinez, A., Unsworth, E. J., Thiele, C. J., Moody, T. W., Elsasser, T., and Cuttitta, F. Adrenomedullin expression in human tumor cell lines: its potential role as an autocrine growth factor. J. Biol. Chem., 271: 23345-23351, 1996.
29. Horio, T., Nishikimi, T., Yoshihara, F., Nagaya, N., Matsuo, H., Takishita, S., and Kangawa, K. Production and secretion of adrenomedullin in cultured rat cardiac myocytes and nonmyocytes: stimulation by interleukin-1β and tumor necrosis factor-α. Endocrinology, 139: 4576-4580, 1998.
30. Isumi, Y., Shoji, H., Sugo, S., Tochimoto, T., Yoshioka, M., Kangawa, K., Matsuo, H., and Minamino, N. Regulation of adrenomedullin production in rat endothelial cells. Endocrinology, 139: 838-846, 1998.
31. Sugo, S., Minamino, N., Shoji, H., Kangawa, K., Kitamura, K., Eto, T., and Matsuo, H. Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor α. Biochem. Biophys. Res. Commun., 203: 719-726, 1994.
32. Laird, S. M., Tuckerman, E. M., Saravelos, H., and Li, T. C. The production of tumour necrosis factor α (TNF-α) by human endometrial cells in culture. Hum. Reprod., 11: 1318-1323, 1996.
33. De, M., Sanford, T. H., and Wood, G. W. Detection of interleukin-1, interleukin-6 and tumor necrosis factor-α in the uterus during the second half of pregnancy in the mouse. Endocrinology, 131: 14-20, 1992.
34. Vikhlyaeva, E. M., Khodzhaeva, Z. S., and Fantschenko, N. D. Familial predisposition to uterine leiomyomas. Int. J. Gynaecol. Obstet., 51: 127-131, 1995.
35. Hickey, M., Lau, T. M., Russell, P., Fraser, I. S., and Rogers, P. A. Microvascular density in conditions of endometrial atrophy. Hum. Reprod., 11: 2009-2013, 1996.
36. Rees, M. C., Dunhill, M. S., Anderson, A. B., and Turnbull, A. C. Quantitative uterine histology during the menstrual cycle in relation to measured menstrual blood loss. Br. J. Obstet. Gynaecol., 91: 662-666, 1984.
37. Anania, C. A., Stewart, E. A., Quade, B. J., Hill, J. A., and Nowak, R. A. Expression of the fibroblast growth factor receptor in women with leiomyomas and abnormal uterine bleeding. Mol. Hum. Reprod., 3: 685-691, 1997.
38. Brown, N. S., and Bicknell, R. Thymidine phosphorylase 2-deoxy-D-ribose and angiogenesis. Biochem. J., 334: 1-8, 1998.
39. Zhang, H-T., and Bicknell, R. Therapeutic inhibition of angiogenesis. In: J. C. Murray (ed.), Methods in Molecular Medicine Angiogenesis-Reviews and Protocols. Totowa, NJ: Humana Press, 1998.
40. Kim, K. J., Li, B., Winer, J., Armani, M., Gillet, N., Phillips, H. S., and Ferrara, N. Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumor growth in vivo. Nature (Lond.), 362: 841-844, 1993.
41. Fraser, H. M., Dickson, S. E., Lunn, S. F., Morris, K. D., Carroll, V., and Bicknell, R. Suppression of luteal angiogenesis and pregnancy in the primate after neutralization of vascular endothelial growth factor: new prospects for manipulation of fertility, Endocrinology, 141: 995-1000, 2000.
42. Benjamin, L. E., Colijanin, D., Itin, A., Pode, D., and Keshet, E. Selective ablation of immature blood vessels in established human tumours follows vascular endothelial growth factor withdrawal. J. Clin. Investig., 103: 159-165, 1999.