Glucose-6-phosphatase catalytic enzyme inhibitors: Synthesis and in vitro evaluation of novel 4,5,6,7-tetrahydrothieno[3,2-c]- and -[2,3-c]pyridines

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 9, 2000, Pages 2277-2289

  Madsen, Peter ^a   Lundbeck, Jane M ^a   Jakobsen, Palle ^a   Varming, Annemarie R ^a   Westergaard, Niels ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

[4 (4 TRIFLUOROMETHYLPHENYL) 4,5,6,7 TETRAHYDROTHINO[3,2 C]PYRIDIN 5 YL] (4 METHOXYPHENYL)METHANONE; [7 (4 TRIFLUOROMETHYLPHENYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDIN 6 YL] (4 METHOXYPHENYL)METHANONE; ENZYME INHIBITOR; GLUCOSE 6 PHOSPHATASE; THIENO[2,3 C]PYRIDINE DERIVATIVE; THIENO[3,2 C]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; GLUCONEOGENESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; MICROSOME; NONHUMAN; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; GLUCOSE-6-PHOSPHATASE; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; MICROSOMES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; THIOPHENES;

EID: 0033898081     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00153-X     Document Type: Article

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