Acute inhibition of hepatic glucose-6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats. A pharmacological study with the chlorogenic acid derivative S4048

Journal of Biological Chemistry

Volumn 276, Issue 28, 2001, Pages 25727-25735

  Van Dijk, Theo H ^a   Van Der Sluijs, Fjodor H ^a   Wiegman, Coen H ^a   Baller, Julius F W ^a   Gustafson, Lori A ^b   Burger, Hans Joerg ^c   Herling, Andreas W ^c   Kuipers, Folkert ^a   Meijer, Alfred J ^b   Reijngoud, Dirk Jan ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYME INHIBITION; GLUCOSE;

GLUCONEOGENESIS;

BIOCHEMISTRY;

CHLOROGENIC ACID; DIHYDROXYACETONE; GALACTOSE; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCURONIDE; GLYCEROL; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; LACTIC ACID; MESSENGER RNA; PARACETAMOL; S 4048; UNCLASSIFIED DRUG; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE 6 PHOSPHATE HYDROLASE GENE; GLUCOSE 6 PHOSPHATE TRANSLOCASE GENE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCOGEN SYNTHASE GENE; GLYCOGEN SYNTHESIS; LIVER CELL CULTURE; MALE; NONHUMAN; PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRUVATE KINASE GENE; RAT; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; LIVER; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALIA;

ANIMALS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; ENZYME INHIBITORS; GLUCOSE; GLUCOSE-6-PHOSPHATASE; GLYCOGEN; IMIDAZOLES; LIVER; MALE; PYRIDINES; RATS; RATS, WISTAR;

EID: 0035854660     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101223200     Document Type: Article

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