Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6-phosphatase gene expression

Biochemical Journal

Volumn 357, Issue 3, 2001, Pages 867-873

  Schmoll, D ^a   Grempler, R ^a   Barthel, A ^a   Joost, H G ^a   Walther, R ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Diabetes; Gluconeogenesis; Insulin; Liver; Protein kinase B

Indexed keywords

ENZYME INHIBITION; INSULIN; MUTAGENESIS; PROTEINS;

HOMOEOSTASIS;

GENETIC ENGINEERING;

2 MORPHOLINO 8 PHENYLCHROMONE; GLUCOSE 6 PHOSPHATASE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL ESTER;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; HEPATOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; CELL CYCLE PROTEINS; ENZYME ACTIVATION; FLAVONOIDS; GENE EXPRESSION; GLUCOSE-6-PHOSPHATASE; IMMEDIATE-EARLY PROTEINS; INSULIN; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASE; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0035424541     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570867     Document Type: Article

References (24)

1. Regulation of glucose production by the liver
2. Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes
3. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats
4. Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin
5. Regulation of glucose-6-phosphatase gene expression by protein kinase Bα and the forkhead transcription factor FKHR: Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity
6. The PI3K-PDK1 connection: More than just a road to PKB
7. Mechanism of activation of protein kinase B by insulin and IGF-1
8. A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin
9. Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: Transcription factor FKHR binds the insulin response sequence
10. + influx, and protein kinase C activation in sustained cellular responses
11. Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
12. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
13. Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells
14. Signal transduction convergence: Phorbol esters and insulin inhibit phosphoenolpyruvate carboxykinase gene transcription through the same 10-base-pair sequence
15. Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway
16. Insulin-like growth factor binding protein-1: Recent findings and new directions
17. Mitogen-activated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes
18. Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1)
19. Specificity and mechanism of action of some commonly used protein kinase inhibitors
20. JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes
21. The amiloride-sensitive epithelial sodium channel α-subunit is transcriptionally down-regulated in rat parotid cells by the extracellular signal-regulated protein kinase pathway
22. Regulation of the glucose-6-phosphatase gene by glucose occurs by transcriptional and post-transcriptional mechanisms. Differential effect of glucose and xylitol
23. Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor
24. Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling