No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease

Annals of Neurology

Volumn 49, Issue 1, 2001, Pages 114-116

  Bertram, Lars ^a   Guénette, Suzanne ^a   Jones, Jennifer ^a   Keeney, Devon ^a   Mullin, Kristina ^b   Crystal, Adam ^b   Basu, Sanjay ^c   Yhu, Stephen ^a   Deng, Amy ^a   William Rebeck, G ^c   Hyman, Bradley T ^a   Go, Rodney ^d   McInnis, Melvin ^a   Blacker, Deborah ^c   Tanzi, Rudolph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN D;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; EXON; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

AGED; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; CATHEPSIN D; EXONS; GENOTYPE; HUMANS; LINKAGE (GENETICS); POLYMORPHISM, GENETIC;

EID: 0035109419     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(200101)49:1<114::AID-ANA18>3.0.CO;2-M     Document Type: Article

References (16)

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2. Degradation of Alzheimer's beta-amyloid protein by human cathepsin D
3. Cathepsin D displays in vitro beta-secretase-like specificity
4. Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction - Single strand conformational polymorphism analysis and possible consequences in cancer cells
5. Genetic polymor-phism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
6. A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease
7. Cathepsin D gene exon 2 polymorphism and sporadic Alzheimer's disease
8. Reliability and validity of NINCDS-ADRDA criteria for Alzheimer's disease
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13. The sib transmission/ disequilibrium test is a Mantel-Haenszel test
14. Alpha-2 macroglobulin is genetically associated with Alzheimer disease
15. A full genome scan for late onset Alzheimer's disease
16. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis