Intracellular cell-autonomous association of Notch and its ligands: A novel mechanism of Notch signal modification

Developmental Biology

Volumn 241, Issue 2, 2002, Pages 313-326

  Sakamoto, Kei ^a   Ohara, Osamu ^b   Takagi, Minoru ^a   Takeda, Shinichi ^c   Katsube, Ken ichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Association; Cell autonomous; Delta; Notch; Serrate

Indexed keywords

EPIDERMAL GROWTH FACTOR; LIGAND; NOTCH RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; CELL PROLIFERATION; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; GENE DELETION; GENE OVEREXPRESSION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0037081076     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0517     Document Type: Article

References (79)

1. Molecular genetics of Delta, a locus required for ectodermal differentiation in Drosophila
2. The Notch locus and the cell biology of neuroblast segregation
3. Notch signaling: Cell fate control and signal integration in development
4. Transient and restricted expression during mouse embryogenesis of DII1, a murine gene closely related to Drosophila Delta
5. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
6. Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila
7. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
8. Ligand-induced signaling in the absence of furin processing of Notch1
9. Lateral inhibition and cell fate during neurogenesis in Drosophila: The interactions between scute, Notch and Delta
10. Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: Epidermogenesis or neurogenesis
11. Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta
12. Notch1 is required for the coordinate segmentation of somites
13. The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe
14. Conservation of the Notch signalling pathway in mammalian neurogenesis
15. Early events in insect neurogenesis. I. Development and segmental differences in the pattern of neuronal precursor cells
16. Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells
17. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
18. Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo
19. The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster
20. Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1
21. LIN-12/Notch signaling: Lessons from worms and flies
22. Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans
23. Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo
24. Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
25. A dual function of the Notch gene in Drosophila sensillum development
26. The choice of cell fate in the epidermis of Drosophila
27. Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions
28. Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina
29. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
30. Maintenance of somite borders in mice requires the Delta homologue DII1
31. A dominant-negative form of Serrate acts as a general antagonist of Notch activation
32. Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila
33. Signalling downstream of activated mammalian Notch
34. Delta-1 activation of notch-1 signaling results in HES-1 transactivation
35. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
36. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
37. The Notch-Hes pathway in mammalian neural development
38. Structure and distribution of the Notch protein in developing Drosophila
39. Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing
40. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis
41. Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: Members of the Notch signalling pathway in Drosophila
42. Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development
43. The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
44. Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
45. Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation
46. The scabrous protein can act as an extracellular antagonist of notch signaling in the Drosophila wing
47. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
48. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
49. Jagged: A mammalian ligand that activates Notch1
50. The Notch1 receptor is cleaved constitutively by a furin-like convertase
51. Human deltex is a conserved regulator of Notch signalling
52. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
53. Inhibition of granulocytic differentiation by mNotch1
54. Fringe is a glycosyltransferase that modifies Notch
55. A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis
56. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
57. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
58. Fringe modulates Notch-ligand interactions
59. Scabrous complexes with Notch to mediate boundary formation
60. Processing of the notch ligand delta by the metalloprotease Kuzbanian
61. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor
62. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
63. Ectopic expression of lunatic Fringe leads to downregulation of Serrate-1 in the developing chick neural tube; analysis using in ovo electroporation transfection technique
64. Identification of a chick homologue of Fringe and C-Fringe 1: Involvement in the neurogenesis and the somitogenesis
65. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
66. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
67. Lateral inhibition during vulval induction in Caenorhabditis elegans
68. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins
69. Nuclear access and action of notch in vivo
70. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
71. The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands
72. Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element
73. Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb
74. Notch and wingless regulate expression of cuticle patterning genes
75. Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats
76. The Notch locus and the genetic circuitry involved m early Drosophila neurogenesis
77. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
78. glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins
79. The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch