The CD154-CD40 costimulatory pathway in transplantation

Transplantation

Volumn 73, Issue 1 SUPPL., 2002, Pages

  Yamada, Akira ^a   Sayegh, Mohamed H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ALLOIMMUNITY; APOPTOSIS; AUTOIMMUNE DISEASE; BIOLOGICAL MODEL; CLONAL ANERGY; CONFERENCE PAPER; GRAFT SURVIVAL; HUMAN; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SKIN TRANSPLANTATION; T LYMPHOCYTE ACTIVATION; THROMBOEMBOLISM; TRANSPLANTATION TOLERANCE; TREATMENT OUTCOME; VASCULAR DISEASE;

EID: 0037080947     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200201151-00012     Document Type: Conference Paper

References (50)

1. The role of T-cell costimulatory activation pathways in transplant rejection
2. CD40-gp39 interactions play a critical role during allograft rejection: Suppression of allograft rejection by blockade of the CD40-gp39 pathway
3. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
4. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
5. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
6. The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo
7. + T cells contribute to the development of transplant arteriosclerosis despite CD 154 blockade
8. + T cells
9. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis
10. Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allografts
11. + T cells and prolonged graft survival in a CTLA4-dependent manner
12. + T cells can trigger allograft rejection
13. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand
14. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
15. NOD mice have a generalized defect in their response to transplantation tolerance induction
16. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: Absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice
17. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance
18. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
19. Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning
20. Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models
21. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4
22. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
23. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival
24. Il-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
25. + T cell tolerance and linked suppression
26. Cutting edge: Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance
27. Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo
28. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
29. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
30. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
31. Activation-induced death of mature T cells in the regulation of immune responses
32. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
33. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
34. Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice
35. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
36. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens
37. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
38. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
39. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
40. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
41. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death
42. Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain
43. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
44. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
45. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
46. Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154
47. Costimulatory blockade for induction of mixed chimerism and renal allograft tolerance in nonhuman primates
48. Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection
49. T cell co-stimulatory molecules other than CD28
50. The role of novel T cell costimulatory pathways in autoimmunity and transplantation