Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine- rich region within IL-2 receptor βc chain

Blood

Volumn 88, Issue 11, 1996, Pages 4118-4123

  Adachi, Masaaki ^a   Sekiya, Masuo ^b   Torigoe, Toshihiko ^b   Takayama, Shinichi ^b   Reed, John C ^b   Miyazaki, Tadaaki ^b   Minami, Yasuhiro ^b   Taniguchi, Tadatsugu ^b   Imai, Kohzoh ^b  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA FRAGMENT; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA; MUTANT PROTEIN; PROTEIN TYROSINE KINASE; RAPAMYCIN;

ANIMAL CELL; ARTICLE; BETA CHAIN; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DNA DETERMINATION; ENZYME ACTIVATION; GENE DELETION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE TRANSFER; HEMATOPOIETIC CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0029909769     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.11.4118.4118     Document Type: Article

References (24)

1. Tsujimoto Y, Cossman J, Jaffe E, Croce C: Involvement of the bcl-2 gene in human follicular lymphoma. Science 228:1440, 1985
2. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1, 1994
3. Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC: Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity. Cell 80:279, 1995
4. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K: Cloning of the y chain of the human IL-2 receptor. Science 257:379, 1992
5. Hatakeyama M, Mori H, Doi T, Taniguchi T: A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization. Cell 59:837, 1989
6. Shibuya H, Yoneyama M, Ninomiya-Tsuji J, Matsumoto K, Taniguchi T: IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc. Cell 70:57, 1992
7. Reed JC, Tsujimoto Y, Alpers JD, Croce CM, Nowell PC: Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. Science 236:1295, 1987
8. Deng G, Podack ER: Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2. Proc Natl Acad Sci USA 90:2189, 1993
9. Miyazaki T, Liu Z-J, Kawahara A, Minami Y, Yamada K, Tsujimoto Y, Barsoumian EL, Perlmutter RM, Taniguchi T: Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81:223, 1995
10. Kawahara A, Minami Y, Miyazaki T, Ihle JN, Taniguchi T: Critical role of the interleukin 2 (IL-2) receptor γ-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. Proc Natl Acad Sci USA 92:8724, 1995
11. 2+/calmodulin-dependent protein kinase II. J Biol Chem 265:4315, 1990
12. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S-I, Itoh N, Shibuya M, Fukami Y: Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592, 1978
13. Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807, 1991
14. Tsujimoto Y, Croce CM: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 83:5214, 1986
15. Adachi M, Sekiya M, Isobe M, Kumura Y, Ogita Z-I, Hinoda Y, Imai K, Yachi A: Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP. Biochem Biophys Res Commun 186:1607, 1992
16. Adachi M, Torigoe T, Sekiya M, Minami Y, Taniguchi T, Hinoda Y, Yachi A, Reed JC, Imai K: IL-2-induced gene expression of protein-tyrosine phosphatase LC-PTP requires acidic and serinerich regions within IL-2 receptor β chain. FEBS Lett 372:113, 1995
17. Minami Y, Nakagawa Y, Kawahara A, Miyazaki T, Sada K, Yamamura H, Taniguchi T: Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: Possible link with the c-myc induction pathway. Immunity 2:1, 1995
18. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu Z-J, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN, Taniguchi T: Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045, 1994
19. Sato T, Hanada M, Bodrug S, Irie S, Iwana N, Boise LH, Thompson CB, Golemis E, Fong L, Wang H-G, Reed JC: Interaction among members of the bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci USA 91:9238, 1994
20. Zha H, Aimé-Sempé C, Sato T, Reed JC: Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2. J Biol Chem 271:7440, 1996
21. Rechsteiner M: Natural substrates of the ubiquitin proteolytic pathway. Cell 66:615, 1991
22. Wang HG, Miyashita T, Takayama S, Sato T, Torigoe T, Krajewski S, Tanaka S, Hovey L, Troppmair J, Rapp UR, Reed JC: Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene 9:2751, 1994
23. Taniguchi T: Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251, 1995
24. Hartley KO, Cell D, Smith GCM, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW, Jackson SP: DNA-dependent kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82:849, 1995