Intragraft interleukin-4 mRNA expression after short-term CD154 blockade may trigger delayed development of transplant arteriosclerosis in the absence of CD8+ T cells

Transplantation

Volumn 70, Issue 6, 2000, Pages 955-963

  Ensminger, Stephan M ^a   Spriewald, Bernd M ^a   Witzke, Oliver ^a   Morrison, Karen ^b   Van Maurik, Andre ^a   Morris, Peter J ^a   Rose, Marlene L ^b   Wood, Kathryn J ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HAREFIELD HOSPITAL   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND MONOCLONAL ANTIBODY; CD8 ANTIGEN; IMMUNOGLOBULIN G1; INTERLEUKIN 4; MESSENGER RNA; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTERIOSCLEROSIS; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOMODULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; T LYMPHOCYTE ACTIVATION;

EID: 0034721482     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200009270-00013     Document Type: Article

References (35)

1. CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection
2. CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression
3. Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection
4. CD8+ T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade
5. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
6. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
7. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
8. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
9. Monoclonal xenogeneic antibodies to murine cell surface antigens: Identification of novel leukocyte differentiation antigens
10. Development of a mouse aortic transplant model of chronic rejection
11. Mechanisms of tolerance induction after intrathymic islet injection: Determination of the fate of alloreactive thymocytes
12. Tolerance induction ameliorates allograft vasculopathy in rat aortic transplants: Influence of Fas-mediated apoptosis
13. Donor resting B cells induce indefinite prolongation of fully allogeneic cardiac grafts when delivered with anti-immunoglobulin-D monoclonal antibody: Evidence for tolerogenicity of donor resting B cells in vivo
14. Constructing poly-competitor cDNAs for quantitative PCR
15. Chronic rejection and its risk factors
16. Current knowledge of the pathogenesis of chronic allograft dysfunction
17. Chronic rejection: An update on the mechanism
18. Transplantation tolerance: Putting the pieces together
19. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
20. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB
21. The Th1/Th2 paradigm and the allograft response
22. T cell regulation in adult transplantation tolerance
23. Evidence for immune regulation in the induction of transplantation tolerance: A conditional but limited role for IL-4
24. Chronic allograft rejection
25. Predominant expression of T helper 2 cytokines and altered expression of T helper 1 cytokines in long-term allograft survival induced by intrathymic immune modulation with donor class I major histocompatibility complex peptides
26. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
27. Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection
28. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
29. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
30. Tissue-specific expression of interleukin-4 induces extracellular matrix accumulation and extravasation of B cells
31. Problem of chronic rejection
32. Interferon-γ elicits arteriosclerosis in the absence of leukocytes
33. Immunoregulation by interleukin-12
34. In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection
35. Synergism between tumor necrosis factor-alpha and interferon-γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism