High-throughput analytical techniques for reaction optimization

Drug Discovery Today

Volumn 7, Issue 2, 2002, Pages 139-142

  Congreve, Miles S ^a   Jamieson, Craig ^b  

^a ASTEX PHARMACEUTICALS   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTIC METHOD; CATALYSIS; CATALYST; ENZYME LINKED IMMUNOSORBENT ASSAY; FOURIER TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED PHOTOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; REACTION OPTIMIZATION; REVIEW; SCREENING; ULTRAVIOLET SPECTROSCOPY; ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; INFRARED SPECTROPHOTOMETRY; INFRARED SPECTROSCOPY; ORGANIZATION AND MANAGEMENT; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HECK REACTION; STOICHIOMETRY;

COMBINATORIAL CHEMISTRY TECHNIQUES; PHARMACEUTICAL PREPARATIONS; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTRUM ANALYSIS, MASS; MASS SPECTROMETRY;

DRUG; COUMARIN; FLUORESCENT DYE;

EID: 0037079605     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)02094-3     Document Type: Review

References (40)

1. Combinatorial and evolution-based methods in the creation of enantioselective catalysts
2. Combinatorial materials science and catalysis
3. Enantioselective enzymes for organic synthesis created by directed evolution
4. Rapid optimization of organic reactions on solid phase using the multipin approach: Synthesis of 4-aminoproline analogues by reductive amination
5. Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array
6. Phosphatase catalysis developed via combinatorial organic chemistry
7. New catalysts and conditions for a C-H insertion reaction identified by high throughput catalyst screening
8. A parallel combinatorial approach to locating homochiral Lewis acid catalysts for the asymmetric aza-Diels-Alder reaction of an imino dienophile
9. A general solid-phase synthesis strategy for the preparation of 2-pyrrolidinemethanol ligands
10. Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides
11. Schiff base catalysts for the asymmetric Strecker reaction identified and optimized from parallel synthetic libraries
12. Discovery of novel catalysts for alkene epoxidation from metal-binding combinatorial libraries
13. A practical approach to accelerated process screening and optimisation
14. A rapid approach for the optimisation of polymer supported reagents in synthesis
15. Design and optimization of new phosphine oxazoline ligands via high-throughput catalyst screening
16. Enantioselective synthesis of arylamines through Zr-catalyzed addition of dialkylzincs to imines. Reaction development by screening of parallel libraries
17. A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double-stranded DNA
18. One-pot multi-substrate screening in asymmetric catalysis
19. Catalytic diastereoselective reductive Aldol reaction: Optimization of interdependent reaction variables by arrayed catalyst evaluation
20. Palladium-catalyzed hydroamination of 1,3-dienes: A colorimetric assay and enantioselective additions
21. Transition metal-catalyzed addition of amines to acrylic acid derivatives. A high-throughput method for evaluating hydroamination of primary and secondary alkylamines
22. Reactive dyes as a method for rapid screening of homogeneous catalysts
23. A chemosensor-based approach to catalyst discovery in solution and on solid support
24. A fluorescence-based assay for high throughput screening of coupling reactions. Application to Heck chemistry
25. Screening of homogeneous catalysts by fluorescence resonance energy transfer. Identification of catalysts for room-temperature Heck reactions
26. Solid-phase synthesis and encoding strategies for olefin polymerization catalyst libraries
27. A method for high-throughput screening of enantioselective catalysts
28. Measurement of enatiomeric excess by kinetic resolution and mass spectrometry
29. Time-resolved IR-thermographic detection and screening of enantioselectivity in catalytic reactions
30. IR-thermographic screening of thermoneutral or endothermic transformations: The ring-closing olefin metathesis reaction
31. Thermographic selection of effective catalysts from an encoded polymer-bound library
32. Super-high-throughput screening of enantioselective catalysts by using capillary array electrophoresis
33. Super high throughput screening (SHTS) of chiral ligands and activators: Asymmetric activation of chiral diol-zinc catalysts by chiral nitrogen activators for the enantioselective addition of diethylzinc to aldehydes
34. Selection of enantioselective acyl transfer catalysts from a pooled peptide library through a fluorescence based activity assay
35. A comparison of various FTIR and FT Raman methods: Applications in the reaction optimization stage of combinatorial chemistry
36. Mechanistic insights into Cu-catalyzed asymmetric aldol reactions: Chemical and spectroscopic evidence for a metalloenolate intermediate
37. Rapid reaction scanning of solid phase chemistry using resins incorporating analytical constructs
38. Analysis of solid-phase reactions: Product identification and quantification by use of UV-chromophore-containing dual-linker analytical constructs
39. Digital light-directed synthesis. A microarray platform that permits rapid reaction optimization on a combinatorial basis
40. Discovery and optimization of heterogeneous catalysts by using combinatorial chemistry