Digital light-directed synthesis. A microarray platform that permits rapid reaction optimization on a combinatorial basis

Journal of Combinatorial Chemistry

Volumn 2, Issue 4, 2000, Pages 349-354

  LeProust, Eric ^a   Pellois, Jean Philippe ^a   Yu, Peilin ^a   Zhang, Hua ^a   Gao, Xiaolian ^a   Srivannavit, Onnop ^b   Gulari, Erdogan ^b   Zhou, Xiaochuan ^c  

^a University of Houston   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c Xeotron Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE;

ARTICLE; CHEMISTRY; DRUG DESIGN; METHODOLOGY; ORGANIC CHEMISTRY; PHOTOCHEMISTRY; SOLUTION AND SOLUBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CHEMISTRY, ORGANIC; DRUG DESIGN; NUCLEOTIDES; PHOTOCHEMISTRY; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034218627     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc000009x     Document Type: Article

References (20)

1. Numerous reviews and books are present. Representative ones are (a) Combinatorial peptide and nonpeptide libraries; Jung, G., Ed.; VCH: New York, 1996.
2. (b) Dolle, R. E. Mol. Diversity 1998, 3, 199-233.
3. (c) Dolle, R. E.; Nelson, K. H., Jr. J. Comb. Chem. 1999, 1, 235-282.
4. (d) Lebl, M. J. Comb. Chem. 1999, 1, 3-24.
5. Instrument development will be described in a separate publication.
6. Gao, X.; Yu, P.; LeProust, E.; Sonigo, L.; Pellois, J. P.; Zhang, H. J. Am. Chem. Soc. 1998, 120, 12698-12699.
7. (a) Willson, C. G. In Organic Resist Materials in Introduction to Microlithography, 2nd ed.; Thompson, L. F., Willson, C. G., Bowden, M. J., Eds.; ACS Professional Reference Book: New York, 1994; pp 216-267.
8. (b) Beecher, J. E.; McGall, G. H.; Goldberg, M. Polym. Mater. Sci. Eng. 1997, 76, 394-395.
9. (c) Beecher, J. E.; McGall, G. H.; Goldberg, M. Polym. Mater. Sci. Eng. 1997, 76, 597-598.
10. (d) Wallraff, G.; Labadie, J.; Brock, P.; DiPietro, R.; Nguyen, T.; Huynh, T.; Hinsberg, W.; McGall, G. Chemtech 1997, 27, 22-32.
11. Brennan, T. M. Method and apparatus for conducting an array of chemical reactions on a support surface. U.S. Patent 5,474,796.
12. Madou M. In Fundamentals of Microfabrication; CRC Press: Boca Raton, FL, 1997.
13. Pintchovski, F.; Price, J. B.; Tobin, P. J.; Peavy, J.; Kobold, K. J. Electrochem. Soc. 1979, 126, 1428-1431.
14. Arkles, B. Chemtech 1977, 7, 766-778.
15. McBride, L. J.; Caruthers, M. H. Tetrahedron Lett. 1983, 24, 245-248.
16. McGall, G. H.; Barone, A. D.; Diggelmann, M.; Fodor, S. P. A.; Gentalen, E.; Ngo, N. J. Am. Chem. Soc. 1997, 119, 5081-5090.
17. Oligonucleotides of various sequences, including a 21-mer sequence of the hCMV gene and 30-mer gene probes, have been prepared. Their analysis indicates a high quality of the synthesis that is comparable to that of the TCA products.
18. (a) Fodor, S. P. A.; Leighton, J.; Pirrung, M. C.; Stryer, L.; Lu, A. T.; Solas, D. Science 1991, 251, 767-773.
19. (b) Pellois, J. P.; Wang, W.; Gao, X. J. Comb. Chem. 2000, 2, 355-360.
20. Cameron, J. F.; Fréchet, J. M. J. J. Am. Chem. Soc. 1991, 113, 4303-4313.