SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin

Archives of Dermatological Research

Volumn 289, Issue 9, 1997, Pages 540-546

  Reynolds, N J ^a,c   McCombie, S W ^b   Shankar, B B ^b   Bishop, W R ^b   Fisher, G J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Epidermal hyperplasia; Inflammation; Mouse skin; SCH 47112; TPA

Indexed keywords

PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN KINASE C; SCG 47112; STAUROSPORINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; DERMIS; ENZYME ACTIVATION; ENZYME INHIBITION; EPIDERMIS; EPIDERMIS HYPERPLASIA; HUMAN; HUMAN CELL; KERATINOCYTE; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PSORIASIS; SKIN BIOPSY; SKIN INFLAMMATION; THICKNESS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; ENZYME INHIBITORS; EPIDERMIS; HUMANS; HYPERPLASIA; KERATINOCYTES; MALE; MICE; MICE, INBRED HRS; MOLECULAR STRUCTURE; PROTEIN KINASE C; STAUROSPORINE; TETRADECANOYLPHORBOL ACETATE;

EID: 0030839618     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004030050236     Document Type: Article

References (35)

1. Hawley-Nelson P, Stanley JR, Schmidt J, Gullino M, Yuspa SH (1982) The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate accelerates keratinocyte differentiation and stimulates growth of an unidentified cell type in cultured human epidermis. Exp Cell Res 137:155-167
2. Jetten AM, George MA, Pettit GR, Herald CL, Rearick JI (1989) Action of phorhol esters, bryostatins, and retinoic acid on cholesterol sulfate synthesis: relation to the mullistep process of differentiation in human epidermal keratinocytes. J Invest Dermatol 93:108-115
3. Gupta AK, Fisher GJ, Elder JT, Talwar HS, Esmann J, Duell EA, Nickoloff BJ, Voorhees JJ (1989) Topical cyclosporine A inhibits the phorbol ester induced hyperplastic inflammatory response but not protein kinase C activation in mouse epidermis. J Invest Dermatol 93:379-386
4. Dlugosz M, Yuspa SH (1993) Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C. J Cell Biol 120: 217-225
5. Barker JN, Mitra RS, Griffiths CE, Dixit VM, Nickoloff BJ (1991) Keratinocytes as initiators of inflammation. Lancet 337: 211-214
6. Fisher GJ, Talwar HS, Baldassare JJ, Henderson PA, Voorhees JJ (1990) Increased phospholipase C-catalyzed hydrolysis of phosphatidylinositol-4,5-bisphosphate and 1,2-sn-diacylglycerol content in psoriatic involved compared to uninvolved and normal epidermis. J Invest Dermatol 95:428-435
7. Fisher GJ, Tavakkol A, Leach K, Burns K, Basta P, Loomis C, Griffiths CEM, Cooper KD, Reynolds NJ, Elder JT, Livneh E, Voorhees JJ (1993) Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin. J Invest Dermatol 101:553-559
8. Rasmussen HH, Celis JE (1993) Evidence for an altered protein kinase C (PKC) signaling pathway in psoriasis. J Invest Dermatol 101:560-566
9. Wilson E, Olcott MC, Bell RM, Merrill AJ, Lambeth JD (1986) Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. J Biol Chem 261:12616-12623
10. Hannun YA, Loomis CR, Merrill AJ, Bell RM (1986) Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem 261:12604-12609
11. Gupta AK, Fisher GJ, Elder JT, Nickoloff BJ, Voorhees JJ (1988) Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin. J Invest Dermatol 91:486-491
12. Jefferson AB, Schulman H (1988) Sphingosine inhibits calmodulin-dependent enzymes. J Biol Chem 263:15241-15244
13. Areces LB, Kazanietz-MG, Blumberg PM (1994) Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors. J Biol Chem 269:19553-19558
14. ++-dependent protein kinase. Biochem Biophys Res Commun 135:397-402
15. Nakadate T, Jeng AY, Blumberg PM (1988) Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action. Biochem Pharmacol 37:1541-1545
16. Yumamoto S, Kiyoto I, Aizu E, Nakadate T, Hosoda Y, Kato R (1989) Differential inhibition by staurosporine, a potent protein kinase C inhibitor, of 12-O-tetradecanoylphorbol-13-acetate-caused skin tumor promotion, epidermal ornithine decarboxylase induction, hyperplasia and inflammation. Carcinogenesis 10:1315-1322
17. Dlugosz AA, Yuspa SH (1991) Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro. Cancer Res 51:4677-4684
18. Davis PD, Hill CH, Keech E, Lawton G, Nixon JS, Sedgwick AD, Wadsworth J, Westmacott D, Wilkinson SE (1989) Potent selective inhibitors of protein kinase C. FEBS Lett 259:61-63
19. Dieter P, Fitzke E (1991) RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages. Biochem Biophys Res Commun 181:396-401
20. Toullec D, Pianett LP, Coste H, Bellevergue P, Grand PT, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, et al. (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-15781
21. Ishli H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL (1996) Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272:728-731
22. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268: 9194-9197
23. Gschwendt M, Furstenberger G, Leibersperger H, Kittstein W, Lindner D, Rudolph C, Barth H, Kleinschroth J, Marme D, Schachtele C, Marks F (1995) Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo. Carcinogenesis 16:107-111
24. McCombie SW, Bishop RW, Carr D, Dobek E, Kirkup P, Kirschmeier P, Lin SI, Petrin J, Rosinski K, Shankar BB, Wilson O (1993) Indolocarbazole. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c. Biomed Chem Lett 3:1537-1542
25. Vice SF, Bishop WR, McCombie SW, Dao H, Frank E, Ganguly AK (1994) Indolocarbazole nitrogens linked by three-atom bridges: a potent new class of PKC inhibitors. Biomed Chem Lett 4:1333-1338
26. Maruyama IN, Brenner S (1991) A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proc Natl Acad Sci USA 88:5729-5733
27. Fisher GJ, Esmann J, Griffiths CE, Talwar HS, Duell EA, Hammerberg C, Elder JT, Karabin GD, Nickoloff BJ, Cooper KD, Voorhces JJ (1991) Cellular, immunologic and biochemical characterization of topical retinoic acid-treated human skin. J Invest Dermatol 96:699-707
28. Babich H, Borenfreund H (1987) Structure-activity relationship (SAR) models established in vitro with the neutral red cytotoxicity assay. Toxicol In Vitro 1:3-9
29. Michel S, Courseaux A, Miquel C, Bernardon JM, Schmidt R, Shroot B, Thacher SM, Reichert U (1991) Determination of retinoid activity by an enzyme-linked immunosorbent assay. Anal Biochem 192:232-236
30. Reynolds NJ, Fisher GJ, Griffiths CE, Tavakkol A, Talwar HS, Rowse PE, Hamilton TA, Voorhees JJ (1993) Retinoic acid metabolites exhibit biological activity in human keratinocytes, mouse melanoma cells and hairless mouse skin in vivo. J Pharmacol Exp Ther 266:1636-1642
31. Jones KT, Sharpe GR (1994) Staurosporine, a non-specific PKC inhibitor, induces keratinocyte differentiation and raises intracellular calcium, but Ro31-8220, a specific inhibitor, does not. J Cell Physiol 159:324-330
32. Kuchera S, Barth H, Jacobson P, Metz A, Schaechtele C, Schrier D (1993) Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino)propyl]-1 H-indol-3-yl]4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model. Agents Actions 39:C169-C173
33. Horn F, Marks F, Fisher GJ, Marcelo CL, Voorhees JJ (1987) Decreased protein kinase C activity in psoriatic versus normal epidermis. J Invest Dermatol 88:220-222
34. Bergers M, van de Kerkhof PC, Happle R, Mier PD (1990) Membrane-bound phospholipase C activity in normal and psoriatic epidermis. Acta Derm Venereol (Stockh) 70:57-59
35. Hegemann L, Fruchtmann R, Rooijen LA van, Muller-Peddinghaus R, Mahrle G (1992) The antipsoriatic drug, anthralin, inhibits protein kinase C - implications for its mechanism of action. Arch Dermatol Res 284:179-183