New type of metalloproteinase inhibitor: Design and synthesis of new phosphonamide-based hydroxamic acids

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 919-929

  Sawa, Masaaki ^a,b   Kiyoi, Takao ^b   Kurokawa, Kiriko ^b   Kumihara, Hiroshi ^b   Yamamoto, Minoru ^b   Miyasaka, Tomohiro ^b   Ito, Yasuko ^b   Hirayama, Ryoichi ^b   Inoue, Tomomi ^b   Kirii, Yasuyuki ^b   Nishiwaki, Eiji ^b   Ohmoto, Hiroshi ^b   Maeda, Yu ^b   Ishibushi, Etsuko ^b   Inoue, Yoshimasa ^b   Yoshino, Kohichiro ^b   Kondo, Hirosato ^c  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b Nippon Organon KK   (Japan)

^c SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; GELATINASE B; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HYDROXAMIC ACID DERIVATIVE; INTERSTITIAL COLLAGENASE; METALLOPROTEINASE INHIBITOR; PHOSPHONAMIDE DERIVATIVE; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; COMPUTER MODEL; CONTROLLED STUDY; DIASTEREOISOMER; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; FIBROSARCOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

AMIDES; CRYSTALLOGRAPHY, X-RAY; EPIDERMAL GROWTH FACTOR; HUMANS; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; PHOSPHONIC ACIDS; PROTEASE INHIBITORS; PROTEIN BINDING; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037075135     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0103211     Document Type: Article

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