Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 6, 2001, Pages 833-835

  Reichenberg, Armin ^a   Wiesner, Jochen ^a,b   Weidemeyer, Claus ^a   Dreiseidler, Erhard ^a   Sanderbrand, Silke ^a,b   Altincicek, Boran ^a,b   Beck, Ewald ^b   Schlitzer, Martin ^c   Jomaa, Hassan ^a  

^a Jomaa Pharmaka GmbH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 3 (N ACETYL N HYDROXYAMINO)PROPYLPHOSPHONIC ACID; BIS(2 METHYLPHENYL)ESTER; BIS(4 METHOXYPHENYL)ESTER; DIPHENYL ESTER; ESTER DERIVATIVE; FOSMIDOMYCIN; ISOMERASE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; MALARIA; MOUSE; NONHUMAN; PLASMODIUM VINCKEI;

ALDOSE-KETOSE ISOMERASES; ANIMALS; ANTIMALARIALS; DISEASE MODELS, ANIMAL; FOSFOMYCIN; MALARIA; MICE; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; PHOSPHONIC ACIDS; PLASMODIUM; PRODRUGS; TREATMENT OUTCOME;

PLASMODIUM VINCKEI; RODENTIA;

EID: 0035953022     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00075-0     Document Type: Article

References (14)