Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor protein

Neuroscience

Volumn 113, Issue 4, 2002, Pages 785-796

  Bates, K A ^a   Fonte, J ^a   Robertson, T A ^a   Martins, R N ^a   Harvey, A R ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

amyloid; Apolipoprotein E; Astrogliosis; Presenilin 1; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; M PROTEIN; MUTANT PROTEIN; PROTEIN PRECURSOR; PROTEIN PRESENILIN 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN GRAFT; CELL ACTIVITY; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; EXTRACELLULAR SPACE; GLIOSIS; HETEROTOPIC TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; IMPLANT; MESENCEPHALON; MOUSE; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, NEWBORN; APOLIPOPROTEINS E; BRAIN TISSUE TRANSPLANTATION; CEREBRAL CORTEX; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; EMBRYO; FEMALE; FETAL TISSUE TRANSPLANTATION; GLIOSIS; HUMANS; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PREGNANCY; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 0037055981     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00230-0     Document Type: Article

References (74)

1. Bancroft, J.D., Stevens, A., 1982. Theory and Practice of Histological Techniques. Churchill Livingstone, London, p. 163.
2. Boyles J.K., Pitas R.E., Wilson E., Mahley R.W., Taylor J.M. Apolipoprotein E associated with astrocytic glia of the central nervous system. J. Clin. Invest. 76:1985;1501-1513.
3. Breitner J.C., Gau B.A., Welsh K.A., Plassman B.L., McDonald W.M., Helms M.J., Anthony J.C. Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin study. Neurology. 44:1994;227-232.
4. Broe G.A., Henderson A.S., Creasey H., McCusker E., Korten A.E., Jorm A.F., Longley W., Anthony J.C. A case control study of Alzheimer's disease in Australia. Neurology. 40:1999;1698-1707.
5. Casadei V.M., Ferri C., Veglia F., Gavazzi A., Salani G., Cattaneo M., Sorbi S., Annoni G., Licastro F., Mariani C., Franceschi M., Grimaldi L. APOE-491 promoter polymorphism is a risk factor for late onset Alzheimer's disease. Neurology. 53:1999;1888-1889.
6. Castillo G.M., Ngo C., Cummings J., Wight T.N., Snow A.D. Perlecan binds to the β-amyloid proteins (Aβ) of Alzheimer's disease, accelerates Aβ fibril formation, and maintains Aβ fibril stability. J. Neurochem. 69:1997;2452-2465.
7. Chan C.W., Dharmarajan A., Atwood C.S., Huang X., Tanzi R.E., Bush A.I., Martins R.N. Anti-apoptotic action of Alzheimer Aβ Alzheimer's Rep. 2:1999;113-119.
8. Christen Y. Oxidative stress and Alzheimer's disease. Am. J. Clin. Nutr. 71:(Suppl.):2000;621S-629S.
9. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
10. Davis E.J., Foster T.D., Thomas W.E. Cellular forms and function of brain microglia. Brain Res. Bull. 34:1994;73-78.
11. Du Y., Dodel R.C., Eastwood B.J., Bales K.R., Gao F., Lohmuller F., Muller U., Kurz A., Zimmer R., Evans R.M., Hake A., Gasser T., Oertel W.H., Griffin W.S.T., Paul S., Farlow M.R. Association of an interleukin-1α polymorphism with Alzheimer's disease. Neurology. 455:2000;480-484.
12. Dyrks T., Dyrks E., Masters C.L., Beyreuther K. Amyloidogenicity of rodent and human βA4 sequences. FEBS Lett. 324:1993;231-236.
13. Eddleston M., Mucke L. Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience. 54:1993;15-36.
14. Emilien G., Beyreuther K., Masters C.L., Maloteaux J.-M. Prospects for pharmacological intervention in Alzheimer's disease. Arch. Neurol. 57:2000;454-459.
15. Gentleman S.M., Graham D.I., Roberts G.W. Molecular pathology of head trauma: altered βAPP metabolism and the aetiology of Alzheimer's disease. Prog. Brain. Res. 96:1993;237-246.
16. Geula C., Wu C.-K., Saroff D., Lorenzo A., Yuan M., Yankner B.A. Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nature Med. 4:1998;827-830.
17. Giulian D. Microglia and the immune pathology of Alzheimer's disease. Am. J. Hum. Genet. 65:1999;13-18.
18. Goate A., Chartier-Harlin M.C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., Mant R., Newton P., Rook K., Rogues P., Talbot C., Pericak-Vance M., Roses A., Williamson R., Rossor M., Owen W., Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706.
19. Guo Z., Cuppels L.A., Kurz A., Auerbach S.H., Volicer L., Chui H., Green R.C., Sadovnick A.D., Durara R., DeCarli C., Johnson K., Go R.C., Growdon J.H., Haines J.L., Kukull W.A., Farrer L.A. Head injury and risk of AD in the MIRAGE study. Neurology. 54:2000;1316-1323.
20. Hartley D.M., Walsh D.M., Chianping P.Y., Diehl T., Vasquez S., Vassilev P.M., Teplow D.B., Selkoe D.J. Protofibrillar intermediates if amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J. Neurosci. 19:1999;8876-8884.
21. Harvey A.R., Kendall C.L., Sykovà E. The status and organisation of astrocytes, oligodendroglia and microglia in grafts of fetal cerebral cortex. Neurosci. Lett. 228:1997;58-62.
22. Hauss-Wergrzyniak B., Dobrzanski P., Stoehr J.D., Wenk G.L. Chronic inflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain Res. 780:1998;294-303.
23. Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., Sanders S., Zehr C., O'Campo K., Hardy J., Prada C.M., Eckman C., Younkin S., Hsiao K., Duff K. Accelerated Alzheimer's-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Med. 4:1998;97-100.
24. Holtzman D.M., Bales K.R., Tenkova T., Fagan A.M., Parsadanian M., Sartorius L.J., Mackey B., Olney J., McKeel D., Wozniak D., Paul S.M. Apolipoprotein E isoform dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 97:1999;2892-2897.
25. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice. Science. 274:1996;99-102.
26. Jenkinson M.L., Bliss M.R., Brain A.T., Scott D.L. Rheumatoid arthritis and senile dementia of the Alzheimer's type. Br. J. Rheumatol. 28:1989;6-88.
27. Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., Muller B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature. 325:1987;733-736.
28. Kwok J.B., Taddei K., Hallup M., Fisher C., Brooks W.S., Broe G.A., Hardy J., Fulham M.J., Nicholson G.A., Stell R., St. George Hyslop P.H., Fraser P.E., Kakulas B., Clarnette R., Relkin N., Gandy S.E., Schofield P.R., Martins R.N. Two novel (M233T and R287T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of Presenilin-1 mutations with a novel phenotype. NeuroReport. 8:1997;1537-1542.
29. Laws S.M., Taddei K., Martins G., Paton A., Fisher C., Clarnette R., Hallmayer J., Brooks W.S., Gandy S.E., Martins R.N. The -491 AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease. NeuroReport. 10:1999;879-882.
30. Lee C.-K., Weindruch R., Prolla T.A. Gene-expression profile of the ageing brain in mice. Nature Genet. 25:2000;294-297.
31. Lendon C., Ashall F., Goate A.M. Exploring the aetiology of Alzheimer's disease using molecular genetics. J. Am. Med. Assoc. 277:1997;825-831.
32. Licastro F., Campell L., Kincaid C., Veibbergs I., Uden E.V., Rockenstein E., Mallory M., Gilbert J.R., Masaliah E. Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease. Neurosci. Lett. 270:1999;129-132.
33. Lucca U., Tettamanti M., Forline G., Spagnoli A. Nonsteroidal anti-inflammatory drug use in Alzheimer's disease. Biol. Psychiatry. 36:1994;854-856.
34. Lue L.-F., Kuo Y.-M., Roher A.E., Brachova L., Shen Y., Sue L., Beach T., Kurth J.H., Rydel R.E., Rogers J. Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155:1999;853-862.
35. Martins R.N., Clarnette R., Fisher C., Broe G.A., Brooks W.S., Montgomery P., Gandy S.E. APOE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome. NeuroReport. 6:1995;1513-1516.
36. Martins R.N., Taddei K., Kendall C., Evan G., Bates K.A., Harvey A.R. Altered expression of apolipoprotein E, amyloid precursor protein and presenilin-1 is associated with chronic reactive gliosis in rat cortical tissue. Neuroscience. 106:2001;555-567.
37. McGeer P.L., McGeer E.G. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzheimer Dis. Assoc. Disord. 12:(Suppl. 2):1998;S1-S6.
38. McGeer P.L., Rogers J. Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology. 42:1992;447-449.
39. McMillan P.J., Leverenz J.B., Dorsa D.M. Specific down regulation of presenilin 2 gene expression is prominent during early stages of sporadic late-onset Alzheimer's disease. Mol. Brain Res. 78:2000;138-145.
40. Mouchel Y., Lefrancois T., Fages C., Tardy M. Apolipoprotein E gene expression in astrocytes: developmental pattern and regulation. NeuroReport. 7:1995;205-208.
41. Myllykangas-Luosujarvi R., Isomaki H. Alzheimer's disease and rheumatoid arthritis. Br. J. Rheumatol. 33:1994;501-502.
42. Nunan J., Small D.H. Regulation of APP cleavage by α-, β- and γ-secretases. FEBS Lett. 483:2000;6-10.
43. Overmyer M., Helisalmi S., Soininen H., Laakso M., Riekkinen P., Alafuzoff I. Reactive microglia in aging and dementia: an immunohisotchemical study of postmortem human brain tissue. Acta Neuropathol. 97:1999;383-392.
44. Pangalos M.N., Shioi J., Robakis N.K. Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2. J. Neurochem. 65:1995;762-769.
45. Pike C.J., Cummings B.J., Cotman C.W. Early association of reactive astrocytes with senile plaques in Alzheimer's disease. Exp. Neurol. 132:1995;172-179.
46. Rebeck G.W., Reiter J.S., Strickland D.K., Hyman B.T. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron. 11:1993;575-580.
47. Ren R.F., Lah J.J., Diehlmann A., Kim E.S., Hawver D.B., Levey A.I., Beyreuther K., Flanders K.C. Differential effects of transforming growth factor β and glial cell derived neurotrophic factor on gene expression of presenilin-1 in human post mitotic neurons and astrocytes. Neuroscience. 93:1999;1041-1049.
48. Ringheim G.E., Szczepanik A.M., Petkow W., Burgher K.L., Zhu S.Z., Charo C.C. Enhancement of beta amyloid precursor protein transcription and expression of the soluble interleukin-6 receptor/interleukin-6 complex. Mol. Brain Res. 55:1998;35-44.
49. Roberts G.W., Gentleman S.M., Lynch A., Murray L., Landon M., Graham D.I. Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry. 57:1994;419-425.
50. Rogaev E.I., Sherrington R., Rogaeva E.A., Levesque G., Ikeda M., Liang Y., Chi H., Lin C., Holman K., Tsuda T., St. George-Hyslop P.H. Familial Alzheimer's disease kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 376:1995;775-778.
51. Rogers J.T., Leiter L.M., McPhee J., Cahill C.M., Zhan S.-S., Potter H., Nilsson L.N.G. Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5-untranslated region sequences. J. Biol. Chem. 274:1999;6421-6431.
52. Rothwell, N. (Ed.), 1995. Cytokines and Neurodegeneration. Immune Responses in the CNS. Oxford Bioscientific, London, pp. 77-97.
53. Salbaum J.M., Weidmann A., Lemaire H.G., Masters C.L., Beyreuther K. The promoter of Alzheimer's disease A4 precursor gene. EMBO J. 7:1988;2807-2813.
54. Salinero O., Garrido J., Wandosell F. Amyloid precursor protein proteoglycan is increased after brain damage. Biochim. Biophys. Acta. 1406:1998;237-250.
55. Sato J.-I., Kuroda Y. Constitutive and cytokine-regulated expression of presenilin-1 and presenilin-2 genes in human neural cell lines. Neuropathol. Appl. Neurobiol. 25:1999;492-503.
56. Schmued J.C. A rapid and sensitive histochemical stain for myelin in frozen brain sections. J. Histol. Chem. 38:1990;707-720.
57. Schwab S.G., Bagli M., Papassotiropoulos A., Jessen F., Maier W., Rao M.L., Heun R. Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population. Dement. Geriatr. Cogn. Disord. 10:1999;469-472.
58. Shen Y., Sullivan T., Lee C.-M., Meri S., Shiosaki K., Lin C.W. Induced expression of neuronal membrane attack complex and cell death by Alzheimer's α-amyloid peptide. Brain Res. 796:1998;187-197.
59. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Marl L., Foncin L.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brooks A., Sanseau P., Polinsky R.J., Wasco W., da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Ronimens J.M., St. George-Hyslop P.H. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
60. Shioi J., Pangalos M.N., Ripellino J.A., Vassilacopoulou D., Mytilineou C., Margolis R.U., Robakis N.K. The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary cell Cultures. J. Biol. Chem. 27:1995;11839-11944.
61. Snow A., Sekiguchi R., Nochlin D., Fraser P., Kimata K., Mizutani A., Arai M., Schreier W.A., Morgan D.G. An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar Aβ-amyloid in rat brain. Neuron. 12:1994;219-234.
62. Stoltzner S.E., Grenfell T.J., Mori C., Wisniewski K.E., Wisniewski T.M., Selkoe D.J., Lemere C.A. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. Am. J. Pathol. 156:2000;489-499.
63. Storey E., Cappai R. The amyloid precursor protein of Alzheimer's disease and the Aβ peptide. Neuropathol. Appl. Neurobiol. 25:1999;81-97.
64. Sykovà E., Roitbak T., Mazel T., Simonova Z., Harvey A.R. Astrocytes, oligodendroglia, extracellular space volume and geometry in rat fetal brain grafts. Neuroscience. 91:1999;783-798.
65. Takami K., Terai K., Matsuo A., Walker D.G., McGeer P.L. Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brain. Brain Res. 748:1997;122-130.
66. Van Leeuwen F.W., de Kleijn D.P.V., van den Hurk H.H., Neubauer A., Sonnemans M.A.F., Sluijs J.A., Koycu S., Ramdjielal R.D.J., Salehi A., Martens G.J.M., Grosveld F.G., Burbach J.P.H., Hol E.M. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down's patients. Science. 279:1998;242-247.
67. Vassar R., Bennet B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.-C., Collins F., Treanor J., Rogers G., Martin C. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286:1999;735-741.
68. Veerhuis R., Janssen I., De Groot C.J., Van Muiswinkel F.L., Hack C.E., Eikelenboom P. Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor. Exp. Neurol. 160:1999;289-299.
69. Verdile G., Martins R.N., Duthie M., Holmes E., St. George-Hyslop P.H., Fraser P.E. Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin-1. J. Biol. Chem. 275:2000;20794-20798.
70. Vincent B., Smith J.D. Effect of estradiol on Swedish mutated β-amyloid precursor protein metabolism: reversal by astrocytic cells. Biochem. Biophys. Res. Commun. 271:2000;82-85.
71. Wisniewski K.E., Wisniewski H.M., Wen G.Y. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 17:1985;278-282.
72. Yaffe K., Haan M., Byres A., Tangen C., Kuller L. Estrogen use, APOE and cognitive decline: evidence of gene-environment interaction. Neurology. 54:2000;1949-1954.
73. Yamin R., Malgeri E.G., Sloane J.A., McGraw W.T., Abraham C.R. Metalloendopeptidase EC3.4.24.15 is necessary for Alzheimer's amyloid-beta-peptide degradation. J. Biol. Chem. 274:1999;18777-187784.
74. Yasojima K., Schwab C., McGeer E.G., McGeer P.L. Up regulated production and activation of the complement system in Alzheimer's disease brain. Am. J. Pathol. 54:1999;927-936.