Establishment of ionic channels and signalling cascades in the embryonic stem cell-derived primitive endoderm and cardiovascular system

Cells Tissues Organs

Volumn 165, Issue 3-4, 1999, Pages 153-164

  Hescheler, J ^b   Fleischmann, B K ^b   Wartenberg, M ^b   Bloch, W ^b   Kolossov, E ^b   Ji, G ^b   Addicks, K ^b   Sauer, Heinrich ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b NONE

Author keywords

Angiogenesis; Cardiomyogenesis; Embryoid body; Embryonic stem cells; Primitive endoderm

Indexed keywords

ALPHA ACTIN; CALCIUM CHANNEL; CALCIUM ION; GREEN FLUORESCENT PROTEIN; ION CHANNEL;

ANGIOGENESIS; ARTICLE; CARDIOVASCULAR SYSTEM; CHANNEL GATING; EMBRYO DEVELOPMENT; ENDODERM; HEART DEVELOPMENT; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; STEM CELL;

EID: 0032722837     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000016695     Document Type: Article

References (72)

1. Abe, K., H. Niwa, K. Iwase, M. Takiguchi, M. Mori, S.I. Abe, K.I. Yamamura (1996) Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies. Exp Cell Res 229: 27-34.
2. 2+ channels in embryonic mouse heart. Circ Res 78: 371-378.
3. Angelov, D.N., S. Arnhold, C. Andressen, H. Grabsch, M. Puschmann, J. Hescheler, K. Addicks (1998) Temporospatial relationship between macroglia and microglia during in vitro differentiation of murine stem cells. Dev Neurosci 20: 42-51.
4. i transients in guinea pig ventricular myocytes. Circ Res 61: 148-154.
5. Bers, D.M. (1997) Ca transport during contraction and relaxation in mammalian ventricular muscle. Basic Res Cardiol 92 (suppl 1): 1-10.
6. Blank, P.S., M.S. Cho, S.S. Vogel, D. Kap an, A. Kang, J. Malley, J. Zimmerberg (1998) Submaximal responses in calcium-triggered exocytosis are explained by differences in the calcium sensitivity of individual secretory vesicles. J Gen Physiol 112: 559-567.
7. 2+ oscillations affect cell composition in resulting blastocysts. Dev Biol 182: 172-179.
8. Chalfie, M., Y. Tu, G. Euskirchen, W.W. Ward, D.C. Prasher (1994) Green fluorescent protein as a marker for gene expression. Science 263: 802-805.
9. Chin, T.K., W.F. Friedman, T.S. Klitzner (1990) Developmental changes in cardiac myocyte calcium regulation. Circ Res 67: 574-579.
10. Cody, C.W., D.C. Prasher, W.M. Westler, F.G. Prendergast, W.W. Ward (1993) Chemical structure of the hexapeptide chromophore of the Acquorea green-fluorescent protein. Biochemistry 32: 1212-1218.
11. Doetschman, T., A. Gossler, E. Serfling, W. Schaffner, K. Marcu, L. Stanton, R. Kemler (1986) Introduction of genes into mouse embryonic stem cells. Prog Clin Biol Res 217A: 47-50.
12. Doetschman, T., M. Shull, A. Kier, J.D. Coffin (1993) Embryonic stem cell model systems for vascular morphogenesis and cardiac disorders. Hypertension 22: 618-629.
13. Doetschman, T.C., H. Eistetter, M. Katz, W. Schmidt, R. Kemler (1985) The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac. blood islands and myocardium. J Embryol Exp Morphol 87: 27-45.
14. Drab, M., H. Haller, R. Bychkov, B. Erdmann, C. Lindschau, H. Haase, I. Morano, F.C Luft, A.M. Wobus (1997) From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: A retinoic acid and dbcAMP in vitro differentiation model. FASEB J 11: 905-915.
15. 2+ in resting feline and rat ventricular myocytes. Cell Calcium 8: 259-268.
16. Evans, M.J., M.H. Kaufman (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292: 154-156.
17. Fabiato, A. (1985) Effects of ryanodine in skinned cardiac cells. Fed Proc 44: 2970-2976.
18. Fässler, R., M. Meyer (1995) Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 9: 1896-1908.
19. Fässler, R., M. Pfaff, J. Murphy, A.A. Noegel, S. Johansson, R. Timpl, R. Albrecht (1995) Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts. J Cell Biol 128: 979-988.
20. Fässler, R., J. Rohwedel, V. Maltsev, W. Bloch, S. Lentini, K. Guan, D. Gullberg, J. Hescheler, K. Addicks, A.M. Wobus (1996) Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. J Cell Sci 109: 2989-2999.
21. Fishman, M.C., K.R. Chien (1997) Fashioning the vertebrate heart: Earliest embryonic decisions. Development 124: 2099-2117.
22. Fleischmann, M., W. Bloch, E. Kolossov, C. Andressen, M. Muller, G. Brem, J. Hescheler, K. Addicks, B.K. Fleischmann (1998) Cardiac specific expression of the green fluorescent protein during early murine embryonic development. FEBS Lett 440: 370-376.
23. Freyer, J.P., R.M. Sutherland (1986) Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply. Cancer Res 46: 3504-3512.
24. Gassmann, M., J. Fandrey, S. Bichet, M. Wartenberg, H.H. Marti, C. Bauer, R.H. Wenger, H. Acker (1996) Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells. Proc Natl Acad Sci USA 93: 2867-2872.
25. Gossler, A., T. Doetschman, R. Korn, E. Serfling, R. Kemler (1986) Transgenesis by means of blastocyst-derived embryonic stem cell lines. Proc Natl Acad Sci USA 83: 9065-9069.
26. 2+ current in single heart cells. Nature 323: 273-275.
27. Heim, R., D.C. Prasher, R.Y. Tsien (1994) Wavelength mutations and posttranslational autoxidation of green fluorescent protein. Proc Natl Acad Sci USA 91: 12501-12504.
28. Hescheler, J., B.K. Fleischmann, S. Lentini, V.A. Maltsev, J. Rohwedel, A.M. Wobus, K. Addicks (1997) Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis. Cardiovasc Res 36: 149-162.
29. 2+ channels by S-nitrosothiol nitric oxide donors. Circ Res 81: 742-752.
30. Igelmund, P., B.K. Fleischmann, I.R. Fischer, J. Soest, O. Gryshchenko, M.M. Bohm-Pinger, H. Sauer, Q. Liu, J. Hescheler (1999) Action potential propagation failures in long-term recordings from embryonic stem-cell derived cardiomyocytes in tissue culture. Pflügers Arch 437: 669-679.
31. 2+-channel during cardiomyogenesis: Switch from NO to adenylyl-cyclase-mediated inhibition. FASEB J 13: 313-324.
32. 2+ in mouse pancreatic beta-cells. Diabetes 47: 1266-1273.
33. Kennedy, M., M. Firpo, K. Choi, C. Wall, S. Robertson, N. Kabrun, G. Keller (1997) A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature 386: 488-493.
34. 2+ responses and secretion in individual RBL-2H3 mucosal mast cells. J Biol Chem 272: 31225-31229.
35. Klitzner, T.S., W.F. Friedman (1989) A diminished role for the sarcoplasmic reticulum in newborn myocardial contraction: Effects of ryanodine. Pediatr Res 26: 98-101.
36. Kolossov E., B.K. Fleischmann, Q. Liu, W. Bloch, S. Viatchenko-Karpinski, O. Manzke, G.J. Ji. H. Bohlen, K. Addicks, J. Hescheler (1998) Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue specific expression of the green fluorescent protein. J Cell Biol 143: 2045-2056.
37. 2+ transients in mouse embryos during the first mitotic division. J Cell Biol 132:915-923.
38. Kuzin, B., I. Roberts, N. Peunova, G. Enikolopov (1996) Nitric oxide regulates cell proliferation during drosophila development. Cell 87: 639-649.
39. 2+ oscillations by anterior pituitary cells: A comparative overview. Neuroendocrinology 68: 135-151.
40. Mahony, L., L.R. Jones (1986) Developmental changes in cardiac sarcoplasmic reticulum in sheep. J Biol Chem 261: 15257-15265.
41. Maltsev, V.A., G.J. Ji, A.M. Wobus, B.K. Fleischmann, J. Hescheler (1999) Establishment of β-adrenergic modulation of L-type calcium current in the early stages of cardiomyocyte development. Circ Res 84: 136-145.
42. Maltsev, V.A., A.M. Wobus, J. Rohwedel, M. Bader, J. Hescheler (1994) Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ Res 75: 233-244.
43. Metzger, J.M., W.I. Lin, L.C. Samuelson (1996) Vital staining of cardiac myocytes during embryonic stem cell cardiogencsis in vitro. Circ Res 78: 547-552.
44. Nabauer, M., G. Callewaert, L. Cleemann, M. Morad (1989) Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes. Science 244: 800-803.
45. Nakao, K., W. Minobe, R. Roden, M.R. Bristow, L.A. Leinwand (1997) Myosin heavy chain gene expression in human heart failure. J Clin Invest 100: 2362-2370.
46. Nayler, W.G., E. Fassold (1977) Calcium accumulating and ATPase activity of cardiac sarcoplasmic reticulum before and after birth. Cardiovasc Res 11: 231-237.
47. Nishikawa, S.I., S. Nishikawa, M. Hirashima, N. Matsuyoshi, H. Kodama (1998) Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. Development 125: 1747-1757.
48. 2+ current. Nature 298: 576-578.
49. Pari, G., K. Jardine, M.W. McBurney (1991) Multiple CArG boxes in the human cardiac actin gene promoter required for expression in embryonic cardiac muscle cells developing in vitro from embryonal carcinoma cells. Mol Cell Biol 11: 4796-4803.
50. Peunova, N., G. Enikolopov (1995) Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells. Nature 375: 68-73.
51. Prasher, D.C., V.K. Eckenrode, W.W. Ward, F.G. Prendergast, M.J. Cormier (1992) Primary structure of the Acquorea victoria green-fluorescent protein. Gene 111: 229-233.
52. Rathjen, P.D., J. Lake, L.M. Whyatt, M.D. Bettess, J. Rathjen (1998) Properties and uses of embryonic stem cells: Prospects for application to human biology and gene therapy. Reprod Fertil Dev 10: 31-47.
53. Risau, W. (1995) Differentiation of endothelium. FASEB J 9: 926-933.
54. Risau, W. (1997) Mechanisms of angiogenesis. Nature 386: 671-674.
55. Rohwedel, J., V. Maltsev, E. Bober, H.H. Arnold, J. Hescheler, A.M. Wobus (1994) Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: Developmentally regulated expression of myogenic determination genes and functional expression of ionic currents. Dev Biol 164: 87-101.
56. Sartorelli, V., N.A. Hong, N.H. Bishopric, L. Kedes (1992) Myocardial activation of the human cardiac alpha-actin promoter by helix-loop-helix proteins. Proc Natl Acad Sci USA 89: 4047-4051.
57. Sauer, H., C. Hofmann, M. Wartenberg, A.M. Wobus, J. Hescheler (1998) Spontaneous calcium oscillations in embryonic stem cell-derived primitive endodermal cells. Exp Cell Res 238: 13-22.
58. Shamblott, M.J., J. Axelmann, S. Wang, E.M. Bugg, J.W. Littlefield, P.J. Donovan, P.D. Blumenthal, G.R. Huggins, J.D. Gearhart (1998) Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci USA 95: 13726-13731.
59. Slotkin, T.A., C. Lau, F.J. Seidler (1994) Beta-adrenergic receptor overexpression in the fetal rat: Distribution, receptor subtypes, and coupling to adenylate cyclase activity via G-proteins. Toxicol Appl Pharmacol 129: 223-234.
60. Strübing, C., G. Ahnert Hilger, J. Shan, B. Wiedenmann, J. Hescheler, A.M. Wobus (1995) Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons. Mech Dev 53: 275-287.
61. Swanson, C.A., A.P. Arkin, J. Ross (1997) An endogenous calcium oscillator may control early embryonic division. Proc Natl Acad Sci USA 94: 1194-1199.
62. Takeshima, H., S. Komazaki, K. Hirose, M. Nishi, T. Noda, M. Iino (1998) Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2. EMBO J 17: 3309-3316.
63. Thomson, J.A., J. Itskovitz-Eldo, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, J.M. Jones (1998) Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147.
64. Trautwein, W., J. Hescheler (1990) Regulation of cardiac L-type calcium current by phosphorylation and G proteins. Annu Rev Physiol 52: 257-274.
65. 2+ oscillations and exocytosis in identified rat corticotrophs. J Physiol (Lond) 512: 385-393.
66. Vittet, D., M.H. Prandini, R. Berthier, A. Schweitzer, H. Martin-Sisteron, G. Uzan, E. Dejana (1996) Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps. Blood 88: 3424-3431.
67. Wartenberg, M., H. Acker (1995) Quantitative recording of vitality patterns in living multicellular spheroids by confocal microscopy. Micron 26: 395-404.
68. Wartenberg, M., J. Gunther, J. Hescheler, H. Sauer (1998) The embryoid body as a novel in vitro assay system for antiangiogenic agents. Lab Invest 78: 1301-1314.
69. Wiles, M.V., G. Keller (1991) Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development 111: 259-267.
70. Wobus, A.M., G. Kaomei, J. Shan, M.C. Wellner, J. Rohwedel, G.J. Ji, B. Fleischmann, H.A. Katus, J. Hescheler, W.M. Franz (1997) Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes. J Mol Cell Cardiol 29: 1525-1539.
71. 2+ channel blockers. Differentiation. 48: 173-182.
72. Yatani, A., A.M. Brown (1989) Rapid beta-adrenergic modulation of cardiac calcium channel currents by a fast G protein pathway. Science 245: 71-74.