메뉴 건너뛰기




Volumn 16, Issue 3-4, 1998, Pages 397-426

Leukemia inhibitory factor: Part of a large ingathering family

Author keywords

Cytokines; Gp130; Gp190; Immune response; Leukemia inhibitory factor; Oncostatin M

Indexed keywords


EID: 0031914865     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830189809043003     Document Type: Article
Times cited : (66)

References (215)
  • 1
    • 0014620997 scopus 로고
    • Differentiation of a cell line of myeloid leukemia
    • Ishikawa, Y. Differentiation of a cell line of myeloid leukemia. J. Cell Physiol. 74, 223-34, 1969.
    • (1969) J. Cell Physiol. , vol.74 , pp. 223-234
    • Ishikawa, Y.1
  • 2
    • 0023951261 scopus 로고
    • Clonal variation in susceptibility to differentiation by different protein inducers in the myeloid leukemia cell line MI
    • Metcalf, D., Hilton, D. J., and Nicola, N. A. Clonal variation in susceptibility to differentiation by different protein inducers in the myeloid leukemia cell line MI. Leukemia 2, 216-21, 1988.
    • (1988) Leukemia , vol.2 , pp. 216-221
    • Metcalf, D.1    Hilton, D.J.2    Nicola, N.A.3
  • 4
    • 0021208035 scopus 로고
    • Purification of a factor inducing differentiation of mouse myeloid leukemic MI cells from conditioned medium of mouse fibroblast L929 cells
    • Tomida, M., Yamamoto-Yamaguchi, Y., and Hozumi, M. Purification of a factor inducing differentiation of mouse myeloid leukemic MI cells from conditioned medium of mouse fibroblast L929 cells. J. Biol. Chem. 259, 10978-82, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 10978-10982
    • Tomida, M.1    Yamamoto-Yamaguchi, Y.2    Hozumi, M.3
  • 5
    • 0024391023 scopus 로고
    • Macrophage differentiation inducing factor from human monocytic cells is equivalent to murine LIF
    • Abe, T., Murakami, M., Sato, T., Kajiki, M., Olino, M., and Kodaira, R. Macrophage differentiation inducing factor from human monocytic cells is equivalent to murine LIF. J. Biol. Chem. 264, 8941-8945, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 8941-8945
    • Abe, T.1    Murakami, M.2    Sato, T.3    Kajiki, M.4    Olino, M.5    Kodaira, R.6
  • 6
    • 0019450975 scopus 로고
    • Characterization of macrophage and granulocyte inducing proteins for normal and leukemic myeloid cells produced by the Krebs ascities tumor
    • Lipton, J. H. and Sachs, L. Characterization of macrophage and granulocyte inducing proteins for normal and leukemic myeloid cells produced by the Krebs ascities tumor. Biochem. Biophys Acta 673. 552-69, 1981.
    • (1981) Biochem. Biophys Acta , vol.673 , pp. 552-569
    • Lipton, J.H.1    Sachs, L.2
  • 7
    • 0023762649 scopus 로고
    • Purification of a murine leukemia inhibitory factor from Krebs ascites cells
    • Hilton, D. J., Nicola, N. A., and Metcalf, D. Purification of a murine leukemia inhibitory factor from Krebs ascites cells. Anal. Biochem. 173, 359-67, 1988.
    • (1988) Anal. Biochem. , vol.173 , pp. 359-367
    • Hilton, D.J.1    Nicola, N.A.2    Metcalf, D.3
  • 10
    • 0023723940 scopus 로고
    • Complete sequence of murine leukemia inhibitory factor
    • Gearing, D. P., King, J. A., and Gough, N. M. Complete sequence of murine leukemia inhibitory factor. Nucleic Acid Res. 16, 9857, 1988.
    • (1988) Nucleic Acid Res. , vol.16 , pp. 9857
    • Gearing, D.P.1    King, J.A.2    Gough, N.M.3
  • 12
    • 0022636687 scopus 로고
    • Capacity of alloreactive human T cell clones to produce factor(s) inducing proliferation of the IL3-dependent DA-1 murine cell line
    • Moreau, J. F., Bonneville, M., Peyrat, M. A., Jacques, Y., and Soulillou, J. P. Capacity of alloreactive human T cell clones to produce factor(s) inducing proliferation of the IL3-dependent DA-1 murine cell line. Ann Inst. Pasteur Immunol. 137C, 25-37, 1986.
    • (1986) Ann Inst. Pasteur Immunol. , vol.137 C , pp. 25-37
    • Moreau, J.F.1    Bonneville, M.2    Peyrat, M.A.3    Jacques, Y.4    Soulillou, J.P.5
  • 13
    • 0023240961 scopus 로고
    • Characterization of a factor produced by human T cell clones exhibiting eosinophil-activating and burst-promoting activities
    • Moreau, J. F., Bonneville, M., Godard, A., Gascan, H., Gruart, V., Moore, M. A., and Soulillou, J. P. Characterization of a factor produced by human T cell clones exhibiting eosinophil-activating and burst-promoting activities. J. Immunol. 138, 3844-49, 1987.
    • (1987) J. Immunol. , vol.138 , pp. 3844-3849
    • Moreau, J.F.1    Bonneville, M.2    Godard, A.3    Gascan, H.4    Gruart, V.5    Moore, M.A.6    Soulillou, J.P.7
  • 14
    • 0023939033 scopus 로고
    • Biochemical characterization and purification of HILDA, a human lymphokine active on eosinophils and bone marrow cells
    • Godard, A., Gascan, H., Naulet, J., Peyrat, M. A., Jacques, Y., Soulillou, J. P., and Moreau, J. F. Biochemical characterization and purification of HILDA, a human lymphokine active on eosinophils and bone marrow cells. Blood 71, 1618-23, 1988.
    • (1988) Blood , vol.71 , pp. 1618-1623
    • Godard, A.1    Gascan, H.2    Naulet, J.3    Peyrat, M.A.4    Jacques, Y.5    Soulillou, J.P.6    Moreau, J.F.7
  • 15
    • 0024210526 scopus 로고
    • Leukemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells
    • Moreau, J. F., Donaldson, D. D., Bennett, F., Witek-Giannotti, J. A., Clark, S. C., and Wong, G. G. Leukemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336, 690-692, 1988.
    • (1988) Nature , vol.336 , pp. 690-692
    • Moreau, J.F.1    Donaldson, D.D.2    Bennett, F.3    Witek-Giannotti, J.A.4    Clark, S.C.5    Wong, G.G.6
  • 16
    • 0024245022 scopus 로고
    • Inhibition of pluripotential embryonic stem cells differentiation by purified polypeptides
    • Smith, A. G., Heath, J. K., Donaldson, D. D., Wong, G. G., Moreau, J. F., Stahl, M., and Rogers, D. Inhibition of pluripotential embryonic stem cells differentiation by purified polypeptides. Nature 336, 688-690, 1988.
    • (1988) Nature , vol.336 , pp. 688-690
    • Smith, A.G.1    Heath, J.K.2    Donaldson, D.D.3    Wong, G.G.4    Moreau, J.F.5    Stahl, M.6    Rogers, D.7
  • 17
    • 0023989479 scopus 로고
    • Molecular cloning and expression of the human homologue of the murine gene encoding myeloid Leukemia Inhibitory Factor
    • Gough, N. M., Gearing, D. P., King, J. A., Willson, T. A., Hilton, D. J., Nicola, N. A., and Metcalf, D. Molecular cloning and expression of the human homologue of the murine gene encoding myeloid Leukemia Inhibitory Factor. Proc. Natl. Acad. Sci. USA 88, 2623-27, 1988.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2623-2627
    • Gough, N.M.1    Gearing, D.P.2    King, J.A.3    Willson, T.A.4    Hilton, D.J.5    Nicola, N.A.6    Metcalf, D.7
  • 18
    • 0021194425 scopus 로고
    • A factor produced by feeder cells which inhibits embryonal carcinoma cell differentiation. Characterization and partial purification
    • Koopman, P. and Cotton, R. G.H. A factor produced by feeder cells which inhibits embryonal carcinoma cell differentiation. Characterization and partial purification. Exp. Cell Res. 154, 233-42, 1984.
    • (1984) Exp. Cell Res. , vol.154 , pp. 233-242
    • Koopman, P.1    Cotton, R.G.H.2
  • 20
    • 0026760877 scopus 로고
    • Can there be life without LIF?
    • Heath, J. K. Can there be life without LIF? Nature 359, 17, 1992.
    • (1992) Nature , vol.359 , pp. 17
    • Heath, J.K.1
  • 21
    • 0024790913 scopus 로고
    • The Cholinergic Neuronal Differentiation Factor from heart cells is identical to Leukemia Inhibitory Factor
    • Yamamori, T., Fukada, K., Aebersold, R., Korsching, S., Fann, M. J., and Patterson, P. H. The Cholinergic Neuronal Differentiation Factor from heart cells is identical to Leukemia Inhibitory Factor. Science 246, 1412-16, 1989.
    • (1989) Science , vol.246 , pp. 1412-1416
    • Yamamori, T.1    Fukada, K.2    Aebersold, R.3    Korsching, S.4    Fann, M.J.5    Patterson, P.H.6
  • 22
    • 0028306032 scopus 로고
    • Target determination of neurotransmitter phenotype in sympathetic neurons
    • Schotzinger, R., Yin, X., and Landis, S. Target determination of neurotransmitter phenotype in sympathetic neurons. J. Neurobiol. 25, 620-39, 1994.
    • (1994) J. Neurobiol. , vol.25 , pp. 620-639
    • Schotzinger, R.1    Yin, X.2    Landis, S.3
  • 24
    • 0027407272 scopus 로고
    • The effect of leukemia inhibitory factor on bone in vivo
    • Cornish, J., Callon, K., King, A., Edgar, S., and Reid, I. R. The effect of leukemia inhibitory factor on bone in vivo. Endocrinology 132, 1359-1366, 1993.
    • (1993) Endocrinology , vol.132 , pp. 1359-1366
    • Cornish, J.1    Callon, K.2    King, A.3    Edgar, S.4    Reid, I.R.5
  • 25
    • 0024324795 scopus 로고
    • Purification of a lipoprotein lipase inhibiting protein produced by a melanoma cell line associated with cancer cachexia
    • Mori, M., Yamaguchi, K., and Abe, K. Purification of a lipoprotein lipase inhibiting protein produced by a melanoma cell line associated with cancer cachexia. Biochem. Biophys. Res. Commun. 160, 1085-92, 1989.
    • (1989) Biochem. Biophys. Res. Commun. , vol.160 , pp. 1085-1092
    • Mori, M.1    Yamaguchi, K.2    Abe, K.3
  • 26
    • 0028225295 scopus 로고
    • Leukemia inhibitory factor induces changes in lipid metabolism in cultured adipocytes
    • Marshall, M. K., Doerrler, W., Feingold, K. R., and Grunfeld, C. Leukemia inhibitory factor induces changes in lipid metabolism in cultured adipocytes. Endocrinology 135, 141-7, 1994.
    • (1994) Endocrinology , vol.135 , pp. 141-147
    • Marshall, M.K.1    Doerrler, W.2    Feingold, K.R.3    Grunfeld, C.4
  • 27
    • 0026470466 scopus 로고
    • Effects of leukaemia inhibitory factor and other cytokines on murine and human myoblast proliferation
    • Austin, L., Bower, J., Kurek, J., and Vakakis, N. Effects of leukaemia inhibitory factor and other cytokines on murine and human myoblast proliferation. J. Neurol. Sci. 112, 185-91, 1992.
    • (1992) J. Neurol. Sci. , vol.112 , pp. 185-191
    • Austin, L.1    Bower, J.2    Kurek, J.3    Vakakis, N.4
  • 28
    • 0029007118 scopus 로고
    • Specific binding of leukemia inhibitory factor to murine myoblasts in culture
    • Bower, J., Vakakis, N., Nicola, N. A., and Austin, L. Specific binding of leukemia inhibitory factor to murine myoblasts in culture. J. cell. Physiol. 164, 93-8, 1995.
    • (1995) J. Cell. Physiol. , vol.164 , pp. 93-98
    • Bower, J.1    Vakakis, N.2    Nicola, N.A.3    Austin, L.4
  • 29
    • 0029081497 scopus 로고
    • Extracellular matrix, growth factors, genetics: Their influence on cell proliferation and myotube formation in primary cultures of adult mouse skeletal muscle
    • Maley, M. A., Davies, M. J., and Grounds, M. D. Extracellular matrix, growth factors, genetics: their influence on cell proliferation and myotube formation in primary cultures of adult mouse skeletal muscle. Exp. cell. Res. 219, 169-79, 1995.
    • (1995) Exp. Cell. Res. , vol.219 , pp. 169-179
    • Maley, M.A.1    Davies, M.J.2    Grounds, M.D.3
  • 30
    • 0026658025 scopus 로고
    • Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord
    • Kushima, Y. and Hatanaka, H. Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord. Neurosci. Lett. 143, 110-4, 1992.
    • (1992) Neurosci. Lett. , vol.143 , pp. 110-114
    • Kushima, Y.1    Hatanaka, H.2
  • 31
    • 0025939841 scopus 로고
    • Effect of Steel Factor and leukemia inhibitory factor on murine primordial germ cells in culture
    • Matsui, Y., Toksoz, D., Nishikawa, S., Nishikawa, S. I., Williams, D., Zsebo, K., and Hogan, B. L. M. Effect of Steel Factor and leukemia inhibitory factor on murine primordial germ cells in culture. Nature 353, 750-752, 1991.
    • (1991) Nature , vol.353 , pp. 750-752
    • Matsui, Y.1    Toksoz, D.2    Nishikawa, S.3    Nishikawa, S.I.4    Williams, D.5    Zsebo, K.6    Hogan, B.L.M.7
  • 32
    • 0025941491 scopus 로고
    • Leukemia Inhibitory Factor sustains the survival of mouse primordial germ cells cultured on TM4 feeder layers
    • De Felici, M. and Dolci, S. Leukemia Inhibitory Factor sustains the survival of mouse primordial germ cells cultured on TM4 feeder layers. Dev. Biol. 147, 281-84, 1991.
    • (1991) Dev. Biol. , vol.147 , pp. 281-284
    • De Felici, M.1    Dolci, S.2
  • 33
    • 0026699762 scopus 로고
    • Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture
    • Matsui, Y., Zsebo, K., and Hogan, B. L. Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell 70, 841-7, 1992.
    • (1992) Cell , vol.70 , pp. 841-847
    • Matsui, Y.1    Zsebo, K.2    Hogan, B.L.3
  • 35
    • 0026699346 scopus 로고
    • The modulatory hematopoietic activities of leukemia inhibitory factor
    • Estrov, Z., Talpaz, M., Wetzler, M., and Kurzrock, R. The modulatory hematopoietic activities of leukemia inhibitory factor. Leuk. Lymphoma. 8, 1-7, 1992.
    • (1992) Leuk. Lymphoma. , vol.8 , pp. 1-7
    • Estrov, Z.1    Talpaz, M.2    Wetzler, M.3    Kurzrock, R.4
  • 36
    • 0028911746 scopus 로고
    • Human and murine pituitary expression of leukemia inhibitory factor. Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion
    • Akita, S., Webster, J., Ren, S. G., Takino, H., Said, J., Zand, O., and Melmed, S. Human and murine pituitary expression of leukemia inhibitory factor. Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion. J. Clin. Invest. 95, 1288-98, 1995.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1288-1298
    • Akita, S.1    Webster, J.2    Ren, S.G.3    Takino, H.4    Said, J.5    Zand, O.6    Melmed, S.7
  • 37
    • 0030069456 scopus 로고    scopus 로고
    • Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1
    • Benigni, F., Fantuzzi, G., Sacco, S., Sironi, M., Pozzi, P., Dinarello, C A., Sipe, J. D., Poli, V., Cappelletti, M., Paonessa, G., Pennica, D., Panayotatos, N., and Ghezzi, P. Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. Blood 87, 1851-4, 1996.
    • (1996) Blood , vol.87 , pp. 1851-1854
    • Benigni, F.1    Fantuzzi, G.2    Sacco, S.3    Sironi, M.4    Pozzi, P.5    Dinarello, C.A.6    Sipe, J.D.7    Poli, V.8    Cappelletti, M.9    Paonessa, G.10    Pennica, D.11    Panayotatos, N.12    Ghezzi, P.13
  • 38
    • 0026584255 scopus 로고
    • Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: Identification as leukemia inhibitory factor
    • Ferrara, N., Winer, J., and Henzel, W. J. Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor. Proc. Natl. Acad. Sci. USA 89, 698-702, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 698-702
    • Ferrara, N.1    Winer, J.2    Henzel, W.J.3
  • 39
    • 0027744333 scopus 로고
    • Leukemia inhibitory factor expression in human carotid plaques: Possible mechanism for inhibition of large vessel endothelial regrowth
    • Gillett, N. A., Lowe, D., Lu, L., Chan, C., and Ferrara, N. Leukemia inhibitory factor expression in human carotid plaques: possible mechanism for inhibition of large vessel endothelial regrowth. Growth Factors 9, 301-5, 1993.
    • (1993) Growth Factors , vol.9 , pp. 301-305
    • Gillett, N.A.1    Lowe, D.2    Lu, L.3    Chan, C.4    Ferrara, N.5
  • 40
    • 0028810982 scopus 로고
    • In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells: Differential regulation by interleukin-1 alpha and glucocorticoids
    • Grosset, C., Jazwiec, B., Taupin, J. L., Liu, H., Richard, S., Mahon, F. X., Reiffers, J., Moreau, J. F., and Ripoche, J. In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells: differential regulation by interleukin-1 alpha and glucocorticoids. Blood 86, 3763-70, 1995.
    • (1995) Blood , vol.86 , pp. 3763-3770
    • Grosset, C.1    Jazwiec, B.2    Taupin, J.L.3    Liu, H.4    Richard, S.5    Mahon, F.X.6    Reiffers, J.7    Moreau, J.F.8    Ripoche, J.9
  • 41
    • 0024400598 scopus 로고
    • Hepalocyte Stimulating Factor III shares structural and functional identity with Leukemia Inhibitory Factor
    • Baumann, H. and Wong, G. G. Hepalocyte Stimulating Factor III shares structural and functional identity with Leukemia Inhibitory Factor. J. Immunol. 143, 1163-1167, 1989.
    • (1989) J. Immunol. , vol.143 , pp. 1163-1167
    • Baumann, H.1    Wong, G.G.2
  • 43
    • 0026510625 scopus 로고
    • Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro
    • Richards, C. D., Brown, T. J., Shoyab, M., Baumann, H., and Gauldie, J. Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro. J. Immunol. 148, 1731-6, 1992
    • (1992) J. Immunol. , vol.148 , pp. 1731-1736
    • Richards, C.D.1    Brown, T.J.2    Shoyab, M.3    Baumann, H.4    Gauldie, J.5
  • 44
    • 0027312489 scopus 로고
    • Recombinant human leukemia inhibitory factor induces acute phase proteins and raises the blood platelet counts in nonhuman primates
    • Mayer, P., Geissler, K., Ward, M., and Metcalf, D. Recombinant human leukemia inhibitory factor induces acute phase proteins and raises the blood platelet counts in nonhuman primates. Blood 81, 3226-33, 1993.
    • (1993) Blood , vol.81 , pp. 3226-3233
    • Mayer, P.1    Geissler, K.2    Ward, M.3    Metcalf, D.4
  • 45
    • 0026570632 scopus 로고
    • Synthesis of alpha 1-microglobulin in cultured rat hepatocytes is stimulated by interleukin-6, leukemia inhibitory factor, dexamethasone and retinoic acid
    • Pierzchalski, P., Rokita, H., Koj, A., Fries, E., and Akerstrom, B. Synthesis of alpha 1-microglobulin in cultured rat hepatocytes is stimulated by interleukin-6, leukemia inhibitory factor, dexamethasone and retinoic acid. FEBS Lett. 298, 165-8, 1992.
    • (1992) FEBS Lett. , vol.298 , pp. 165-168
    • Pierzchalski, P.1    Rokita, H.2    Koj, A.3    Fries, E.4    Akerstrom, B.5
  • 46
    • 0025202575 scopus 로고
    • Human thymic epithelial cells produce IL-6, Granulocyte-Monocyte-CSF, and Leukemia Inhibitory Factor
    • Le, P. T., Lazorick, S., Whichard, L. P., Yang, Y. C., Clark, C. S., Haynes, B. F., and Singer, K. H. Human thymic epithelial cells produce IL-6, Granulocyte-Monocyte-CSF, and Leukemia Inhibitory Factor. J. Immunol. 145, 3310-15, 1990.
    • (1990) J. Immunol. , vol.145 , pp. 3310-3315
    • Le, P.T.1    Lazorick, S.2    Whichard, L.P.3    Yang, Y.C.4    Clark, C.S.5    Haynes, B.F.6    Singer, K.H.7
  • 47
    • 0026551878 scopus 로고
    • Constitutive expression of leukemia inhibitory factor (LIF) mRNA and production of LIF by a cloned murine thymic stromal cell line
    • Sakata, T., Iwagami, S., Tsuruta, Y., Yamaguchi, M., Michishita, M., Nagata, K., Takai, Y., Ogata, M. Teraoka, H., and Fujiwara, H. Constitutive expression of leukemia inhibitory factor (LIF) mRNA and production of LIF by a cloned murine thymic stromal cell line. Thymus 19, 89-95, 1992.
    • (1992) Thymus , vol.19 , pp. 89-95
    • Sakata, T.1    Iwagami, S.2    Tsuruta, Y.3    Yamaguchi, M.4    Michishita, M.5    Nagata, K.6    Takai, Y.7    Ogata, M.8    Teraoka, H.9    Fujiwara, H.10
  • 48
    • 0027233526 scopus 로고
    • Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation
    • Escary, J. L., Perreau, J., Dumenil, D., Ezine, S., and Brulet, P. Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 363, 361-4, 1993.
    • (1993) Nature , vol.363 , pp. 361-364
    • Escary, J.L.1    Perreau, J.2    Dumenil, D.3    Ezine, S.4    Brulet, P.5
  • 49
    • 0028273756 scopus 로고
    • Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies
    • Shen, M. M., Skoda, R. C., Cardiff, R. D., Campos-Torres, J., Leder, P., and Ornitz, D. M. Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J. 13, 1375-85, 1994.
    • (1994) EMBO J. , vol.13 , pp. 1375-1385
    • Shen, M.M.1    Skoda, R.C.2    Cardiff, R.D.3    Campos-Torres, J.4    Leder, P.5    Ornitz, D.M.6
  • 51
    • 0024433304 scopus 로고
    • Production of leukemia inhibitory factor in E. coli by a novel procedure and its use in maintaining embryonic stem cells in culture
    • Gearing, D. P., Nicola, N. A., Metcalf, D., Foote, S., Willson, T. A., Gough, N. M., and Williams, R. L. Production of leukemia inhibitory factor in E. coli by a novel procedure and its use in maintaining embryonic stem cells in culture. Biotechnology 7, 1157-1161, 1989.
    • (1989) Biotechnology , vol.7 , pp. 1157-1161
    • Gearing, D.P.1    Nicola, N.A.2    Metcalf, D.3    Foote, S.4    Willson, T.A.5    Gough, N.M.6    Williams, R.L.7
  • 52
    • 0023058975 scopus 로고
    • A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • Shaw, G., and Kamen, R. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46, 659-66, 1986.
    • (1986) Cell , vol.46 , pp. 659-666
    • Shaw, G.1    Kamen, R.2
  • 54
    • 0026920444 scopus 로고
    • Simultaneous transcription of eleven cytokines in human alloreactive T lymphocyte clones after stimulation by phorbol ester and A23187
    • Hallet, M. M., Peyrat, M. A., Soulillou, J. P., and Moreau, J. F. Simultaneous transcription of eleven cytokines in human alloreactive T lymphocyte clones after stimulation by phorbol ester and A23187. Eur. Cytokine Netw. 3, 477-83, 1992.
    • (1992) Eur. Cytokine Netw. , vol.3 , pp. 477-483
    • Hallet, M.M.1    Peyrat, M.A.2    Soulillou, J.P.3    Moreau, J.F.4
  • 55
    • 0027155470 scopus 로고
    • Induction of leukemia inhibitory factor in human synovial fibroblasts by IL-1 and tumor necrosis factor-alpha
    • Hamilton, J. A., Waring, P. M., and Filonzi, E. L Induction of leukemia inhibitory factor in human synovial fibroblasts by IL-1 and tumor necrosis factor-alpha. J. Immunol. 150, 1496-502, 1993.
    • (1993) J. Immunol. , vol.150 , pp. 1496-1502
    • Hamilton, J.A.1    Waring, P.M.2    Filonzi, E.L.3
  • 56
    • 0027298229 scopus 로고
    • Production of leukemia inhibitory factor by human articular chondrocytes and cartilage in response to interleukin-1 and tumor necrosis factor alpha
    • Campbell, I. K., Waring, P., Novak, U., and Hamilton, J. A. Production of leukemia inhibitory factor by human articular chondrocytes and cartilage in response to interleukin-1 and tumor necrosis factor alpha. Arthritis Rheum. 36, 790-4, 1993.
    • (1993) Arthritis Rheum. , vol.36 , pp. 790-794
    • Campbell, I.K.1    Waring, P.2    Novak, U.3    Hamilton, J.A.4
  • 57
    • 0028211970 scopus 로고
    • Tumor necrosis factor alpha stimulates production of leukemia inhibitory factor in human dermal fibroblast cultures
    • Lorenzo, J. A., Jastrzebski, S. L., Kalinowski, J. F., Downie, E., and Korn, J. H. Tumor necrosis factor alpha stimulates production of leukemia inhibitory factor in human dermal fibroblast cultures. Clin. Immunol. Immunopathol. 70, 260-5, 1994.
    • (1994) Clin. Immunol. Immunopathol. , vol.70 , pp. 260-265
    • Lorenzo, J.A.1    Jastrzebski, S.L.2    Kalinowski, J.F.3    Downie, E.4    Korn, J.H.5
  • 58
    • 0028605693 scopus 로고
    • Interleukin-4 but not interleukin-10 inhibits the production of leukemia inhibitory factor by rheumatoid synovium and synoviocytes
    • Dechanet, J., Taupin, J. L., Chomarat, P., Rissoan, M. C., Moreau, J. F., Banchereau, J., and Miossec, P. Interleukin-4 but not interleukin-10 inhibits the production of leukemia inhibitory factor by rheumatoid synovium and synoviocytes. Eur. J. Immunol. 24, 3222-8, 1994.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3222-3228
    • Dechanet, J.1    Taupin, J.L.2    Chomarat, P.3    Rissoan, M.C.4    Moreau, J.F.5    Banchereau, J.6    Miossec, P.7
  • 59
    • 0028997150 scopus 로고
    • Hematologic effects of stem cell factor (SCF) and leukemia inhibitory factor (LIF) in vivo: LIF-induced thrombocytosis in SCF-primed mice
    • Ulich, T. R., del Castillo, J., Shin, S. S., Yin, S., Duryea, D., Tarpley, J., and Samal, B. Hematologic effects of stem cell factor (SCF) and leukemia inhibitory factor (LIF) in vivo: LIF-induced thrombocytosis in SCF-primed mice. Eur. J. Haematol. 54, 217-25, 1995.
    • (1995) Eur. J. Haematol. , vol.54 , pp. 217-225
    • Ulich, T.R.1    Del Castillo, J.2    Shin, S.S.3    Yin, S.4    Duryea, D.5    Tarpley, J.6    Samal, B.7
  • 60
    • 0028329958 scopus 로고
    • Leukemia inhibitory factor in long-term adherent layer cultures: Increased levels of bioactive protein in leukemia and modulation by IL-4, IL-1 beta, and TNF-alpha
    • Wetzler, M., Estrov, Z., Talpaz, M., Kim, K. J., Alphonso, M., Srinivasan, R., and Kurzrock, R. Leukemia inhibitory factor in long-term adherent layer cultures: increased levels of bioactive protein in leukemia and modulation by IL-4, IL-1 beta, and TNF-alpha. Cancer Res. 54, 1837-42, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 1837-1842
    • Wetzler, M.1    Estrov, Z.2    Talpaz, M.3    Kim, K.J.4    Alphonso, M.5    Srinivasan, R.6    Kurzrock, R.7
  • 61
    • 0027478791 scopus 로고
    • High circulating LIF in patients with giant cell arteritis: Independent regulation of LIF and IL6 under corticosteroid therapy
    • Lecron, J. C., Roblot, P., Chevalier, S., Morel, F., Alderman, E., Gombert, J., and Gascan, H. High circulating LIF in patients with giant cell arteritis: independent regulation of LIF and IL6 under corticosteroid therapy. Clin. Exp. Immunol. 92, 23-26, 1993.
    • (1993) Clin. Exp. Immunol. , vol.92 , pp. 23-26
    • Lecron, J.C.1    Roblot, P.2    Chevalier, S.3    Morel, F.4    Alderman, E.5    Gombert, J.6    Gascan, H.7
  • 64
    • 0028852652 scopus 로고
    • Cytokine expression in adherent layers from patients with myelodysplastic syndrome and acute myelogenous leukemia
    • Wetzler, M., Kurzrock, R., Estrov, Z., Estey, E., and Talpaz, M. Cytokine expression in adherent layers from patients with myelodysplastic syndrome and acute myelogenous leukemia. Leuk. Res. 19, 23-34, 1995.
    • (1995) Leuk. Res. , vol.19 , pp. 23-34
    • Wetzler, M.1    Kurzrock, R.2    Estrov, Z.3    Estey, E.4    Talpaz, M.5
  • 66
    • 0028238505 scopus 로고
    • Analysis of chromosome 22 loci in meningioma. Alterations in the leukemia inhibitory factor (LIF) locus
    • Pergolizzi, R. G., and Erster, S. H. Analysis of chromosome 22 loci in meningioma. Alterations in the leukemia inhibitory factor (LIF) locus. Mol. Chem. Neuropathol. 21, 189-217, 1994.
    • (1994) Mol. Chem. Neuropathol. , vol.21 , pp. 189-217
    • Pergolizzi, R.G.1    Erster, S.H.2
  • 67
    • 0025139311 scopus 로고
    • Localization of the murine leukemia inhibitory factor gene near the centromere on chromosome 11
    • Kola, I., Davey, A., and Gough, N. A. Localization of the murine leukemia inhibitory factor gene near the centromere on chromosome 11. Growth Factors 2, 235-40, 1990.
    • (1990) Growth Factors , vol.2 , pp. 235-240
    • Kola, I.1    Davey, A.2    Gough, N.A.3
  • 68
    • 0027013563 scopus 로고
    • The murine leukemia inhibition factor gene (LIF) is located on proximal chromosome 11, not chromosome 13
    • Bottorff, D. and Stone, J. C. The murine leukemia inhibition factor gene (LIF) is located on proximal chromosome 11, not chromosome 13. Mamm. Genome 3, 681-4, 1992.
    • (1992) Mamm. Genome , vol.3 , pp. 681-684
    • Bottorff, D.1    Stone, J.C.2
  • 69
    • 0024789926 scopus 로고
    • Human differentiation-stimulating factor (leukemia inhibitory factor, human interleukin DA) gene maps distal to the Ewing sarcoma breakpoint on 22q
    • Budarf, M., Emanuel, B. S., Mohandas, T., Goeddel, D. V., and Lowe, D. G. Human differentiation-stimulating factor (leukemia inhibitory factor, human interleukin DA) gene maps distal to the Ewing sarcoma breakpoint on 22q Cytogenet. Cell Genet. 52, 19-22, 1989.
    • (1989) Cytogenet. Cell Genet. , vol.52 , pp. 19-22
    • Budarf, M.1    Emanuel, B.S.2    Mohandas, T.3    Goeddel, D.V.4    Lowe, D.G.5
  • 70
    • 0025349192 scopus 로고
    • Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions
    • Stahl, J., Gearing, D. P., Willson, T. A., Brown, M. A., King, J. A., and Gough, N. M. Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions. J. Biol. Chem. 265, 8833-41, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8833-8841
    • Stahl, J.1    Gearing, D.P.2    Willson, T.A.3    Brown, M.A.4    King, J.A.5    Gough, N.M.6
  • 71
    • 0027494238 scopus 로고
    • Delineation of positive and negative control elements within the promoter region of the murine leukemia inhibitory factor (LIF) gene
    • Stahl, J. and Gough, N. M. Delineation of positive and negative control elements within the promoter region of the murine leukemia inhibitory factor (LIF) gene. Cytokine 5, 386-93, 1993.
    • (1993) Cytokine , vol.5 , pp. 386-393
    • Stahl, J.1    Gough, N.M.2
  • 73
    • 0027463696 scopus 로고
    • Localization of the human oncostatin M gene (OSM) to chromosome 22q12, distal to the Ewing's sarcoma breakpoint
    • Giovannini, M., Selleri, L., Hermanson, G. G., and Evans, G. A. Localization of the human oncostatin M gene (OSM) to chromosome 22q12, distal to the Ewing's sarcoma breakpoint. Cytogenet. Cell Genet, 62, 32-4, 1993.
    • (1993) Cytogenet. Cell Genet , vol.62 , pp. 32-34
    • Giovannini, M.1    Selleri, L.2    Hermanson, G.G.3    Evans, G.A.4
  • 74
    • 0027287791 scopus 로고
    • Close proximity of the genes for leukemia inhibitory factor and oncostatin M
    • Jeffery, E., Price, V., and Gearing, D. P. Close proximity of the genes for leukemia inhibitory factor and oncostatin M. Cytokine 5, 107-11, 1993.
    • (1993) Cytokine , vol.5 , pp. 107-111
    • Jeffery, E.1    Price, V.2    Gearing, D.P.3
  • 75
    • 0027491994 scopus 로고
    • Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22
    • Giovannini, M., Djabali, M., McElligott, D., Selleri, L., and Evans, G. A. Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22. Cytogenet. Cell Genet. 64, 240-4, 1993.
    • (1993) Cytogenet. Cell Genet. , vol.64 , pp. 240-244
    • Giovannini, M.1    Djabali, M.2    McElligott, D.3    Selleri, L.4    Evans, G.A.5
  • 77
    • 0026519068 scopus 로고
    • Oncostatin M binds the high-affinity leukemia inhibitory factor receptor
    • Gearing, D. P. and Bruce, A. G. Oncostatin M binds the high-affinity leukemia inhibitory factor receptor. New Biologist 4, 61-5, 1992.
    • (1992) New Biologist , vol.4 , pp. 61-65
    • Gearing, D.P.1    Bruce, A.G.2
  • 78
    • 0028085950 scopus 로고
    • Interactions between OSM and the IL6 signal transducer, gp130
    • Liu, J., Modrell, B., Aruffo, A., Scharnowske, S., and Shoyab, M. Interactions between OSM and the IL6 signal transducer, gp130. Cytokine 6, 272-78, 1994.
    • (1994) Cytokine , vol.6 , pp. 272-278
    • Liu, J.1    Modrell, B.2    Aruffo, A.3    Scharnowske, S.4    Shoyab, M.5
  • 79
    • 0025018297 scopus 로고
    • Differentiation inhibiting activity/leukemia inhibitory factor (DIA/LIF) is produced in matrix-associated and diffusible forms generated by alternate promoter usage
    • Rathjen, P. D., Toth, S., Willis, A., Heath, J. K., and Smith, A. G. Differentiation inhibiting activity/leukemia inhibitory factor (DIA/LIF) is produced in matrix-associated and diffusible forms generated by alternate promoter usage. Cell 62, 1105-1114, 1990.
    • (1990) Cell , vol.62 , pp. 1105-1114
    • Rathjen, P.D.1    Toth, S.2    Willis, A.3    Heath, J.K.4    Smith, A.G.5
  • 80
    • 0026601658 scopus 로고
    • Cross-species comparison of the sequence of the leukemia inhibitory factor gene and its protein
    • Willson, T. A., Metcalf, D., and Gough, N. M. Cross-species comparison of the sequence of the leukemia inhibitory factor gene and its protein. Eur. J. Biochem. 204, 21-30, 1992.
    • (1992) Eur. J. Biochem. , vol.204 , pp. 21-30
    • Willson, T.A.1    Metcalf, D.2    Gough, N.M.3
  • 81
    • 0027220603 scopus 로고
    • Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissues
    • Robertson, M., Chambers, I., Rathjen, P., Nichols, J., and Smith, A. Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissues. Dev. Genet. 14, 165-73, 1993.
    • (1993) Dev. Genet. , vol.14 , pp. 165-173
    • Robertson, M.1    Chambers, I.2    Rathjen, P.3    Nichols, J.4    Smith, A.5
  • 82
    • 0026656933 scopus 로고
    • Inhibited gastrulation in mouse embryos overexpressing the leukemia inhibitory factor
    • Conquet, F., Peyrieras, N., Tiret, L., and Brulet, P. Inhibited gastrulation in mouse embryos overexpressing the leukemia inhibitory factor. Proc. Natl. Acad. Sci. USA 89, 8195-19, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8195-8219
    • Conquet, F.1    Peyrieras, N.2    Tiret, L.3    Brulet, P.4
  • 83
    • 0026738694 scopus 로고
    • Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro
    • Shen, M. M. and Leder, P. Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro. Proc. Natl. Acad. Sci. USA 89, 8240-4, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8240-8244
    • Shen, M.M.1    Leder, P.2
  • 84
    • 0029915836 scopus 로고    scopus 로고
    • Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells
    • Gupta, P., McCarthy, J. B., and Verfaillie, C. M. Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells. Blood 87, 3229-36, 1996.
    • (1996) Blood , vol.87 , pp. 3229-3236
    • Gupta, P.1    McCarthy, J.B.2    Verfaillie, C.M.3
  • 85
    • 0028197649 scopus 로고
    • Three different cDNAs encoding mouse D-factor/LIF receptor
    • Tomida, M., Yamamoto-Yamaguchi, Y., and Hozumi, M. Three different cDNAs encoding mouse D-factor/LIF receptor. J. Biochem. 115, 557-62, 1994.
    • (1994) J. Biochem. , vol.115 , pp. 557-562
    • Tomida, M.1    Yamamoto-Yamaguchi, Y.2    Hozumi, M.3
  • 86
    • 0028997598 scopus 로고
    • Analysis of recombinant soluble mouse D-factor/LIF receptor
    • Tomida, M. Analysis of recombinant soluble mouse D-factor/LIF receptor. J. Biochem. 117, 1228-31, 1995.
    • (1995) J. Biochem. , vol.117 , pp. 1228-1231
    • Tomida, M.1
  • 87
    • 0029978857 scopus 로고    scopus 로고
    • Molecular basis of the soluble and membrane-bound forms of the murine leukemia inhibitory factor receptor alpha-chain. Expression in normal, gestating, and leukemia inhibitory factor nullizygous mice
    • Owczarek, C. M., Layton, M. J., Robb, L. G., Nicola, N. A., and Begley, C. G. Molecular basis of the soluble and membrane-bound forms of the murine leukemia inhibitory factor receptor alpha-chain. Expression in normal, gestating, and leukemia inhibitory factor nullizygous mice. J. Biol. Chem. 271, 5495-504, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5495-5504
    • Owczarek, C.M.1    Layton, M.J.2    Robb, L.G.3    Nicola, N.A.4    Begley, C.G.5
  • 88
    • 0027244821 scopus 로고
    • Characterization of a binding protein for leukemia inhibitory factor localized in extracellular matrix
    • Mereau, A., Grey, L., Piquet-Pellorce, C., and Heath, J. K. Characterization of a binding protein for leukemia inhibitory factor localized in extracellular matrix. J. Cell. Biol. 122, 713-9, 1993.
    • (1993) J. Cell. Biol. , vol.122 , pp. 713-719
    • Mereau, A.1    Grey, L.2    Piquet-Pellorce, C.3    Heath, J.K.4
  • 89
    • 0026775147 scopus 로고
    • A major binding protein for leukemia inhibitory factor in normal mouse serum: Identification as a soluble form of the cellular receptor
    • Layton, M. J., Cross, B. A., Metcalf, D., Ward, L. D., Simpson, R. J., and Nicola, N. A. A major binding protein for leukemia inhibitory factor in normal mouse serum: identification as a soluble form of the cellular receptor, Proc. Natl. Acad. Sci. USA 89, 8616-20, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8616-8620
    • Layton, M.J.1    Cross, B.A.2    Metcalf, D.3    Ward, L.D.4    Simpson, R.J.5    Nicola, N.A.6
  • 90
    • 0027227584 scopus 로고
    • The disulfide bond arrangement of leukemia inhibitory factor: Homology to oncostatin M and structural implications
    • Nicola, N. A., Cross, B., and Simpson, R. J. The disulfide bond arrangement of leukemia inhibitory factor: homology to oncostatin M and structural implications. Biochem. Biophys. Res. Comm. 190, 20-6, 1993.
    • (1993) Biochem. Biophys. Res. Comm. , vol.190 , pp. 20-26
    • Nicola, N.A.1    Cross, B.2    Simpson, R.J.3
  • 95
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • de Vos, A. M., Ultsch, M., and Kossiakoff, A. A. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312, 1992.
    • (1992) Science , vol.255 , pp. 306-312
    • De Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 96
    • 0025895320 scopus 로고
    • Neuropoietic cytokines in the hematopoietic fold
    • Bazan, J. F. Neuropoietic cytokines in the hematopoietic fold. Neuron 7, 197-208, 1991.
    • (1991) Neuron , vol.7 , pp. 197-208
    • Bazan, J.F.1
  • 97
    • 0027258762 scopus 로고
    • The structure of granulocyte colony stimulating factor and its relationship to other growth factors
    • Hill, C. P., Osslund, T. D., and Eisenberg, D. The structure of granulocyte colony stimulating factor and its relationship to other growth factors. Proc. Natl. Acad. Sci. USA 90, 5167-5171, 1993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5167-5171
    • Hill, C.P.1    Osslund, T.D.2    Eisenberg, D.3
  • 100
    • 0026073694 scopus 로고
    • Distribution and comparison of the receptors for LIF on murine hemopoietic and hepatic Cells
    • Hilton, D. J., Nicola, N. A., and Metcalf, D. Distribution and comparison of the receptors for LIF on murine hemopoietic and hepatic Cells. J. Cell Physiol. 146, 207-215, 1991.
    • (1991) J. Cell Physiol. , vol.146 , pp. 207-215
    • Hilton, D.J.1    Nicola, N.A.2    Metcalf, D.3
  • 101
    • 0026727770 scopus 로고
    • Kinetic analyses of the binding of leukemia inhibitory factor to receptor on cells and membranes and in detergent solution
    • Hilton, D. J. and Nicola, N. A. Kinetic analyses of the binding of leukemia inhibitory factor to receptor on cells and membranes and in detergent solution. J. Biol. Chem. 267, 10238-47, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10238-10247
    • Hilton, D.J.1    Nicola, N.A.2
  • 103
    • 0026484862 scopus 로고
    • Human growth factor for murine interleukin IL9 responsive T cell lines: Co-induction with IL-6 in fibroblasts and identification as LIF/HILDA
    • Van Damme, J., Uyttenhove, C., Houssiau, F., Put, W., Proost, P., and Van Snick, J. Human growth factor for murine interleukin IL9 responsive T cell lines: co-induction with IL-6 in fibroblasts and identification as LIF/HILDA. Eur. J. Immunol. 22, 2801-8, 1992.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2801-2808
    • Van Damme, J.1    Uyttenhove, C.2    Houssiau, F.3    Put, W.4    Proost, P.5    Van Snick, J.6
  • 104
    • 0028265160 scopus 로고
    • Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130
    • Zhang, X. G., Gu, J. J., Lu, Z. Y., Yasukawa, K., Yancopoulos, G. D., Turner, K., Shoyab, M., Taga, T., Kishimoto, T., Bataille, R., and Klein, B. Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130. J. Exp. Med. 179, 1337-42, 1994.
    • (1994) J. Exp. Med. , vol.179 , pp. 1337-1342
    • Zhang, X.G.1    Gu, J.J.2    Lu, Z.Y.3    Yasukawa, K.4    Yancopoulos, G.D.5    Turner, K.6    Shoyab, M.7    Taga, T.8    Kishimoto, T.9    Bataille, R.10    Klein, B.11
  • 105
    • 0028344845 scopus 로고
    • Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130
    • Nishimoto, N., Ogata, A., Shima, Y., Tani, Y., Ogawa, H., Nakagawa, M., Sugiyama, H., Yoshizaki, K., and Kishimoto, T. Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130. J. Exp. Med. 179, 1343-7, 1994.
    • (1994) J. Exp. Med. , vol.179 , pp. 1343-1347
    • Nishimoto, N.1    Ogata, A.2    Shima, Y.3    Tani, Y.4    Ogawa, H.5    Nakagawa, M.6    Sugiyama, H.7    Yoshizaki, K.8    Kishimoto, T.9
  • 106
    • 0028324596 scopus 로고
    • Expression of cytokine/growth Factors and their receptors in human melanoma and melanocytes
    • Mattel, S., Colombo, M. P., Melani, C., Silvani, A., Parmiani, G., and Herlyn, M. Expression of cytokine/growth Factors and their receptors in human melanoma and melanocytes. Int. J. Cancer 56, 853-7, 1994.
    • (1994) Int. J. Cancer , vol.56 , pp. 853-857
    • Mattel, S.1    Colombo, M.P.2    Melani, C.3    Silvani, A.4    Parmiani, G.5    Herlyn, M.6
  • 108
    • 0030025735 scopus 로고    scopus 로고
    • Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells
    • Bellido, T., Stahl, N., Farruggella, T. J., Borba, V., Yancopoulos, G. D., and Manolagas, S. C. Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells. J. Clin. Invest. 97, 431-7, 1996.
    • (1996) J. Clin. Invest. , vol.97 , pp. 431-437
    • Bellido, T.1    Stahl, N.2    Farruggella, T.J.3    Borba, V.4    Yancopoulos, G.D.5    Manolagas, S.C.6
  • 110
    • 0027414621 scopus 로고
    • The effects of leukemia inhibitory factor and interleukin 6 on the growth of acute myeloid leukemia cells
    • Takanashi, M., Motoji, T., Masuda, M., Oshimi, K., and Mizoguchi, H. The effects of leukemia inhibitory factor and interleukin 6 on the growth of acute myeloid leukemia cells. Leuk. Res. 17, 217-22, 1993.
    • (1993) Leuk. Res. , vol.17 , pp. 217-222
    • Takanashi, M.1    Motoji, T.2    Masuda, M.3    Oshimi, K.4    Mizoguchi, H.5
  • 113
    • 0029888789 scopus 로고    scopus 로고
    • Leukemia inhibitory factor stimulates breast, kidney and prostate cancer cell proliferation by paracrine and autocrine pathways
    • Kellokumpu-Lehtinen, P., Talpaz, M., Harris, D., Van, Q., Kurzrock, R., and Estrov, Z. Leukemia inhibitory factor stimulates breast, kidney and prostate cancer cell proliferation by paracrine and autocrine pathways. Int. J. Cancer 66, 515-9, 1996.
    • (1996) Int. J. Cancer , vol.66 , pp. 515-519
    • Kellokumpu-Lehtinen, P.1    Talpaz, M.2    Harris, D.3    Van, Q.4    Kurzrock, R.5    Estrov, Z.6
  • 115
    • 0026758799 scopus 로고
    • Molecular genetics of LIF and its receptor
    • Gough, N. M. Molecular genetics of LIF and its receptor. Growth Factors 7, 175-9, 1992.
    • (1992) Growth Factors , vol.7 , pp. 175-179
    • Gough, N.M.1
  • 117
    • 0029881372 scopus 로고    scopus 로고
    • Functional inactivation in mice of the gene for the IL3-specific receptor beta-chain: Implications for IL3 function and the mechanism of the receptor transmodulation in hematopoietic cells
    • Nicola, N. A., Robb, L., Metcalf, D., Cary, D., Drinkwater, C. C., and Begley, G. Functional inactivation in mice of the gene for the IL3-specific receptor beta-chain: implications for IL3 function and the mechanism of the receptor transmodulation in hematopoietic cells. Blood 87, 2665-74, 1996.
    • (1996) Blood , vol.87 , pp. 2665-2674
    • Nicola, N.A.1    Robb, L.2    Metcalf, D.3    Cary, D.4    Drinkwater, C.C.5    Begley, G.6
  • 119
    • 0024469936 scopus 로고
    • A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, IL6 and erythropoietin receptors, and the p75 IL2 receptor beta-chain
    • Bazan, J. F. A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, IL6 and erythropoietin receptors, and the p75 IL2 receptor beta-chain. Biochem. Biophys. Res. Commun. 164, 788-796, 1989.
    • (1989) Biochem. Biophys. Res. Commun. , vol.164 , pp. 788-796
    • Bazan, J.F.1
  • 120
    • 0025102756 scopus 로고
    • Haematopoietic receptors and helical cytokines
    • Bazan, J. F. Haematopoietic receptors and helical cytokines. Immunol. Today 11, 350-354, 1990.
    • (1990) Immunol. Today , vol.11 , pp. 350-354
    • Bazan, J.F.1
  • 124
    • 0027469866 scopus 로고
    • Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component
    • Stahl, N., Davis, S., Wong, V., Taga, T., Kishimoto, T., Ip, N. Y., and Yancopoulos, G. D. Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component. J. Biol. Chem. 268, 7628-31, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 7628-7631
    • Stahl, N.1    Davis, S.2    Wong, V.3    Taga, T.4    Kishimoto, T.5    Ip, N.Y.6    Yancopoulos, G.D.7
  • 125
    • 0027320024 scopus 로고
    • LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor
    • Davis, S., Aldrich, T. H., Stahl, N., Pan, L., Taga, T., Kishimoto, T., Ip, N. Y., and Yancopoulos, G. D. LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 260, 1805-8, 1993
    • (1993) Science , vol.260 , pp. 1805-1808
    • Davis, S.1    Aldrich, T.H.2    Stahl, N.3    Pan, L.4    Taga, T.5    Kishimoto, T.6    Ip, N.Y.7    Yancopoulos, G.D.8
  • 127
    • 0028093250 scopus 로고
    • Oncostatin M and Leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes
    • Thoma, B., Bird, T. A., Friend, D. J., Gearing, D. P., and Dower, S. K. Oncostatin M and Leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes. J. Biol. Chem. 269, 6215-22, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6215-6222
    • Thoma, B.1    Bird, T.A.2    Friend, D.J.3    Gearing, D.P.4    Dower, S.K.5
  • 129
    • 0028245609 scopus 로고
    • Cytokines that associate witn the signal transducer gp130 activate the interferon-induced transcription factor p91 by tyrosine phosphorylation
    • Feldman, M., Petricoin, E. F., David, M., Larner, A. C., and Finbloom, D. S. Cytokines that associate witn the signal transducer gp130 activate the interferon-induced transcription factor p91 by tyrosine phosphorylation. J. Biol. Chem. 269, 10747-52, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10747-10752
    • Feldman, M.1    Petricoin, E.F.2    David, M.3    Larner, A.C.4    Finbloom, D.S.5
  • 130
    • 0028215282 scopus 로고
    • Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells
    • Ernst, M., Gearing, D. P., and Dunn, A. R. Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells. EMBO J. 13, 1574-84, 1994.
    • (1994) EMBO J. , vol.13 , pp. 1574-1584
    • Ernst, M.1    Gearing, D.P.2    Dunn, A.R.3
  • 132
    • 0027508708 scopus 로고
    • The cholinergic stimulating effects of ciliary neurotrophic factor and leukemia inhibitory factor are mediated by protein kinase C
    • Kalberg, C., Yung, S. Y., and Kessler, J. A. The cholinergic stimulating effects of ciliary neurotrophic factor and leukemia inhibitory factor are mediated by protein kinase C. J. Neurochem. 60, 145-52, 1993.
    • (1993) J. Neurochem. , vol.60 , pp. 145-152
    • Kalberg, C.1    Yung, S.Y.2    Kessler, J.A.3
  • 133
    • 0028041191 scopus 로고
    • Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells
    • Yin, T. and Yang, Y. C. Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells. J. Biol. Chem. 269, 3731-8, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3731-3738
    • Yin, T.1    Yang, Y.C.2
  • 134
    • 0028300547 scopus 로고
    • Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor. Evidence for participation of multiple signaling pathways
    • Schiemann, W. P. and Nathanson, N. M. Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor. Evidence for participation of multiple signaling pathways. J. Biol. Chem. 269, 6376-82, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6376-6382
    • Schiemann, W.P.1    Nathanson, N.M.2
  • 135
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira, S., Nishio, Y., Inoue, M., Wang, X. J., Wei, S., Matsusaka, T., K, Y., Sudo, T., Naruto, M., and Kishimoto, T. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77, 63-71, 1994.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.J.4    Wei, S.5    Matsusaka, T.K.Y.6    Sudo, T.7    Naruto, M.8    Kishimoto, T.9
  • 136
    • 0028279791 scopus 로고
    • Ciliary neurotrophic factor/ leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
    • Boulton, T. G., Stahl, N., and Yancopoulos, G. D. Ciliary neurotrophic factor/ leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 269, 11648-55, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 11648-11655
    • Boulton, T.G.1    Stahl, N.2    Yancopoulos, G.D.3
  • 137
    • 0029017123 scopus 로고
    • Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation
    • Schiemann, W. P., Graves, L. M., Baumann, H., Morella, K. K., Gearing, D. P., Nielsen, M. D., Krebs, E. G., and Nathanson, N. M. Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation. Proc. Natl. Acad. Sci. USA 92, 5361-5, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5361-5365
    • Schiemann, W.P.1    Graves, L.M.2    Baumann, H.3    Morella, K.K.4    Gearing, D.P.5    Nielsen, M.D.6    Krebs, E.G.7    Nathanson, N.M.8
  • 138
    • 0029052318 scopus 로고
    • Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association
    • Matsuda, T., Fukada, T., Takahashi-Tezuka, M., Okuyama, Y., Fujitani, Y., Hanazono, Y., Hirai, H., and Hirano, T. Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association. J. Biol. Chem. 270, 11037-9, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11037-11039
    • Matsuda, T.1    Fukada, T.2    Takahashi-Tezuka, M.3    Okuyama, Y.4    Fujitani, Y.5    Hanazono, Y.6    Hirai, H.7    Hirano, T.8
  • 141
    • 0027232919 scopus 로고
    • The hematopoietin receptor superfamily
    • Cosman, D. The hematopoietin receptor superfamily. Cytokine 5, 95-106, 1993.
    • (1993) Cytokine , vol.5 , pp. 95-106
    • Cosman, D.1
  • 142
    • 0025942918 scopus 로고
    • The integrity of the conserved "WS motif" common to IL2 and other cytokine receptors is essential for ligand binding and signal transduction
    • Miyasaki, T., Maruyama, M., Yamada, G., Hatakeyama, M., and Taniguchi, T. The integrity of the conserved "WS motif" common to IL2 and other cytokine receptors is essential for ligand binding and signal transduction. EMBO J. 10, 3191-97, 1991.
    • (1991) EMBO J. , vol.10 , pp. 3191-3197
    • Miyasaki, T.1    Maruyama, M.2    Yamada, G.3    Hatakeyama, M.4    Taniguchi, T.5
  • 143
    • 0029928504 scopus 로고    scopus 로고
    • Saturation mutagenesis of the WSXWS motif of the erthropoietin receptor
    • Hilton, D. J., Watowich, S. S., Katz, L., and Lodish, H. F. Saturation mutagenesis of the WSXWS motif of the erthropoietin receptor. J. Biol. Chem. 271, 4699-4708, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 4699-4708
    • Hilton, D.J.1    Watowich, S.S.2    Katz, L.3    Lodish, H.F.4
  • 144
    • 0028843914 scopus 로고    scopus 로고
    • Requirement for the immunoglobulin-like domain of granulocyte colony-stimulating factor receptor in formation of a 2:1 receptor-ligand complex
    • Hiraoka, O., Anaguchi, H., Asakura, A., and Ota, Y. Requirement for the immunoglobulin-like domain of granulocyte colony-stimulating factor receptor in formation of a 2:1 receptor-ligand complex. J. Biol. Chem. 270, 25928-34, 1996.
    • (1996) J. Biol. Chem. , vol.270 , pp. 25928-25934
    • Hiraoka, O.1    Anaguchi, H.2    Asakura, A.3    Ota, Y.4
  • 145
    • 0027452011 scopus 로고
    • Pregnancy associated increase in mRNA for soluble D-factor/LIF receptor in mouse liver
    • Tomida, M., Yamamoto-Yamaguchi, Y., and Hozumi, M. Pregnancy associated increase in mRNA for soluble D-factor/LIF receptor in mouse liver. FEBS Lett. 334, 193-7, 1993.
    • (1993) FEBS Lett. , vol.334 , pp. 193-197
    • Tomida, M.1    Yamamoto-Yamaguchi, Y.2    Hozumi, M.3
  • 146
    • 0027221779 scopus 로고
    • Pregnancy associated increase in differentiation-stimulating factor (D-factor)/leukemia inhibitory factor (LIF)-binding substance(s) in mouse serum
    • Yamaguchi-Yamamoto, Y., Tomida, M., and Hozumi, M. Pregnancy associated increase in differentiation-stimulating factor (D-factor)/leukemia inhibitory factor (LIF)-binding substance(s) in mouse serum. Leuk. Res. 17, 515-22, 1993.
    • (1993) Leuk. Res. , vol.17 , pp. 515-522
    • Yamaguchi-Yamamoto, Y.1    Tomida, M.2    Hozumi, M.3
  • 148
    • 0029657884 scopus 로고    scopus 로고
    • Leukemia Inhibitory Factor and Oncostatin M high affinity binding require additional receptor subunits besides gp130 and gp190
    • Heymann, D., Godard, A., Raher, S., Bentouimou, S., Blanchard, F., Cherel, M., Hallet, M. M., and Jacques, Y. Leukemia Inhibitory Factor and Oncostatin M high affinity binding require additional receptor subunits besides gp130 and gp190. Cytokine 8, 197-205, 1996.
    • (1996) Cytokine , vol.8 , pp. 197-205
    • Heymann, D.1    Godard, A.2    Raher, S.3    Bentouimou, S.4    Blanchard, F.5    Cherel, M.6    Hallet, M.M.7    Jacques, Y.8
  • 149
    • 0343186481 scopus 로고
    • The OSM receptor: Cloning of a novel subunit related to the LIF receptor
    • Mosley, B., Delmus, C., Friend, D., Thoma, B., and Cosman, D. The OSM receptor: cloning of a novel subunit related to the LIF receptor (Abstract A92). Cytokine 6, 554, 1994.
    • (1994) Cytokine , vol.6 , pp. 554
    • Mosley, B.1    Delmus, C.2    Friend, D.3    Thoma, B.4    Cosman, D.5
  • 150
    • 0028301594 scopus 로고
    • OSM binds directly to gp130 and behaves as IL6 antagonist on a cell line expressing gp130 but lacking functional OSM receptors
    • Sporeno, E., Paonessa, G., Salvati, A. L., Graziani, R., Delmastro, P., Ciliberto, G., and Toniatti, C. OSM binds directly to gp130 and behaves as IL6 antagonist on a cell line expressing gp130 but lacking functional OSM receptors. J. Biol. Chem. 269, 10991-95, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10991-10995
    • Sporeno, E.1    Paonessa, G.2    Salvati, A.L.3    Graziani, R.4    Delmastro, P.5    Ciliberto, G.6    Toniatti, C.7
  • 151
    • 0028356453 scopus 로고
    • Cross-species receptor binding characteristics of human and mouse leukemia inhibitory factor suggest a complex binding interaction
    • Layton, M. J., Lock, P., Metcalf, D., and Nicola, N. A. Cross-species receptor binding characteristics of human and mouse leukemia inhibitory factor suggest a complex binding interaction. J. Biol. Chem. 269, 17048-55, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17048-17055
    • Layton, M.J.1    Lock, P.2    Metcalf, D.3    Nicola, N.A.4
  • 152
    • 0027293729 scopus 로고
    • Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant
    • Owczarek, C. M., Layton, M. J., Metcalf, D., Lock, P., Willson, T. A., Gough, N. M., and Nicola, N. A. Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant. EMBO J. 12, 3487-95, 1993.
    • (1993) EMBO J. , vol.12 , pp. 3487-3495
    • Owczarek, C.M.1    Layton, M.J.2    Metcalf, D.3    Lock, P.4    Willson, T.A.5    Gough, N.M.6    Nicola, N.A.7
  • 153
    • 0028034448 scopus 로고
    • Conversion of the biological specificity of murine to human leukemia inhibitory factor by replacing 6 amino acid residues
    • Layton, M. J., Owczarek, C. M., Metcalf, D., Clark, R. L., Smith, D. K., Treutlein, H. R., and Nicola, N. A. Conversion of the biological specificity of murine to human leukemia inhibitory factor by replacing 6 amino acid residues. J. Biol. Chem. 269, 29891-6, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 29891-29896
    • Layton, M.J.1    Owczarek, C.M.2    Metcalf, D.3    Clark, R.L.4    Smith, D.K.5    Treutlein, H.R.6    Nicola, N.A.7
  • 154
    • 6844228812 scopus 로고
    • Comparison of a structural and functional epitope
    • Cunningham, B. C. and Wells, J. A. Comparison of a structural and functional epitope. Mol. Biol. 234, 5554-63, 1993.
    • (1993) Mol. Biol. , vol.234 , pp. 5554-5563
    • Cunningham, B.C.1    Wells, J.A.2
  • 156
    • 0343474047 scopus 로고
    • Fatal syndrome in mice engrafted with cells producing high levels of LIF
    • Metcalf, D. and Gearing, D. P. Fatal syndrome in mice engrafted with cells producing high levels of LIF. Proc. Natl. Acad. Sci. USA 86, 5948-52, 1989.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5948-5952
    • Metcalf, D.1    Gearing, D.P.2
  • 157
    • 0024345320 scopus 로고
    • A myelosclerotic syndrome in mice engrafted with cells producing high levels of LIF
    • Metcalf, D. and Gearing, D. P A myelosclerotic syndrome in mice engrafted with cells producing high levels of LIF. Leukemia 3, 847-52, 1990.
    • (1990) Leukemia , vol.3 , pp. 847-852
    • Metcalf, D.1    Gearing, D.P.2
  • 158
    • 0025340041 scopus 로고
    • Effects of injected LIF on hematopoietic and other tissues in mice
    • Metcalf, D., Nicola, N. A., and Gearing, D. P. Effects of injected LIF on hematopoietic and other tissues in mice. Blood 76, 50-6, 1990.
    • (1990) Blood , vol.76 , pp. 50-56
    • Metcalf, D.1    Nicola, N.A.2    Gearing, D.P.3
  • 159
    • 0026467339 scopus 로고
    • Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids
    • Waring, P., Wycherley, K., Cary, D., Nicola, N., and Metcalf, D. Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids. J. Clin. Invest. 90, 2031-7, 1992.
    • (1992) J. Clin. Invest. , vol.90 , pp. 2031-2037
    • Waring, P.1    Wycherley, K.2    Cary, D.3    Nicola, N.4    Metcalf, D.5
  • 160
    • 0028144815 scopus 로고
    • Leukaemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation
    • Brown, M. A., Metcalf, D., and Gough, N. M. Leukaemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation. Cytokine 6, 300-9, 1994.
    • (1994) Cytokine , vol.6 , pp. 300-309
    • Brown, M.A.1    Metcalf, D.2    Gough, N.M.3
  • 163
    • 0028945787 scopus 로고
    • Leukemia inhibitory factor protects against experimental lethal Escherichia coli septic shock in mice
    • Waring, P. M., Waring, L. J., Billington, T., and Metcalf, D. Leukemia inhibitory factor protects against experimental lethal Escherichia coli septic shock in mice. Proc. Natl. Acad. Sci. USA 92, 1337-41, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1337-1341
    • Waring, P.M.1    Waring, L.J.2    Billington, T.3    Metcalf, D.4
  • 164
    • 0028151446 scopus 로고
    • Circulating leukemia inhibitory factor levels correlate with disease severity in meningococcemia
    • Waring, P. M., Waring, L. J., and Metcalf, D. Circulating leukemia inhibitory factor levels correlate with disease severity in meningococcemia. J. Infect. Dis. 170, 1224-8, 1994.
    • (1994) J. Infect. Dis. , vol.170 , pp. 1224-1228
    • Waring, P.M.1    Waring, L.J.2    Metcalf, D.3
  • 165
    • 0026521963 scopus 로고
    • Differentiation factor/leukemia inhibitory factor protection against lethal endotoxemia in mice: Synergistic effect with interleukin 1 and tumor necrosis factor
    • Alexander, H. R., Wong, G. G., Doherty, G. M., Venzon, D. J., Fraker, D. L., and Norton, J. A. Differentiation factor/leukemia inhibitory factor protection against lethal endotoxemia in mice: synergistic effect with interleukin 1 and tumor necrosis factor. J. Exp. Med. 175, 1139-42, 1992.
    • (1992) J. Exp. Med. , vol.175 , pp. 1139-1142
    • Alexander, H.R.1    Wong, G.G.2    Doherty, G.M.3    Venzon, D.J.4    Fraker, D.L.5    Norton, J.A.6
  • 167
    • 0027970190 scopus 로고
    • Leukemia inhibitory factor: Association with intraamniotic infection
    • Waring, P. M., Romero, R., Laham, N., Gomez, R., and Rice, G. E. Leukemia inhibitory factor: association with intraamniotic infection. Am. J. Obstet. Gynecol. 171, 1335-41, 1994.
    • (1994) Am. J. Obstet. Gynecol. , vol.171 , pp. 1335-1341
    • Waring, P.M.1    Romero, R.2    Laham, N.3    Gomez, R.4    Rice, G.E.5
  • 169
    • 0027304410 scopus 로고
    • Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia
    • Block, M. I., Berg, M., McNamara, M. J., Norton, J. A., Fraker, D. L., and Alexander, H. R. Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia. J. Exp. Med. 178, 1085-90, 1993.
    • (1993) J. Exp. Med. , vol.178 , pp. 1085-1090
    • Block, M.I.1    Berg, M.2    McNamara, M.J.3    Norton, J.A.4    Fraker, D.L.5    Alexander, H.R.6
  • 170
    • 0029875561 scopus 로고    scopus 로고
    • Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway
    • Ray, D. W., Ren, S., and Melmed, S. Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway. J. Clin. Invest. 97, 1852-9, 1996.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1852-1859
    • Ray, D.W.1    Ren, S.2    Melmed, S.3
  • 171
    • 0026739813 scopus 로고
    • Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid
    • Villiger, P. M., Terkeltaub, R., and Lotz, M. Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid. J. Clin. Invest. 90, 488-96, 1992.
    • (1992) J. Clin. Invest. , vol.90 , pp. 488-496
    • Villiger, P.M.1    Terkeltaub, R.2    Lotz, M.3
  • 172
    • 0029156297 scopus 로고
    • Leukemia inhibitory factor induces interleukin-8 and monocyte chemotactic and activating factor in human monocytes: Differential regulation by interferon-gamma
    • Musso, T., Badolato, R., Longo, D. L., Gusella, G. L., and Varesio, L. Leukemia inhibitory factor induces interleukin-8 and monocyte chemotactic and activating factor in human monocytes: differential regulation by interferon-gamma. Blood 86, 1961-7, 1995.
    • (1995) Blood , vol.86 , pp. 1961-1967
    • Musso, T.1    Badolato, R.2    Longo, D.L.3    Gusella, G.L.4    Varesio, L.5
  • 175
    • 0026825817 scopus 로고
    • HILDA/LIF is present in the urine of rejecting kidney graft recipients
    • Blancho, G., Moreau, J. F., Anegon, I., and Soulillou, J. P. HILDA/LIF is present in the urine of rejecting kidney graft recipients. Transpl. Int. 5, 57-8, 1992.
    • (1992) Transpl. Int. , vol.5 , pp. 57-58
    • Blancho, G.1    Moreau, J.F.2    Anegon, I.3    Soulillou, J.P.4
  • 176
    • 0027384318 scopus 로고
    • HILDA/LIF, G.CSF, IL-1 beta, IL-6, and TNF alpha production during acute rejection of human kidney allografts
    • Blancho, G., Moreau, J. F., Chabannes, D., Chatenoud, L., and Soulillou, J. P. HILDA/LIF, G.CSF, IL-1 beta, IL-6, and TNF alpha production during acute rejection of human kidney allografts. Transplantation 56, 597-602, 1993.
    • (1993) Transplantation , vol.56 , pp. 597-602
    • Blancho, G.1    Moreau, J.F.2    Chabannes, D.3    Chatenoud, L.4    Soulillou, J.P.5
  • 177
    • 0027465306 scopus 로고
    • Human interleukin DA-1a HILDA/LIF,G-CSF, IL-1 beta, IL-6, and TNF alpha production during acute kidney graft rejection episodes
    • Blancho, G., Moreau, J. F., Chabannes, D., Chatenoud, L., and Soulillou, J. P. Human interleukin DA-1a HILDA/LIF,G-CSF, IL-1 beta, IL-6, and TNF alpha production during acute kidney graft rejection episodes. Transplant. Proc. 25, 891-2, 1993.
    • (1993) Transplant. Proc. , vol.25 , pp. 891-892
    • Blancho, G.1    Moreau, J.F.2    Chabannes, D.3    Chatenoud, L.4    Soulillou, J.P.5
  • 178
    • 0028557166 scopus 로고
    • One-year enzyme-linked immunosorbent assay follow-up of human interleukin for Da cells/leukemia inhibitory factor in blood and urine of 22 kidney transplant recipients
    • Morel, D., Taupin, J. L., Combe, C., Potaux, L., Gualde, N., and Moreau, J. F. One-year enzyme-linked immunosorbent assay follow-up of human interleukin for Da cells/leukemia inhibitory factor in blood and urine of 22 kidney transplant recipients. Transplantation 58, 1190-5, 1994.
    • (1994) Transplantation , vol.58 , pp. 1190-1195
    • Morel, D.1    Taupin, J.L.2    Combe, C.3    Potaux, L.4    Gualde, N.5    Moreau, J.F.6
  • 179
    • 0026071616 scopus 로고
    • LIF/HILDA: A growth factor that stimulates the in vitro development of multipotential human hematopoietic progenitors
    • Verfaillie, C., and McGlave, P. LIF/HILDA: a growth factor that stimulates the in vitro development of multipotential human hematopoietic progenitors. Blood 77, 263-70, 1991.
    • (1991) Blood , vol.77 , pp. 263-270
    • Verfaillie, C.1    McGlave, P.2
  • 180
    • 0026548940 scopus 로고
    • Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors
    • Leary, A. G., Zeng, H. Q., Clark, S. C., and Ogawa, M. Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors. Proc. Natl. Acad. Sci. USA 89, 4013-7, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4013-4017
    • Leary, A.G.1    Zeng, H.Q.2    Clark, S.C.3    Ogawa, M.4
  • 181
    • 0027366275 scopus 로고
    • Soluble factor(s) produced by human bone marrow stroma increase cytokine-induced proliferation and maturation of primitive hematopoietic progenitors while preventing their terminal differentiation
    • Verfaillie, C. M. Soluble factor(s) produced by human bone marrow stroma increase cytokine-induced proliferation and maturation of primitive hematopoietic progenitors while preventing their terminal differentiation. Blood 82, 2045-53, 1993.
    • (1993) Blood , vol.82 , pp. 2045-2053
    • Verfaillie, C.M.1
  • 183
    • 0026768292 scopus 로고
    • Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
    • Stewart, C. L., Kaspar, P., Brunet, L. J., Bhatt, H., Gadi, I., Kontgen, F., and Abbondanzo, S. J. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359, 76-9, 1992.
    • (1992) Nature , vol.359 , pp. 76-79
    • Stewart, C.L.1    Kaspar, P.2    Brunet, L.J.3    Bhatt, H.4    Gadi, I.5    Kontgen, F.6    Abbondanzo, S.J.7
  • 184
    • 0026517449 scopus 로고
    • Human interleukin for DA cells (HILDA) does not affect the proliferation and differentiation of hematopoietic progenitor cells in human long-term bone marrow cultures
    • Schaafsma, M. R., Falkenburg, J. H., Duinkerken, N., Moreau, J. F., Soulillou, J. P., Willemze, R., and Fibbe, W. E. Human interleukin for DA cells (HILDA) does not affect the proliferation and differentiation of hematopoietic progenitor cells in human long-term bone marrow cultures. Exp. Hematol. 20, 6-10, 1992.
    • (1992) Exp. Hematol. , vol.20 , pp. 6-10
    • Schaafsma, M.R.1    Falkenburg, J.H.2    Duinkerken, N.3    Moreau, J.F.4    Soulillou, J.P.5    Willemze, R.6    Fibbe, W.E.7
  • 185
    • 0027158190 scopus 로고
    • Differential action of diffusible molecules in long-term marrow culture on proliferation of leukaemic and normal haemopoietic cells
    • Firkin, F. C., Birner, R., and Farag, S. Differential action of diffusible molecules in long-term marrow culture on proliferation of leukaemic and normal haemopoietic cells. Br. J. Haematol. 84, 8-15, 1993.
    • (1993) Br. J. Haematol. , vol.84 , pp. 8-15
    • Firkin, F.C.1    Birner, R.2    Farag, S.3
  • 188
    • 0028302741 scopus 로고
    • Efficient retroviral gene transfer to purified long-term repopulating hematopoietic stem cells
    • Szilvassy, S. J. and Cory, S. Efficient retroviral gene transfer to purified long-term repopulating hematopoietic stem cells. Blood 84, 74-83, 1994.
    • (1994) Blood , vol.84 , pp. 74-83
    • Szilvassy, S.J.1    Cory, S.2
  • 189
    • 0030000911 scopus 로고    scopus 로고
    • Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells
    • Szilvassy, S. J., Weller, K. P., Lin, W., Sharma, A. K., Ho, A. S., Tsukamoto, A., Hoffman, R., Leiby, K. R., and Gearing, D. P. Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells. Blood 87, 4618-28, 1996.
    • (1996) Blood , vol.87 , pp. 4618-4628
    • Szilvassy, S.J.1    Weller, K.P.2    Lin, W.3    Sharma, A.K.4    Ho, A.S.5    Tsukamoto, A.6    Hoffman, R.7    Leiby, K.R.8    Gearing, D.P.9
  • 191
    • 0029620955 scopus 로고
    • Essential function of LIF receptor in motor neurons
    • Li, M., Sendtner, M., and Smith, A. Essential function of LIF receptor in motor neurons. Nature 378, 724-27, 1995.
    • (1995) Nature , vol.378 , pp. 724-727
    • Li, M.1    Sendtner, M.2    Smith, A.3
  • 195
    • 0030039948 scopus 로고    scopus 로고
    • Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival
    • Sheng, Z., Pennica, D, Wood, W. I., and Chien, K. R. Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. Development 122, 419-28, 1996.
    • (1996) Development , vol.122 , pp. 419-428
    • Sheng, Z.1    Pennica, D.2    Wood, W.I.3    Chien, K.R.4
  • 196
    • 0029933362 scopus 로고    scopus 로고
    • Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series via gp130/leukemia inhibitory factor receptor-dependent pathways
    • Wollert, K. C., Taga, T., Saito, M., Narazaki, M., Kishimoto, T., Glembotski, C. C., Vernallis, A. B., Heath, J. K., Pennica, D., Wood, W. I., and Chien, K. R. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series via gp130/leukemia inhibitory factor receptor-dependent pathways. J. Biol. Chem. 271, 9535-45, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9535-9545
    • Wollert, K.C.1    Taga, T.2    Saito, M.3    Narazaki, M.4    Kishimoto, T.5    Glembotski, C.C.6    Vernallis, A.B.7    Heath, J.K.8    Pennica, D.9    Wood, W.I.10    Chien, K.R.11
  • 197
    • 0027350369 scopus 로고
    • Pathology induced by leukemia inhibitory factor
    • Ryffel, B. Pathology induced by leukemia inhibitory factor. Int. Rev. Exp. Pathol. 34, 69-72, 1993.
    • (1993) Int. Rev. Exp. Pathol. , vol.34 , pp. 69-72
    • Ryffel, B.1
  • 198
    • 0027278857 scopus 로고
    • Induction of cytokine expression by leukemia inhibitory factor
    • Villiger, P. M., Geng, Y., and Lotz, M. Induction of cytokine expression by leukemia inhibitory factor. J. Clin. Invest. 91, 1575-81, 1993.
    • (1993) J. Clin. Invest. , vol.91 , pp. 1575-1581
    • Villiger, P.M.1    Geng, Y.2    Lotz, M.3
  • 199
    • 0027339724 scopus 로고
    • The effects of leukaemia inhibitory factor on platelet function
    • Waring, P., Wall, D., Dauer, R., Parkin, D., and Metcalf, D. The effects of leukaemia inhibitory factor on platelet function. Brit. J. Haematol. 83, 80-87, 1993.
    • (1993) Brit. J. Haematol. , vol.83 , pp. 80-87
    • Waring, P.1    Wall, D.2    Dauer, R.3    Parkin, D.4    Metcalf, D.5
  • 200
    • 0028077228 scopus 로고
    • Therapeutic efficacy of recombinant human leukemia inhibitory factor in primate model of radiation - Induced marrow aplasia
    • Farese, A. M., Myers, L. A., and MacVittie, T. J. Therapeutic efficacy of recombinant human leukemia inhibitory factor in primate model of radiation - induced marrow aplasia. Blood 84, 3675-8, 1994.
    • (1994) Blood , vol.84 , pp. 3675-3678
    • Farese, A.M.1    Myers, L.A.2    MacVittie, T.J.3
  • 201
    • 0028793326 scopus 로고
    • Endogenous D-factor activity partially mediates the toxic but not the therapeutic effects of tumor necrosis factor
    • Block, M. I., Fraker, D. L., Strassmann, G., Billingsley, K. G., Arnold, W. S., Perus, C., and Alexander, H. R. Endogenous D-factor activity partially mediates the toxic but not the therapeutic effects of tumor necrosis factor. Int. J. Cancer. 63, 245-9, 1995.
    • (1995) Int. J. Cancer. , vol.63 , pp. 245-249
    • Block, M.I.1    Fraker, D.L.2    Strassmann, G.3    Billingsley, K.G.4    Arnold, W.S.5    Perus, C.6    Alexander, H.R.7
  • 202
    • 0027520928 scopus 로고
    • Infection with human T-lymphotropic viruses leads to constitutive expression of LIF anf IL6
    • Lal, R. B., Rudolph, D., Buckner, C., Pardi, D., and Hooper, W. C. Infection with human T-lymphotropic viruses leads to constitutive expression of LIF anf IL6. Blood 81, 1827-32, 1993.
    • (1993) Blood , vol.81 , pp. 1827-1832
    • Lal, R.B.1    Rudolph, D.2    Buckner, C.3    Pardi, D.4    Hooper, W.C.5
  • 204
    • 0028048001 scopus 로고
    • Human leukemia inhibitory factor inhibits development of experimental atherosclerosis
    • Moran, C. S., Campbell, J. H., Simmons, D. L., and Campbell, G. R. Human leukemia inhibitory factor inhibits development of experimental atherosclerosis. Arterioscler. Thromb. 14, 1356-63, 1994.
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 1356-1363
    • Moran, C.S.1    Campbell, J.H.2    Simmons, D.L.3    Campbell, G.R.4
  • 205
    • 0027298586 scopus 로고
    • Production of leukemia inhibitory factor mRNA and protein by malignant and immortalized bone cells
    • Marusic, A., Kalinowski, J. F., Jastrzebski, S., and Lorenzo, J. A. Production of leukemia inhibitory factor mRNA and protein by malignant and immortalized bone cells. J. Bone. Miner. Res. 8, 617-24, 1993.
    • (1993) J. Bone. Miner. Res. , vol.8 , pp. 617-624
    • Marusic, A.1    Kalinowski, J.F.2    Jastrzebski, S.3    Lorenzo, J.A.4
  • 206
    • 0027787813 scopus 로고
    • Back-transplantation of chick cardiac neural crest cells cultured in LIF rescues heart development
    • Kirby, M. L., Kumiski, D. H., Myers, T., Cerjan, C., and Mishima, N. Back-transplantation of chick cardiac neural crest cells cultured in LIF rescues heart development. Dev. Dyn. 198, 296-311, 1993.
    • (1993) Dev. Dyn. , vol.198 , pp. 296-311
    • Kirby, M.L.1    Kumiski, D.H.2    Myers, T.3    Cerjan, C.4    Mishima, N.5
  • 207
    • 0028263872 scopus 로고
    • Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: Injured muscle expresses LIF mRNA
    • Barnard, W., Bower, J., Brown, M. A., Murphy, M., and Austin, L. Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: Injured muscle expresses LIF mRNA. J. Neurol. Sci. 123, 108-113, 1994.
    • (1994) J. Neurol. Sci. , vol.123 , pp. 108-113
    • Barnard, W.1    Bower, J.2    Brown, M.A.3    Murphy, M.4    Austin, L.5
  • 208
    • 0027934738 scopus 로고
    • Human interleukin for DA cells or leukemia inhibitory factor is released by Vero cells in human embryo coculture
    • Papaxanthos-Roche, A., Taupin, J. L., Mayer, G., Daniel, J. Y., and Moreau, J. F. Human interleukin for DA cells or leukemia inhibitory factor is released by Vero cells in human embryo coculture. Fertil. Steril. 62, 648-50, 1994.
    • (1994) Fertil. Steril. , vol.62 , pp. 648-650
    • Papaxanthos-Roche, A.1    Taupin, J.L.2    Mayer, G.3    Daniel, J.Y.4    Moreau, J.F.5
  • 209
    • 0028899123 scopus 로고
    • Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: Its possible implication during pregnancy, including implantation period
    • Sawai, K., Matsuzaki, N., Kameda, T., Hashimoto, K., Okada, T., Shimoya, K., Nobunaga, T., Taga, T., Kishimoto, T., and Saji, F. Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: its possible implication during pregnancy, including implantation period. J. Clin. Endocrinol. Metab. 80, 1449-56, 1995.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 1449-1456
    • Sawai, K.1    Matsuzaki, N.2    Kameda, T.3    Hashimoto, K.4    Okada, T.5    Shimoya, K.6    Nobunaga, T.7    Taga, T.8    Kishimoto, T.9    Saji, F.10
  • 210
    • 0025328821 scopus 로고
    • LIF/ DIA/HILDA augments proliferation of human hematopoietic stem cells
    • Leary, A. G., Wong, G. G., Clark, S. C., Smith, A. G., and Ogawa, M. LIF/ DIA/HILDA augments proliferation of human hematopoietic stem cells. Blood 75, 1960-64, 1990.
    • (1990) Blood , vol.75 , pp. 1960-1964
    • Leary, A.G.1    Wong, G.G.2    Clark, S.C.3    Smith, A.G.4    Ogawa, M.5
  • 211
    • 0025182248 scopus 로고
    • Murine LIF enhances retroviral-vector infection efficiency of hematopoietic progenitors
    • Fletcher, F. A., Williams, D. E., Maliszewski, C., Anderson, D., Rives, M., and Belmont, J. W. Murine LIF enhances retroviral-vector infection efficiency of hematopoietic progenitors. Blood 76, 1098-1103, 1990.
    • (1990) Blood , vol.76 , pp. 1098-1103
    • Fletcher, F.A.1    Williams, D.E.2    Maliszewski, C.3    Anderson, D.4    Rives, M.5    Belmont, J.W.6
  • 212
    • 0025944679 scopus 로고
    • LIF improves survival of retroviral vector-infected hematopoietic stem cells in vitro, allowing efficient long-term expression of vector-encoded human adenosine deaminase in vivo
    • Fletcher, F. A., Moore, K. A., Ashkenazi, M., de Vries, P., Overbeek, P. A., Williams, D. E., and Belmont, J. W. LIF improves survival of retroviral vector-infected hematopoietic stem cells in vitro, allowing efficient long-term expression of vector-encoded human adenosine deaminase in vivo. J. Exp. Med. 174, 837-845, 1991.
    • (1991) J. Exp. Med. , vol.174 , pp. 837-845
    • Fletcher, F.A.1    Moore, K.A.2    Ashkenazi, M.3    De Vries, P.4    Overbeek, P.A.5    Williams, D.E.6    Belmont, J.W.7
  • 213
    • 0026514847 scopus 로고
    • Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells
    • Moore, K. A., Deisseroth, A. B., Reading, C. L., Williams, D. E., and Belmont, J. W. Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells. Blood 79, 1393-99, 1992.
    • (1992) Blood , vol.79 , pp. 1393-1399
    • Moore, K.A.1    Deisseroth, A.B.2    Reading, C.L.3    Williams, D.E.4    Belmont, J.W.5
  • 214
    • 0026640964 scopus 로고
    • Leukemia inhibitory factor and interleukin-11 promote maturation of murine and human megakaryocytes in vitro
    • Burstein, S. A., Mei, R. L., Henthorn, J., Friese, P., and Turner, K. Leukemia inhibitory factor and interleukin-11 promote maturation of murine and human megakaryocytes in vitro. J. cell. Physiology. 153, 305-12, 1992.
    • (1992) J. Cell. Physiology , vol.153 , pp. 305-312
    • Burstein, S.A.1    Mei, R.L.2    Henthorn, J.3    Friese, P.4    Turner, K.5
  • 215
    • 0028344332 scopus 로고
    • Regulation of bone marrow stromal cell differentiation by cytokines whose receptors share the gp130 protein
    • Gimble, J. M., Wanker, F., Wang, C. S., Bass, H., Wu, X., Kelly, K., Yancopoulos, G. D., and Hill, M. R. Regulation of bone marrow stromal cell differentiation by cytokines whose receptors share the gp130 protein J. cell. Biochem. 54, 122-33, 1994.
    • (1994) J. Cell. Biochem. , vol.54 , pp. 122-133
    • Gimble, J.M.1    Wanker, F.2    Wang, C.S.3    Bass, H.4    Wu, X.5    Kelly, K.6    Yancopoulos, G.D.7    Hill, M.R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.