Allosteric effects of mutations in the extracellular S5-P loop on the gating and ion permeation properties of the hERG potassium channel

Pflugers Archiv European Journal of Physiology

Volumn 439, Issue 1-2, 1999, Pages 141-149

  Dun, Wen ^a   Jiang, Min ^a   Tseng, Gea Ny ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Activation gating; C type inactivation; I(Kr); Ion selectivity; LQT2; Structure function relation

Indexed keywords

AMINO ACID; CYSTEINE; DITHIOTHREITOL; GLUTAMIC ACID; HISTIDINE; LYSINE; POTASSIUM CHANNEL; POTASSIUM ION; PROLINE;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HYPERPOLARIZATION; ION TRANSPORT; MUTATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN CONFORMATION; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; CATION TRANSPORT PROTEINS; DITHIOTHREITOL; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; PERMEABILITY; PHENOTYPE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; RNA, MESSENGER; SULFHYDRYL COMPOUNDS; TRANSCRIPTION, GENETIC; XENOPUS LAEVIS;

EID: 0033370465     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240051138     Document Type: Article

References (26)

1. 1. Benson DW, MacRae CA, Vesely MR, Walsh EP, Seidman JG, Seidman CE, Satler CA (1996) Missense mutation in the pore region of HERG causes familial long QT syndrome. Circulation 93:1791-1795
2. 2. Costa PF, Emilio MG, Fernandes PL, Ferreira HG, Ferreira KG (1989) Determination of ionic permeability coefficients of the plasma membrane of Xenopus laevis oocytes under voltage clamp. J Physiol (Lond) 413:199-211
3. 3. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80:795-803
4. + conduction and selectivity. Science 280:69-77
5. 5. Fan J-S, Jiang M, Dun W, McDonald TV, Tseng G-N (1999) Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in Shaker. Biophys J 76:3128-3140
6. + channel signature sequence. Biophys J 66:1061-1067
7. + channel can be trapped in the open state by an intersubunit metal bridge. Neuron 21:617-621
8. 8. Jiang M, Dun W, Tseng G-N (1999) Mechanism for the effects of extracellular acidification on HERG channel function. Am J Physiol 277:H1283-H1292
9. 9. Kiss L, LoTurco J, Korn SJ (1999) Contribution of the selectivity filter to inactivation in potassium channels. Biophys J 76:253-263
10. + channel S4. Neuron 16:387-397
11. + current in human ventricular myocytes. Circ Res 78:689-696
12. + channel during gating. Neuron 16:859-867
13. + channel. J Gen Physiol 112:377-389
14. 14. Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG (1996) Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol 50:1672-1679
15. 15. Papazian DM, Timpe LC, Jan YN, Jan LY (1991) Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature 349:305-310
16. 16. Rose GD, Gierasch LM, Smith JA (1985) Turns in peptides and proteins. Adv Protein Chem 37:1-109
17. +-channel dysfunction in an inherited cardiac arrhythmia (long QT syndrome). Proc Natl Acad Sci USA 93:2208-2212
18. Kr potassium channel. Cell 81:299-307
19. 19. Schreibmayer W, Lester HA, Dascal N (1994) Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes. Pflügers Arch 426:453-458
20. + channels. J Gen Physiol 109:767-778
21. 21. Smith PA, Baukrowitz T, Yellen G (1996) The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379:833-836
22. Kr channel. J Gen Physiol 107:611-619
23. 23. Wang Z, Fermini B, Nattel S (1994) Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc Res 28:1540-1546
24. + channel allows inactivation to be modulated by metal binding. Biophys J 66:1068-1075
25. + current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circ Res 77:140-152
26. 26. Zhou Z, Gong Q, Epstein ML, January CT (1998) Intracellular transport defect as a mechanism of HERG channel dysfunction in human long QT syndrome (abstract). Circulation 98:1-56