An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: Computational analysis and x-ray crystal structure of the enzyme complex

Journal of Medicinal Chemistry

Volumn 40, Issue 16, 1997, Pages 2440-2444

  Smith III, A B ^a   Hirschmann, R ^a   Pasternak, A ^a   Yao, W ^a   Sprengeler, P A ^a   Holloway, M K ^a   Kuo, L C ^a   Chen, Z ^a   Darke, P L ^a   Schleif, W A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CHLOROFORM; PROTEINASE; PYRROLINONE INHIBITOR; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS; HYDROGEN BOND; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; RETROVIRUS; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HYDROGEN BONDING; INDINAVIR; INDOLES; MODELS, MOLECULAR; MOLECULAR WEIGHT; PROTEIN CONFORMATION; PYRROLES;

EID: 0030806489     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970195u     Document Type: Article

References (28)