Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: Implications for anti-cancer and anti-viral therapy

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 2817-2824

  Shaw, Samuel G ^a,c,d,e   Maung, Adrian A ^a,c,d   Steptoe, Raymond J ^a   Thomson, Angus W ^a,b,d   Vujanovic, Nikola L ^c,d  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; CANCER; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOREGULATION; LYMPHOKINE ACTIVATED KILLER CELL; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION;

EID: 0032530754     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.161.6.2817     Document Type: Article

References (45)

1. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
2. Chambers, W. H., and C. S. Brissette-Storkus. 1995. Hanging in the balance: natural killer cell recognition of target cells. Chem. Biol. 2:429.
3. Lanier, L. L., and J. H. Phillips. 1996. Inhibitory MHC class I receptors on NK and T cells. Immunol. Today 17:86.
4. Vujanovic, N. L., P. Basse, R. B. Herberman, and T. L. Whiteside. 1996. Anti-tumor functions of natural killer cells and control of metastases. Method Companion Methods Enzymol. 9:394.
5. Biron, C. A. 1997. Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol. 9:24.
6. Vitolo, D., N. L. Vujanovic, H. Rabinowich, M. Schlesinger, R. B. Herberman, and T. L. Whiteside. 1993. Rapid IL-2-induced adherence of human natural killer cells: expression of mRNA for cytokines and IL-2 receptors in adherent NK cells. J. Immunol. 151:1926.
7. Roncarolo, M. G., M. Bigler, J. B. Haanen, H. Yssel, R. Bacchetta, J. E. de Vries, and H. Spits. 1991. Natural killer cell clones can efficiently process and present protein antigens. J. Immunol. 147:781.
8. Yu, Y. Y. L., V. Kumar, and M. Bennett. 1992. Murine natural killer cells and marrow graft rejection. Annu. Rev. Immunol. 10:189.
9. + hematopoietic progenitor cells. Blood 87:2632.
10. Vecchini, F., D. Delfino, K. D. Patrene, A. DeLeo, L. Lu, R. B. Herberman, and S. S. Boggs. 1993. Generation of natural killer cells from long-term cultures of mouse bone marrow. Nat. Immun. 12:1.
11. Leclercq, G., V. Debacker, M. De Smedt, and J. Plum. 1996. Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells. J. Exp. Med. 184:325.
12. - bone marrow progenitors. J. Immunol. 150:5263.
13. 89strontium: normal target-binding cell numbers but inability to kill even after interferon administration. J. Immunol. 123:1832.
14. Robertson, M. J., and J. Ritz. 1990. Biology and clinical relevance of human natural killer cells. Blood 76:2421.
15. + natural killer cells in tissues from normal and tumor-bearing rats. Cancer Res. 51:4931.
16. Peel, S. 1989. Granulated metrial gland cells. Adv. Anal. Embryol. Cell Biol. 115:1.
17. Itoh, H., T. Abo, S. Sugawara, A. Kanno, and K. Kumagai. 1988. Age-related variation in the proportion and activity of murine liver natural killer cells and their cytotoxicity against regenerating hepatocytes. J. Immunol. 141:315.
18. Vanderkerken, K., L. Bouwens, and E. Wisse. 1990. Characterization of a phenotypically and functionally distinct subset of large granular lymphocytes (Pit cells) in rat liver sinusoids. Hepatology 12:70.
19. Wiltrout, R. H., B. J. Mathieson, J. E. Talmadge, C. W. Reynolds, S.-R. Zhang, R. B. Herberman, and J. R. Ortaldo. 1984. Augmentation of organ-associated natural killer activity by biological response modifiers: isolation and characterization of large granular lymphocytes from the liver. J. Exp. Med. 160:1431.
20. Lefrenier, R., K. Borkenhagen, L. D. Bryant, A. R. Anton, A. Chung, and M.-C. Poon. 1990. Analysis of liver lymphoid cell subsets pre-and post-in vivo administration of human recombinant interleukin 2 in a C57BL/6 murine system. Cancer Res. 50:1658.
21. Fogler, W. E., K. Volker, K. L. McCormick, M. Watanabe, J. R. Ortaldo, and R. H. Wiltrout. 1996. NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156:4707.
22. Rosenberg, S. A. 1985. Lymphokine-activated killer cells: a new approach to immunotherapy of cancer. J. Natl. Cancer Inst. 75:595.
23. Rosenberg, S. A., M. T. Lotze, J. C. Yang, S. L. Topalian, A. E. Chang, D. J. Schwartzentruber, P. Aebersold, S. Leitman, W. M. Linehan, C. A, Seip, D. E. White, and S. M Steinberg. 1994. Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for treatment of patients with advanced cancer. J. Natl. Cancer Inst. 85:622.
24. Lyman, S. D., L. James, T. Vanden Bos, P. De Vries, K. Brasel, B. Gliniak, L. T. Hollingworth, K. S. Picha, H. J. McKenna, R. R. Splett, F. A. Fletcher, E. Maraskovsky, T. Farrah, D. Foxworth, D. E. Williams, and M. P. Beckmann. 1993. Molecular cloning of a ligand for the Flt3/Flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell 75:1157.
25. Brasel, K., H. J. McKenna, P. Morrissey, K. Charrier, A. E. Morris, C. C. Lee, D. E. Williams, and S. D. Lyman. 1996. Hematologic effects of Flt3 ligand in vivo in mice. Blood 88:2004.
26. Maraskovsky, E., K. Brasel, M. Teepe, E. R. Roux, S. D. Lyman, K. Shortman, and H. J. McKenna. 1996. Dramatic increase in the number of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J. Exp. Med. 184:1.
27. Steptoe, R. J., F. Fu, W. Li, M. L. Drakes, L. Lu, A. J. Demetris, S. Qian, H. J. McKenna, and A. W. Thomson. 1997. Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity. J. Immunol. 159:5483.
28. Drakes, M. L., L. Lu, V. M. Subbotin, and A. W. Thomson. 1997. In vivo administration of Flt3 ligand markedly stimulates generation of dendritic cell progenitors from mouse liver. J. Immunol. 159:4268.
29. Lu, L., J. Woo, A. S. Rao, Y. Li, S. C. Watkins, S. Qian, T. E. Starzl, A. J. Demetris, and A. W. Thomson. 1994. Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-I collagen. J. Exp. Med. 179:1823.
30. Vujanovic, N. L., L. Polimeno, A. Azzarone, A. Francavilla, W. H. Chambers, T. E. Starzl, R. B. Herberman, and T. L. Whiteside. 1995. Changes in liver-resident NK cells during liver regeneration in rats. J. Immunol. 154:6324.
31. Vujanovic, N. L., R. B. Herberman, A. A. Maghazachi, and J. C. Hiserodt. 1988. A simple method for the purification of large granular lymphocytes and their rapid expansion and conversion into lymphokine-activated killer cells. J. Exp. Med. 167:15.
32. Vujanovic, N. L., R. B. Herberman, M. W. Olszoway, D. V. Cramer, R. R. Salup, C. W. Reynolds, and J. C. Hiserodt. 1988. Lymphokine-activated killer cells in rats: analysis of progenitor and effector cell phenotype and relationship to natural killer cells. Cancer Res. 48:884.
33. Robertson, M. J., R. J. Soiffer, S. F. Wolf, T. J. Manley, C. Donahue, D. Young, S. H. Herrmann, and J. Ritz. 1992. Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J. Exp. Med. 175:779.
34. Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, D. Anderson, J. Eisenmann, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin-15 is a novel cytokine which activates human natural killer cells via components of the interleukin-2 receptor. J. Exp. Med. 180:1395.
35. Van den Brink, M. R. M., S. S. Boggs, R. B. Herberman, and J. C. Hiserodt. 1990. The generation of natural killer (NK) cells from NK precursor cells in rat long term bone marrow cultures. J. Exp. Med. 172:303.
36. + progenitor cells: evidence for redundancy with c-kit ligand. Nat. Immun. 15:168.
37. - cells from multipotential murine bone marrow progenitors in a stroma-free culture: definition of cytokine requirements and developmental intermediates J. Exp. Med. 186:1609.
38. + cells into T cells. J. Immunol. 159:694.
39. Lyman, S. D., and S. E. W. Jacobsen. 1998. c-kit ligand and Flt3 ligand: stem/ progenitor cell factors with overlapping yet distinct activities. Blood 91:1101.
40. 2+-dependent mechanism. J. Exp. Med. 186:467.
41. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183:187.
42. Jacobsen, S. E. W., O. P. Veiby, J. Myklebust, C. Okkenhaug, and S. D. Lyman. 1996. Ability of Flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-β and tumor necrosis factor-a. Blood 87:5016.
43. Lynch, D. H., A. Andreasen, E. Maraskovsky, J. Whitmore, R. E. Miller, and J. C. L Schuh. 1997. Flt3 ligand induces tumor regression and antitumor immune responses in vivo. Nat. Med. 3:625.
44. Chen, K. S. Braun, S. Lyman, Y. Fan, C. M. Traycoff, E. A. Wibke, J. Gaddy, G. Sledge, H. E. Broxmeyer, and K. Cornetta. 1997. Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model. Cancer Res. 57:3511.
45. Fernandez, N., L. Zitvogel, E. Maraskovsky, N. DiFalco, P. Opolon, L. Cordier, M. Perricaudet, and H. Haddada. 1997. Antitumor effects of Flt3L in poorly immunogenic mouse tumor model. Immunol. Lett. 56:224.