A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters

Journal of Cell Science

Volumn 115, Issue 3, 2002, Pages 563-574

  Meissner, Markus ^a   Reiss, Matthias ^a   Viebig, Nicola ^a   Carruthers, Vern B ^a   Toursel, Catherine ^a   Tomavo, Stanislas ^a   Ajioka, James W ^a   Soldati, Dominique ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Apicomplexa; Epidermal growth factor like domain; Escorter; Micronemes; Processing; Secretion; Toxoplasma gondii

Indexed keywords

ADHESIN; EPIDERMAL GROWTH FACTOR; MEMBRANE PROTEIN; THROMBOSPONDIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; COMPLEX FORMATION; CONTROLLED STUDY; GENETIC CODE; GOLGI COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SECRETION; STORAGE; TOXOPLASMA GONDII;

ADHESINS, BACTERIAL; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; TOXOPLASMA;

APICOMPLEXA; PROTOZOA; TOXOPLASMA GONDII;

EID: 0036473089     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Toxoplasma gondii: ESTs and gene discovery
2. Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa
3. A novel multi-domain mucin-like glycoprotein of Cryptosporidium parvum mediates invasion
4. Proteolytic processing of the Plasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains
5. The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains
6. Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii
7. Epidermal growth factor-like modules
8. 2+] and stimulate microneme discharge in Toxoplasma gondii
9. The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases
10. Two conserved amino acid motifs mediate protein targeting to the micronemes of the apicomplexan parasite Toxoplasma gondii
11. The toxoplasma homolog of plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels
12. Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation
13. The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin that binds to both the surface of the host cells and the surface of the parasite
14. An exported protein of Plasmodium falciparum is synthesized as an integral membrane protein
15. Immunoprecipitation
16. Identification and characterization of SRS1, a Toxoplasma gondii surface antigen upstream of and related to SAG1
17. Toxoplasma gondii homologue of plasmodium apical membrane antigen 1 is involved in invasion of host cells
18. A dibasic motif in the tail of an Apicomplexan myosin is an essential determinant of plasma membrane localization
19. Toxoplasma gondii: Molecular cloning and characterization of a novel 18-kDa secretory antigen, TgMIC10
20. Conservation of a gliding motility and cell invasion machinery in apicomplexan parasites
21. A vaccine candidate from the sexual stage of human malaria that contains EGF-like domains
22. Close linkage of three merozoite surface protein genes on chromosome 2 of Plasmodium falciparum
23. The α- and β-tubulins of Toxoplasma gondii are encoded by single copy genes containing multiple introns
24. TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2
25. Identification and characterisation of an Escorter for two secretory adhesins in Toxoplasma gondii
26. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
27. Virulent strains of Toxoplasma gondii comprise a single clonal lineage
28. Transient transfection and expression in the obligate intracellular parasite Toxoplasma gondii
29. Microneme proteins: Structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii
30. Processing of Toxoplasma ROP1 protein in nascent rhoptries
31. Molecular characterization of a novel microneme antigen in Neospora caninum
32. EtMIC4: A microneme protein from Eimeria tenella that contains tandem arrays of epidermal growth factor- like repeats and thrombospondin type-I repeats
33. Femtomole sequencing of proteins from polyacrylamide gels by nano- electrospray mass spectrometry
34. Isolation and characterization of a subtractive library enriched for developmentally regulated transcripts expressed during encystation of Toxoplasma gondii