Targeted disruption of the Plasmodium berghei CTRP gene reveals its essential role in malaria infection of the vector mosquito

Journal of Experimental Medicine

Volumn 190, Issue 11, 1999, Pages 1711-1715

  Yuda, Masao ^a   Sakaida, Hiroshi ^a   Chinzei, Yasuo ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

Gene targeting; Malaria; Midgut; Ookinete; Plasmodium berghei

Indexed keywords

ARTICLE; DISEASE CARRIER; GENE DISRUPTION; GENE TARGETING; MALARIA; MIDGUT; MOSQUITO; NONHUMAN; PLASMODIUM BERGHEI; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANIMALS; ANOPHELES; DIGESTIVE SYSTEM; EPITHELIAL CELLS; GENOMIC LIBRARY; MUTAGENESIS, SITE-DIRECTED; PLASMODIUM BERGHEI; POINT MUTATION; PROTOZOAN PROTEINS; RECEPTORS, CELL SURFACE; THYMIDYLATE SYNTHASE;

EID: 0033429047     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.11.1711     Document Type: Article

References (11)

1. Yuda, M., T. Sawai, and Y. Chinzei. 1999. Structure and expression of an adhesive protein-like molecule of mosquito invasive-stage malarial parasite. J. Exp. Med. 189:1947-1952.
2. Trottein, F., T. Triglia, and A.F. Cowman. 1995. Molecular cloning of a gene from Plasmodium falciparum that codes for a protein sharing motifs found in adhesive molecules from mammals and plasmodia. Mol. Biochem. Parasitol. 74:129-141.
3. Robson, K.J., S. Naiza, G. Barker, R.E. Sinden, and A. Crisanti. 1998. Cloning and expression of the thrombospondin related adhesive protein gene of Plasmodium berghei. Mol. Biochem. Parasitol. 84:1-12.
4. Wan, K.L., V.B. Carruthers, L.D. Sibley, and J.W. Ajioka. 1997. Molecular characterisation of an expressed sequence tag locus of Toxoplasma gondii encoding the micronemal protein MIC2. Mol. Biochem. Parasitol. 84:203-214.
5. Naitza, S., F. Spano, K.J. Robson, and A. Crisanti. 1998. The thrombospondin-related protein family of apicomplexan parasites: the gears of the cell invasion machinery. Parasitol. Today. 14:479-484.
6. Dubremetz, J.F., N. Garcia-Reguet, V. Conseil, and M.N. Fourmaux. 1998. Apical organelles and host-cell invasion by Apicomplexa. Int. J. Parasitol. 28:1007-1013.
7. Sultan, A.A., V. Thathy, U. Frevert, K.J. Robson, A. Crisanti, V. Nussenzweig, and R.S. Nussenzweig. 1997. TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites. Cell. 90:511-522.
8. van Dijk, M.R., G.A. McConkey, R. Vinkenoog, A.P. Waters, and C.J. Janse. 1994. Mechanisms of pyrimethamine resistance in two different strains of Plasmodium berghei. Mol. Biochem. Parasitol. 68:167-171.
9. van Dijk, M.R., A.P. Waters, and C.J. Janse. 1995. Stable transfection of malaria parasite blood stages. Science. 268: 1358-1362.
10. Menard, R., A.A. Sultan, C. Cortes, R. Altszuler, M.R. van Dijk, C.J. Janse, A.P. Waters, R.S. Nussenzweig, and V. Nussenzweig. 1997. Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature. 385:336-340.
11. Seitz, H.M., W.A. Maier, M. Rottok, and H. Becker-Feldmann. 1987. Concomitant infections of Anopheles stephensi with Plasmodium berghei and Serratia marcescens: additive detrimental effects. Zentralbl. Bakteriol. Mikrobiol. Hyg. 266:155-166.