Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms

Nature Cell Biology

Volumn 2, Issue 7, 2000, Pages 449-456

  Hoppe, H C ^a   Ngo, H M ^a   Yang, M ^a   Joiner, K A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN RHOPTRY; PROTOZOAL PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APICOMPLEXA; ARTICLE; CELL GRANULE; CELL INVASION; CELL ORGANELLE; CELL SELECTION; CELL VACUOLE; GOLGI COMPLEX; HOST PARASITE INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; TOXOPLASMA GONDII;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMAL; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD; BIOLOGICAL TRANSPORT; CHIMERIC PROTEINS; CLATHRIN; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; FLUORESCENT ANTIBODY TECHNIQUE; GOLGI APPARATUS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICROSCOPY, IMMUNOELECTRON; MOLECULAR SEQUENCE DATA; ORGANELLES; PROTEIN BINDING; PROTEIN SORTING SIGNALS; PROTOZOAN PROTEINS; RECEPTORS, LDL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TOXOPLASMA; TWO-HYBRID SYSTEM TECHNIQUES; TYROSINE;

TOXOPLASMA GONDII;

EID: 0033772272     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35017090     Document Type: Article

References (54)

1. Texoplasma gondii: Fusion competence of parasitiphorous vacuoles in Fc receptor transfected fibrobfasts
2. Biology of Texoplasma gondii
3. Molecular genetic strategies in Toxoplasma gondii: Close in on a successful invader
4. Sequential protein secretion from three distinct organelles of Texoplasma gondii accompanies invasion of human fibroblasts
5. Rhoptry organalles of the Apicomplexa: Their role in host cell invasion and intracellular survival
6. Differential sorting and post-secretory targeting of proteins in parasitic invasion
7. Protein sorting by tyrosine-based signals: Adapting to the Ys and wherefores
8. Clathrin and adaptors
9. Molecular bases for the recognition of tyrosine-based sorting signals
10. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor
11. The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation
12. Sorting of membrane proteins in the yeast secretory pathway
13. The expression of Toxoplasma proteins in Neospora caninum and the identification of a gene encoding a novel rhoptry protein
14. A structural explanation for the recognition of tyrosine-based endocytic signals
15. Structural determinants of interaction of tyrosine-based sorting signals with the adaptor medium chains
16. The protozoan parasite Toxoplasma gandii targets proteins to dense granules and the vacuolar space using both conserved and unusual mechanisms
17. Transport of the lysosomal membrane glycoprotein lgp 120 (lgp-A) to lysosomes does not require appearance on the plasma membrane
18. Cytoplasmic determinants involved in direct lysosomal sorting, endocytosis, and basolateral targeting of rat lgp120 (lamp-1) in MDCK cells
19. Transmembrane domain mutations influence the cellular distribution of lysosomal membrane glycoprotein A
20. Lumenal and transmembrane domains playa role in sorting type I membrane proteins on endocytic pathways
21. An investigation of the role of transmambrane domains in Golgi protein retention
22. Rapid redistribution of Golgi proteins into the ER in cells treated with brefaldin A: Evidence for membrane cycling from Golgi to ER
23. Brefaldin A's effect on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic
24. Perturbation of the morphology of the trans-Golgi network following brefeldin-A treatment - Redistribution of a TGN-specific integral membrane protein, TGN38
25. The nuclear envelope serves as an intermediary between the ER and golgi complex in the intracellular parasite Toxoplasma gondii
26. Basolateral sorting of LDL receptor in MDCK cells: The cytoplasmic domain contains two tyrosine-dependent targeting determinants
27. A novel dathfin adaptor complex mediates basolateral targeting in polarized epithelial cells
28. Processing of Toxoplasma ROPI protein in nascent rhoptries
29. The Toxoplasma gondii rhoptry protein ROP2 is inserted into the parasitophorous vacuole membrane, surrounding the intracellular parasite, and is exposed to the host cell cytoplasm
30. Acidic compartments and rhoptry formation in Toxoplasma gondii
31. Biogenesis of rhoptry organelles in Plasmodium falciparum
32. The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor
33. Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negativa mutant μ2 subunit and its effect on endocytosis
34. Targeted disruption of nucleoside triphosphate hydrolase by antisense RNA inhibits Toxoplasma gondii proliferation
35. Characterization of a family of rhoptry proteins of Toxoplasma gondii
36. Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet
37. A candidate gene for the mouse pearl (pe) mutation which affects subcellular organelles
38. Mouse models of Hermansky Pudlak syndrome: A review
39. Acidocalcisomes in Toxoplasma gondii tachyzoites
40. The pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes
41. Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail
42. Arf proteins: The membrane traffic police?
43. An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells
44. An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the call surface
45. Low density lipoprotein receptor and cation-independent mannose-6-phosphate receptor are transported from the cell surface to the Golgi apparatus at equal rates in PC12 cells
46. Endocytosis at the micropore of Toxoplasma gondii
47. The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network
48. Targeting the secretory pathway of Toxoplasma gondii
49. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gandii
50. Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa
51. Characterization of the extreme apical antigens from Toxoplasma gondii
52. Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family