TGF-β induced G1 cell cycle arrest requires the activity of the proteasome pathway

Experimental Cell Research

Volumn 281, Issue 2, 2002, Pages 190-196

  Zhang, Fan ^a   Mönkkönen, Mia ^a   Roth, Stina ^a   Laiho, Marikki ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

CDK; Cell cycle; Proteasomal inhibitors; TGF

Indexed keywords

CYCLIN D; DNA; GROWTH INHIBITOR; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL CYCLE; CONTROLLED STUDY; DNA REPLICATION; ENZYME ACTIVITY; ENZYME ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RETINOBLASTOMA;

EID: 0036999416     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5670     Document Type: Article

References (36)

1. Massagué, J. (1990). The transforming growth factor-β family. Annu. Rev. Cell Biol. 6, 597-641.
2. Moses, H. L., Yang, E. Y., and Pietenpol, J. (1990). TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights. Cell 63, 245-247.
3. Polyak, K. (1996). Negative regulation of cell growth by TGF-β. Biochim. Biophys. Acta 1242, 185-199.
4. Ink4b is a potential effector of TGF-β-induced cell cycle arrest. Nature 371, 257-261.
5. Kip1 coordinate their inhibitory interactions with cdk4 and ckd2. Genes Dev. 11, 492-503.
6. Laiho, M., DeCaprio, J. A., Ludlow, J. W., Livingston, D. M., and Massagué J. (1990). Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell 62, 175-185.
7. INK4b G1 arrest pathway. Mol. Cell. Biol. 19, 5913-5922.
8. INK4b. Nat. Cell Biol. 3, 400-408.
9. Ewen, M. E., Sluss, H. K., Whitehouse, L. L., and Livingston, D. M. (1993). TGF-β inhibition of CDK4 synthesis is linked to cell cycle arrest. Cell 74, 1009-1020.
10. Tsubari, M., Taipale, J., Tiihonen, E., Keski-Oja, J., and Laiho, M. (1999). Hepatocyte growth factor releases mink epithelial cells from transforming growth factor β1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity. Mol. Cell. Biol. 19, 3654-3663.
11. Zhang, F., Taipale, M., Heiskanen, A., and Laiho, M. (2001). Ectopic expression of Cdk6 circumvents transforming growth factor-β mediated growth inhibition. Oncogene 20, 5888-5896.
12. Iavarone, A., and Massagué, J. (1997). Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15. Nature 387, 417-422.
13. Ciechanover, A. (1998). The ubiquitin-proteasome pathway: On protein death and cell life. EMBO J. 17, 7151-7160.
14. Schwartz, A. L., and Ciechanover, A. (1999). The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu. Rev. Med. 50, 57-74.
15. Vu, P. K., and Sakamoto, K. M. (2000). Ubiquitin-mediated proteolysis and human disease. Mol. Genet. Metab. 71, 261-266.
16. Heldin, C. H., and ten Dijke, P. (1999). SMAD destruction turns off signalling. Nat. Cell Biol. 1, E195-197.
17. Massagué, J., and Chen, Y.-G. (2000). Controlling TGF-β signaling. Genes Dev. 14, 627-644.
18. Derynck, R., Akhurst, R. J., and Balmain, A. (2001). TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 29, 117-129.
19. Zhang, F., Mönkkönen, M., Roth, S., and Laiho, M. (2002). Proteasomal activity modulates TGF-β signaling in a gene-specific manner. FEBS Lett. 527, 58-62.
20. Matsushime, H., Quelle, D. E., Shurtleff, S. A., Shibuya, M., Sherr, C. J., and Kato, J. Y. (1994). D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14, 2066-2076.
21. Yamaguchi, R., and Dutta, A. (2000). Proteasome inhibitors alter the orderly progression of DNA synthesis during S-phase in HeLa cells and lead to rereplication of DNA. Exp. Cell Res. 261, 271-283.
22. Carrano, A. C., Eytan, E., Hershko, A., and Pagano, M. (1999). SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1, 193-199.
23. Kip1 degradation and induces S phase in quiescent cells. Nat. Cell Biol. 1, 207-214.
24. Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S., and Nakayama, K. (2001). Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. J. Biol. Chem. 276, 48937-48943.
25. Koepp, D. M., Harper, J. W., and Elledge, S. T. (1999). How the cyclins became a cyclin: Regulated proteolysis in the cell cycle. Cell 97, 431-434.
26. Yew, P. R. (2001). Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators. J. Cell Physiol. 187, 1-10.
27. Blain, S. W., Montalvo, E., and Massague, J. (1997). Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J. Biol. Chem. 272, 25863-25872.
28. Bonni, S., Wang, H., Causing, C. G., Kavsak, P., Stroschein, S. L., Luo, K., and Wrana, J. L. (2001). TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol. 3, 587-595.
29. Stroschein, S. L., Bonni, S., Wrana, J. L., and Luo, K. (2001). Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev. 15, 2822-2836.
30. Wan, Y., Liu, X., and Kirschner, M. W. (2001). The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction. Mol. Cell 8, 1027-1039.
31. Malumbres, M., and Barbacid, M. (2001). To cycle or not to cycle: A critical decision in cancer. Nat. Rev. Cancer 1, 222-231.
32. Harbour, J. M., and Dean, D. C. (2000). Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2, E65-67.
33. Yew, P. R., and Kirschner, M. (1997). Proteolysis and DNA replication: The CDC34 requirement in the Xenopus egg cell cycle. Science 277, 1672-1676.
34. Schwarz, J. K., Bassing, C. H., Kovesdi, I., Datto, M. B., Blazing, M., George, S., Wang, X. F., and Nevins, J. R. (1995). Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. Proc. Natl. Acad. Sci. USA 92, 483-487.
35. Adams, J. (2002). Development of the proteasome inhibitor PS-341. Oncologist 7, 9-16.
36. Shah, S. A., Potter, M. W., and Callery, M. P. (2001). Ubiquitin proteasome pathway: Implications and advances in cancer therapy. Surg. Oncol. 10, 43-52.