The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylation

Carcinogenesis

Volumn 23, Issue 12, 2002, Pages 2025-2030

  Guilleret, Isabelle ^a   Yan, Pu ^a   Guillou, Louis ^a   Braunschweig, Richard ^a   Coindre, Jean Michel ^b   Benhattar, Jean ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b INSTITUT BERGONIÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; DNA; RIBONUCLEOPROTEIN; RNA; TELOMERASE;

CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; ENZYME ACTIVITY; ENZYME REACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN METHYLATION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SINGLE STRAND CONFORMATION POLYMORPHISM; SOFT TISSUE SARCOMA; TELOMERE; TUMOR CELL LINE; UPREGULATION;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CELL DIVISION; CELL LINE; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; NEOPLASMS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROTEIN CONFORMATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SARCOMA; SULFITES; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 0036949605     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.12.2025     Document Type: Review

References (32)

1. Blackburn,E.H. (2001) Switching and signaling at the telomere. Cell, 106, 661-673.
2. Campisi,J., Kim,S.H., Lim,C.S. and Rubio,M. (2001) Cellular senescence, cancer and aging: the telomere connection. Exp. Gerontol., 36, 1619-1637.
3. Liu,J.P. (2000) Telomerase: not just black and white, but shades of gray. Mol. Cell. Biol. Res. Commun., 3, 129-135.
4. Nakamura,T.M., Morin,G.B., Chapman,K.B., Weinrich,S.L., Andrews,W.H., Lingner,J., Harley,C.B. and Cech,T.R. (1997) Telomerase catalytic subunit homologs from fission yeast and human. Science, 277, 955-959.
5. Weinrich,S.L., Pruzan,R., Ma,L. et al. (1997) Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nature Genet., 17, 498-502.
6. Ramakrishnan,S., Eppenberger,U., Mueller,H., Shinkai,Y. and Narayanan,R. (1998) Expression profile of the putative catalytic subunit of the telomerase gene. Cancer Res., 58, 622-625.
7. Liu,Y., Snow,B.E., Hande,M.P. et al. (2000) The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr. Biol., 10, 1459-1462.
8. Zhao,J.Q., Hoare,S.F., McFarlane,R., Muir,S., Parkinson,E.K., Black,D.M. and Keith,W.N. (1998) Cloning and characterization of human and mouse telomerase RNA gene promoter sequences. Oncogene, 16, 1345-1350.
9. Feng,J., Funk,W.D., Wang,S.S. et al. (1995) The RNA component of human telomerase. Science, 269, 1236-1241.
10. Yi,X., Shay,J.W. and Wright,W.E. (2001) Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res., 29, 4818-4825.
11. Soder,A.I., Going,J.J., Kaye,S.B. and Keith,W.N. (1998) Tumour specific regulation of telomerase RNA gene expression visualized by in situ hybridization. Oncogene, 16, 979-983.
12. Heine,B., Hummel,M., Demel,G. and Stein,H. (1998). Demonstration of constant upregulation of the telomerase RNA component in human gastric carcinomas using in situ hybridization. J. Pathol., 185, 139-144.
13. Paradis,V., Dargere,D., Laurendeau,I., Benoit,G., Vidaud,M., Jardin,A. and Bedossa,P. (1999) Expression of the RNA component of human telomerase (hTR) in prostate cancer, prostatic intraepithelial neoplasia and normal prostate tissue. J. Pathol., 189, 213-218.
14. Hiyama,T., Yokozaki,H., Kitadai,Y., Haruma,K., Yasui,W., Kajiyama,G. and Tahara,E. (1999) Overexpression of human telomerase RNA is an early event in oesophageal carcinogenesis. Virchows Arch., 434, 483-487.
15. Yan,P., Saraga,E.P., Bouzourene,H., Bosman,F.T. and Benhattar,J. (2001) Expression of telomerase genes correlates with telomerase activity in human colorectal carcinogenesis. J. Pathol., 193, 21-26.
16. Zhao,J.Q., Glasspool,R.M., Hoare,S.F., Bilsland,A., Szatmari,I. and Keith,W.N. (2000) Activation of telomerase ma gene promoter activity by NF-Y, Sp1 and the retinoblastoma protein and repression by Sp3. Neoplasia, 2, 531-539.
17. Hoare,S.F., Bryce,L.A., Wisman,G.B., Burns,S., Going,J.J., van der Zee,A.G. and Keith,W.N. (2001) Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter. Cancer Res., 61, 27-32.
18. Reddel,R.R., Bryan,T.M., Colgin,L.M., Perrem,K.T. and Yeager,T.R. (2001) Alternative lengthening of telomeres in human cells. Radiat. Res., 155, 194-200.
19. Bryan,T.M., Englezou,A., Dalla-Pozza,L., Dunham,M.A. and Reddel,R.R. (1997) Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nature Med., 3, 1271-1274.
20. Henson,J.D., Neumann,A.A., Yeager,T.R. and Reddel,R.R. (2002) Alternative lengthening of telomeres in mammalian cells. Oncogene, 21, 598-610.
21. Dunham,M.A., Neumann,A.A., Fasching,C.L. and Reddel,R.R. (2000) Telomere maintenance by recombination in human cells. Nature Genet., 26, 447-450.
22. Varley,H., Pickett,H.A., Foxon,J.L., Reddel,R.R. and Royle,N.J. (2002) Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nature Genet., 30, 301-305.
23. Yan,P., Coindre,J.M., Benhattar,J., Bosman,F.T. and Guillou,L. (1999) Telomerase activity and human telomerase reverse transcriptase mRNA expression in soft tissue tumors: correlation with grade, histology and proliferative activity. Cancer Res., 59, 3166-3170.
24. Aogi,K., Woodman,A., Urquidi,V., Mangham,D.C., Tarin,D. and Goodison,S. (2000) Telomerase activity in soft-tissue and bone sarcomas. Clin. Cancer Res., 12, 4776-4781.
25. Yan,P., Benhattar,J., Coindre,J.M. and Guillou,L. (2002) Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcoma. Int. J. Cancer, 98, 851-856.
26. Raizis,A.M., Schmitt,F. and Jost,J.P. (1995) A bisulfite method of 5-methylcytosine mapping that minimizes template degradation. Anal. Biochem., 226, 161-166.
27. Bian,Y.S., Yan,P., Osterheld,M.C., Fontolliet,C. and Benhattar,J. (2001) Promoter methylation analysis on microdissected paraffin-embedded tissues using bisulfite treatment and PCR-SSCP. Biotechniques, 30, 66-72.
28. Paradis,V., Bieche,I., Dargere,D. et al. (2001) hTERT expression in sporadic renal cell carcinomas. J. Pathol., 195, 209-217.
29. Stanta,G., Bonin,S., Niccolini,B., Raccanelli,A. and Baralle,F. (1999) Catalytic subunit of telomerase expression is related to RNA component expression. FEBS Lett., 460, 285-288.
30. Pieper,R.O., Lester,K.A. and Fanton,C.P. (1999) Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts. Nucleic Acids Res., 27, 3229-3235.
31. Yoo,J. and Robinson,R.A. (2000) Expression of telomerase activity and telomerase RNA in human soft tissue sarcomas. Arch. Pathol. Lab. Med., 124, 393-397.
32. Ulaner,G.A., Hu,J.F., Vu,T.H., Giudice,L.C. and Hoffman,A.R. (2001) Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development. Int. J. Cancer, 91, 644-649.