Mannan-binding lectin and its role in innate immunity

Transfusion Medicine

Volumn 12, Issue 6, 2002, Pages 335-352

  Kilpatrick, D C ^a  

^a SCOTTISH NATIONAL BLOOD TRANSFUSION SERVICE   (United Kingdom)

Author keywords

Collectins; Innate immunity; Mannan binding lectin; MBL therapy

Indexed keywords

ANTIBODY; CARBOHYDRATE; COLLECTIN; FUCOSE; MANNAN BINDING LECTIN; MANNOSE; N ACETYLGLUCOSAMINE; PHOSPHOLIPID; RECOMBINANT MANNAN BINDING LECTIN; UNCLASSIFIED DRUG; MANNOSE BINDING LECTIN;

ANTIBACTERIAL ACTIVITY; BLOOD LEVEL; CHEMOTHERAPY; CHRONIC DISEASE; COMPLEMENT ACTIVATION; CYSTIC FIBROSIS; DISEASE ASSOCIATION; DNA FINGERPRINTING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; INFECTION SENSITIVITY; LECTIN BINDING; MOLECULAR BIOLOGY; NEWBORN INFECTION; NONHUMAN; OPSONIZATION; ORGAN TRANSPLANTATION; PLASMA TRANSFUSION; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN FUNCTION; RECURRENT ABORTION; RESPIRATORY TRACT INFECTION; REVIEW; RHEUMATOID ARTHRITIS; SUBSTITUTION THERAPY; SYSTEMIC LUPUS ERYTHEMATOSUS; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY;

GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY; MANNOSE-BINDING LECTIN; VARIATION (GENETICS);

EID: 0036900287     PISSN: 09587578     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3148.2002.00408.x     Document Type: Review

References (142)

1. Aittoniemi, J., Miettinen, A., Laippala, P., Isolauri, E., Viikari, J., Ruuska, T. & Soppi, E. (1996) Age-dependent variation in the serum concentration of mannan-binding protein. Acta Paediatrica, 85, 906-909.
2. Aittoniemi, J., Baer, M., Soppi, E., Vesikari, T. & Miettinen, A. (1998) Mannan binding lectin deficiency and concomitant immunodefects. Archives of Disease in Childhood, 78, 245-248.
3. Angata, T. & Brinkman-van der Linden, E.C.M. (2002) I-type lectins. Biochimica et Biophysica Acta, 1572, 294-316.
4. Baxter, N., Sumiya, M., Cheng, S., Erlich, H., Regan, L., Simons, A. & Summerfield, J.A. (2001) Recurrent miscarriage and variant alleles of mannose binding lectin, tumour necrosis factor and lymphotoxin alpha genes. Clinical and Experimental Immunology, 126, 529-534.
5. Beate, A., Boldt, W. & Petzl-Erler, M.L. (2002) A new strategy for mannose-binding lectin gene haplotyping. Human Mutation, 19, 296-306.
6. Bellamy, R., Ruwende, C., McAdam, K.P.W.J., Thursz, M., Sumiya, M., Summerfield, J., Gilbert, S.C., Corrah, T., Kwiatkowski, D., Whittle, H.C. & Hill, A.V.S. (1998) Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. Quarterly Journal of Medicine, 91, 13-18.
7. Borregaard, N., Elsbach, P., Ganz, T., Garred, P. & Svejgaard, A. (2000) Innate immunity: From plants to humans. Immunology Today, 21, 68-70.
8. Brandrup, F., Homburg, K.M., Wang, P., Garred, P. & Madsen, H.O. (1999) Mannan-binding lectin deficiency associated with recurrrent cutaneous abscesses, prurigo and possibly atopic dermatitis. A family study. British Journal of Dermatology, 140, 168-192.
9. Candy, D.C.A., Larcher, V.F., Tripp, J.H., Harries, J.T., Harvey, B.A.M. & Soothill, J.F. (1980) Yeast opsonisation in children with chronic diarrhoeal states. Archives of Disease in Childhood, 55, 189-193.
10. Cebo, C., Vergoten, G. & Zanetta, J.-P. (2002) Lectin activities of cytokines: Functions and putative carbohydrate recognition domains. Biochimica et Biophysica Acta, 1572, 422-434.
11. Christiansen, O.B., Kilpatrick, D.C., Souter, V., Varming, K., Thiel, S. & Jensenius, J.C. (1999) Mannan-binding lectin deficiency is associated with unexplained recurrent miscarriage. Scandinavian Journal of Immunology, 49, 193-196.
12. Collard, C.D., Montalto, M.C., Reenstra, W.R., Buras, J.A. & Stahl, G.L. (2001) Endothelial oxidative stress activates the lectin complement pathway - Role of cytokeratin 1. American Journal of Pathology, 159, 1045-1054.
13. Crosdale, D.J., Ollier, W.E.R., Thomson, W., Dyer, P.A., Jensenius, J., Johnson, R.W.G. & Poulton, K.V. (2000) Mannose-binding lectin (MBL) genotype distributions with relation to serum levels in UK Caucasoids. European Journal of Immunogenetics, 27, 111-117.
14. Crosdale, D.J., Poulton, K.V., Ollier, W.E.R., Thomson, W. & Denning, D.W. (2001) Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. The Journal of Infectious Diseases, 184, 653-656.
15. Cummings, R.D. & Lowe, J.-B. (1999) Selectins. In: Essentials of Glycobiology (eds Varki, A., Cummings, R., Esko, J. & Freeze, H., Hart, G. & Marth, J.), 391-415. Cold Spring Harbor Laboratory Press, New York.
16. Davies, J., Neth, O., Alton, E., Klein, N. & Turner, M.W. (2000) Differential binding of mannose-binding lectin to respiratory pathogens in cystic fibrosis. Lancet, 355, 1885-1886.
17. Davies, E.J., Snowden, N., Hillarby, M.C., Carthy, D., Grennan, D.M., Thomson, W. & Ollier, W.E.R. (1995) Mannose-binding protein gene polymorphism in systemic lupus erythematosus. Arthritis and Rheumatism, 38, 110-114.
18. Davies, E.J., Teh, L.-S., Ordi-Ros, J., Snowden, N., Hillarby, M.C., Hajeer, A., Donn, R., Perez-Pemen, P., Vilardell-Tarres, M. & Ollier, W.E.R. (1997) A dysfunctional allele of the mannose binding protein gene associates with systemic lupus erythematosus in a Spanish population. The Journal of Rheumatology, 24, 485-488.
19. Dempsey, P.W., Allison, M.E.D., Akkaraju, S., Goodnow, C.C. & Fearon, D.T. (1996) C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity. Science, 271, 348-350.
20. Drenkart, E. & Ausubel, F.M. (2002) Pseudomonas biofilm formation and antibiotic resistance are linked to phenotype variation. Nature, 416, 740-743.
21. Fischer, P.B., Ellermann-Eriksen, S., Thiel, S., Jensenius, J.C. & Morgensen, S.C. (1994) Mannan-binding protein and bovine conglutinin mediate enhancement of herpes simplex virus type 2 infection in mice. Scandinavian Journal of Immunology, 39, 439-445.
22. Foster, C.B., Lehrnbecher, T., Mol, F., Steinberg, S.M., Venzon, D.J., Walsh, T.J., Noack, D., Rae, J., Winkelstein, J.A., Curnutte, J.T. & Chanock, S.J. (1998) Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease. The Journal of Clinical Investigation, 102, 2146-2155.
23. Gabolde, M., Guilloud-Bataille, M., Feingold, J. & Besmond, C. (1999) Association of variant alleles of mannose binding lectin with severity of pulmonary disease in cystic fibrosis: Cohort study. British Medical Journal, 319, 1166-1167.
24. Gabolde, M., Hubert, D., Guilloud-Bataille, M., Lenaerts, C., Feingold, J. & Besmond, C. (2001) The mannose binding lectin gene influences the severity of chronic liver disease in cystic fibrosis. Journal of Medical Genetics, 38, 310-311.
25. Garred, P., Harboe, M., Oettinger, T., Koch, C. & Svejgaard, A. (1994) Dual role of mannan-binding protein in infections: Another case of heterosis? European Journal of Immunogenetics, 21, 125-131.
26. Garred, P., Madsen, H.O., Balslev, U., Hofmann, B., Pedersen, C., Gerstoft, J. & Svejgaard, A. (1997b) Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin. Lancet, 349, 236-240.
27. Garred, P., Madsen, H.O., Halberg, P., Petersen, J., Kronborg, G., Svejgaard, A., Andersen, V. & Jacobsen, S. (1999a) Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus. Arthritis and Rheumatism, 42, 2145-2152.
28. Garred, P., Madsen, H.O., Marquart, H., Hansen, T.M., Sorensen, S.F., Peterson, J., Volck, B., Svejgaard, A., Graudal, N.A., Rudd, P.M., Dwek, R.A., Sim, R.B. & Andersen, V. (2000) Two edged role of mannose binding lectin in rheumatoid arthritis: A cross sectional study. The Journal of Rheumatology, 27, 26-34.
29. Garred, P., Pressler, T., Lanng, S., Madsen, H.O., Moser, C., Laursen, I., Balstrup, F., Koch, C. & Koch, C. (2002) Mannose-binding lectin (MBL) substitution in an MBL deficient patient with severe cystic fibrosis. Pediatric Pulmonology, 33, 201-207.
30. Garred, P., Pressler, T., Madsen, H.O., Fredericksen, B., Svejgaard, A., Hoily, N., Schwartz, M. & Koch, C. (1999b) Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. The Journal of Clinical Investigation, 104, 431-437.
31. Garred, P., Richter, M.C., Andersen, A.B., Madsen, H.O., Mtoni, I., Svejgaard, A. & Shao, J. (1997a) Mannan-binding lectin in the sub-Saharan HIV and tuberculosis epidemics. Scandinavian Journal of Immunology, 46, 204-208.
32. Garred, P., Voss, A., Madsen, H.O. & Junker, P. (2001) Association of mannose-binding lectin gene variation with disease severity and infections in a populationbased cohort of systemic lupus erythematosus patients. Genes and Immunity, 2, 442-450.
33. Ghiran, I., Barbashov, S.F., Klickstein, L.B., Tas, S.W., Jensenius, J.C. & Nicolson-Weller, A. (2000) Complement receptor 1/CD35 is a receptor for mannan-binding lectin. The Journal of Experimental Medicine, 192, 1792-1807.
34. Graudal, N.A., Homann, C., Madsen, H.O., Svejaard, A., Jurik, A.G., Graudal, H.K. & Garred, P. (1998) Mannan binding lectin in rheumatoid arthritis, a longitudinal study. The Journal of Rheumatology, 25, 629-635.
35. Graudal, N., Madsen, H.O., Tarp, U., Svejgaard, A., Jurik, A.G., Graudal, H.K. & Garred, P. (2000) The association of variant mannose binding lectin genotypes with radiographic outcome in rheumatoid arthritis. Arthritis and Rheumatism, 43, 515-521.
36. Hansen, S. & Holmskov, U. (1998) Structural aspects of collectins and receptors for collectins. Immunobiology, 199, 165-189.
37. Hansen, T.K., Thiel, S., Dall, R., Rosenfalck, A.M., Trainer, P., Flyvbjerg, A., Jorgensen, J.O.L. & Christiansen, J.S. (2001) GH strongly affects serum concentrations of mannan-binding lectin: Evidence for a new IGF-independent immunodulatory effect of GH. The Journal of Clinical Endocrinology and Metabolism, 86, 5383-5388.
38. Hartshorn, K.L., Sastry, K., White, M.R., Anders, E.M., Super, M., Ezekowitz, R.A. & Tauber, A.I. (1993) Human mannose-binding protein functions as an opsonin for influenza A viruses. The Journal of Clinical Investigation, 91, 1414-1420.
39. Hibbert, M.L., Sumiya, M., Summerfield, J.A., Booy, R., Levin, M. & The Meningococcal Research Group (1999) Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Lancet, 353, 1049-1053.
40. Hoal-van Helden, E.G., Epstein, J., Victor, T.C., Hon, D.N., Lewis, L.A., Beyers, N., Zurakowski, D., Ezekowitz, R.A.B. & von Helden, P.D. (1999) Mannose-binding protein B allele confers protection against tuberculous meningitis. Pediatric Research, 45, 459-464.
41. Holders, V.M. (1999) Complement deficiency states, disease susceptibility, and infection risk in systemic lupus erythematosus. Arthritis and Rheumatism, 42, 2023-2025.
42. Hundt, M., Heiken, D. & Schmidt, R.E. (2000) Association of low mannose-binding lectin serum concentrations and bacterial pneumonia in HIV infection. AIDS, 14, 1853-1854.
43. Ip, W.K., Chan, S.Y., Lau, C.S. & Lau, Y.L. (1998) Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene. Arthritis and Rheumatism, 41, 1663-1668.
44. Ip, W.K., Lau, Y.L., Chan, S.Y., Mok, C.C., Chan, D.D., Tong, K.K. & Lau, C.S. (2000) Mannose binding lectin and rheumatoid arthritis in southern Chinese. Arthritis and Rheumatism, 43, 1679-1687.
45. Iwanaga, S. (2002) The molecular basis of innate immunity in the horseshoe crab. Current Opinion in Immunology, 14, 87-95.
46. Jack, D.L., Bidwell, J., Turner, M.W. & Wood, N. (1997) Simultaneous genotyping for all three known structural mutations in the human mannose-binding lectin gene. Human Mutation, 9, 41-46.
47. Jack, D.L., Read, R.C., Tenner, A.J., Frosch, M., Turner, M.W. & Klein, N.J. (2001) Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B. The Journal of Infectious Diseases, 184, 1152-1162.
48. Jacobson, S., Madsen, H.O., Klarlund, M., Jensen, T., Skjodt, H., Jensen, K.E., Svejgaard, A., Garred, P. & The TIRA Group (2001) The influence of mannose binding polymorphisms on disease outcome in early polyarthritis. The Journal of Rheumatology, 28, 935-942.
49. Jensenius, J.C. (2002) Mannose-binding lectin. Lancet, 359, 82-83.
50. Kahn, S.J., Wieklinski, M., Ezekowitz, R.A.B., Coder, D., Aruffo, A. & Farr, A. (1996) The major surface glycoproteins of Trypanosoma cruzi amastigotes are ligands of the human serum mannose-binding protein. Infection and Immunity, 64, 2649-2656.
51. Kakkanaiah, V.N., Shen, G.Q., Ojo-Amaize, E.A. & Peter, J.B. (1998) Association of low concentrations of serum mannose-binding protein with recurrent infections in adults. Clinical and Diagnostic Laboratory Immunology, 5, 319-321.
52. Kase, T., Suzuki, Y., Kawai, T., Sakamoto, T., Ohtani, K., Eda, S., Maeda, A., Okuno, Y., Kurimura, T. & Wakamiya, N. (1999) Human mannan-binding lectin inhibits the infection of influenza A virus without complement. Immunology, 97, 385-392.
53. Kawasaki, T. (1999) Structure and biology of mannan-binding protein, MBP, an important component of innate immunity. Biochimica et Biophysica Acta, 1473, 186-195.
54. Kelly, P., Jack, D.L., Naeem, A., Mandanda, B., Pollok, R.C.G., Klein, N.J., Turner, M.W. & Farthing, M.J.G. (2000) Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS. Gastroenterology, 119, 1236-1242.
55. Kilpatrick, D.C. (1997a) Mannan binding protein in sera positive for rheumatoid factor. British Journal of Rheumatology, 36, 207-209.
56. Kilpatrick, D.C. (1997b) Isolation of human mannan binding lectin, serum amyloid P component and related factors from Cohn fraction III. Transfusion Medicine, 7, 289-294.
57. Kilpatrick, D.C. (1998) Phospholipid-binding activity of human mannan-binding lectin. Immunology Letters, 61, 191-195.
58. Kilpatrick, D.C. (2000) Handbook of Animal Lectins: Properties and Biomedical Applications. John Wiley and Sons, Chichester.
59. Kilpatrick, D.C., Bevan, B.H. & Liston, W.A. (1995) Association between mannan binding protein deficiency and recurrent miscarriage. Molecular Human Reproduction, 1 in: Human Reproduction, 10, 2501-2505.
60. Kilpatrick, D.C., James, V.S., Blackwell, C.C., Weir, D.M., Hallam, N.F. & Busuttil, A. (1998) Mannan binding lectin and the sudden infant death syndrome. Forensic Science International, 97, 135-138.
61. Kilpatrick, D.C., Liston, W.A. & Midgley, P.C. (1997) Mannan binding protein in human umbilical cord blood. Natural Immunity, 15, 234-240.
62. Kilpatrick, D.C., Starrs, L., Moore, S., Souter, V. & Liston, W. (1999) Mannan binding lectin concentration and risk of miscarriage. Human Reproduction, 14, 2379-2380.
63. Kilpatrick, D.C. (2002) Mannan-binding lectin: Clinical significance and applications. Biochimica et Biophysica Acta, 1572, 401-413.
64. Klabunde, J., Uhlemann, A.C., Tebo, A.E., Kimmel, J., Schwarz, P.G., Kremnsner, P.G. & Kun, J.F.J. (2002) Recognition of Plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system. Parasitology Research, 88, 113-117.
65. Koch, A., Melbye, M., Sorensen, P., Homoe, P., Madsen, H.O., Molbak, K., Hansen, C.H., Andersen, L.H., Hahn, G.W. & Garred, P. (2001) Acute respiratory tract infections and mannose binding lectin insufficiency during early childhood. Journal of the American Medical Association, 285, 1316-1321.
66. Koppel, R. & Solomon, B. (2001) IgM detection via selective recognition by mannose-binding protein. Journal of Biochemical and Biophysical Methods, 49, 641-647.
67. Kronborg, G., Weis, N., Madsen, H.O., Pedersen, S.S., Wejse, C., Nielsen, H., Skinhoj, P. & Garred, P. (2002) Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. The Journal of Infectious Diseases, 185, 1517-1520.
68. Kruse, C., Rosgaard, A., Steffensen, R., Varming, K., Jensenius, J.C. & Christiansen, O.B. (2002) Low serum level of mannan-binding lectin is a determinant for pregnancy outcome in women with recurrent spontaneous abortion. American Journal of Obstetrics and Gynecology (in press).
69. Kuhlman, M., Joiner, K. & Ezekowitz, R.A.B. (1989) The human mannose-binding protein functions as an opsonin. The Journal of Experimental Medicine, 169, 1733-1745.
70. Kurata, H., Sannoh, T., Kozutsumi, Y., Yokota, Y. & Kawasaki, T. (1994) Structure and function of mannan-binding proteins isolated from human liver and serum. Journal of Biochemistry, 115, 1148-1154.
71. Kuroki, Y., Honma, T., Chiba, H., Sano, H., Saitoh, M., Ogasawara, Y., Sohma, H. & Akino, T. (1997) A novel type of binding specificity to phospholipids for rat mannose-binding proteins isolated from serum and liver. FEBS Letters, 414, 387-392.
72. Lau, Y.L., Lau, C.S., Chan, S.Y. & Karlberg, J. (1996) Mannose-binding protein in Chinese patients with systemic lupus erythematosus. Arthritis and Rheumatism, 39, 706-708.
73. Laursen, S.B., Hedemand, J.E., Thiel, S., Willis, A.C., Skriver, E., Madsen, P.S. & Jensenius, J.C. (1995) Collectin in a non-mammalian species: Isolation and characterization of mannan-binding protein (MBP) from chicken serum. Glycobiology, 5, 553-561.
74. Lipscombe, R.J., Sumiya, M., Hill, A.V.S., Lau, Y.L., Levinsky, R.J., Summerfield, J.A. & Turner, M.W. (1992) High frequencies in African and non-African populations of independent mutations in the mannose-binding protein gene. Human Molecular Genetics, 1, 709-715.
75. Lipscombe, R.J., Sumiya, M., Summerfield, J.A. & Turner, M.W. (1995) Distinct physiochemical characteristics of human mannose binding protein expressed by individuals of differing genotype. Immunology, 85, 660-667.
76. Lu, J. (1997) Collectins: Collectors of microorganisms for the innate immune system. Bioessays, 19, 509-518.
77. Lu, J., Teh, C., Kishore, U. & Reid, K.B.M. (2002) Collectins and ficolins; sugar pattern recognition molecules of the mammalian innate immune system. Biochimica et Biophysica Acta, 1572, 387-400.
78. 2 complex, of the classical pathway of complement, without involvement of Clq. Journal of Immunology, 144, 2287-2294.
79. Luty, A.J.F., Kun, J.F.J. & Kremsner, P.G. (1998) Mannosebinding lectin plasma levels and gene polymorphisms in Plasmodium falciparum malaria. The Journal of Infectious Diseases, 178, 1221-1224.
80. Mackay, I.R. & Rosen, F.S. (2001) Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. The New England Journal of Medicine, 345, 747-755.
81. Madsen, H.O., Garred, P., Kurtzhals, J.A.L., Lamm, L.U., Ryder, L.P., Thiel, S. & Svejgaard, A. (1994) A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics, 40, 37-44.
82. Madsen, H.O., Garred, P., Thiel, S., Kurtzhals, J.A.L., Lamm, L.U., Ryder, L.P. & Svejgaard, A. (1995) Interplay between promoter and structural gene variants control basal serum levels of mannan-binding protein. Journal of Immunology, 155, 3013-3020.
83. Madsen, H.O., Satz, M.L., Hogh, B., Svejgaard, A. & Garred, P. (1998a) Different molecular events result in low protein levels of mannan binding lectin in populations from Southeast Africa and South America. Journal of Immunology, 161, 3169-3175.
84. Madsen, H.O., Videm, V., Svejgaard, A., Svennevig, J.L. & Garred, P. (1998b) Association of mannose-binding lectin deficiency with severe atherosclerosis. Lancet, 352, 959-960.
85. Matsushita, M. & Fujita, T. (2001) Ficolins and the lectin complement pathway. Immunological Reviews, 180, 78-85.
86. Matsushita, M., Hijikata, M., Matsushita, M., Ohta, Y. & Mishiro, S. (1998) Association of mannose-binding lectin gene haplotype LXPA and LYPB with interferonresistant hepatitis C virus infection. Journal of Hepatology, 29, 695-700.
87. Miller, M.E., Seals, J., Kaye, R. & Levitsky, L.C. (1968) A familial plasma associated defect of phagocytosis. Lancet, 2, 60-63.
88. Mullighan, C.G., Heatley, S., Doherty, K., Szabo, F., Grigg, A., Hughes, T.P., Schwarer, A.P., Szer, J., Tait, B.D., To, L.B. & Bardy, B.G. (2002) Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation. Blood, 99, 3524-3529.
89. Mullighan, C.G., Marshall, S.E. & Welsh, K.I. (2000) Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency. Scandinavian Journal of Immunology, 51, 11-22.
90. Nair, S.V., Pearce, S., Green, P.L., Mahajan, D., Newton, R.A. & Raftos, D.A. (2000) A collectin-like protein from tunicates. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 125, 279-289.
91. Naito, H., Ikeda, A., Hasegawa, K., Oka, S., Uemura, K., Kawasaki, N. & Kawasaki, T. (1999) Characterization of human mannan-binding protein promoter. Journal of Biochemistry, 126, 1004-1012.
92. Neth, O., Hann, I., Turner, M.W. & Klein, N.J. (2001) Deficiency of mannose-binding lectin and burden of infection in children with malignancy: A prospective study. Lancet, 358, 614-618.
93. Neth, O., Jack, D.L., Dodds, A.W., Holzel, H., Klein, N.J. & Turner, M.W. (2000) Mannose-binding lectin binds a range of clinically relevant microorganisms and promotes complement deposition. Infection and Immunity, 68, 688-693.
94. Nevens, J.R., Mallia, A.K., Wendt, M.W. & Smith, P.K. (1992) Affinity chromatographic purification of immunoglobulin M antibodies utilizing immobilized mannan binding protein. Journal of Chromatography, 597, 247-256.
95. Nielsen, S.L., Andersen, P.L., Koch, C., Jensenius, J.C. & Thiel, S. (1995) The level of the serum opsonin, mannan-binding protein in HIV-1 antibody-positive patients. Clinical and Experimental Immunology, 100, 219-222.
96. Ochsenbein, A.F. & Zinkernagel, R.M. (2000) Natural antibodies and complement link innate and acquired immunity. Immunology Today, 21, 624-630.
97. Ogden, C.A., de Cathehneau, A., Hoffmann, P.R., Bratton, D., Ghebrehiwet, B., Fadok, V.A. & Henson, P.M. (2001) Clq and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptic cells. The Journal of Experimental Medicine, 194, 781-795.
98. Ohtani, K., Suzuki, Y., Eda, S., Kawai, T., Kase, T., Keshi, H., Sakai, Y., Yamamoto, S., Sakamoto, T. & Wakamiya, N. (1999) High-level and effective production of human mannan-binding lectin (MBL) in Chinese hamster ovary (CHO) cells. Journal of Immunological Methods, 222, 135-144.
99. Palucka, K. & Banchereau, J. (1999) Dendritic cells: A link between innate and adaptive immunity. Journal of Clinical Immunology, 19, 12-25.
100. Petersen, S.V., Thiel, S. & Jensenius, J.C. (2001) The mannan-binding lectin pathway of complement activation: biology and disease associations. Molecular Immunology, 38, 133-149.
101. Peterslund, N.A., Koch, C., Jensenius, J.C. & Thiel, S. (2001) Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet, 358, 637-638.
102. Polotsky, V.Y., Belisle, B.T., Mukosova, K., Ezekowitz, R.A.B. & Joiner, K.A. (1997) Interaction of human mannose-binding lectin with Mycobacterium avium. Journal of Infectious Diseases, 175, 1159-1168.
103. Richardson, V.F., Larcher, V.F. & Price, J.F. (1983) A common congenital immunodeficiency predisposing to infection and atopy in infancy. Archives of Disease in Childhood, 58, 799-802.
104. Roy, S., Knox, K., Segal, S., Griffiths, D., Moore, C.E., Welsh, K.I., Smarason, A., Day, N.P., McPheat, W.L., Crooke, D.W., Hill, A.V.S. & The Oxford Pneumococcal Surveillance Group. (2002) MBL genotype and risk of invasive pneumococcal disease: A case-control study. Lancet, 359, 1569-1573.
105. Sacher, R.A. & The Advisory Panel (2001) Intravenous immunoglobulin consensus statement. The Journal of Allergy and Clinical Immunology, 108, 5139-5146.
106. Saevarsdottir, S., Vikingsdottir, T., Vikingsson, A., Manfredsdottir, V., Geirsson, A.J. & Valdimarsson, H. (2001) Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis. A prospective study. The Journal of Rheumatology, 28, 728-734.
107. Saifuddin, M., Hart, M.L., Gewurz, H., Zhang, Y. & Spear, G.T. (2000) Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1. The Journal of General Virology, 81, 949-955.
108. Santos de Miranda, I.K.F., Costa, C.H.N., Krieger, H., Feitosa, M.F., Zurakowski, D., Fardin, B., Gomes, R.B.B., Weiner, D.L., Harn, D.A., Ezekowitz, R.A.B. & Epstein, J.E. (2001) Mannan-binding lectin enhances susceptibility to visceral leishmaniasis. Infection and Immunity, 69, 5212-5215.
109. Schelenz, S., Malhotra, R., Sim, R.B., Holmskov, U. & Bancroft, G.J. (1995) Binding of host collectins to the pathogenic yeast, Cryptococcus neoformans: human surfactant protein D acts as an agglutinin for acapsular yeast cells. Infection and Immunity, 63, 3360-3366.
110. Senaldi, G., Davies, E.T., Peakman, M., Vergani, D., Lu, J. & Reid, K.B.M. (1995) Frequency of mannose binding protein deficiency in patients with systemic lupus erythematosus. Arthritis and Rheumatism, 38, 1713-1714.
111. Singh, P.K., Parsek, M.R., Greenberg, E.P. & Welsh, M.J. (2002) A component of innate immunity prevents bacterial development. Nature, 417, 552-555.
112. Soothill, J.F. & Harvey, B.A.M. (1976) Defective opsonization: a common immunity deficiency. Archives of Disease in Childhood, 51, 91-99.
113. Stanworth, S.J., Donn, R.P., Hassall, A., Dawes, P., Ollier, W. & Snowden, N. (1998) Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis. British Journal of Rheumatology, 37, 186-188.
114. Steffensen, R., Thiel, S., Varming, K., Jersild, C. & Jensenius, J.C. (2000) Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. Journal of Immunological Methods, 241, 23-42.
115. Stuart, G.R., Lynch, N.J., Day, A.J., Schwaeble, W.J. & Sim, R.B. (1997) The Clq and collectin binding site within Clq receptor (cell surface calreticulin). Immunopharmacology, 38, 73-80.
116. Sullivan, K.E., Wooten, C., Goldman, D. & Petri, M. (1996) Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus. Arthritis and Rheumatism, 39, 2046-2051.
117. Sumiya, M., Super, M., Tabona, P., Levinsky, R.J., Arai, T., Turner, M.W. & Summerfield, J.A. (1991) Molecular basis of opsonic defect in immunodeficient children. Lancet, 337, 1569-1570.
118. Summerfield, J.A., Sumiya, M., Levin, M. & Turner, M.W. (1997) Associations of mutations in mannose binding protein gene with childhood infection in consecutive hospital series. British Medical Journal, 314, 1229-1232.
119. Super, M., Levinsky, R.J. & Turner, M.W. (1990) The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrations. Clinical and Experimental Immunology, 79, 144-150.
120. Super, M., Lu, J., Thiel, S., Levinsky, R.J. & Turner, M.W. (1989) Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet, 2, 1236-1239.
121. Swanson, A.F., Ezekowitz, A.B., Lee, A. & Kuo, C.C. (1998) Human mannose-binding protein inhibits infection of HeLa cells by Chlamydia trachomatis. Infection and Immunity, 66, 1607-1612.
122. Tabona, P., Mellor, A. & Summerfield, J.A. (1995) Mannose binding protein is involved in first-line host defence: Evidence from transgenic mice. Immunology, 85, 153-159.
123. Ten, R.M., Carmona, E.M., Babovic-Vuksanovic, D. & Katzmann, J.A. (1999) Mannose-binding lectin deficiency associated with neutrophil chemotactic unresponsiveness to C5a. The Journal of Allergy and Clinical Immunology, 104, 419-424.
124. Terai, I. & Kobayashi, K. (1993) Perinatal changes in serum mannose-binding protein (MBP) levels. Immunology Letters, 38, 185-187.
125. Terai, I., Kobayashi, K., Fujita, T. & Hagiwara, K. (1993) Human serum mannose binding protein (MBP): Development of an enzyme-linked immunosorbent assay (ELISA) and determination of levels in serum from 1085 normal Japanese and in some body fluids. Biochemical Medicine and Metabolic Biology, 50, 111-119.
126. Thiel, S., Bjerke, T., Hansen, D., Poulsen, L.K., Schiotz, P.O. & Jensenius, J.C. (1995) Ontogeny of human mannan-binding protein, a lectin of the innate immune system. Pediatric Allergy and Immunology, 6, 20-23.
127. Thiel, S., Holmskov, U., Hviid, L., Laursen, S.B. & Jensenius, J.C. (1992) The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. Clinical and Experimental Immunology, 90, 31-35.
128. cIntosh, D., Jack, D.L., Turner, M.W. & Summerfield, J.A. (1996) Mutation of gene for mannose-binding protein associated with chronic hepatitis B viral infection. Lancet, 348, 1417-1419.
129. Townsend, R., Read, R.C., Turner, M.W., Klein, N.J. & Jack, D.L. (2001) Differential recognition of obligate bacteria by human mannose binding lectin. Clinical and Experimental Immunology, 124, 223-228.
130. Turner, M.W. & Hamvas, R.M.J. (2000) Mannose-binding lectin: Structure, function, genetics and disease associations. Reviews in Immunogenetics, 2, 305-322.
131. Uemura, K., Yokota, Y., Kozutsumi, Y. & Kawasaki, T. (1996) A unique CD45 glycoform recognised by the serum mannan-binding protein in immature thymocytes. The Journal of Biological Chemistry, 271, 4581-4584.
132. Valdimarsson, H., Stefansson, M., Vikingsdottir, T., Arason, G.J., Koch, C., Thiel, S. & Jensenius, J.-C. (1998) Reconstitution of opsonizing activity by infusion of mannanbinding lectin (MBL) to MBL-deficient humans. Scandinavian Journal of Immunology, 48, 116-123.
133. Van Emmerik, L.C., Kuijper, E.J., Fijen, C.A.P., Dankert, J. & Thiel, S. (1994) Binding of mannan-binding protein to various bacterial pathogens of meningitis. Clinical and Experimental Immunology, 97, 411-416.
134. Vitved, L., Holmskov, U., Koch, C., Teisner, B., Hansen, S. & Skjodt, K. (2000) The homologue of mannose-binding lectin in the carp family Cyprinidae is expressed at high level in spleen, and the deduced primary structure predicts affinity for galactose. Immunogenetics, 51, 955-964.
135. Volanakis, J.E. (2001) Human C-reactive protein: Expression, structure, and function. Molecular Immunology, 38, 189-197.
136. Vorup-Jensen, T., Jensen, U.B., Lui, A., Kawasaki, T., Uemura, K., Thiel, S., Dagnaes-Hansen, F. & Jensen, T.G. (2001b) Tail-vein injection of human mannan-binding lectin DNA leads to high expression levels of multimeric protein in liver. Molecular Therapy, 3, 867-874.
137. Vorup-Jensen, T., Sorensen, E.-S., Jensen, U.B., Schwaeble, W., Kawasaki, T., Ma, Y., Uemura, K., Wakamiya, N., Suzuki, Y., Jensen, Y.G., Takahashi, K., Ezekowitz, R.A.B., Thiel, S. & Jensenius, J.C. (2001a) Recombinant expression of human mannan-binding lectin. International Immunopharmacology, 1, 677-687.
138. Wallis, R. (2002) Dominant effects of mutations in the collagenous domain of mannose-binding protein. Journal of Immunology, 168, 4553-4558.
139. Wilson, R., Chen, C. & Ratcliffe, N.A. (1999) Innate immunity in insects: The role of multiple endogenous serum lectins in the recognition of foreign invaders in the cockroach, Blaberous discoidalis. Journal of Immunology, 162, 1590-1596.
140. Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U., Cekeci, A., Meyer, K.C., Birrer, P., Bellon, G., Berger, J., Weiss, T., Botzenhart, K., Yankaskas, J.R., Randell, S., Boucher, R.C. & Döring, G. (2002) Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. The Journal of Clinical Investigation, 109, 317-325.
141. Yokota, Y., Arai, T. & Kawasaki, T. (1995) Oligomeric structures required for complement activation of serum mannanbinding proteins. Journal of Biochemistry, 117, 414-419.
142. Zimmermann-Nielsen, E., Baatrup, G., Thorbacius-Ussing, O., Agnholt, J. & Svehag, S.-E. (2002) Complement activation mediated by mannan-binding lectin in plasma from healthy individuals and from patients with SLE, Crohn's disease and colorectal cancer. Suppressed activation by SLE plasma. Scandinavian Journal of Immunology, 55, 105-110.