GH strongly affects serum concentrations of mannan-binding lectin: Evidence for a new IGF-I independent immunomodulatory effect of GH

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 11, 2001, Pages 5383-5388

  Hansen, Troels Krarup ^a   Thiel, Steffen ^b   Dall, Rolf ^a   Rosenfalck, Anne Mette ^c   Trainer, Peter ^d   Flyvbjerg, Allan ^a   Jørgensen, Jens Otto Lunde ^a   Christiansen, Jens Sandahl ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c HVIDOVRE HOSPITAL   (Denmark)

^d CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RECEPTOR; HUMAN GROWTH HORMONE; MANNAN BINDING LECTIN; OCTREOTIDE; PEGVISOMANT; PLACEBO; RECEPTOR BLOCKING AGENT; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ACROMEGALY; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; ENDOCRINE SYSTEM; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; INFLAMMATION; MALE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL;

ANIMALIA;

EID: 0035181768     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.11.8009     Document Type: Article

References (35)

1. Increased mortality associated with growth hormone treatment in critically ill adults
2. Growth hormone potentiates the in vivo biological activities of endotoxin in the rat
3. Contrasting effects of growth hormone and insulin-like growth factor 1 on the biological activities of endotoxin in the rat
4. Growth hormone increases and IGF-1 reduces the response to Escherichia coli infusion in injured pigs
5. The pituitary gland is required for protection against lethal effects of Salmonella typhimurium
6. Premature mortality in 1014 patients with hypopituitarism
7. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease
8. A second serine protease associated with mannan-binding lectin that activates complement
9. Mannose-binding lectin: The pluripotent molecule of the innate immune system
10. Mannosebinding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition
11. Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease
12. Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin
13. Association of low levels of mannan-binding protein with a common defect of opsonisation
14. Complement activation following oxidative stress
15. Complement activation after oxidative stress: Role of the lectin complement pathway
16. Mannan-binding lectin serum concentrations in HIV-infected patients are influenced by the stage of disease
17. Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II
18. Reconstitution of opsonizing activity by infusion of mannan-binding lectin (MBL) to MBL-defident humans
19. Effect of elevated growth hormone concentrations on the phenotype and functions of human lymphocytes and natural killer cells
20. High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene
21. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome
22. Hypophysectomy inhibits the synthesis of tumor necrosis factor alpha by rat macrophages: Partial restoration by exogenous growth hormone or interferon gamma
23. Growth hormone and insulin-like growth factor I enhance host defense in a murine sepsis model
24. Recombinant bovine somatotropin blunts plasma tumor necrosis factor-alpha, cortisol, and thromboxane-B2 responses to endotoxin in vivo
25. In vitro effects of human growth hormone on the proliferative responses and cytokine production of blood mononuclear cells
26. High-dose growth hormone does not affect proinflammatory cytokine (tumor necrosis factor-alpha, interleukin-6, and interferon-gamma) release from activated peripheral blood mononuclear cells or after minimal to moderate surgical stress
27. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein
28. Control of the classical and the MBL pathway of complement activation
29. Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation
30. Treatment with growth hormone and insulin-like growth factor-1 in septicemia: Effects on carbohydrate metabolism
31. Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure
32. The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response
33. Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial
34. The combination of growth hormone with hepatocyte growth factor alters the acute phase response
35. Increases in hemoglobin concentration and iron needs in response to growth hormone treatment