Mannose-binding lectin: Structure, function, genetics and disease associations

Reviews in Immunogenetics

Volumn 2, Issue 3, 2000, Pages 305-322

  Turner, M W ^a   Hamvas, R M J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Collectin; Genotyping; Infectious disease; Innate immunity; Polymorphisms; Population studies; Rheumatoid arthritis; SLE

Indexed keywords

COLLAGEN; COLLECTIN; LECTIN; PROTEINASE;

AUTOIMMUNE DISEASE; COMPLEMENT SYSTEM; DISEASE ASSOCIATION; ENZYME BLOOD LEVEL; EXON; GENE CLUSTER; GENE MUTATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IMMUNITY; IMMUNOMODULATION; INFECTION; OLIGOMERIZATION; PROMOTER REGION; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; TRIPLE HELIX;

ACUTE-PHASE REACTION; ALLELES; ALTERNATIVE SPLICING; ANIMALS; AUTOIMMUNE DISEASES; BACTERIA; CALCIUM; CARRIER PROTEINS; CHROMOSOMES, HUMAN, PAIR 10; COLLECTINS; COMPLEMENT ACTIVATION; DNA MUTATIONAL ANALYSIS; ETHNIC GROUPS; EVOLUTION, MOLECULAR; EXONS; FUNGI; GENE FREQUENCY; GENES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFECTION; MACROMOLECULAR SUBSTANCES; MANNOSE; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MODELS, IMMUNOLOGICAL; MODELS, MOLECULAR; MUTATION; OPSONIN PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTOZOA; SERINE ENDOPEPTIDASES; SPECIES SPECIFICITY; VIRUSES;

EID: 0034521609     PISSN: 13981714     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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13. A second serine protease associated with mannan-binding lectin that activates complement
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15. Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis
16. Mannose-binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 m(r) component of the C1q receptor
17. Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release
18. Induction of TNF-α in human peripheral blood mononuclear cells by the mannoprotein of Cryptococus neoformans involves human mannose binding protein
19. Two edged role of mannose binding lectin in rheumatoid arthritis: A cross sectional study
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27. Mannose-binding proteins isolated from rat liver contain carbohydrate-recognition domains linked to callagenous tails
28. The human ortholog of rhesus mannose-binding protein-A gene is an expressed pseudogene that localizes to Chromosome 10
29. Cloning and sequencing of a cDNA encoding chicken mannan-binding lectin (MBL) and comparison with mammalian analogues
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40. Cleavage of the third component of complement (C3) by mannose-binding protein-associated protease (MASP) with subsequent complement activation
41. Human serum mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1): Determination of levels in body fluids and identification of two forms in serum
42. Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates
43. Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin
44. Human genes for complement components C1r and C1s in a close tail-to-tail arrangement
45. Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene
46. Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease
47. Molecular basis of opsonic defect in immunodeficient children
48. Mannose-binding lectin alleles in a prospectively recruited UK population
49. High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene
50. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein
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52. Molecular defects in variant forms of mannose-binding protein associated with immunodeficiency
53. Molecular determinants of oligomer formation and complement fixation in mannose-binding proteins
54. The Gly-54→Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine-protease
55. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein
56. Different molecular events result in low protein levels of mannan-binding lectin in populations from Southeast Africa and South America
57. Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus
58. Simultaneous genotyping for all three known structural mutations in the human mannose-binding lectin gene
59. Mannose-binding protein gene polymorphism in systemic lupus erythematosus
60. Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in Common Variable Immunodeficiency
61. Association of mannose-binding lectin gene haplotype LXPA and LYPB with interferon-resistant hepatitis C virus infection in Japanese patients
62. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers
63. Genotyping of the three major allelic variants of the human mannose-binding lectin gene by denaturing gradient gel electrophoresis
64. Mutations in the human mannan-binding protein gene: Frequencies in several population groups
65. Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene
66. Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans
67. Single nucleotide polymorphic discrimination by an electronic dot blot assay on semiconductor microchips
68. Restricted polymorphism of the mannose-binding lectin gene of indigenous Australians
69. Mannose-binding protein B allele confers protection against tuberculous meningitis
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79. No association between mannose-binding lectin alleles and susceptibility to chronic hepatitis B virus infection in German patients
80. Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL
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85. Mannan-binding lectin deficiency is associated with unexplained recurrent miscarriage
86. Association of mannose-binding lectin deficiency with severe atherosclerosis
87. Human mannose-binding protein inhibits infection of HeLa cells by Chlamydia trachomatis
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90. A dysfunctional allele of the mannose-binding protein gene associates with systematic lupus erythematosus in a Spanish population
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