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Volumn 8, Issue 12, 2002, Pages 3646-3657

Testing of new agents in childhood cancer preclinical models: Meeting summary

(19)  Houghton, Peter J a   Adamson, Peter C b   Blaney, Susan c   Fine, Howard A d   Gorlick, Richard e   Haber, Michelle f   Helman, Lee g   Hirschfeld, Steve h   Hollingshead, Melinda G i   Israel, Mark A j   Lock, Richard B f   Maris, John M b   Merlino, Glenn g   Patterson, Wendy g   Reynolds, C Patrick k   Shannon, Kevin l   Yu, Alice m   Yu, John n   Smith, Malcolm A g  


Author keywords

[No Author keywords available]

Indexed keywords

BIOSTATISTICS; CHILDHOOD CANCER; CORRELATION ANALYSIS; DISEASE MODEL; HUMAN; IMMUNE DEFICIENCY; IN VITRO STUDY; MEDICAL SOCIETY; PRIORITY JOURNAL; REVIEW; UNITED STATES; XENOGRAFT;

EID: 0036896670     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (50)

References (109)
  • 1
    • 0003471508 scopus 로고    scopus 로고
    • Washington, DC: Pharmaceutical Research and Manufacturers of America
    • Pharmaceutical Research and Manufacturers of America. New Medicines in Development for Cancer 2001. Washington, DC: Pharmaceutical Research and Manufacturers of America, 2001.
    • (2001) New Medicines in Development for Cancer 2001
  • 2
    • 0001900976 scopus 로고
    • Drug sensitivity and resistance in the xenograft model
    • H. M. Maurer, F. B. Ruymann, and C. Pochedly (eds.). Boca Raton, FL: CRC Press
    • Houghton, P. J., Horton, J. K., and Houghton, J. A. Drug sensitivity and resistance in the xenograft model. In: H. M. Maurer, F. B. Ruymann, and C. Pochedly (eds.), CRC Rhabdomyosarcoma and Related Tumors in Children and Adolescents, pp. 187-203. Boca Raton, FL: CRC Press, 1991.
    • (1991) CRC Rhabdomyosarcoma and Related Tumors in Children and Adolescents , pp. 187-203
    • Houghton, P.J.1    Horton, J.K.2    Houghton, J.A.3
  • 3
    • 0023832837 scopus 로고
    • Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: A model for anticancer drug development
    • Horowitz, M. E., Etcubanas, E., Christensen, M. L., Houghton, J. A., George, S. L., Green, A. A., and Houghton, P. J. Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: A model for anticancer drug development. J. Clin. Oncol., 6: 308-314, 1988.
    • (1988) J. Clin. Oncol. , vol.6 , pp. 308-314
    • Horowitz, M.E.1    Etcubanas, E.2    Christensen, M.L.3    Houghton, J.A.4    George, S.L.5    Green, A.A.6    Houghton, P.J.7
  • 4
    • 0029116438 scopus 로고
    • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors
    • Houghton, P. J., Cheshire, P. J., Hallman, J. D., Lutz, L., Friedman, H. S., Danks, M. K., and Houghton, J. A. Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. Cancer Chemother. Pharmacol., 36: 393-403, 1995.
    • (1995) Cancer Chemother. Pharmacol. , vol.36 , pp. 393-403
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman, J.D.3    Lutz, L.4    Friedman, H.S.5    Danks, M.K.6    Houghton, J.A.7
  • 5
    • 0035155499 scopus 로고    scopus 로고
    • Up-front window trial of topotecan in previously untreated children and adolescents with metastatic rhabdomyosarcoma: An intergroup rhabdomyosarcoma study
    • Pappo, A. S., Lyden, E., Breneman, J., Wiener, E., Teot, L., Meza, J., Crist, W., and Vietti, T. Up-front window trial of topotecan in previously untreated children and adolescents with metastatic rhabdomyosarcoma: An intergroup rhabdomyosarcoma study. J. Clin. Oncol., 19: 213-219, 2001.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 213-219
    • Pappo, A.S.1    Lyden, E.2    Breneman, J.3    Wiener, E.4    Teot, L.5    Meza, J.6    Crist, W.7    Vietti, T.8
  • 6
    • 0001146173 scopus 로고
    • Upfront Phase II therapy with Taxol and topotecan in untreated children (>365 days) with disseminated (INSS stage 4) neuroblastoma: A Pediatric Oncology Group study
    • Kretschmar, C., Kletzel, M., Murray, K., Joshi, V., Smith, E., Pao, P., and Castleberry, R. Upfront Phase II therapy with Taxol and topotecan in untreated children (>365 days) with disseminated (INSS stage 4) neuroblastoma: a Pediatric Oncology Group study. Med. Pediatr. Oncol., 25: 243, 1995.
    • (1995) Med. Pediatr. Oncol. , vol.25 , pp. 243
    • Kretschmar, C.1    Kletzel, M.2    Murray, K.3    Joshi, V.4    Smith, E.5    Pao, P.6    Castleberry, R.7
  • 7
    • 0032401845 scopus 로고    scopus 로고
    • Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy
    • Keshelava, N., Seeger, R. C., Groshen, S., and Reynolds, C. P. Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy. Cancer Res., 58: 5396-5405, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 5396-5405
    • Keshelava, N.1    Seeger, R.C.2    Groshen, S.3    Reynolds, C.P.4
  • 10
    • 0025367455 scopus 로고
    • Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines
    • Rubinstein, L. V., Shoemaker, R. H., Paull, K. D., Simon, R. M., Tosini, S., Skehan, P., Scudiero, D. A., Monks, A., and Boyd, M. R. Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J. Natl. Cancer Inst. (Bethesda), 82: 1113-1118. 1990.
    • (1990) J. Natl. Cancer Inst. (Bethesda) , vol.82 , pp. 1113-1118
    • Rubinstein, L.V.1    Shoemaker, R.H.2    Paull, K.D.3    Simon, R.M.4    Tosini, S.5    Skehan, P.6    Scudiero, D.A.7    Monks, A.8    Boyd, M.R.9
  • 11
    • 0033951987 scopus 로고    scopus 로고
    • Cross-resistance of topoisomerase I and II inhibitors in neuroblastoma cell lines
    • Keshelava, N., Groshen, S., and Reynolds, C. P. Cross-resistance of topoisomerase I and II inhibitors in neuroblastoma cell lines. Cancer Chemother. Pharmacol., 45: 1-8, 2000.
    • (2000) Cancer Chemother. Pharmacol. , vol.45 , pp. 1-8
    • Keshelava, N.1    Groshen, S.2    Reynolds, C.P.3
  • 13
    • 0033653618 scopus 로고    scopus 로고
    • Synergism of buthionine sulfoximine and melphalan against neuroblastoma cell lines derived after disease progression
    • Anderson, C. P., Keshelava, N., Satake, N., Meek, W. H., and Reynolds, C. P. Synergism of buthionine sulfoximine and melphalan against neuroblastoma cell lines derived after disease progression. Med. Pediatr. Oncol., 35: 659-662, 2000.
    • (2000) Med. Pediatr. Oncol. , vol.35 , pp. 659-662
    • Anderson, C.P.1    Keshelava, N.2    Satake, N.3    Meek, W.H.4    Reynolds, C.P.5
  • 14
    • 0034614095 scopus 로고    scopus 로고
    • Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism
    • Maurer. B. J., Melton, L., Billups, C., Cabot, M. C., and Reynolds, C. P. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J. Natl. Cancer Inst. (Bethesda), 92: 1897-1909, 2000.
    • (2000) J. Natl. Cancer Inst. (Bethesda) , vol.92 , pp. 1897-1909
    • Maurer, B.J.1    Melton, L.2    Billups, C.3    Cabot, M.C.4    Reynolds, C.P.5
  • 15
    • 0034544675 scopus 로고    scopus 로고
    • In vitro sensitivity of T-cell lymphoblastic leukemia to UCN-01 (7-hydroxystaurosporine) is dependent on p16 protein status: A Pediatric Oncology Group study
    • Omura-Minamisawa, M., Diccianni, M. B., Batova, A., Chang, R. C., Bridgeman, L. J., Yu, J., de Wit, E., Kung, F. H., Pullen, J. D., and Yu, A. L. In vitro sensitivity of T-cell lymphoblastic leukemia to UCN-01 (7-hydroxystaurosporine) is dependent on p16 protein status: a Pediatric Oncology Group study. Cancer Res., 60: 6573-6576, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 6573-6576
    • Omura-Minamisawa, M.1    Diccianni, M.B.2    Batova, A.3    Chang, R.C.4    Bridgeman, L.J.5    Yu, J.6    De Wit, E.7    Kung, F.H.8    Pullen, J.D.9    Yu, A.L.10
  • 19
    • 0034906623 scopus 로고    scopus 로고
    • The angiogenesis inhibitor TNP-470 effectively inhibits human neuroblastoma xenograft growth, especially in the setting of subclinical disease
    • Shusterman, S., Grupp, S. A., Barr, R., Carpentieri, D., Zhao, H., and Maris, J. M. The angiogenesis inhibitor TNP-470 effectively inhibits human neuroblastoma xenograft growth, especially in the setting of subclinical disease. Clin. Cancer Res., 7: 977-984, 2001.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 977-984
    • Shusterman, S.1    Grupp, S.A.2    Barr, R.3    Carpentieri, D.4    Zhao, H.5    Maris, J.M.6
  • 24
    • 0003200669 scopus 로고    scopus 로고
    • Evaluation of ZD1839 (Iressa) alone and in combination with irinotecan (CPT-11) against pediatric solid tumor xenografts
    • Houghton, P. J., Cheshire, P. J., and Harwood, F. C. Evaluation of ZD1839 (Iressa) alone and in combination with irinotecan (CPT-11) against pediatric solid tumor xenografts. Clin. Cancer Res., 6: (Suppl. 11): 379, 2000.
    • (2000) Clin. Cancer Res. , vol.6 , Issue.SUPPL. 11 , pp. 379
    • Houghton, P.J.1    Cheshire, P.J.2    Harwood, F.C.3
  • 25
    • 0011838862 scopus 로고    scopus 로고
    • Suitability of the NOD/SCID mouse for engraftment and chemosensitivity testing of childhood acute lymphoblastic leukemia
    • Lock, R. B., Liem, N., Farnsworth, M. L., Milross, C., Collins, C., and Rice, A. M. Suitability of the NOD/SCID mouse for engraftment and chemosensitivity testing of childhood acute lymphoblastic leukemia. Proc. Am. Assoc. Cancer Res., 42: 480-481, 2001.
    • (2001) Proc. Am. Assoc. Cancer Res. , vol.42 , pp. 480-481
    • Lock, R.B.1    Liem, N.2    Farnsworth, M.L.3    Milross, C.4    Collins, C.5    Rice, A.M.6
  • 26
    • 0034802062 scopus 로고    scopus 로고
    • Engraftment of human T-cell acute lymphoblastic leukemia in immunodeficient NOD/SCID mice which have been preconditioned by injection of human cord blood
    • Dialynas, D. P., Shao, L., Billman, G. F., and Yu, J. Engraftment of human T-cell acute lymphoblastic leukemia in immunodeficient NOD/SCID mice which have been preconditioned by injection of human cord blood. Stem Cells, 19: 443-452, 2001.
    • (2001) Stem Cells , vol.19 , pp. 443-452
    • Dialynas, D.P.1    Shao, L.2    Billman, G.F.3    Yu, J.4
  • 27
    • 0035874526 scopus 로고    scopus 로고
    • Preconditioning with fetal cord blood facilitates engraftment of primary childhood T-cell acute lymphoblastic leukemia in immunodeficient mice
    • Dialynas, D. P., Lee, M. J., Gold, D. P., Shao, L., Yu, A. L., Borowitz, M. J., and Yu, J. Preconditioning with fetal cord blood facilitates engraftment of primary childhood T-cell acute lymphoblastic leukemia in immunodeficient mice. Blood, 97: 3218-3225. 2001.
    • (2001) Blood , vol.97 , pp. 3218-3225
    • Dialynas, D.P.1    Lee, M.J.2    Gold, D.P.3    Shao, L.4    Yu, A.L.5    Borowitz, M.J.6    Yu, J.7
  • 28
    • 0036624736 scopus 로고    scopus 로고
    • The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse
    • Lock, R. B., Liem, N., Farnsworth, M. L., Milross, C. G., Xue, C., Tajbakhsh, M., Haber, M., Norris, M. D., Marshall, G. M., and Rice, A. M. The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse. Blood, 99: 4100-4108, 2002.
    • (2002) Blood , vol.99 , pp. 4100-4108
    • Lock, R.B.1    Liem, N.2    Farnsworth, M.L.3    Milross, C.G.4    Xue, C.5    Tajbakhsh, M.6    Haber, M.7    Norris, M.D.8    Marshall, G.M.9    Rice, A.M.10
  • 30
    • 0034906228 scopus 로고    scopus 로고
    • Fluorescent imaging in a glioma model in vivo
    • Nikas, D. C., Foley, J. W., and Black, P. M. Fluorescent imaging in a glioma model in vivo. Lasers Surg. Med., 29: 11-17, 2001.
    • (2001) Lasers Surg. Med. , vol.29 , pp. 11-17
    • Nikas, D.C.1    Foley, J.W.2    Black, P.M.3
  • 34
    • 0030045594 scopus 로고    scopus 로고
    • Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
    • Largaespada, D. A., Brannan, C. I., Jenkins, N. A., and Copeland, N. G. Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Nat. Genet., 12: 137-143, 1996.
    • (1996) Nat. Genet. , vol.12 , pp. 137-143
    • Largaespada, D.A.1    Brannan, C.I.2    Jenkins, N.A.3    Copeland, N.G.4
  • 35
    • 0032101134 scopus 로고    scopus 로고
    • Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines
    • Zhang, Y. Y., Vik, T. A., Ryder, J. W., Srour, E. F., Jacks, T., Shannon, K., and Clapp, D. W. Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. J. Exp. Med., 187: 1893-1902, 1998.
    • (1998) J. Exp. Med. , vol.187 , pp. 1893-1902
    • Zhang, Y.Y.1    Vik, T.A.2    Ryder, J.W.3    Srour, E.F.4    Jacks, T.5    Shannon, K.6    Clapp, D.W.7
  • 36
    • 0033214846 scopus 로고    scopus 로고
    • In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
    • Mahgoub, N., Taylor, B. R., Gratiot, M., Kohl, N. E., Gibbs, J. B., Jacks, T., and Shannon, K. M. In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells. Blood. 94: 2469-2476, 1999.
    • (1999) Blood , vol.94 , pp. 2469-2476
    • Mahgoub, N.1    Taylor, B.R.2    Gratiot, M.3    Kohl, N.E.4    Gibbs, J.B.5    Jacks, T.6    Shannon, K.M.7
  • 37
    • 0030999641 scopus 로고    scopus 로고
    • Targeted expression of MYCN causes neuroblastoma in transgenic mice
    • Weiss, W. A., Aldape, K., Mohapatra, G., Feuerstein, B. G., and Bishop, J. M. Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J., 16: 2985-2995, 1997.
    • (1997) EMBO J. , vol.16 , pp. 2985-2995
    • Weiss, W.A.1    Aldape, K.2    Mohapatra, G.3    Feuerstein, B.G.4    Bishop, J.M.5
  • 38
    • 0033646540 scopus 로고    scopus 로고
    • Expression of N-myc and MRP genes and their relationship to N-myc gene dosage and tumor formation in a murine neuroblastoma model
    • Norris, M. D., Burkhart, C. A., Marshall, G. M., Weiss, W. A., and Haber, M. Expression of N-myc and MRP genes and their relationship to N-myc gene dosage and tumor formation in a murine neuroblastoma model. Med. Pediatr. Oncol., 35: 585-589. 2000.
    • (2000) Med. Pediatr. Oncol. , vol.35 , pp. 585-589
    • Norris, M.D.1    Burkhart, C.A.2    Marshall, G.M.3    Weiss, W.A.4    Haber, M.5
  • 39
    • 0011901663 scopus 로고    scopus 로고
    • Reduction of neuroblastoma tumorigenesis following N-myc antisense treatment in a transgenic mouse model
    • Burkhart, C. A., Norris, M. D., Marshall, G. M., Weiss, W. A., Mili, M., and Haber, M. Reduction of neuroblastoma tumorigenesis following N-myc antisense treatment in a transgenic mouse model. Proc. Am. Assoc. Cancer Res., 43: 857, 2002.
    • (2002) Proc. Am. Assoc. Cancer Res. , vol.43 , pp. 857
    • Burkhart, C.A.1    Norris, M.D.2    Marshall, G.M.3    Weiss, W.A.4    Mili, M.5    Haber, M.6
  • 40
    • 0034881357 scopus 로고    scopus 로고
    • Pan-trk inhibition decreases metastasis and enhances host survival in experimental models as a result of its selective induction of apoptosis of prostate cancer cells
    • Weeraratna, A. T., Dalrymple, S. L., Lamb, J. C., Denmeade. S. R., Miknyoczki, S., Dionne, C. A., et al. Pan-trk inhibition decreases metastasis and enhances host survival in experimental models as a result of its selective induction of apoptosis of prostate cancer cells. Clin. Cancer Res. 7: 2237-2245, 2001.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2237-2245
    • Weeraratna, A.T.1    Dalrymple, S.L.2    Lamb, J.C.3    Denmeade, S.R.4    Miknyoczki, S.5    Dionne, C.A.6
  • 43
    • 0035211136 scopus 로고    scopus 로고
    • Targeting c-kit mutations in solid tumors: Scientific rationale and novel therapeutic options
    • Demetri, G. D. Targeting c-kit mutations in solid tumors: Scientific rationale and novel therapeutic options. Semin. Oncol., 28: 19-26, 2001.
    • (2001) Semin. Oncol. , vol.28 , pp. 19-26
    • Demetri, G.D.1
  • 44
    • 0035207172 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptors: A therapeutic target in solid tumors
    • George, D. Platelet-derived growth factor receptors: a therapeutic target in solid tumors. Semin. Oncol., 28: 27-33, 2001.
    • (2001) Semin. Oncol. , vol.28 , pp. 27-33
    • George, D.1
  • 46
    • 0032920883 scopus 로고    scopus 로고
    • Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity
    • Parman, T., Wiley, M. J., and Wells, P. G. Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity. Nat. Med., 5: 582-585, 1999.
    • (1999) Nat. Med. , vol.5 , pp. 582-585
    • Parman, T.1    Wiley, M.J.2    Wells, P.G.3
  • 50
    • 0035120420 scopus 로고    scopus 로고
    • Why drugs fail: Of mice and men revisited
    • Takimoto, C. H. Why drugs fail: of mice and men revisited. Clin. Cancer Res., 7: 229-230, 2001.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 229-230
    • Takimoto, C.H.1
  • 51
    • 0035057571 scopus 로고    scopus 로고
    • An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential
    • Khanna, C., Prehn, J., Yeung, C., Caylor, J., Tsokos, M., and Helman, L. An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential. Clin. Exp. Metastasis, 18: 261-271, 2000.
    • (2000) Clin. Exp. Metastasis , vol.18 , pp. 261-271
    • Khanna, C.1    Prehn, J.2    Yeung, C.3    Caylor, J.4    Tsokos, M.5    Helman, L.6
  • 53
    • 0026755969 scopus 로고
    • In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency
    • Uckun, F. M., Manivel, C., Arthur, D., Chelstrom, L. M., Finnegan, D., Tuel-Ahlgren, L., Irvin, J. D., Myers, D. E., and Gunther, R. In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency. Blood, 79: 2201-2214, 1992.
    • (1992) Blood , vol.79 , pp. 2201-2214
    • Uckun, F.M.1    Manivel, C.2    Arthur, D.3    Chelstrom, L.M.4    Finnegan, D.5    Tuel-Ahlgren, L.6    Irvin, J.D.7    Myers, D.E.8    Gunther, R.9
  • 54
    • 0028884016 scopus 로고
    • In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation-resistant human B-cell precursor leukemia cells
    • Waddick, K. G., Myers, D. E., Gunther, R., Chelstrom, L. M., Chandan-Langlie, M., Irvin, J. D., Tumer, N., and Uckun, F. M. In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation-resistant human B-cell precursor leukemia cells. Blood, 86: 4228-4233, 1995.
    • (1995) Blood , vol.86 , pp. 4228-4233
    • Waddick, K.G.1    Myers, D.E.2    Gunther, R.3    Chelstrom, L.M.4    Chandan-Langlie, M.5    Irvin, J.D.6    Tumer, N.7    Uckun, F.M.8
  • 56
    • 0031060230 scopus 로고    scopus 로고
    • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts
    • Hare, C. B., Elion, G. B., Houghton, P. J., Houghton, J. A., Keir, S., Marcelli, S. L., Bigner, D. D., and Friedman, H. S. Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother. Pharmacol., 39: 187-191, 1997.
    • (1997) Cancer Chemother. Pharmacol. , vol.39 , pp. 187-191
    • Hare, C.B.1    Elion, G.B.2    Houghton, P.J.3    Houghton, J.A.4    Keir, S.5    Marcelli, S.L.6    Bigner, D.D.7    Friedman, H.S.8
  • 60
    • 0033003090 scopus 로고    scopus 로고
    • Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations
    • Boland, I., Vassal, G., Morizet, J., Terrier-Lacombe, M. J., Valteau-Couanet, D., Kalifa, C., Hartmann, O., and Gouyette, A. Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations. Br. J. Cancer. 79: 787-792, 1999.
    • (1999) Br. J. Cancer. , vol.79 , pp. 787-792
    • Boland, I.1    Vassal, G.2    Morizet, J.3    Terrier-Lacombe, M.J.4    Valteau-Couanet, D.5    Kalifa, C.6    Hartmann, O.7    Gouyette, A.8
  • 63
    • 0035300569 scopus 로고    scopus 로고
    • A novel metastatic animal model reflecting the clinical appearance of human neuroblastoma: Growth arrest of orthotopic tumors by natural, cytotoxic human immunoglobulin M antibodies
    • Engler, S., Thiel, C., Forster, K., David, K., Bredehorst, R., and Juhl, H. A novel metastatic animal model reflecting the clinical appearance of human neuroblastoma: Growth arrest of orthotopic tumors by natural, cytotoxic human immunoglobulin M antibodies. Cancer Res., 61: 2968-2973, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 2968-2973
    • Engler, S.1    Thiel, C.2    Forster, K.3    David, K.4    Bredehorst, R.5    Juhl, H.6
  • 68
    • 0028935115 scopus 로고
    • In vitro and in vivo cytotoxicity of an anti-osteosarcoma immunotoxin containing pokeweed antiviral protein
    • Anderson, P. M., Meyers, D. E., Hasz, D. E., Covalcuic, K., Saltzman, D., Khanna, C., and Uckun, F. M. In vitro and in vivo cytotoxicity of an anti-osteosarcoma immunotoxin containing pokeweed antiviral protein. Cancer Res., 55: 1321-1327, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 1321-1327
    • Anderson, P.M.1    Meyers, D.E.2    Hasz, D.E.3    Covalcuic, K.4    Saltzman, D.5    Khanna, C.6    Uckun, F.M.7
  • 69
    • 0031746724 scopus 로고    scopus 로고
    • Antitumor activity of TP3 (anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of human osteosarcoma
    • Ek, O., Waurzyniak, B., Myers, D. E., and Uckun, F. M. Antitumor activity of TP3 (anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of human osteosarcoma. Clin. Cancer Res., 4: 1641-1647, 1998.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1641-1647
    • Ek, O.1    Waurzyniak, B.2    Myers, D.E.3    Uckun, F.M.4
  • 70
    • 0026487210 scopus 로고
    • Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors
    • Houghton, P. J., Cheshire, P. J., Myers, L., Stewart, C. F., Synold, T. W., and Houghton, J. A. Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors. Cancer Chemother. Pharmacol., 31: 229-239, 1992.
    • (1992) Cancer Chemother. Pharmacol. , vol.31 , pp. 229-239
    • Houghton, P.J.1    Cheshire, P.J.2    Myers, L.3    Stewart, C.F.4    Synold, T.W.5    Houghton, J.A.6
  • 71
    • 0027324850 scopus 로고
    • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: Lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin
    • Houghton, P. J., Cheshire, P. J., Hallman, J. C., Bissery, M. C., Mathieu-Boue, A., and Houghton, J. A. Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin. Cancer Res., 53: 2823-2829, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 2823-2829
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman, J.C.3    Bissery, M.C.4    Mathieu-Boue, A.5    Houghton, J.A.6
  • 72
    • 0023854161 scopus 로고
    • The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells
    • Harris, A. W., Pinkert, C. A., Crawford, M., Langdon, W. Y., Brinster, R. L., and Adams, J. M. The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J. Exp. Med., 167: 353-371, 1988.
    • (1988) J. Exp. Med. , vol.167 , pp. 353-371
    • Harris, A.W.1    Pinkert, C.A.2    Crawford, M.3    Langdon, W.Y.4    Brinster, R.L.5    Adams, J.M.6
  • 74
    • 0033569423 scopus 로고    scopus 로고
    • INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
    • Schmitt, C. A., McCurrach, M. E., de Stanchina, E., Wallace-Brodeur, R. R., and Lowe, S. W. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev., 13: 2670-2677, 1999.
    • (1999) Genes Dev. , vol.13 , pp. 2670-2677
    • Schmitt, C.A.1    McCurrach, M.E.2    De Stanchina, E.3    Wallace-Brodeur, R.R.4    Lowe, S.W.5
  • 75
    • 0033826530 scopus 로고    scopus 로고
    • Genetic analysis of chemoresistance in primary murine lymphomas
    • Schmitt, C. A., Rosenthal, C. T., and Lowe, S. W. Genetic analysis of chemoresistance in primary murine lymphomas. Nat. Med., 6: 1029-1035, 2000.
    • (2000) Nat. Med. , vol.6 , pp. 1029-1035
    • Schmitt, C.A.1    Rosenthal, C.T.2    Lowe, S.W.3
  • 76
    • 0035049735 scopus 로고    scopus 로고
    • Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo
    • Schmitt, C. A., and Lowe, S. W. Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo. Blood Cells Mol. Dis., 27: 206-216, 2001.
    • (2001) Blood Cells Mol. Dis. , vol.27 , pp. 206-216
    • Schmitt, C.A.1    Lowe, S.W.2
  • 77
    • 0035328722 scopus 로고    scopus 로고
    • Astrocytespecific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas
    • Ding, H., Roncari, L., Shannon, P., Wu, X., Lau, N., Karaskova, J., Gutmann, D. H., Squire, J. A., Nagy, A., and Guha, A. Astrocytespecific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas. Cancer Res., 61: 3826-3836, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 3826-3836
    • Ding, H.1    Roncari, L.2    Shannon, P.3    Wu, X.4    Lau, N.5    Karaskova, J.6    Gutmann, D.H.7    Squire, J.A.8    Nagy, A.9    Guha, A.10
  • 78
    • 0033812187 scopus 로고    scopus 로고
    • Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
    • Reilly, K. M., Loisel, D. A., Bronson, R. T., McLaughlin, M. E., and Jacks, T. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat. Genet., 26: 109-113, 2000.
    • (2000) Nat. Genet. , vol.26 , pp. 109-113
    • Reilly, K.M.1    Loisel, D.A.2    Bronson, R.T.3    McLaughlin, M.E.4    Jacks, T.5
  • 80
    • 0032887746 scopus 로고    scopus 로고
    • No complementation between TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice
    • Maddalena, A. S., Hainfellner, J. A., Hegi, M. E., Glatzel, M., and Aguzzi, A. No complementation between TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice. Brain Pathol., 9: 627-637, 1999.
    • (1999) Brain Pathol. , vol.9 , pp. 627-637
    • Maddalena, A.S.1    Hainfellner, J.A.2    Hegi, M.E.3    Glatzel, M.4    Aguzzi, A.5
  • 81
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich, L. V., Milenkovic,. L., Higgins, K. M., and Scott, M. P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (Wash. DC), 277: 1109-1113, 1997.
    • (1997) Science (Wash. DC) , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 83
    • 0034655270 scopus 로고    scopus 로고
    • The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
    • Wetmore, C., Eberhart, D. E., and Curran, T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res., 60: 2239-2246, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 2239-2246
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 84
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore, C., Eberhart, D. E., and Curran, T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res., 61: 513-516, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 85
    • 0033531233 scopus 로고    scopus 로고
    • Human ubiquitous JCV(CY) T-antigen gene induces brain tumors in experimental animals
    • Krynska, B., Otte, J., Franks, R., Khalili, K., and Croul, S. Human ubiquitous JCV(CY) T-antigen gene induces brain tumors in experimental animals. Oncogene, 18: 39-46, 1999.
    • (1999) Oncogene , vol.18 , pp. 39-46
    • Krynska, B.1    Otte, J.2    Franks, R.3    Khalili, K.4    Croul, S.5
  • 86
    • 0035833343 scopus 로고    scopus 로고
    • Involvement of Wnt signaling pathway in murine medulloblastoma induced by human neurotropic JC virus
    • Gan, D. D., Reiss, K., Carrill, T., Del Valle, L., Croul, S., Giordano, A., Fishman, P., and Khalili, K. Involvement of Wnt signaling pathway in murine medulloblastoma induced by human neurotropic JC virus. Oncogene, 20: 4864-4870, 2001.
    • (2001) Oncogene , vol.20 , pp. 4864-4870
    • Gan, D.D.1    Reiss, K.2    Carrill, T.3    Del Valle, L.4    Croul, S.5    Giordano, A.6    Fishman, P.7    Khalili, K.8
  • 87
    • 0033168716 scopus 로고    scopus 로고
    • The MLL-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis
    • Dobson, C. L., Warren, A. J., Pannell, R., Forster, A., Lavenir, I., Corral, J., Smith, A. J., and Rabbitts, T. H. The MLL-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J., 18: 3564-3574, 1999.
    • (1999) EMBO J. , vol.18 , pp. 3564-3574
    • Dobson, C.L.1    Warren, A.J.2    Pannell, R.3    Forster, A.4    Lavenir, I.5    Corral, J.6    Smith, A.J.7    Rabbitts, T.H.8
  • 90
    • 0035282735 scopus 로고    scopus 로고
    • Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336
    • Reichert, A., Heisterkamp, N., Daley, G. Q., and Groffen, J. Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336. Blood, 97: 1399-1403, 2001.
    • (2001) Blood , vol.97 , pp. 1399-1403
    • Reichert, A.1    Heisterkamp, N.2    Daley, G.Q.3    Groffen, J.4
  • 95
    • 0034730198 scopus 로고    scopus 로고
    • 3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins
    • 3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins. Proc. Natl. Acad. Sci. USA, 97: 10173-10178, 2000.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10173-10178
    • Rego, E.M.1    He, L.Z.2    Warrell R.P., Jr.3    Wang, Z.G.4    Pandolfi, P.P.5
  • 96
    • 0035910748 scopus 로고    scopus 로고
    • BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor α chimeric protein (PMLRARα) to block neutrophil differentiation and initiate acute leukemia
    • Kogan, S. C., Brown, D. E., Shultz, D. B., Truong, B. T., Lallemand-Breitenbach, V., Guillemin, M. C., Lagasse, E., Weissman, I. L., and Bishop, J. M. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor α chimeric protein (PMLRARα) to block neutrophil differentiation and initiate acute leukemia. J. Exp. Med., 193: 531-544, 2001.
    • (2001) J. Exp. Med. , vol.193 , pp. 531-544
    • Kogan, S.C.1    Brown, D.E.2    Shultz, D.B.3    Truong, B.T.4    Lallemand-Breitenbach, V.5    Guillemin, M.C.6    Lagasse, E.7    Weissman, I.L.8    Bishop, J.M.9
  • 97
  • 99
    • 0029815976 scopus 로고    scopus 로고
    • Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIα
    • Kelliher, M. A., Seldin, D. C., and Leder, P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIα. EMBO J., 15: 5160-5166, 1996.
    • (1996) EMBO J. , vol.15 , pp. 5160-5166
    • Kelliher, M.A.1    Seldin, D.C.2    Leder, P.3
  • 100
    • 0035963295 scopus 로고    scopus 로고
    • The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice
    • O'Neil, J., Billa, M., Oikemus, S., and Kelliher, M. The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice. Oncogene, 20: 3897-3905, 2001.
    • (2001) Oncogene , vol.20 , pp. 3897-3905
    • O'Neil, J.1    Billa, M.2    Oikemus, S.3    Kelliher, M.4
  • 101
    • 0030921503 scopus 로고    scopus 로고
    • An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO-to generate T-cell malignancies in transgenic mice
    • Aplan, P. D., Jones, C. A., Chervinsky, D. S., Zhao, X., Ellsworth, M., Wu. C., McGuire, E. A., and Gross, K. W. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO-to generate T-cell malignancies in transgenic mice. EMBO J., 16: 2408-2419, 1997.
    • (1997) EMBO J. , vol.16 , pp. 2408-2419
    • Aplan, P.D.1    Jones, C.A.2    Chervinsky, D.S.3    Zhao, X.4    Ellsworth, M.5    Wu, C.6    McGuire, E.A.7    Gross, K.W.8
  • 102
    • 0029981648 scopus 로고    scopus 로고
    • Protein dimerization between Lmo2 (Rbtn2) and Tall alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
    • Larson, R. C., Lavenir, I., Larson. T. A., Baer, R., Warren, A. J., Wadman, I., Nottage, K., and Rabbitts, T. H. Protein dimerization between Lmo2 (Rbtn2) and Tall alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J., 15: 1021-1027, 1996.
    • (1996) EMBO J. , vol.15 , pp. 1021-1027
    • Larson, R.C.1    Lavenir, I.2    Larson, T.A.3    Baer, R.4    Warren, A.J.5    Wadman, I.6    Nottage, K.7    Rabbitts, T.H.8
  • 103
    • 0030666853 scopus 로고    scopus 로고
    • High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice
    • Yan, W., Young, A. Z., Soares, V. C., Kelley, R., Benezra, R., and Zhuang, Y. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. Mol. Cell. Biol., 17: 7317-7327, 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7317-7327
    • Yan, W.1    Young, A.Z.2    Soares, V.C.3    Kelley, R.4    Benezra, R.5    Zhuang, Y.6
  • 105
    • 0034610395 scopus 로고    scopus 로고
    • Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice
    • Roberts, C. W., Galusha, S. A., McMenamin, M. E., Fletcher, C. D., and Orkin, S. H. Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc. Natl. Acad. Sci. USA, 97: 13796-13800, 2000.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13796-13800
    • Roberts, C.W.1    Galusha, S.A.2    McMenamin, M.E.3    Fletcher, C.D.4    Orkin, S.H.5
  • 107
    • 0034572885 scopus 로고    scopus 로고
    • The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression
    • Klochendler-Yeivin, A., Fiette, L., Barra, J., Muchardt. C., Babinet, C., and Yaniv, M. The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression. EMBO Rep., 1: 500-506, 2000.
    • (2000) EMBO Rep. , vol.1 , pp. 500-506
    • Klochendler-Yeivin, A.1    Fiette, L.2    Barra, J.3    Muchardt, C.4    Babinet, C.5    Yaniv, M.6


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