Striatal and extra-striatal D2/D3 dopamine receptor occupancy by quetiapine in vivo: [123I]-epidepride single photon emission tomography (SPET) study

British Journal of Psychiatry

Volumn 177, Issue NOV., 2000, Pages 408-415

  Stephenson, C M E ^a   Bigliani, V ^a   Jones, H M ^a   Mulligan, R S ^a   Acton, P D ^a   Visvikis, D ^a   Ell, P J ^a   Kerwin, R W ^a   Pilowsky, L S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; EPIDEPRIDE; QUETIAPINE;

ADULT; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; DRUG RECEPTOR BINDING; EXTRAPYRAMIDAL SYMPTOM; FEMALE; HUMAN; IMAGE ANALYSIS; LIMBIC CORTEX; MALE; PSYCHOSIS; RECEPTOR AFFINITY; RECEPTOR BLOCKING; RECEPTOR OCCUPANCY; SCORING SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TEMPORAL CORTEX;

ADULT; ANTIPSYCHOTIC AGENTS; BENZAMIDES; CLOZAPINE; CORPUS STRIATUM; DIBENZOTHIAZEPINES; FEMALE; HUMANS; IODINE RADIOISOTOPES; MALE; MIDDLE AGED; PYRROLIDINES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; TEMPORAL LOBE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0033768430     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.177.5.408     Document Type: Article

References (34)

1. Imaging resting phasic dopamine synaptic activity in schizophrenia
2. Multiple fixed doses of 'Seroquel' (Quetiapine) in patients with acute exacerbation of schizophenia: A comparison with haloperidol and placebo
3. A rating scale for drug-induced akathisia
4. 123I]-epidepride single photon emission tomography (SPET) study
5. 2 sites
6. The Global Assessment Scale: A procedure for measuring overall severity of psychiatric disturbances
7. 2 dopamine receptors in healthy subjects and antipsychotic drug-treated patients
8. 2 receptors
9. 2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia
10. 2 dopamine receptors in the temporal lobe in schizophrenia: A postmortem study
11. Preclinical pharmacology of new atypical antipsychotics in late stage development
12. 2 receptor occupancy by an atypical neuroleptic
13. 123I]epidepride SPECT
14. 123I]-epidepride: Characteristics of uptake in the human brain
15. IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol
16. Increased dopamine transmission in schizophrenia: Relationship to illness phase
17. The cerebral cortex: A case for a common site of action of antipsychotics
18. In vivo assessment of basal and drug-induced dopamine release in cortical and subcortical regions of the anesthetized primate
19. A new depression scale designed to be sensitive to change
20. The brief psychiatric rating scale
21. Limbic selectivity of clozapine
22. 123I-epidepride SPET (single photon emission tomography)
23. Iodine-123-epidepride-SPECT: Studies in Parkinson's disease, multiple system atrophy and Huntington's disease
24. Amisulpride: From animal pharmacology to therapeutic action
25. 3 dopamine receptor in cellular and organismal function
26. 2 receptors: An explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine
27. A rating scale for extra-pyramidal side effects
28. 2 receptor density and affinity in the human brain measured by 3D PET
29. 2 dopamine receptors