IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol

Psychopharmacology

Volumn 133, Issue 4, 1997, Pages 323-328

  Küfferle, Bernd ^a   Tauscher, Johannes ^a   Asenbaum, Susanne ^b   Vesely, Christine ^a   Podreka, Ivo ^b   Brücke, Thomas ^b   Kasper, Siegfried ^a  

^a University Hospital for Psychiatry   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Atypical antipsychotics; Dopamine 2 receptors; IBZM; Neuroleptics; Quetiapine; Schizophrenia; SPECT

Indexed keywords

BENZAMIDE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLOZAPINE; DOPAMINE 2 RECEPTOR; HALOPERIDOL; IODINE 123; IODOBENZAMIDE I 123; QUETIAPINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORPUS STRIATUM; DRUG RECEPTOR BINDING; DRUG SAFETY; EXTRAPYRAMIDAL SYNDROME; FEMALE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOSIS; RECEPTOR OCCUPANCY; SCHIZOIDISM; SCHIZOPHRENIA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TECHNIQUE;

ADULT; ANTIPSYCHOTIC AGENTS; BENZAMIDES; CLOZAPINE; DIBENZOTHIAZEPINES; DOPAMINE ANTAGONISTS; FEMALE; HALOPERIDOL; HUMANS; MALE; MIDDLE AGED; NEOSTRIATUM; PSYCHOTIC DISORDERS; PYRROLIDINES; RECEPTORS, DOPAMINE D2; SCHIZOPHRENIA; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0030781165     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050409     Document Type: Article

References (23)

1. American Psychiatric Association (1994) DSM-IV: diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, D.C.
2. ™ (ICI 204 636): a novel atypical antipsychotic: efficacy and safety results from two phase II, multicenter, placebo-controlled clinical trials. Schizophr Res 15:142
3. Barnes TRE (1989) A rating scale for drug-induced akathisia. Br J Psychiatry 154:672-676
4. Borison RL, Arvanitis LA, Miller BG, Link CGG, Hong WW (1995) Seroquel (ICI 204,636): a novel atypical antipsychotic. Biol Psychiatry 37:661
5. 2 receptor imaging with SPECT: studies in different neuropsychiatric disorders. J Cereb Blood Flow Metab 11:220-228
6. 2-receptor blockade by typical and atypical neuroleptics. Lancet 339:497
7. 2 dopamine receptor occupancy during treatment with conventional and atypical neuroleptics. Psychopharmacology 99: 28-31
8. 2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Arch Gen Psychiatry 49:538-544
9. ™ tid. Eur Neuropsychopharmacol 5:347 (P-4-65)
10. Goldstein JM, Litwin LC, Sutton EB, Malick JB (1993) Seroquel: electrophysiological profile of a potential atypical antipsychotic. Psychopharmacology 112:293-298
11. Kane JM, Honifeld G, Singer J, Meltzer HY (1988) Clozapine in treatment-resistant schizophrenics. Psychopharmacol Bull 24:62-86
12. 2 dopamine receptors in 56 schizophrenic patients taking various neuroleptics. Am J Psychiatry 153:2:183-190
13. Küfferle B, Brücke T, Topitz-Schratzberger A, Tauscher J. Gössler R, Vesely C, Asenbaum S, Podreka I, Kasper S (1996) Striatal dopamine-2 receptor occupancy in psychotic patients treated with risperidone. Psychiatr Res Neuroimag 68:23-30
14. 2 pKi values. J Pharmacol Exp Ther 25:238-246
15. Migler BM, Warawa EJ, Malick JB (1993) Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug. Psychopharmacology 112:299-307
16. National Institute of Mental Health (NIMH) (1976) 028 GGI. Clinical global impressions. In: Guy W (ed) ECDEU assessment manual for psychopharmacology, revised. Rockville, Maryland, pp 217-222
17. Pilowsky LS, Costa DC, Ell PJ et al (1992) Clozapine, single photon emission tomography and the D2 dopamine receptor blockade hypothesis of schizophrenia. Lancet 340:199-202
18. Saller CF, Salama AI (1993) Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology 112: 285-92
19. 2-dopamine receptor occupancy differs between patients with and without extrapyramidal side effects. Acta Psychiatr Scand 90:266-268
20. Schotte A, Janssen PFM, Gommeren W, Luyten WHML, Van Gompel P, Lesage AS, De Loore K, Leysen JE (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 124:57-73
21. 2 receptors in human subjects with iodine 123-IBZM. J Nucl Med 33: 1964-1971
22. Simpson GM, Angus JWS (1970) A rating scale for extrapyramidal side effects. Acta Psychiatr Scand 212 [Suppl 44]:11-19
23. Wetzel H, Szegedi A, Hain C, Wiesner J, Schlegel S, Benkert O (1995) Seroquel (ICI 204 636), a putative "Atypical" antipsychotic, in schizophrenia with positive symptomatology: results of an open clinical trial and changes of neuroendocrinological and EEG parameters. Psychopharmacology 119:231-238