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Volumn 169, Issue 11, 2002, Pages 6564-6569

Antigen-based immunotherapy drives the precocious development of autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE;

EID: 0036884926     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.11.6564     Document Type: Article
Times cited : (24)

References (56)
  • 1
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • Zamvil, S. S., and L. Steinman. 1990. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8:579.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 579
    • Zamvil, S.S.1    Steinman, L.2
  • 3
    • 0029093933 scopus 로고
    • The role of IL-12 in the induction of organ-specific autoimmune diseases
    • Trembleau, S., T. Germann, M. K. Gately, and L. Adorini. 1995. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol. Today 16:383.
    • (1995) Immunol. Today , vol.16 , pp. 383
    • Trembleau, S.1    Germann, T.2    Gately, M.K.3    Adorini, L.4
  • 6
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann, P. V., T. Forsthuber, A. Miller, and E. E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
    • (1992) Nature , vol.358 , pp. 155
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 8
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch, R., X. D. Yang, S. M. Singer, R. S. Liblau, L. Fugger, and H. O. McDevitt, 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72.
    • (1993) Nature , vol.366 , pp. 72
    • Tisch, R.1    Yang, X.D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 9
    • 0029975898 scopus 로고    scopus 로고
    • A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease
    • Yu, M., J. M. Johnson, and V. K. Tuohy. 1996. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J. Exp. Med. 183:1777.
    • (1996) J. Exp. Med. , vol.183 , pp. 1777
    • Yu, M.1    Johnson, J.M.2    Tuohy, V.K.3
  • 12
    • 0033526109 scopus 로고    scopus 로고
    • Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis
    • Tuohy, V. K., M. Yu, L. Yin, J. A. Kawczak, and R. P. Kinkel. 1999. Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis. J. Exp. Med. 189:1033.
    • (1999) J. Exp. Med. , vol.189 , pp. 1033
    • Tuohy, V.K.1    Yu, M.2    Yin, L.3    Kawczak, J.A.4    Kinkel, R.P.5
  • 13
    • 0034327178 scopus 로고    scopus 로고
    • Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected mice
    • Katz-Levy, Y., K. L. Neville, J. Padilla, S. Rahbe, W. S. Begolka, A. M. Girvin, J. K. Olson, C. L. Vanderlugt, and S. D. Miller. 2000. Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected mice. J. Immunol. 165:5304.
    • (2000) J. Immunol. , vol.165 , pp. 5304
    • Katz-Levy, Y.1    Neville, K.L.2    Padilla, J.3    Rahbe, S.4    Begolka, W.S.5    Girvin, A.M.6    Olson, J.K.7    Vanderlugt, C.L.8    Miller, S.D.9
  • 14
    • 0035876930 scopus 로고    scopus 로고
    • The frequency of high avidity T cells determines the hierarchy of determinant spreading
    • Tian, J., S. Gregori, L. Adorini, and D. L. Kaufman. 2001. The frequency of high avidity T cells determines the hierarchy of determinant spreading. J. Immunol. 166:7144.
    • (2001) J. Immunol. , vol.166 , pp. 7144
    • Tian, J.1    Gregori, S.2    Adorini, L.3    Kaufman, D.L.4
  • 15
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
    • (1996) Immunol. Today , vol.17 , pp. 138
    • Mosmann, T.R.1    Sad, S.2
  • 16
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
    • (1996) Nature , vol.383 , pp. 787
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 17
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • Weiner, H. L. 1997. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol. Today 18:335.
    • (1997) Immunol. Today , vol.18 , pp. 335
    • Weiner, H.L.1
  • 18
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
    • (2000) J. Exp. Med. , vol.192 , pp. 295
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 20
    • 0027156737 scopus 로고
    • Cytokine regulation of T-cell function: Potential for therapeutic intervention
    • Powrie, F., and R. L. Coffman. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol. Today 14:270.
    • (1993) Immunol. Today , vol.14 , pp. 270
    • Powrie, F.1    Coffman, R.L.2
  • 21
    • 0027954364 scopus 로고
    • Antigen-specific immunotherapy: Is it a real possibility to combat T-cell-mediated autoimmunity?
    • Tisch, R., and H. O. McDevitt. 1994, Antigen-specific immunotherapy: is it a real possibility to combat T-cell-mediated autoimmunity? Proc. Natl. Acad. Sci. USA 91:437.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 437
    • Tisch, R.1    McDevitt, H.O.2
  • 23
    • 0029965137 scopus 로고    scopus 로고
    • A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry
    • Steinman, L. 1996. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. Proc. Natl. Acad. Sci. USA 93:2253.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2253
    • Steinman, L.1
  • 24
    • 0029659057 scopus 로고    scopus 로고
    • Immune deviation: The third dimension of nondeletional T cell tolerance
    • Rocken, M., and E. M. Shevach. 1996. Immune deviation: the third dimension of nondeletional T cell tolerance. Immunol. Rev. 149:175.
    • (1996) Immunol. Rev. , vol.149 , pp. 175
    • Rocken, M.1    Shevach, E.M.2
  • 25
    • 0032940106 scopus 로고    scopus 로고
    • Antigen-based immunotherapy for autoimmune disease: From animal models to humans?
    • Tian, J., A. Olcott, L. Hanssen, D. Zekzer, and D. L. Kaufman, 1999. Antigen-based immunotherapy for autoimmune disease: from animal models to humans? Immunol. Today 20:190.
    • (1999) Immunol. Today , vol.20 , pp. 190
    • Tian, J.1    Olcott, A.2    Hanssen, L.3    Zekzer, D.4    Kaufman, D.L.5
  • 26
    • 0033738813 scopus 로고    scopus 로고
    • Antigen-specific therapy for autoimmune disease
    • Harrison, L. C., and D. A. Hafler. 2000. Antigen-specific therapy for autoimmune disease. Curr. Opin. Immunol. 12:704.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 704
    • Harrison, L.C.1    Hafler, D.A.2
  • 27
    • 0035944844 scopus 로고    scopus 로고
    • β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • Raz, I., D. Elias, A. Avron, M. Tamir, M. Metzger, and I. R. Cohen. 2001. β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 358:1749.
    • (2001) Lancet , vol.358 , pp. 1749
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 28
    • 0031452948 scopus 로고    scopus 로고
    • Determinant spreading of T helper 2 (TH2) responses to pancreatic islet autoantigens
    • Tian, J., P. V. Lehmann, and D. L. Kaufman. 1997. Determinant spreading of T helper 2 (TH2) responses to pancreatic islet autoantigens. J. Exp. Med. 186:2039.
    • (1997) J. Exp. Med. , vol.186 , pp. 2039
    • Tian, J.1    Lehmann, P.V.2    Kaufman, D.L.3
  • 29
    • 0033178763 scopus 로고    scopus 로고
    • Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent
    • Tisch, R., B. Wang, and D. V. Serreze. 1999. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent. J. Immunol. 163:1178.
    • (1999) J. Immunol. , vol.163 , pp. 1178
    • Tisch, R.1    Wang, B.2    Serreze, D.V.3
  • 30
    • 0030960632 scopus 로고    scopus 로고
    • Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens
    • Elias, D., A. Meilin, V. Ablamunits, O. S. Birk, P. Carmi, S. Konen-Waisman, and I. R. Cohen. 1997. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens. Diabetes 46:758.
    • (1997) Diabetes , vol.46 , pp. 758
    • Elias, D.1    Meilin, A.2    Ablamunits, V.3    Birk, O.S.4    Carmi, P.5    Konen-Waisman, S.6    Cohen, I.R.7
  • 31
    • 0028122043 scopus 로고
    • Properties and functions of interleukin-10
    • Mosmann, T. R. 1994. Properties and functions of interleukin-10. Adv. Immunol. 56:1.
    • (1994) Adv. Immunol. , vol.56 , pp. 1
    • Mosmann, T.R.1
  • 32
    • 0035337721 scopus 로고    scopus 로고
    • A glutamic acid decarboxylase 65-specific th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice
    • Tisch, R., B. Wang, M. A. Atkinson, D. V. Serreze, and R. Friedline. 2001. A glutamic acid decarboxylase 65-specific th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice. J. Immunol. 166:6925.
    • (2001) J. Immunol. , vol.166 , pp. 6925
    • Tisch, R.1    Wang, B.2    Atkinson, M.A.3    Serreze, D.V.4    Friedline, R.5
  • 33
    • 0026322837 scopus 로고
    • Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein
    • Elias, D., T. Reshef, O. S. Birk, R. van der Zee, M. D. Walker, and I. R. Cohen. 1991. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc. Natl. Acad. Sci. USA 88:3088.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3088
    • Elias, D.1    Reshef, T.2    Birk, O.S.3    Van der Zee, R.4    Walker, M.D.5    Cohen, I.R.6
  • 34
    • 0028861576 scopus 로고
    • Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription
    • Muir, A., A. Peck, M. Clare-Salzler. Y. H. Song, J. Cornelius, R. Luchetta, J. Krischer, and N. Maclaren. 1995. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J. Clin. Invest. 95:628.
    • (1995) J. Clin. Invest. , vol.95 , pp. 628
    • Muir, A.1    Peck, A.2    Clare-Salzler, M.3    Song, Y.H.4    Cornelius, J.5    Luchetta, R.6    Krischer, J.7    Maclaren, N.8
  • 35
    • 0028007192 scopus 로고
    • Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
    • Atkinson, M. A., M. A. Bowman, L. Campbell, B. L. Darrow, D. L. Kaufman, and N. K. Maclaren. 1994. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94:2125.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2125
    • Atkinson, M.A.1    Bowman, M.A.2    Campbell, L.3    Darrow, B.L.4    Kaufman, D.L.5    Maclaren, N.K.6
  • 36
    • 0027441931 scopus 로고
    • Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease
    • Deng, H., R. Apple, M. Clare-Salzler, S. Trembleau, D. Mathis, L. Adorini, and E. Sercarz. 1993. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J. Exp. Med. 178:1675.
    • (1993) J. Exp. Med. , vol.178 , pp. 1675
    • Deng, H.1    Apple, R.2    Clare-Salzler, M.3    Trembleau, S.4    Mathis, D.5    Adorini, L.6    Sercarz, E.7
  • 37
    • 0029670540 scopus 로고    scopus 로고
    • Induction of TH1 and TH2 immunity in neonatal mice
    • Forsthuber, T., H. C. Yip, and P. V. Lehmann. 1996. Induction of TH1 and TH2 immunity in neonatal mice. Science 271:1728.
    • (1996) Science , vol.271 , pp. 1728
    • Forsthuber, T.1    Yip, H.C.2    Lehmann, P.V.3
  • 39
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • Daniel, D., and D. R. Wegmann. 1996. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. USA 93:956.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 956
    • Daniel, D.1    Wegmann, D.R.2
  • 41
    • 0034671983 scopus 로고    scopus 로고
    • Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes
    • Trembleau, S., G. Penna, S. Gregori, G. Magistrelli, A. Isacchi, and L. Adorini. 2000. Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes. J. Immunol. 165:6748.
    • (2000) J. Immunol. , vol.165 , pp. 6748
    • Trembleau, S.1    Penna, G.2    Gregori, S.3    Magistrelli, G.4    Isacchi, A.5    Adorini, L.6
  • 45
    • 0032563231 scopus 로고    scopus 로고
    • Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation
    • Kersh, E. N., A. S. Shaw, and P. M. Allen. 1998. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281:572.
    • (1998) Science , vol.281 , pp. 572
    • Kersh, E.N.1    Shaw, A.S.2    Allen, P.M.3
  • 46
    • 0028017808 scopus 로고
    • A differential-avidity model for T-cell selection
    • Ashton-Rickardt, P. G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15:362.
    • (1994) Immunol. Today , vol.15 , pp. 362
    • Ashton-Rickardt, P.G.1    Tonegawa, S.2
  • 47
    • 0031756746 scopus 로고    scopus 로고
    • Shifting T-cell activation thresholds in autoimmunity and determinant spreading
    • Lehmann, P. V., O. S. Targoni, and T. G. Forsthuber. 1998. Shifting T-cell activation thresholds in autoimmunity and determinant spreading, Immunol. Rev. 164:53.
    • (1998) Immunol. Rev. , vol.164 , pp. 53
    • Lehmann, P.V.1    Targoni, O.S.2    Forsthuber, T.G.3
  • 48
    • 0034680105 scopus 로고    scopus 로고
    • Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
    • Amrani, A., J. Verdaguer, P. Serra, S. Tafuro, R. Tan, and P. Santamaria. 2000. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 406:739.
    • (2000) Nature , vol.406 , pp. 739
    • Amrani, A.1    Verdaguer, J.2    Serra, P.3    Tafuro, S.4    Tan, R.5    Santamaria, P.6
  • 50
    • 0031423760 scopus 로고    scopus 로고
    • The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
    • Delovitch, T. L., and B. Singh. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7:727.
    • (1997) Immunity , vol.7 , pp. 727
    • Delovitch, T.L.1    Singh, B.2
  • 51
    • 0035284810 scopus 로고    scopus 로고
    • Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct Vβ genes
    • Quinn, A., B. McInerney, E. P. Reich, O. Kim, K. P. Jensen, and E. E. Sercarz, 2001. Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct Vβ genes. J. Immunol. 166:2982.
    • (2001) J. Immunol. , vol.166 , pp. 2982
    • Quinn, A.1    McInerney, B.2    Reich, E.P.3    Kim, O.4    Jensen, K.P.5    Sercarz, E.E.6
  • 52
    • 0032543998 scopus 로고    scopus 로고
    • Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease
    • Geng, L., M. Solimena, R. A. Flavell, R. S. Sherwin, and A. C. Hayday. 1998. Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease. Proc. Natl. Acad. Sci. USA 95:10055.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10055
    • Geng, L.1    Solimena, M.2    Flavell, R.A.3    Sherwin, R.S.4    Hayday, A.C.5
  • 53
    • 0028026652 scopus 로고
    • Insulin-dependent diabetes mellitus as an autoimmune disease
    • Bach, J. F. 1994. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15:516.
    • (1994) Endocr. Rev. , vol.15 , pp. 516
    • Bach, J.F.1
  • 54
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch, R., and H. McDevitt. 1996. Insulin-dependent diabetes mellitus. Cell 85:291.
    • (1996) Cell , vol.85 , pp. 291
    • Tisch, R.1    McDevitt, H.2
  • 55
    • 0033579875 scopus 로고    scopus 로고
    • Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
    • Hoglund, P., J. Mintern, C. Waltzinger, W. Heath, C. Benoist, and D. Mathis. 1999. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J. Exp. Med. 189:331.
    • (1999) J. Exp. Med. , vol.189 , pp. 331
    • Hoglund, P.1    Mintern, J.2    Waltzinger, C.3    Heath, W.4    Benoist, C.5    Mathis, D.6
  • 56
    • 0035856952 scopus 로고    scopus 로고
    • β-cell death during progression to diabetes
    • Mathis, D., L. Vence, and C. Benoist. 2001. β-Cell death during progression to diabetes. Nature 414:792.
    • (2001) Nature , vol.414 , pp. 792
    • Mathis, D.1    Vence, L.2    Benoist, C.3


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