메뉴 건너뛰기




Volumn 63, Issue 5-6, 1998, Pages 271-277

Metabolism of synthetic corticosteroids by 11β-hydroxysteroid- dehydrogenases in man

Author keywords

11 hydroxysteroid dehydrogenase; 9 fluorocortisol; Dexamethasone; Glucocorticoid targeting; Isoenzymes; Kinetics

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; DEXAMETHASONE; FLUDROCORTISONE; GLUCOCORTICOID; ISOENZYME;

EID: 0032076302     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(98)00039-7     Document Type: Conference Paper
Times cited : (46)

References (32)
  • 1
    • 0000445323 scopus 로고
    • Chemical and biologic factors in the activity of adrenocortical steroids
    • 1. Bush IE (1962). Chemical and biologic factors in the activity of adrenocortical steroids. Pharmacol Rev 14:317-445.
    • (1962) Pharmacol Rev , vol.14 , pp. 317-445
    • Bush, I.E.1
  • 2
    • 0028273784 scopus 로고
    • Pharmacology of 11 beta-hydroxysteroid dehydrogenase
    • 2. Frey FJ, Escher G, Frey BM (1994). Pharmacology of 11 beta-hydroxysteroid dehydrogenase. Steroids 59:74-79.
    • (1994) Steroids , vol.59 , pp. 74-79
    • Frey, F.J.1    Escher, G.2    Frey, B.M.3
  • 3
    • 0016708110 scopus 로고
    • A radioreceptor assay for evaluation of the plasma glucocorticoid activity of natural and synthetic steroids in man
    • 3. Ballard PL, Carter JP, Graham BS, Baxter JD (1975). A radioreceptor assay for evaluation of the plasma glucocorticoid activity of natural and synthetic steroids in man. J Clin Endocrinol Metab 41:290-304.
    • (1975) J Clin Endocrinol Metab , vol.41 , pp. 290-304
    • Ballard, P.L.1    Carter, J.P.2    Graham, B.S.3    Baxter, J.D.4
  • 4
    • 0024354933 scopus 로고
    • How can aldosterone act as a mineralocorticoid?
    • 4. Funder JW (1989). How can aldosterone act as a mineralocorticoid? Endocr Res 15:227-238.
    • (1989) Endocr Res , vol.15 , pp. 227-238
    • Funder, J.W.1
  • 6
    • 0023631854 scopus 로고
    • Immunohistological observations in rat kidney allo-grafts after local steroid administration
    • 6. Ruers TJ, Buurman WA, van Boxtel CJ, van der Linden CJ, Kootstra G (1987). Immunohistological observations in rat kidney allo-grafts after local steroid administration. J Exp Med 166:1205-1220.
    • (1987) J Exp Med , vol.166 , pp. 1205-1220
    • Ruers, T.J.1    Buurman, W.A.2    Van Boxtel, C.J.3    Van Der Linden, C.J.4    Kootstra, G.5
  • 8
    • 0023743171 scopus 로고
    • Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated
    • 8. Funder JW, Pearce PT, Smith R, Smith AI (1988). Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science (Washington DC) 242:583-585.
    • (1988) Science (Washington DC) , vol.242 , pp. 583-585
    • Funder, J.W.1    Pearce, P.T.2    Smith, R.3    Smith, A.I.4
  • 9
    • 0026095840 scopus 로고
    • The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization
    • 9. Tannin GM, Agarwal AK, Monder C, New MI, White PC (1991). The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem 266:16653-16658.
    • (1991) J Biol Chem , vol.266 , pp. 16653-16658
    • Tannin, G.M.1    Agarwal, A.K.2    Monder, C.3    New, M.I.4    White, P.C.5
  • 10
    • 0028034209 scopus 로고
    • Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme
    • 10. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS (1994). Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105:R11-R17.
    • (1994) Mol Cell Endocrinol , vol.105
    • Albiston, A.L.1    Obeyesekere, V.R.2    Smith, R.E.3    Krozowski, Z.S.4
  • 11
    • 0027374874 scopus 로고
    • 11 Beta-hydroxysteroid dehydrogenase isoforms and their implications for blood pressure regulation
    • 11. Seckl JR (1993). 11 beta-hydroxysteroid dehydrogenase isoforms and their implications for blood pressure regulation. Eur J Clin Invest 23:589-601.
    • (1993) Eur J Clin Invest , vol.23 , pp. 589-601
    • Seckl, J.R.1
  • 12
    • 0028172907 scopus 로고
    • Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells
    • 12. Low SC, Chapman KE, Edwards CR, Seckl JR (1994). 'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells. J Mol Endocrinol 13:167-174.
    • (1994) J Mol Endocrinol , vol.13 , pp. 167-174
    • Low, S.C.1    Chapman, K.E.2    Edwards, C.R.3    Seckl, J.R.4
  • 13
    • 0028973283 scopus 로고
    • 11β-hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: Effect of physiochemical and hormonal manipulations
    • 13. Jamieson PM, Chapman KE, Edwards CRW, Seckl JR (1995). 11β-hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: Effect of physiochemical and hormonal manipulations. Endocrinology 136:4754-4761.
    • (1995) Endocrinology , vol.136 , pp. 4754-4761
    • Jamieson, P.M.1    Chapman, K.E.2    Edwards, C.R.W.3    Seckl, J.R.4
  • 14
    • 0028169395 scopus 로고
    • Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform
    • 14. Stewart PM, Murry BA, Mason JI (1994). Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform. J Clin Endocrinol Metab 79:480-484.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 480-484
    • Stewart, P.M.1    Murry, B.A.2    Mason, J.I.3
  • 15
    • 0022372136 scopus 로고
    • Determination of urinary free cortisol by "on-line" liquid chromatography
    • 15. Schöneshöfer M, Kage A, Weber B, Lenz I, Kottgen E (1985). Determination of urinary free cortisol by "on-line" liquid chromatography. Clin Chem 31:564-568.
    • (1985) Clin Chem , vol.31 , pp. 564-568
    • Schöneshöfer, M.1    Kage, A.2    Weber, B.3    Lenz, I.4    Kottgen, E.5
  • 16
    • 84995839597 scopus 로고
    • Impaired renal 11-beta-oxidation of 9 alpha-fluorocortisol: An explanation for its mineralocorticoid potency
    • 16. Oelkers W, Buchen S, Diederich S, Krain J, Muhme S, Schöneshöfer M (1994). Impaired renal 11-beta-oxidation of 9 alpha-fluorocortisol: An explanation for its mineralocorticoid potency. J Clin Endocrinol Metab 78:928-932.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 928-932
    • Oelkers, W.1    Buchen, S.2    Diederich, S.3    Krain, J.4    Muhme, S.5    Schöneshöfer, M.6
  • 17
    • 0031008086 scopus 로고    scopus 로고
    • Metabolism of dexamethasone in the human kidney: Nicotinamide adenine dinucleotide-dependent 11β-reduction
    • 17. Diederich S, Hanke B, Oelkers W, Bähr V (1997). Metabolism of dexamethasone in the human kidney: Nicotinamide adenine dinucleotide-dependent 11β-reduction. J Clin Endocrinol Metab 82:1598-1602.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1598-1602
    • Diederich, S.1    Hanke, B.2    Oelkers, W.3    Bähr, V.4
  • 18
    • 0001490456 scopus 로고
    • Applications of chromatographic and spectometric techniques to the study of dexamethasone related compounds
    • 18. Gaignage P, Lognay G, Marlier M, Severin M, Dreze P (1989). Applications of chromatographic and spectometric techniques to the study of dexamethasone related compounds. Chromatographia 28: 623-630.
    • (1989) Chromatographia , vol.28 , pp. 623-630
    • Gaignage, P.1    Lognay, G.2    Marlier, M.3    Severin, M.4    Dreze, P.5
  • 20
    • 0010418994 scopus 로고
    • A comparison of seven methods for fitting the Michaelis-Menten equation
    • 20. Atkins GL, Nimmo IA, Newman PF (1974). A comparison of seven methods for fitting the Michaelis-Menten equation. Biochem J 143: 779-781.
    • (1974) Biochem J , vol.143 , pp. 779-781
    • Atkins, G.L.1    Nimmo, I.A.2    Newman, P.F.3
  • 21
    • 0028342648 scopus 로고
    • Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
    • 21. Houston JB (1994). Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem Pharmacol 47: 1469-1479.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1469-1479
    • Houston, J.B.1
  • 22
    • 0026740705 scopus 로고
    • Diagnosis and therapy surveillance in Addison's disease: Rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone
    • 22. Oelkers W, Diederich S, Bähr V (1992). Diagnosis and therapy surveillance in Addison's disease: Rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone. J Clin Endocrinol Metab 75:259-264.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 259-264
    • Oelkers, W.1    Diederich, S.2    Bähr, V.3
  • 23
    • 2542624590 scopus 로고
    • Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity
    • 23. Krozowski ZS, Funder JW (1983). Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity. Proc Natl Acad Sci USA 80:6056-6060.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 6056-6060
    • Krozowski, Z.S.1    Funder, J.W.2
  • 24
    • 0010783229 scopus 로고
    • Synthetic derivates of cortical hormones
    • 24. Fried J, Borman A (1958). Synthetic derivates of cortical hormones. Vitam Horm 16:303-374.
    • (1958) Vitam Horm , vol.16 , pp. 303-374
    • Fried, J.1    Borman, A.2
  • 25
    • 0029999371 scopus 로고    scopus 로고
    • Substrate and inhibitor specificity of the cloned human 11β-hydroxysteroid dehydrogenase type 2 isoform
    • 25. Ferrari P, Smith RE, Funder JW, Krozowski ZS (1996). Substrate and inhibitor specificity of the cloned human 11β-hydroxysteroid dehydrogenase type 2 isoform. Am J Physiol Endocrinol Metab 270:E900-E904.
    • (1996) Am J Physiol Endocrinol Metab , vol.270
    • Ferrari, P.1    Smith, R.E.2    Funder, J.W.3    Krozowski, Z.S.4
  • 26
    • 0030903739 scopus 로고    scopus 로고
    • Dexamethasone and 11-dehydrodexamethasone as tools to investigate the isozymes of 11β-hydroxysteroid dehydrogenase in vitro and in vivo
    • 26. Best R, Nelson SM, Walker BR (1997). Dexamethasone and 11-dehydrodexamethasone as tools to investigate the isozymes of 11β-hydroxysteroid dehydrogenase in vitro and in vivo. J Endocrinol 153:41-48.
    • (1997) J Endocrinol , vol.153 , pp. 41-48
    • Best, R.1    Nelson, S.M.2    Walker, B.R.3
  • 27
    • 0027740168 scopus 로고
    • Cortisol metabolism by human liver in vitro-IV. Metabolism of 9 alpha-fluorocortisol by human liver microsomes and cytosol
    • 27. Abel SM, Back DJ, Maggs JL, Park BK (1993). Cortisol metabolism by human liver in vitro-IV. Metabolism of 9 alpha-fluorocortisol by human liver microsomes and cytosol. J Steroid Biochem Mol Biol 46:833-839.
    • (1993) J Steroid Biochem Mol Biol , vol.46 , pp. 833-839
    • Abel, S.M.1    Back, D.J.2    Maggs, J.L.3    Park, B.K.4
  • 28
    • 0027175669 scopus 로고
    • Transactivation and synergistic properties of the mineralocorticoid receptor: Relationship to the glucocorticoid receptor
    • 28. Rupprecht R, Arriza JL, Spengler D, Reul JM, Evans RM, Holsboer F, Damm K (1993). Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor. Mol Endocrinol 7:597-603.
    • (1993) Mol Endocrinol , vol.7 , pp. 597-603
    • Rupprecht, R.1    Arriza, J.L.2    Spengler, D.3    Reul, J.M.4    Evans, R.M.5    Holsboer, F.6    Damm, K.7
  • 29
    • 0019991754 scopus 로고
    • Binding of steroids to mineralocorticoid receptors: Implications for in vivo occupancy by glucocorticoids
    • 29. Lan NC, Graham B, Bartter FC, Baxter JD (1982). Binding of steroids to mineralocorticoid receptors: implications for in vivo occupancy by glucocorticoids. J Clin Endocrinol Metab 54:332-342.
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 332-342
    • Lan, N.C.1    Graham, B.2    Bartter, F.C.3    Baxter, J.D.4
  • 31
    • 0030920285 scopus 로고    scopus 로고
    • Oxoreductase and dehydrogenase activities of the human and rat 11β-hydroxysteroid dehydrogenase type 2 enzyme
    • 31. Li KXZ, Obeyesekere VR, Krozowski ZS, Ferrari P (1997). Oxoreductase and dehydrogenase activities of the human and rat 11β-hydroxysteroid dehydrogenase type 2 enzyme. Endocrinology 138: 2948-2952.
    • (1997) Endocrinology , vol.138 , pp. 2948-2952
    • Li, K.X.Z.1    Obeyesekere, V.R.2    Krozowski, Z.S.3    Ferrari, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.