-
1
-
-
0024518123
-
The 21-aminosteroids: Potent inhibitors of lipid peroxidation for the treatment of central nervous system trauma and ischemia
-
Braughler JM, Hall ED, Jacobsen J, McCall JM, Means ED: The 21-aminosteroids: potent inhibitors of lipid peroxidation for the treatment of central nervous system trauma and ischemia. Drugs Future 1989;14:143-152.
-
(1989)
Drugs Future
, vol.14
, pp. 143-152
-
-
Braughler, J.M.1
Hall, E.D.2
Jacobsen, J.3
McCall, J.M.4
Means, E.D.5
-
2
-
-
13344261979
-
A randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: A cooperative study in Europe/Australia/New Zealand
-
Kassell NF, Haley EC, Apperson-Hansen C, Alves WM, and the participants: A randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe/Australia/New Zealand. J Neurosurg 1996;84:221-228.
-
(1996)
J Neurosurg
, vol.84
, pp. 221-228
-
-
Kassell, N.F.1
Haley, E.C.2
Apperson-Hansen, C.3
Alves, W.M.4
-
3
-
-
0002864876
-
Phase two trial of tirilazad in aneurysmal subarachnoid hemorrhage
-
Kassell NF, Haley EC, Alves WM, Hansen CA, Weir B, and participants: Phase two trial of tirilazad in aneurysmal subarachnoid hemorrhage (abstract). Can J Neurol Sci 1993;20(Suppl 1):S29.
-
(1993)
Can J Neurol Sci
, vol.20
, Issue.1 SUPPL.
-
-
Kassell, N.F.1
Haley, E.C.2
Alves, W.M.3
Hansen, C.A.4
Weir, B.5
-
4
-
-
0345159165
-
Phase II. Tirilazad mesylate is safe in patients with moderate or severe head trauma
-
Bleck TP, Germanson TP, Jane JA, and the Participants in the Tirilazad Head Trauma Trial: Phase II. Tirilazad mesylate is safe in patients with moderate or severe head trauma (abstract). Neurology 1995;45(Suppl 4):A345.
-
(1995)
Neurology
, vol.45
, Issue.4 SUPPL.
-
-
Bleck, T.P.1
Germanson, T.P.2
Jane, J.A.3
-
5
-
-
0028036213
-
Safety study of tirilazad mesylate in patients with acute ischemic stroke
-
Haley EC, for the STIPAS Investigators: Safety study of tirilazad mesylate in patients with acute ischemic stroke. Stroke 1994;25: 418-423.
-
(1994)
Stroke
, vol.25
, pp. 418-423
-
-
Haley, E.C.1
-
6
-
-
0027419603
-
Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger. I. Single-dose administration
-
Fleishaker JC, Peters GR, Cathcart KS: Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger. I. Single-dose administration. J Clin Pharmacol 1993;33:175-181.
-
(1993)
J Clin Pharmacol
, vol.33
, pp. 175-181
-
-
Fleishaker, J.C.1
Peters, G.R.2
Cathcart, K.S.3
-
7
-
-
0013486541
-
Single dose proportionality of tirilazad mesylate pharmacokinetics in healthy male volunteers
-
Hulst LK, Fleishaker JC, Peters GR: Single dose proportionality of tirilazad mesylate pharmacokinetics in healthy male volunteers [abstract]. Pharm Res 1993;10(Suppl):S-334.
-
(1993)
Pharm Res
, vol.10
, Issue.SUPPL.
-
-
Hulst, L.K.1
Fleishaker, J.C.2
Peters, G.R.3
-
8
-
-
0030058338
-
Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury
-
Smith SL, Scherch HM, Hall ED: Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury. J Neurosurg 1996;84:229-233.
-
(1996)
J Neurosurg
, vol.84
, pp. 229-233
-
-
Smith, S.L.1
Scherch, H.M.2
Hall, E.D.3
-
9
-
-
0028274007
-
Multiple dose tolerability and pharmacokinetics of tirilazad mesylate at doses of up to 10 mg/kg/day administered over 5-10 days in healthy volunteers
-
Fleishaker JC, Hulst LK, Peters GR: Multiple dose tolerability and pharmacokinetics of tirilazad mesylate at doses of up to 10 mg/kg/day administered over 5-10 days in healthy volunteers. Int J Clin Pharmacol Ther 1994;32:223-230.
-
(1994)
Int J Clin Pharmacol Ther
, vol.32
, pp. 223-230
-
-
Fleishaker, J.C.1
Hulst, L.K.2
Peters, G.R.3
-
10
-
-
0030431440
-
Biotransformation of tirilazad in humans. I. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes
-
Wienkers LC, Steenwyk RC, Sanders PE, Pearson PG: Biotransformation of tirilazad in humans. I. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. J Pharmacol Exp Ther 1996;277:982-990.
-
(1996)
J Pharmacol Exp Ther
, vol.277
, pp. 982-990
-
-
Wienkers, L.C.1
Steenwyk, R.C.2
Sanders, P.E.3
Pearson, P.G.4
-
11
-
-
0028075944
-
The effect of phenytoin on the pharmacokinetics of tirilazad mesylate in healthy male volunteers
-
Fleishaker JC, Hulst-Pearson LK, Peters GR: The effect of phenytoin on the pharmacokinetics of tirilazad mesylate in healthy male volunteers. Clin Pharmacol Ther 1994;56:389-397.
-
(1994)
Clin Pharmacol Ther
, vol.56
, pp. 389-397
-
-
Fleishaker, J.C.1
Hulst-Pearson, L.K.2
Peters, G.R.3
-
12
-
-
0029878029
-
Gender does not affect the degree of induction of tirilazad clearance by phenobarbital
-
Fleishaker JC, Pearson LK, Peters GR: Gender does not affect the degree of induction of tirilazad clearance by phenobarbital. Eur J Clin Pharmacol 1996;50:139-145.
-
(1996)
Eur J Clin Pharmacol
, vol.50
, pp. 139-145
-
-
Fleishaker, J.C.1
Pearson, L.K.2
Peters, G.R.3
-
13
-
-
0030430049
-
Biotransformation of tirilazad in humans. II. Effect of ketoconazole on tirilazad clearance and oral bioavailability
-
Fleishaker JC, Pearson PG, Wienkers LC, Pearson LK, Peters GR: Biotransformation of tirilazad in humans. II. Effect of ketoconazole on tirilazad clearance and oral bioavailability. J Pharmacol Exp Ther 1996;277:991-998.
-
(1996)
J Pharmacol Exp Ther
, vol.277
, pp. 991-998
-
-
Fleishaker, J.C.1
Pearson, P.G.2
Wienkers, L.C.3
Pearson, L.K.4
Peters, G.R.5
-
14
-
-
0000685983
-
Effect of gender and menopausal status on the pharmacokinetics of tirilazad mesylate in healthy subjects
-
Fleishaker JC, Hulst-Pearson LK, Peters GR: Effect of gender and menopausal status on the pharmacokinetics of tirilazad mesylate in healthy subjects. Am J Ther 1995;2:553-560.
-
(1995)
Am J Ther
, vol.2
, pp. 553-560
-
-
Fleishaker, J.C.1
Hulst-Pearson, L.K.2
Peters, G.R.3
-
15
-
-
0028356191
-
Effect of age and gender on tirilazad pharmacokinetics in humans
-
Hulst LK, Fleishaker JC, Peters GR, Harry, JD, Wright DM, Ward P: Effect of age and gender on tirilazad pharmacokinetics in humans. Clin Pharmacol Ther 1994;55:378-384.
-
(1994)
Clin Pharmacol Ther
, vol.55
, pp. 378-384
-
-
Hulst, L.K.1
Fleishaker, J.C.2
Peters, G.R.3
Harry, J.D.4
Wright, D.M.5
Ward, P.6
-
16
-
-
0026452126
-
A unified form for neurological scoring of hemispheric stroke with motor impairment
-
Orgogozo JM, Asplund K, Boysen G: A unified form for neurological scoring of hemispheric stroke with motor impairment. Stroke 1992;23:1678-1679.
-
(1992)
Stroke
, vol.23
, pp. 1678-1679
-
-
Orgogozo, J.M.1
Asplund, K.2
Boysen, G.3
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