HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation

Cell Death and Differentiation

Volumn 9, Issue 11, 2002, Pages 1172-1184

  Nie, Z ^a,b   Phenix, B N ^a,b   Lum, J J ^a,b   Alam, A ^c   Lynch, D H ^d   Beckett, B ^b   Krammer, P H ^e   Sekaly, R P ^c   Badley, A D ^a,b,f  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^d AMGEN INC   (United States)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^f MAYO CLINIC   (United States)

Author keywords

Apoptosis; Caspase 8; Cytochrome c; HIV; HIV 1 protease; Mitochondrial; Pemeability transition pore complex

Indexed keywords

CASP3 PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; ENZYME PRECURSOR; PROTEINASE; CELL EXTRACT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 8; PROTEIN BID; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; ENZYMOLOGY; HELA CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKEMIA CELL LINE; METABOLISM; MITOCHONDRION; PHYSIOLOGY; CELL KILLING; CELL NUCLEUS; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME SPECIFICITY; FRAGMENTATION REACTION; GENETIC CODE; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; T LYMPHOCYTE;

APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYTOCHROME C GROUP; DNA FRAGMENTATION; ENZYME PRECURSORS; HELA CELLS; HIV PROTEASE; HIV-1; HUMANS; JURKAT CELLS; MITOCHONDRIA;

EID: 0036848194     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401094     Document Type: Article

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