Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells

Journal of Virology

Volumn 72, Issue 6, 1998, Pages 4686-4693

  Yao, Xiao Jian ^a   Mouland, Andrew J ^a   Subbramanian, Ramu A ^a   Forget, Janique ^a   Rougeau, Nicole ^a   Bergeron, Dominique ^a   Cohen, Eric A ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA CONTENT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LIFESPAN; PRIORITY JOURNAL; VIRUS EXPRESSION; VIRUS REPLICATION;

EID: 0031950195     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.6.4686-4693.1998     Document Type: Article

References (41)

1. Agostini, I., J. M. Navarro, F. Rey, M. Bouhamdan, B. Spire, R. Vigne, and J. Sire. 1996. The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. J. Mol. Biol. 261:599-606.
2. Ayyavoo, V., A. Mahboubi, S. Mahalingam, R. Ramalingam, S. Kudchodkar, W. V. Williams, D. R. Green, and D. B. Weiner. 1997. HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor κB. Nat. Med. 3:1117-1123.
3. Balliet, J. W., D. L. Kolson, G. Eiger, F. M. Kim, K. A. McGann, A. Srinivasan, and R. Collman. 1994. Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate. Virology 200:623-631.
4. Bartz, S. R., M. E. Rogel, and M. Emerman. 1996. Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control. J. Virol. 70:2324-2331.
5. + T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI. J. Virol. 71:4436-4444.
6. Cohen, E. A., G. Dehni, J. G. Sodroski, and W. A. Haseltine. 1990. Human immunodeficiency virus vpr product is a virion-associated regulatory protein. J. Virol. 64:3097-3099.
7. Cohen, E. A., E. F. Terwilliger, Y. Jalinoos, J. Proulx, J. G. Sodroski, and W. A. Haseltine. 1990. Identification of HIV-1 Vpr product and function. J. Acquired Immune Defic. Syndr. 1:11-18.
8. Connor, R. I., B. K. Chen, S. Choe, and N. R. Landau. 1995. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 206:935-944.
9. Di Marzio, P., S. Choe, M. Ebright, R. Knoblauch, and N. R. Landau. 1995. Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. J. Virol. 69:7909-7916.
10. Echaniz, P., M. D. de Juan, and E. Cuadrado. 1995. DNA staining changes associated with apoptosis and necrosis in blood lymphocytes of individuals with HIV infection. Cytometry 19:164-170.
11. Emermnan, M. 1996. HIV-1, Vpr and the cell cycle. Curr. Biol. 6:1096-1103. (Review.)
12. Glynn, J. M., D. L. McElligott, and D. E. Mosier. 1996. Apoptosis induced by HIV infection in H9 T cells is blocked by ICE-family protease inhibition but not by a Fas (CD95) antagonist. J. Immunol. 157:2754-2758.
13. Goh, W. C., M. E. Rogel, C. M. Kinsey, S. F. Michael, P. N. Fultz, M. A. Nowak, B. H. Hahn, and M. Emermnan. 1998. HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat. Med. 4:65-71.
14. Hattori, N., F. Michaels, K. Fargnoli, L. Marcon, R. C. Gallo, and G. Franchini. 1990. The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages. Proc. Natl. Acad. Sci. USA 87:8080-8084.
15. cdc2 activity. J. Virol. 69:6705-6711.
16. He, J.-L., C. M. deCastro, G. R. Vandenbark, J. Busciglio, and D. Gabuzda. 1997. Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene. Proc. Natl. Acad. Sci. USA 94:3954-3959.
17. Heinzinger, N. K., M. I. Bukrinsky, S. A. Haggerty, A. M. Ragland, V. Kewalramani, M.-A. Lee, H. E. Gendelman, L. Ratner, M. Stevenson, and M. Emerman. 1994. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc. Natl. Acad. Sci. USA 91:7311-7315.
18. Ho, D. D., A. U. Neuman, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Science 373:123-126.
19. 2 + M phase of the cell cycle. J. Virol. 69:6304-6313.
20. Kimpton, J., and M. Emerman. 1992. Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β-galactosidase gene. J. Virol. 66: 2232-2239.
21. Kolesnitchenko, V., L. M. Wahl, H. Tian, I. Sunila, Y. Tani, D.-P. Hartmann, J. Cossman, M. Raffeld, J. Orenstein, L. E. Samelson, and D. I. Cohen. 1995. Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death. Proc. Natl. Acad. Sci. USA 92:11889-11893.
22. gag domain of human immunodeficiency type 1 is sufficient for the incorporation of Vpr into heterologous viral particles. J. Virol. 69:2759-2764.
23. Kornbluth, R. S. 1994. Significance of T cell apoptosis for macrophages in HIV infection. J. Leukocyte Biol. 56:247-256.
24. gag precursor for incorporation of the Vpr product into human immunodeficiency type 1 viral particles. J. Virol. 68: 1926-1934.
25. Maio, J. J., G. J. Graham, and F. L. Brown. 1995. Induction of G2 arrest and gene expression by 2-aminopurine in human U937 promonocyte-macrophage cells. Exp. Cell Res. 219:442-448.
26. Martin, J. S., C. P. M. Reutelingsperger, A. J. McGahon, J. A. Rader, R. C. A. A. van Schie, D. M. LaFace, and D. R. Green. 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of BcL-2 and Ab1. J. Exp. Med. 182:1545-1556.
27. Miele, G., A. J. Mouland, G. P. Harrison, E. A. Cohen, and A. M. L. Lever. 1996. The human immunodeficiency virus type 1 5′ packaging signal structure affects translation but does not function as an internal ribosome entry site. J. Virol. 70:944-951.
28. Mouland, A. J., and G. N. Hendy. 1991. Regulation of synthesis and secretion of chromogranin A by calcium and 1,25-dihydroxycholecalciferol in cultured bovine parathyroid cells. Endocrinology 128:441-449.
29. Ogawa, K., R. Shibata, T. Kiyomasu, I. Higuchi, Y. Kishida, A. Ishimoto, and A. Adachi. 1989. Mutational analysis of the human immunodeficiency virus vpr open reading frame. J. Virol. 63:4110-4114.
30. Paxton, W., R. I. Connor, and N. R. Landau. 1993. Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of Gag and mutational analysis. J. Virol. 67:7229-7237.
31. cdc2-cyclin B. J. Virol. 69:6859-6864.
32. Rogel, M. E., L. I. Wu, and M. Emerman. 1995. The human immunodeficiency virus type 1 Vpr gene prevents cell proliferation during chronic infection. J. Virol. 69:882-888.
33. Stewart, S. A., B. Poon, J. B. M. Jowett, and I. S. Chen. 1997. Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest. J. Virol. 71:5579-5592.
34. Stivahtis, G. L., M. A. Soares, M. A. Vodicka, B. H. Hahn, and M. Emerman. 1997. Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology. J. Virol. 71:4331-4338.
35. Subbramanian, R. A., and E. A. Cohen. 1994. Molecular biology of the human immunodeficiency virus accessory proteins. J. Virol. 68:6831-6835.
36. Subbramanian, R. A., X.-J. Yao, H. Dilhuydy, N. Rougeau, D. Bergeron, Y. Robitaille, and E. A. Cohen. Human immunodeficiency virus type 1 Vpr localization: nuclear transport of a viral protein modulated by a putative amphipathic helical structure and its relevance to biological activity. J. Mol. Biol., in press.
37. Wang, L., S. Mukherjee, F. Jia, O. Narayan, and L. J. Zhao. 1995. Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat. J. Biol. Chem. 270:25564-25569.
38. Wei, X., S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A Emini, P. Deutsch, J. D. Lifson, S. Bohoeffer, M. A. Norwak, B. H. Hahn, M. S. Saag, and G. M. Shaw. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117-122.
39. Westendorp, M. O., V. A. Shatrov, K. Schulze-Osthoff, R. Frank, M. Kraft, M. Los, P. H. Krammer, W. Dröge, and V. Lehmann. 1995. HIV-1 Tat potentiates TNF-induced NF-κB activation and cytotoxicity by altering the cellular redox state. EMBO J. 14:546-554.
40. Yao, X.-J., H. Göttlinger, W. A. Haseltine, and E. A. Cohen. 1992. Envelope glycoprotein and CD4 independence of Vpu-facilitated human immunodeficiency virus type 1 capsid export. J. Virol. 66:5119-5126.
41. Yao, X.-J., R. A. Subbramanian, N. Rougeau, F. Boisvert, D. Bergeron, and E. A. Cohen. 1995. Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation. J. Virol. 69:7032-7044.