Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression

Developmental Dynamics

Volumn 225, Issue 3, 2002, Pages 305-315

  Ren, Shu Yue ^a   Angrand, Pierre Olivier ^a   Rijli, Filippo M ^a  

^a l'alimentation et l'Environnement   (France)

Author keywords

Alternative splicing; Cre recombinase; Flp recombinase; Gain of function; Hindbrain; Hoxa1; Hoxa2; Knockout; LoxP; neo; PGK promoter; Targeted insertion; Transcriptional regulation

Indexed keywords

CRE RECOMBINASE; DNA POLYMERASE; HOMEOBOX A1 PROTEIN; HOMEODOMAIN PROTEIN; HOXA2 PROTEIN, MOUSE; HOXA3 PROTEIN, MOUSE; INTEGRASE; NEOMYCIN; PHOSPHOGLYCEROL KINASE; PHOSPHOTRANSFERASE; RECOMBINASE; TRANSCRIPTION FACTOR; VIRUS PROTEIN; PROTEIN; PROTEIN FLP; PROTEIN HOXA2; PROTEIN PGK; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; C57BL MOUSE; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; HOMOZYGOTE; LETHAL GENE; MOUSE; MOUSE MUTANT; PHENOTYPE; PHYSIOLOGY; PRENATAL DEVELOPMENT; RHOMBENCEPHALON; RNA SPLICING; TRANSACTIVATION; 3' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANIMAL CELL; BRANCHIAL ARCH; EMBRYO; EMBRYO PATTERN FORMATION; GENE CASSETTE; GENE EXPRESSION; GENE INSERTION; GENE LOCUS; GENETIC ANALYSIS; KNOCKOUT GENE; MARKER GENE; MOLECULAR MECHANICS; NEUROMERE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA HYBRIDIZATION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

ANIMALS; DNA NUCLEOTIDYLTRANSFERASES; DOWN-REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, LETHAL; HOMEODOMAIN PROTEINS; HOMOZYGOTE; INTEGRASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTAGENESIS, INSERTIONAL; NEOMYCIN; PHENOTYPE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RHOMBENCEPHALON; RNA SPLICING; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; VIRAL PROTEINS;

INSERTION SEQUENCES;

EID: 0036841877     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.10171     Document Type: Article

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