Retinoic acid rescues inner ear defects in Hoxa1 deficient mice

Nature Genetics

Volumn 29, Issue 1, 2001, Pages 34-39

  Pasqualetti, Massimo ^a   Neun, Rüdiger ^a,b   Davenne, Marc ^a,c   Rijli, Filippo M ^a  

^a l'alimentation et l'Environnement   (France)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN HOXA1; RETINOIC ACID; RETINOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCHLEA; CONTROLLED STUDY; EMBRYO; FEMALE; FETUS; FETUS DEVELOPMENT; GENE FUNCTION; GENE MUTATION; INNER EAR; INNER EAR MALFORMATION; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; TERATOGENICITY; VESTIBULAR LABYRINTH;

ANIMALIA; MAMMALIA;

EID: 0034863766     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng702     Document Type: Article

References (49)

1. Two rhombomeres are altered in Hoxa-1 mutant mice
2. Patterning of the mammalian cochlea
3. The development of the vertebrate inner ear
4. Neural inductive message to the developing mammalian inner ear: Contact mediated versus extracelular marix interaction
5. An analysis of induction of the ear from foreign ectoderm in the salamander embryo
6. The kreisler mouse: A hindbrain segmentation mutant that lacks two rhombomeres
7. Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr)
8. The role of FGF-3 in early inner ear development: An analysis in normal and kreisler mutant mice
9. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
10. Competence, specification and commitment in otic placode induction
11. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain
12. Development of the vertebrate ear: Insights from knockouts and mutants
13. In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′ RARE)
14. Retinoids and Hox genes
15. Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse
16. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
17. Genetic interactions between Hoxa 1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
18. The differential sensitivities of inner ear structures to retinoic acid during development
19. Retinoic acidinduced embryopathy of the mouse inner ear
20. Retinoids in embryonal development
21. Teratology of retinoids
22. Teratogens and craniofacial malformations: Relationships to cell death
23. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid
24. Effects of retinoic acid excess on expression of Hox-2,9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos
25. Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo
26. Retinoic acid induces stage-specific antero-posterior transformation of rostral central nervous system
27. Teratogenicity of low doses of all-trans retinoic acid in presomite mouse embryos
28. Development of the mouse inner ear and origin of its sensory organs
29. Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear
30. The Notch ligand Jagged1 is required for inner ear sensory development
31. Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein
32. Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals
33. Pax2 contributes to inner ear patterning and optic nerve trajectory
34. Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
35. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor
36. Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse
37. Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch
38. Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain
39. Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role?
40. Induction of inner ear fate by FGF3
41. Identification of synergistic signals initiating inner ear development
42. FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
43. Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
44. Retinoic acid-regulated expression of fibroblast growth factor 3 requires the interaction between a novel transcription factor and GATA-4
45. A fate map of chick otic cup closure reveals lineage boundaries in the dorsal otocyst
46. Hindbrain respecification in the retinoid-deficient quail
47. Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm
48. A sustained elevation in retinoic acid receptor-beta 2 mRNA and protein occurs during retinoic acid-induced fetal dysmorphogenesis
49. Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus