PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development

Development

Volumn 124, Issue 22, 1997, Pages 4493-4503

  Burrill, John D ^a   Moran, Laura ^a,b   Goulding, Martyn D ^a   Saueressig, Harald ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell fate; Chick; EN1; Interneuron; PAX2; PAX6; Spinal cord

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; EMBRYO; INTERNEURON; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD;

ANIMALS; CHICK EMBRYO; DNA-BINDING PROTEINS; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; INTERNEURONS; MITOSIS; MUSCLE PROTEINS; NERVE TISSUE PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PAX2 TRANSCRIPTION FACTOR; PAX7 TRANSCRIPTION FACTOR; REPRESSOR PROTEINS; SPINAL CORD; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0030690322     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Bang, A. G. and Goulding, M. D. (1996). Regulation of vertebrate neural cell fate by transcription factors. Curr. Opin. Neurobiol. 6, 25-32.
2. Bastian, H. and Gruss, P. (1990). A murine even-skipped homologue. EVXl is expressed during early embryogenesis and neurogenesis in a biphasic manner. KMBO J. 9, 1839-1852.
3. Braisted, J. E. and Raymond, P. A. (1992). Regeneration of doparninergic neurons in goldfish retina. Development 114, 913-919.
4. Brown, A. G. (1981). Organization of the Spinal Cord: the Anatomy and Physiology of Identified Neurones. Berlin: Springer-Verlag.
5. Chiang, C., Litingtung, Y., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A. (1996) Cyclopedia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 383, 407-413.
6. Condron, B. G., Patel, N. H. and Zinn, K (1994) Engrailed controls glial/neuronal cell laic decisions at the midlineof the central nervous system. Neuron 13, 541-554.
7. Davis, C. A., Holmyard, D. P., Millen, K. J. and Joyner, A. L. (1991). Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum. Development 111, 287-98.
8. Davis, J. A. and Reed, R. R. (1996). Role of Olf-l and Pax-6 transcription factors in neurodcvelopmcm. J. Neurvsci. 16, 5082-94.
9. Dickinson, M. K., Selleck, M. A., McMahon, A. P. and Bronner-Fraser, M. (1995). Dorsalization of the neural tube by non-neural ectoderm. Development 121, 2099-2106.
10. Doe, C. Q. and Skeath, J. B. (1996). Neurogenesis in the insect central nervous system. Curr. Opin. Neurobiol. 6, 18-24.
11. Doe, C. Q., Smousc, D. and Goodman, C. S. (1988). Control of neuronal cell fate by the Drosophila segmentation gene even-skipped. Nature 333, 376-378.
12. Dressier, G. R. and bouglass, E. C. (1992). Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor, Proc. Natl. Acad. Sci. USA 89, 1179-83.
13. Dush, M. K. and Martin, G. R. (1992). Analysis of mouse Evx genes: Evxl displays graded expression in the primalive streak. Dev. Biol. 151, 273-287.
14. Ericson, J., Morton, S., Kawakami, A., Roelink, H. and Jessell. T. M. (1996). Two critical periods of Sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.
15. Ericson, J., Rashbass, P., Schedl, A., Brenner-Morion, S., Kawakami, A., van Heyningen, V., Jessell, T. M. and Briscoe, J. (1997). Paxfi controls progenitor cell identity and neuronal cell fate in response to graded Shh signaling. Cell 90, 169-180.
16. Ericson, J., Thor, S., Edlund, T., Jessell, T. M. and Yamada, T. (1992). Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256, 1555-60.
17. Evan, G. L., Lewis, G. K., Ramsay, G. and Bishop, J. M. (1985). Isolation of monoclonal antibodies specific for human c-rnyc proto-oncogene product. Mol. Cell Biol. 5, 3610-3616.
18. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
19. Goulding, M. D., Lumsden, A. and Gruss, P. (1993) Signals from the notochord and floor plate regulate the region specific expression of two Pax-3 genes in the spinal cord. Development 117, 1001-1017.
20. Goulding, M., Lumsden, A. and Paquette, A. J. (1994). Regulation of Pax-3 expression in the dermomyotome and its role in muscle developmental Development 120, 957-971.
21. Gruss, P. and Walther, C. (1992). Pax in development. Cell 69, 719-722.
22. Hamburger, V. and Hamilton, H. L. (1951). A series of normal stages in the development of the chick embryo. J. Morph. 88, 49-92.
23. Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C., Saunders, G. F., Hanson M., Prosser, J., Jordan, T., Hastie, N. D. and van Heyningen, V. (1991) Mouse Small eye results from mutations in a paired like homeobox containing gene. Nature 354, 522-525.
24. Holley, J. A. and Silver, J. (1987). Growth pattern of pioneering chick spinal cord axons. Dev. Biol. 123, 375-88.
25. Hollyday, M. (1980). Organization of motor pools in the chick lumbar latent motor column. J. Comp. Neural. 194, 143-170.
26. Jankowska, E. and Lindstront, S. (1972). Morphology of interneurones mediating la reciprocal inhibition of motor neurons in the spinal cord of the cat. J. Physiol. 226, 805-823
27. Jostes, B., Walther, C. and Grass, P. (1990). The murine paired box gene Pax7. is expressed specifically during the development of the nervous muscular system. Mech. Dev 33, 27-37.
28. Kawakami, A., Kimura-Kawakami, M., Numura, M. and Fujisawa, A. (1995). Identification of chick Pax genes localized in the specific neural circuits. Soc Neunmci. Abstr. 21, 1041.
29. Leber, S. M. and Sancs, J. R. (1995). Migratory paths of neurons and glia the embryonic chick spinal cord. J. Neumsci. 15, 1236-1248.
30. Liem, K. F., Tremml, G., Roelink, H. R. and Jessell, T. M. (1995) Dorsal differentiation of neural plate cells induced by BMP-mediated signals from the epidermal ectoderm Cell 82, 969-979.
31. Liu, I. S., Chen, J. D., Ploder, L., Vidgen, D., van der Kooy, D., Kalnins, V. and Mclnnes, R. R. (1994). Developmental expression of a novel murine homeobox gene (Chx 10): evidence for roles in determination of neuroretina and inner nuclear layer. Neuron 13, 377-93, 93
32. Logan, C., Hanks, M. C., Noble-Topham, S., Nallainathan, D., Provart, J. and Joyner, A. L. (1992). Cloning and sequence comparison of the model human, and chicken engrailed genes reveal potential functional domains regulatory regions. Dev Genet. 13, 345-58.
33. Lumsden, A. (1991). Motorizing the spinal cord. Cell 64, 471-473.
34. Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. P. (1995). Requirement of 19K form of sonic hedgehog peptide for induction of distinct ventral cell types in CNS explants. Nature 375, 322-325.
35. Moody, S. A., Quigg, M. S., Frankfurter, A. (1987). Development of the peripheral trigeminal system in the chick revealed by an isotype-specific antibeia-tubulin monoclonal antibody. J. Comp. Neuml. 279, 567-580.
36. Morgan, B. A. and Kekete, D. M. (1996). Manipulating gene expression with replication-competent rctroviruses. Methods Cell Biol. 51, 185-218.
37. Noll E., and Miller, R. H. Oligodendrocyte precursors originate at the ventral ventricular zone dorsal to the ventral midline region in hte embryonic rat spinal cord. Development 118, 563-573.
38. Nornes, H. O., Dressier, G. R., Knapik, E. W., Deutsch, U. and Gruss, P. (1990). Spatially and temporally restricted expression of Pax2 during murine neurogcnesis. Development 109, 797-809.
39. Oppenheim, R. W., Shneiderman, A., Shimizu, I. and Yaginuma, H. (1988) Onsel and development of intersegmental projections in the chick embryo spinal cord. J. Comp. Neurol. 275, 159-180.
40. Osumi, N., Hirota, A., Ohuchi, H., Nakafuku, M., limura, T., Kuratani, S., Fujiwara, M., Noji, S., and Eto, K. (1997) Pax-6 is involved in the specification of hindbrain motor neuron subtype. Development 124, 2961-2972.
41. Pfaff, S. L., Mendclsohn, M., Stewart, C. L., Fdlund, T. and Jessell, T. M. (1996). Requirement for the LIM homeobox gene Isll in motor neuron generation reveals a motor neuron dependent step in interneuron differentiation. Cell 84, 309-320.
42. Pringle, N. P. and Richardson, W. D. (199.1) A singularity of PDGF alphareceptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage. Development 117, 525-533.
43. Pueschel, A. W., Westerfeld, M. and Dressler, G. R. (1992). Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebralish. Mech. Dev. 38, 197-208.
44. Ramon y Cajal, S. (1909). Histologv of the Nervous System. Reprinted by Oxford University Press, 1995.
45. Rexed, B. (1952). The cytoachiteeionic organization of the spinal cord in the cat. J. Comp. Neuml. 96, 415-495.
46. Roberts, A., Dale, N., Otterson, O. P. and Storm-Mathison, J. (1987). The early development of neurons with GABA immunoreactivity in the CNS of Xenopus laevis embryos. J. Comp. Neurol. 261, 435-449.
47. Roberts, A., Dale, N., Otterson, O. P. and Storm-Mathison, J. (1988) Development and characterization of commissural interneurones in the spinal cord of Xenopus laevis embryos revealed by antibodies to glycine. Development 103, 447-461.
48. Roelink, H., Augsburger, A., Heeemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Kdlund, T., Jessell, T. M. and Dodd, J. (1994). Floor plale and motor neuron induction by vhh-1. a vertebrate homolog of hedgehon expressed by the notochord. Cell 76, 761-775.
49. Scheibel, M. E. and Scheibel, A. B. (1966). A structural analysis of spinal interneurones: Renshaw cells. Arch. ltal, Biol. 104, 3288-3353.
50. Silos-Santiago, I and Snider, W. D. (1992). Development ol commissural neurons in the embryonic spinal cord. J. Comp. Neurol. 325, 514-526.
51. Silos-Santiago, L. and Snider, W. D. (1994). Development of interneurons with ispsilateral projections in embryonic ral spinal cord. J. Comp. Neural. 342, 221-231.
52. Skeath, J. B., Zhang, Y., Holmgren, R., Carroll, S. B. and Doe. C. Q. (1995) Specification of neuroblast identity in the Drosoplnla embryonic central nervous system. Nature 376, 427-430.
53. Soffe, S. R., Clarke, J. D. W. and Roberts, A. (1984). Activity of commissural neurons in the spinal cord of Xenopus embryos. J. Neurophysiol. 51, 1257-1276.
54. Spyropoulos, D. D. and Capecchi, M. R. (1994). Targeted disruption of the even-skipped gene. evxl. causes early postimplantation lethality of the mouse conceptus. Genes Dev. 8, 1949-61.
55. Tanabe, Y. and Jessell, T. M. (1996). Diversity and pattern in the developing spinal cord. Seience 274, 1115-1123.
56. Torres, M., Gómez-Pardo, E., Dressier, G. R. and Gruss, P. (1995) Pax-2 controls multiple steps of urogenital development. Development 121, 4057-4065.
57. Tsuchida, T., Knsini, M., Morion, S. B., Baldassare, M., Edlund, T., Jessell, T. M. and Pfaff, S. L. (1994). Topographic organisation of embryonic motor neurons defined by the expression of Lim homeobox genes. Cell 79, 957-970.
58. Wilkinson, D. G. (1992). Whole-mount In Situ Hybridization of Vertebrate Embryos. Oxford: IRI. Press.
59. Wurst, W., Auerbach, A. B. and Joyner, A. L. (1994) Multiple developmental defects in bngrailed-l mutant mice: an early mid-hindbrain deletion and patterning detects in forelimbs and sternum. Development 120, 2065-75.
60. Yaganuma, H., Shiga, T., Homma, S., Ishihara, R. and Oppenheim, R. W. (1990). Identification of early developing axons projections from spinal interneurons in the chick embryo with a neuron specific β-tubulin antibody. Development 108, 705-716.
61. Yamada, T., Pfaff, S., Kdlund, T and Jessell, T. M. (1993). Control of cell pattern in the neural tube: motor neuron induction bs diffusible factors from notochord and floor plate. cell 73, 673-686.
62. Yamada, T., Placzek, M., Tanaka, H., Dodd, J. and Jessell, T. M. (1991) Control of eell pattern in the developing nervous system: polarizing activty of the floor plate and nolochord. Cell 64, 635-647.