Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20

Development

Volumn 122, Issue 2, 1996, Pages 543-554

  Nonchev, Stefan ^a   Vesque, Christine ^b   Maconochie, Mark ^a   Seitanidou, Tania ^b   Ariza McNaughton, Linda ^a   Frain, Monique ^b   Marshall, Heather ^a   Sham, Mai Har ^c   Krumlauf, Robb ^a   Charnay, Patrick ^b  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b ECOLE NORMALE SUPÉRIEURE   (France)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Enhancers; Hindbrain segmentation; Hoxa 2; Krox 20; Rhombomeres; Transcriptional regulation; Transgenic mice

Indexed keywords

ZINC FINGER PROTEIN;

ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; DEVELOPMENTAL GENETICS; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; ENHANCER REGION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETIC CONSERVATION; MOUSE; MUTANT; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; RHOMBENCEPHALON; SEQUENCE HOMOLOGY; VERTEBRATE;

ANIMALS; BASE SEQUENCE; BETA-GALACTOSIDASE; BINDING SITES; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 2; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, HOMEOBOX; HOMOZYGOTE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OLIGONUCLEOTIDE PROBES; PHENOTYPE; RECOMBINANT PROTEINS; RESTRICTION MAPPING; RHOMBENCEPHALON; TRANSCRIPTION FACTORS; VERTEBRATES; ZINC FINGERS;

EID: 13344278018     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Aparicio, S., Morrison, A., Gould, A., Gilthorpe, J., Chaudhuri, C., Rigby, P. W. J., Krumlauf, R. and Brenner, S. (1995). Detecting conserved regulatory elements with the model genome of the Japanese puffer fish Fugu rubripes. Proc. Natl Acad. Sci. USA 92, 1684-1688.
2. Becker, N., Seitanidou, T., Murphy, P., Mattel, M.-G., Topilko, P., Nieto, M. A., Wilkinson, D. G., Charnay, P. and Gilardi-Hebenstreit, P. (1994). Several tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech. Dev. 47, 3-18.
3. Birgbauer, E. and Fraser, S. E. (1994). Violation of cell lineage restriction compartments in the chick hindbrain. Development 120, 1347-1356
4. Birgbauer, E., Sechrist, J., Bronner-Fraser, M. and Fraser, S. (1995) Rhombomeric origin and rostrocaudal reassortment of neural crest cells revealed by intravital microscopy. Development 121, 935-945.
5. Bradley, L. C., Snape, A., Bhatt, S. and Wilkinson, D. G. (1992) The structure and expression of the Xenopus Krox-20 gene: conserved and divergent patterns of expression in the rhombomeres and neural crest. Mech. Dev. 40, 73-84.
6. Carpenter, E. M., Goddard, J. M., Chisaka, O., Manley, N. R. and Capecchi, M. R. (1993) Loss of HoxAl (Hox-1.6) function results in the reorganization of the murine hidbrain. Development 118, 1063-1075.
7. Chavrier, P., Zerial, M., Lemaire, P., Almendral, J., Bravo, R. and Charnay, P. (1988). A gene encoding a protein with zinc fingers is activated during Go/Gl transition in cultured cells. EMBO J. 7, 29-35.
8. Chavrier, P., Vesque, C., Galliot, B., Vigneron, M., Dolle, P., Duboule, D. and Charnay, P. (1990). The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter of the Hox 1.4 gene. EMBO J. 9, 1209-1218.
9. Condie, B. G. and Capecchi, M. R. (1994). Mice with targeted disruptions in the paralogous genes Hoxa-3 and Hoxd-3 reveal synergistic interactions. Nature 370, 304-307.
10. Dolle, P., Lufkin, T., Krumlauf, R., Mark, M., Duboule, D. and Chambon, P. (1993). Local alterations of Krox-20 and Hox gene expression in the hindbrain of Hox-al (Hox-1.6) homozygote null mutant embryos. Proc. Natl. Acad. Sci. USA 90, 7666-7670.
11. Frasch, M., Chen, X. and Lufkin, T. (1995). Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila. Development 121, 957-974.
12. Fraser, S., Keynes, R. and Lumsden, A. (1990). Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions. Nature 344, 431-435.
13. Gendron-Maguire, M., Mallo, M., Zhang, M. and Gridley, T. (1993). Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest Cell 75, 1317-1331.
14. Gilardi-Hebenstreit, P., Nieto, A., Frain, M., Mattel, M., Chestier, A., Wilkinson, D. and Charnay, P. (1992). An EPH-related receptor protein-tyrosine kinase gene segmentally-expressed in the developing mouse hindbrain. Oncogene. 7, 2499-2506
15. Graham, A., Heyman, I. and Lumsden, A. (1993). Even-numbered rhombomeres control the apoptotic elimination of neural crest cells from odd-numbered rhombomeres in the chick hindbrain. Development 119, 233-245.
16. Graham, A., Francis-West, P., Brickell, P. and Lumsden, A. (1994). The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372, 684-686.
17. Guthrie, S. and Lumsden, A. (1991). Formation and regeneration of rhombomere boundaries in the developing chick hindbrain. Development 112, 221-229.
18. Guthrie, S., Prince, V. and Lumsden, A. (1993). Selective dispersal of avian rhombomere cells in orthotopic and heterotopic grafts. Development 118, 527-538.
19. Hunt, P., Gulisano, M., Cook, M., Sham, M., Faiella, A., Wilkinson, D., Boncinelli, E. and Krumlauf, R. (1991). A distinct Hox code for the branchial region of the head. Nature 353, 861-864.
20. Kadonaga, J., Carner, K., Masiarz, F. and Tjian, R. (1987). Isolation of cDNA encoding transcription factor SP1 and functional analysis of the DNA binding domain. Cell 51, 1079-1090.
21. Keynes, R. and Krumlauf, R. (1994). Hox genes and regionalization of the nervous system. Ann. Rev. Neurosci. 17, 109-132.
22. Krumlauf, R. (1993). Hox genes and pattern formation in the branchial region of the vertebrate head. Trends Genet. 9, 106-112
23. Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78, 191-201.
24. Lumsden, A. (1990). The cellular basis of segmentation in the developing hindbrain. Trends Neurosci. 13, 329-335.
25. Lumsden, A. and Keynes, R. (1989). Segmental patterns of neuronal development in the chick hindbrain. Nature 337, 424-428.
26. Lumsden, A., Sprawson, N. and Graham, A. (1991). Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Development 113, 1281-1291
27. Mark, M., Lufkin, T., Vonesch, J.-L., Rubelte, E., Olivo, J.-C., Dolle, P., Gorry, P., Lumsden, A. and Chambon, P. (1993). Two rhombomeres are altered in Hoxa-1 mutant mice. Development 119, 319-338.
28. Marshall, H., Studer, M., Popperl, H., Aparicio, S., Kuroiwa, A., Brenner, S. and Krumlauf, R. (1994). A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature 370. 567-571.
29. Martinez, S., Geijo, E., Sanchez-Vives, M. V., Puelles, L. and Gallego, R. (1992). Reduced junctional permeability at interrhombomeric boundaries. Development 116, 1069-1076.
30. McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68, 283-302.
31. Morrison, A., Chaudhuri, C., Ariza-McNaughton, L., Muchamore, I., Kuroiwa, A. and Krumlauf, R. (1995). Comparative analysis of chicken Hoxb-4 regulation m transgenic mice. Mech. Dev. 52, 1-13
32. Murphy, P., Davidson, D. R. and Hill, R. E. (1989). Segment-specific expression of a homeobox-containing gene in the mouse hindbrain. Nature 341, 156-159.
33. Nardelli, J., Gibson, T., Vesque, C. and Charnay, P. (1991). Base sequence discrimination by zinc-finger DNA-binding domains. Nature 349, 175-178.
34. Nardelli, J., Gibson, T. and Charnay, P. (1992). Zinc finger-DNA recognition: analysis of base specificity by site-directed mutagenesis Nucl. Acids Res. 20, 4137-4144.
35. Nieto, M. A., Bradley, L. C. and Wilkinson, D. G. (1991). Conserved segmental expression of Krox-20 in the vertebrate hindbrain and its relationship to lineage restriction. Development Supplement 2, 59-62.
36. Nieto, M. A., Gilardi-Hebenstreit, P., Charnay, P. and Wilkinson, D. (1992). A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development 116, 1137-1150.
37. Nieto, M. A., Sechrist, J., Wilkinson, D. and Bronner-Fraser, M. (1995). Relationship between spatially restricted Krox-20 gene expression in branchial neural crest and segmentation in the chick embryo hindbrain. EMBO J. 14, 1697-1710.
38. Oxtoby, E. and Jowett, T. (1993). Cloning of the zebrafish Krox-20 gene (Krx-20) and its expression during hindbrain development. Nucl. Acids Res. 21, No.5, 1087-1095.
39. Paveletich, N. P. and Pabo, C. O. (1991). Zinc finger-DNA recognition:crystal structure of a Zif268-DNA complex at 2.1 Angstroms Science 252, 809-817.
40. Popperl, H., Bienz, M., Studer, M., Chan, S. K., Aparicio, S., Brenner, S., Mann, R. S. and Krumlauf, R. (1995). Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx. Cell 81, 1031-1042.
41. Prince, V. and Lumsden, A. (1994). Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest. Development 120, 911-923.
42. Rijli, F. M., Mark, M., Lakkaraju, S., Dierich, A., Dolle, P. and Chambon, P. (1993). A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2. which acts as a selector gene Cell 75, 1333-1349.
43. Schneider-Maunoury, S., Topilko, P., Seitanidou, T., Levi, G., Cohen-Tannoudji, M., Pournin, S., Babinet, C. and Charnay, P. (1993). Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain Cell 75, 1199-1214.
44. Sechrist, J., Serbedzija, G. N., Scherson, T., Fraser, S. E. and Bronner-Fraser, M. (1993). Segmental migration of the hindbrain neural crest does not arise from its segmental generation. Development 118, 691-703.
45. Serbedzija, G., Fraser, S. and Bronner-Fraser, M. (1992). Vital dye analysis of cranial neural crest cell migration in the mouse embryo. Development 116. 297-307.
46. Sham, M. H., Vesque, C., Nonchev, S., Marshall, H., Frain, M., Das Gupta, R., Whiting, J., Wilkinson, D., Charnay, P. and Krumlauf, R. (1993). The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Cell 72, 183-196.
47. Studer, M., Popperl, H., Marshall.H., Kuroiwa, A. and Krumlauf, R. (1994) Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1. Science 265, 1728-1732.
48. Sundin, O. H. and Eichele, G. (1990). A homeo domain protein reveals the metameric nature of the developing chick hindbrain. Genes Dev. 4, 1267-1276.
49. Swiatek, P. J. and Gridley, T. (1993). Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox-20. Genes Dev. 7, 2071-2084.
50. Topilko, P., Schneider-Maunoury, S., Levi, G., Baron-Van Evercooren, A., Ben Younes Chennoufi, A., Seitanidou, T., Babinet, C. and Charnay, P. (1994). Krox-20 controls myelination in the peripheral nervous system. Nature 371, 796-799
51. Whiting, J., Marshall, H., Cook, M., Krumlauf, R., Rigby, P. W. J., Stott, D. and Allemann, R. K. (1991). Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev. 5, 2048-2059.
52. Wilkinson, D. G. (1993). Molecular mechanisms of segmental patterning in the vertebrate hindbrain and neural crest. BioEssays 15, 499-505.
53. Wilkinson, D. and Green, J. (1990). In situ hybridization and three-dimensional reconstruction of serial sections. In The Practical Approach Series: Postimplantation Mouse Embryos: A Practical Approach (ed. A. J. Copp and D. L. Cockcroft), pp. 155-171, Oxford: IRL Press.
54. Wilkinson, D., Peters, G., Dickson, C. and McMahon., A. (1988). Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J. 7, 691-695.
55. Wilkinson, D. G., Bhatt, S., Chavrier, P., Bravo, R. and Charnay, P. (1989a). Segment-specific expression of a zinc finger gene in the developing nervous system of the mouse. Nature 337, 461-464.
56. Wilkinson, D. G., Bhatt, S., Cook, M., Boncinelli, E. and Krumlauf, R. (1989b). Segmental expression of Hox-2 homeobox-containing genes in the developing mouse hindbrain. Nature 341, 405-409.
57. Yee, S.-P. and Rigby, P. W. J. (1993), The regulation of myogenin gene expression during the embryonic development of the mouse. Genes Dev. 7, 1277-1289.
58. Zhang, M., Kim, H.-J., Marshall, H., Gendron-Maguire, M., Lucas, A. D., Baron, A., Gudas, L. J., Gridley, T., Krumlauf, R. and Grippo, J. F. (1994). Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain. Development 120, 2431-2442.