Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways

Development

Volumn 127, Issue 24, 2000, Pages 5343-5354

  Gaufo, G O ^a   Flodby, P ^a   Capecchi, M R ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Hindbrain neurogenesis; Hox genes; Hoxb1; Motoneurons; Mouse

Indexed keywords

HELIX LOOP HELIX PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR;

ANALYSIS; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL TYPE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION; GENE FUNCTION; HOMEOBOX; MALE; MOLECULE; MORPHOGENESIS; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NEUROMERE; NONHUMAN; PRIORITY JOURNAL; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY PATTERNING; CELL MOVEMENT; DNA PRIMERS; DNA-BINDING PROTEINS; EPISTASIS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GREEN FLUORESCENT PROTEINS; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOTOR NEURONS; PROTEINS; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA; ERINACEIDAE;

EID: 0034524272     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Development of the brain stem in the rat. 11. Thymidine-radiographic study of the time of origin of neurons of the upper medullar, excluding the vestibular and auditory nuclei
2. The determination of the neuronal phenotype
3. Targeted disruption of the hoxb-2 locus in mice interferes with expression of hoxb-1 and hoxb-4
4. Homeotic transformation of rhombomere identity after localized Hoxb1 expression
5. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
6. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
7. The role of Hox genes in hindbrain development
8. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain
9. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
10. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5
11. Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain
12. Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation
13. Vertebrate box gene regulation: Clustering and/or colinearity?
14. Progression from extrinsic to intrinsic signaling in cell fate specification: A view from the nervous system
15. Two critical periods of sonic hedgehog signaling required for specification of motor neuron identity
16. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
17. The ephrins and Eph receptors in neural development
18. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons
19. Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm
20. Mice with targeted disruption of Hoxb1 fail to form the motor nucleus of the VIIth nerve
21. Detection of targeted GFP-Hox gene fusions during mouse embryogenesis
22. Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors
23. The murine and Drosophila homeobox gene complexes have common feature of organization and expression
24. Mammalian achaete-scute homolog 1 is reguired for early development of olfactory and autonomic neurons
25. Genes of the Enhancer of split and achaete-scute complexes are reguired for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
26. Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system
27. Genetic control of cell fate specification in Drosophila peripheral nervous system
28. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors
29. Specification of distinct motor neuron identities by the singular activities of individual Hox genes
30. Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
31. Hox genes in vertebrate development
32. Basic helix-loop-helix genes in neural development
33. Segmental patterns of neuronal development in the chick hindbrain
34. The cellular basis of segmentation in the developing hindbrain
35. Pattering the vertebrate neuraxis
36. Identification of neurogenin, a vertebrate neuronal determination gene
37. Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia
38. Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia
39. Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands
40. The role of hoxa-3 in mouse thymus and thyroid development
41. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutation to non-selecteble genes
42. Morphological fate of rhombomeres in quail/chick chimeras: A segmental analysis of hindbrain nuclei
43. Two rhombomeres are altered in Hoxa-1 mutant mice
44. Constructing the cerebral cortex: Neurogenesis and fate determination
45. Segment-specific expression of a homeobox-containing gene in the mouse hindbrain
46. Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain
47. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
48. Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4
49. Fringe modulates Notch-ligand interactions
50. The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4
51. Control of hindbrain motor neuron diffrentiation by the homeobox gene Phox2b
52. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
53. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
54. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
55. Segmented expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
56. Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
57. Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: The dorsal lip/node, notochord and floor plate
58. Identifying the missing link: Genes that connect neural induction and primary neurogenesis in vertebrate embryos
59. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
60. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons
61. Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb1
62. Time of origin of neurons in the brain stem of the mouse
63. Diversity and pattern in the developing spinal cord
64. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
65. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation
66. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo