Steroid resistance in asthma: Molecular mechanisms

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 2 SUPPL., 1996, Pages

  Adcock, I M ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN; PREDNISOLONE; TRANSCRIPTION FACTOR AP 1;

ASTHMA; BINDING SITE; DNA BINDING; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; STEROID THERAPY; TRANSCRIPTION REGULATION;

EID: 0029741438     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm/154.2_pt_2.s58     Document Type: Review

References (30)

1. Barnes, P. J. 1995. Inhaled glucocorticoids for asthma. N. Engl. J. Med. 332:868-875.
2. Cypcar, D., and W. W. Busse. 1993. Steroid-resistant asthma. J. Allergy Clin. Immunol. 92:362-372.
3. Kirkham, B., M. M. Corkill, S. C. Davison, and G. S. Panayi. 1991. Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell-mediated immune assays predict in vivo response. J. Rheumatol. 18:1130-1133.
4. Langhoff, E., J. Ladedoged, and B. K. Jacobbsen. 1986. Recipient lymphocyte sensitivity to methyl prednisolone affects cadaver kidney graft survival. Lancet 2:1296-1297.
5. Norbato, G., M. Bevilacqua, and T. Vago. 1992. Cortisol resistance in acquired immune deficiency syndrome. J. Clin. Endocrinol. Metab. 74:608-613.
6. Carmichael, J., I. C. Paterson, P. Diaz, G. K. Crompton, A. B. Kay, and I. W. B. Grant. 1981. Corticosteroid resistance in chronic asthma. B.M.J. 282:1419-1422.
7. Schwartz, H. J., F. C. Lowell, and J. C. Melby. 1968. Steroid resistance in bronchial asthma. Am. J. Intern. Med. 69:493-499.
8. Lane, S. J., B. A. Atkinson, R. Swaminathan, and T. H. Lee. 1995. Hypothalamic-pituitary-adrenal axis in corticosteroid-resistant (CR) asthma (abstract). Am. J. Respir. Crit. Care Med. 151:A374.
9. Truss, M., and M. Beato. 1993. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr. Rev. 14:459-479.
10. Ponta, H., A. C. B. Cato, and P. Herrlick. 1992. Interference of specific transcription factors. Biochim. Biophys. Acta 1129:255-261.
11. Barnes, P. J., and I. M. Adcock. 1993. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol. Sci. 14:436-441.
12. Adcock, I. M., H. Shirasaki, C. M. Gelder, M. J. Peters, C. R. Brown, and P. J. Barnes. 1994. The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung. Life Sci. 55:1147-1153.
13. Adcock, I. M., C. R. Brown, C. M. Gelder, H. Shirasaki, M. J. Peters, and P. J. Barnes. 1995. The effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. Am. J. Physiol. 37:C331-C338.
14. Ray, A., and K. E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NK-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U.S.A. 91:752-756.
15. Adcock, I. M., and P. J. Barnes. 1995. Actions of the glucocorticoid receptor on transcription factors within the cytoplasm (abstract). Am. J. Respir. Crit. Care Med. 151:A195.
16. Nelson, P. J., H. T. Kim, W. C. Manning, T. J. Goralski, and A. M. Krensky. 1993. Genomic organisation and transcriptional regulation of the RANTES chemokine gene. J. Immunol. 151:2601-2612.
17. Corrigan, C., P. H. Brown, N. C. Barnes, S. J. Szefler, J. J. Tsai, A. J. Frew, and A. B. Kay. 1991. Glucocorticoid resistance in chronic asthma. Am. Rev. Respir. Dis. 144:1016-1025.
18. Lane, S. J., J. B. D. Palmer, I. F. Skidmore, and T. H. Lee. 1990. Corticosteroid pharmacokinetics in asthma. Lancet 336:126S.
19. Alvarez, J., W. Surs, D. Y. Leung, D. Ikle, E. W. Gelfand, and S. J. Szefler. 1992. Steroid-resistant asthma: immunologic and pharmacologic features. J. Allergy Clin. Immunol. 89:714-721.
20. Brooks, S. M., E. E. Werk, S. J. Ackerman, I. Sullivan, and K. Thrasher. 1972. Adverse effects of phenobarbital on corticosteroid metabolism in patients with bronchial asthma. N. Engl. J. Med. 286:1125-1128.
21. Adcock, I. M., S. J. Lane, C. R. Brown, M. J. Peters, T. H. Lee, and P. J. Barnes. 1995. Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma. J. Immunol. 154:3500-3505.
22. Adcock, I. M., C. R. Brown, H. Virdee, M. J. Peters, C. M. Gelder, S. J. Lane, T. H. Lee, and P. J. Barnes. 1993. Transcription factor interactions in peripheral blood monocytes of steroid sensitive and resistant asthmatic patients (abstract). Am. Rev. Respir. Dis. 147:A292.
23. Adcock, I. M., S. J. Lane, C. R. Brown, T. H. Lee, and P. J. Barnes. 1995. Abnormal glucocorticoid receptor/AP-1 interaction in steroid-resistant asthma. J. Exp. Med. 182:1951-1958.
24. Lane, S. J., J. P. Arm, D. Z. Staynov, and T. H. Lee. 1994. Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma. Am. J. Respir. Cell Mol. Biol. 11:42-48.
25. Lane, S. J., I. M. Adcock, P. J. Barnes, and T. H. Lee. 1995. Increased phorbol ester-induced c-Fos transformation in corticosteroid-resistant asthma (abstract). Thorax 50:A50.
26. Rosewicz, S., A. R. McDonald, B. A. Maddux, I. D. Godfine, R. L. Miesfeld, and C. D. Logsden. 1988. Mechanism of glucocorticoid receptor down-regulation by glucocorticoids. J. Biol. Chem. 263: 2581-2584.
27. Adcock, I. M., C. R. Brown, H. Shirasaki, and P. J. Barnes. Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung. Eur. Respir. J. 7:2117-2123.
28. Yang-Yen, H.-F., J.-C. Chambard, Y.-L. Sun, T. Smeal, T. J. Schmidt, J. Drouin, and M. Karin. 1990. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein interaction. Cell 62:1205-1215.
29. Vacca, A., I. Screpanati, M. Maroder, E. Petrangeli, L. Frati, and A. Guline. 1989. Tumour promoting phorbol ester and ras oncogene expression inhibit the glucocorticoid-dependent transcription from the mouse mammary tumour virus long terminal repeat. Mol. Endocrinol. 3:1659-1665.
30. Sher, E. R., D. Y. M. Leung, W. Surs, J. C. Kamm, G. Zieg, A. K. Kamada, and S. J. Szefler. 1994. Steroid-resistant asthma: cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J. Clin. Invest. 93:33-39.