In vitro analysis of interferon gamma (IFN-γ) and interleukin-12 (IL-12) production and their effects in ileal Crohn's disease

European Cytokine Network

Volumn 13, Issue 4, 2002, Pages 431-437

  Colpaert, Stefaan ^a   Vanstraelen, Kathleen ^b   Liu, Zhanju ^b   Maerten, Philippe ^b   Shen, Chong ^b   Penninckx, Freddy ^b   Geboes, Karel ^b   Rutgeerts, Paul ^b   Ceuppens, Jan L ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b NONE

Author keywords

Anti IL 12 anti IFN ; Crohn's disease; IFN ; IL 12; In vitro

Indexed keywords

B7 ANTIGEN; CD40 LIGAND; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 12; TUMOR NECROSIS FACTOR;

ARTICLE; CELL ACTIVATION; CELL STIMULATION; COCULTURE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN TISSUE; ILEUM; IN VITRO STUDY; LAMINA PROPRIA; MONONUCLEAR CELL; T LYMPHOCYTE ACTIVATION;

CASE-CONTROL STUDIES; CROHN DISEASE; HUMANS; ILEUM; INTERFERON TYPE II; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-12; RECOMBINANT PROTEINS; TH1 CELLS;

EID: 0036824273     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Papadakis KA, Targan SR. 2000. Tumor necrosis factor: biology and therapeutic inhibitors (Review). Gastroenterology 119: 1148.
2. Fais S, Capobianchi MR, Pallone F, Di Marco P, Boirivant M, Dianzani F, Torsoli A. 1991. Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers. Gut 32: 403.
3. Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT. 1993. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 78: 127.
4. Fais S, Capobianchi MR, Silvestri M, Mercuri F, Pallone F, Dianzani F. 1994. Interferon expression in Crohn's disease patients: increased interferon-gamma and - alpha mRNA in the intestinal lamina propria mononuclear cells. J. Interferon. Res. 14: 235.
5. Niessner M, Volk BA. 1995. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). 1995. Clin. Exp. Immunol. 101: 428.
6. Fuss IJ, Neurath M, Boirivant M, Klein JS, de la Motte C, Strong SA, Fiocchi C, Strober W. 1996. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157: 1261.
7. Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L, Maggi E, Pupilli C, Tonelli F, Romagnani S. 1997. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am. J. Pathol. 150: 823.
8. Desreumaux P, Brandt E, Gambiez L, Emilie D, Geboes K, Klein O, Ectors N, Cortot A, Capron M, Colombel JF. 1997. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Gastroenterology 113: 118.
9. Camoglio L, Te Velde AA, Tigges AJ, Das PK, Van Deventer SJ. 1998. Altered expression of interferon-gamma and interleukin-4 in inflammatory bowel disease. Inflamm. Bowel Dis. 4: 285.
10. Schmit A, Van Gossum A, Carol M, Houben JJ, Mascart F. 2000. Diversion of intestinal flow decreases the numbers of interleukin 4 secreting and interferon gamma secreting T lymphocytes in small bowel mucosa. Gut 46: 40.
11. Billiau A, Heremans H, Vermeire K, Matthys P. 1998. Immunomodulatory properties of interferon-gamma. An update (Review). Ann. N. Y. Acad. Sci. 856: 22.
12. Ito H, Fathman CG. 1997. CD45RB high CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease. J. Autoimmun. 10: 455.
13. Manetti R, Parronchi P, Giudizi MG, Piccinni MP, Maggi E, Trinchieri G, Romagnani S. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177: 1199.
14. Manetti R, Gerosa F, Giudizi MG, Biagiotti R, Parronchi P, Piccinni MP, Sampognaro S, Maggi E, Romagnani S, Trinchieri G. 1994. Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J. Exp. Med. 179: 1273.
15. Monteleone G, MacDonald TT, Wathen NC, Pallone F, Pender SL 1999. Enhancing Lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury. Gastroenterology 117: 1069.
16. Schmitt E, Hoehn P, Huels C, Goedert S, Palm N, Rude E, Germann T. 1994. T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta. Eur. J. Immunol. 24: 793.
17. Bradley LM, Dalton DK, Croft M. 1996. A direct role for IFN-gamma in regulation of Th1 cell development. J. Immunol. 157: 1350.
18. Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1: 553.
19. Fuss IJ, Marth T, Neurath MF, Pearlstein GR, Jain A, Strober W. 1999. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice. Gastroenterology 117: 1078.
20. Trinchieri G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes (Review). Blood 84: 4008.
21. Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, Pallone F. 1997. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112: 1169.
22. Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182: 1281.
23. Simpson SJ, Shah S, Comiskey M, de Jong YP, Wang B, Mizoguchi E, Bhan AK, Terhorst C. 1998. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. J. Exp. Med. 187: 1225.
24. Davidson NJ, Hudak SA, Lesley RE, Menon S, Leach MW, Rennick DM. 1998. IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J. Immunol. 161: 3143.
25. Liu Z, Geboes K, Heremans H, Overbergh L, Mathieu C, Rutgeerts P, Ceuppens JL. 2001. Role of interleukin-12 in the induction of mucosal inflammation and abrogation of regulatory T cell function in chronic experimental colitis. Eur. J. Immunol. 31: 1550.
26. Colpaert S, Vanstraelen K, Liu Z, Penninckx F, Geboes K, Rutgeerts P, Ceuppens J. 2002. Decreased lamina propria effector cell responsiveness to interleukin-10 in ileal Crohn's disease. Clin. Immunol. 102: 68.
27. Depraetere H, Depla E, Haelewyn J, De Ley M. 2000. An anti-idiotypic antibody with an internal image of human interferon-gamma and human interferon-gamma-like antiviral activity. Eur. J. Biochem. 267: 2260.
28. Bretscher P, Cohn M. 1970. A theory of self-nonself discrimantion. Science 169: 1042.
29. Rugtveit J, Bakka A, Brandtzaeg P. 1997. Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD). Clin. Exp. Immunol. 110: 104.
30. Kelsall BL, Stuber E, Neurath M, Strober W. 1996. Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses. Ann. N. Y. Acad. Sci. 795: 116.
31. Stuber E, Strober W, Neurath M. 1996. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 183: 693.
32. Liu Z, Colpaert S, D'Haens GR, Kasran A, de Boer M, Rutgeerts P, Geboes K, Ceuppens JL. 1999. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J. Immunol. 163: 4049.
33. Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH. 1998. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses (Review). Annu. Rev. Immunol. 16: 495.
34. Noguchi M, Hiwatashi N, Liu Z, Kinonehi M, Kimura M, Toyota T. 1995. Enhanced production of I1-12 in the mucosa of Crohn's disease. Gastroenterology 108: A885 (Abstract).
35. Rugtveit J, Nilsen EM, Bakka A, Carlsen H, Brandtzaeg P, Scott H. 1997. Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease (Review). Gastroenterology 112: 1493.
36. Colpaert S, Vanstraelen K, Liu Z, Adé M, Geboes K, Ceuppens J, Rutgeerts P. 2000. Phenotypical and functional characterization of the antigen presenting cell in Crohn's disease. Gastroenterology 118: A1337 (Abstract).
37. Wittmann M, Larsson VA, Schmidt P, Begemann G, Kapp A, Werfel T. 1999. Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide. Blood 94: 1717.
38. Parrello T, Monteleone G, Cucchiara S, Monteleone I, Sebkova L, Doldo P, Luzza F, Pallone F. 2000. Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease. J. Immunol. 165: 7234.
39. Chikano S, Sawada K, Shimoyama T, Kashiwamura S, Sugihara A, Sekikawa K, Terada N, Nakanishi K, Okamura H. 2000. IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-γ dependent manner. Gut 47: 779.
40. Nakamura S, Otani T, Ijiri Y, Motoda R, Kurimoto M, Orita K. 2000. IFN-γ dependent and IFN-γ independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12. J. Immunol. 164: 3330.