Osteopontin: a versatile regulator of inflammation and biomineralization

Matrix Biology

Volumn 19, Issue 7, 2000, Pages 615-622

  Giachelli, Cecilia M ^a   Steitz, Susan ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Biomineralization; Inflammation; Macrophages; Matricellular protein; Osteopontin; Vascular calcification; Wound healing

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CELL SURFACE RECEPTOR; GLYCOPROTEIN; MATRICELLULAR PROTEIN; OSTEOPONTIN; SCLEROPROTEIN; UNCLASSIFIED DRUG;

BONE; CALCIFICATION; CELL ADHESION; CELL MIGRATION; CELL SURVIVAL; EPITHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; INFLAMMATION; INFLAMMATORY CELL; KIDNEY; MACROPHAGE; MESENCHYME CELL; MINERALIZATION; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TISSUE LEVEL; WOUND HEALING;

EID: 0033731371     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(00)00108-6     Document Type: Short Survey

References (61)

1. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity
2. 1 integrin
3. Expression of bone matrix proteins in human breast cancer: potential roles in microcalcification formation and in the genesis of bone metastases
4. Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel
5. 3
6. Osteopontin
7. Osteopontin is strongly expressed by histiocytes in granulomas of diverse etiology
8. Osteopontin stimulates gelsolin-associated phosphoinositide levels and phospatidylinositol triphosphate-hydroxyl kinase
9. c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase
10. Rho-a is critical for osteoclast podosome organization, motility and bone resorption
11. Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo
12. Antibody to beta 3 integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat
13. Osteopontin expression and function: role in bone remodeling
14. Integrin-mediated signaling in the regulation of osteoclast adhesion and activation
15. 3 are upregulated during formation of the glial scar after focal stroke
16. A peptidomimetic antagonist of the alpha(v)beta(3) integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo
17. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
18. Inhibition of osteoclastic bone resorptin in vivo by echistatin, an 'arginyl-glycyl-aspartyl' (RGD)-containing protein
19. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques
20. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritris
21. Molecular and cellular biology of osteopontin
22. Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo
23. Possible role of osteopontin in deposition of calcium phosphate in human pilomatricomas
24. Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation
25. Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins
26. Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells
27. Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification
28. 1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
29. Identification of osteopontin in human dental calculus matrix
30. Structure and expression of the mRNA encoding urinary stone protein (osteopontin)
31. Polyclonal B cell activation by the eta-1 cytokine and the development of systemic autoimmune disease
32. 3 in smooth muscle migration to osteopontin
33. 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate RGD-dependent endothelial migration in vitro
34. Altered wound healing in mice lacking a functional osteopontin gene (spp1)
35. 3 integrins are osteosclerotic because of dysfunctional osteoclasts
36. Ultrastructural immunodetection of osteopontin and osteocalcin as major matrix components of renal calculi
37. Secretion of osteopontin by macrophages and its accumulation at tissue surfaces during wound healing in mineralized tissues: a potential requirement for macrophage adhesion and phagocytosis
38. Osteopontin at mineralized interfaces in bone, teeth, and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover and repair
39. Macrophages express osteopontin during repair of myocardial necrosis
40. Expression of wild-type and mutated rabbit osteopontin in Escherichia coli and their effects on adhesion and migration of P388D1 cells
41. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
42. Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin
43. Osteopontin is expressed in human aortic valvular lesions: evidence that aortic valve calcification may be actively regulated
44. Osteopontin is synthesized by macrophage, smooth muscle and endothelial cells in primary and restenotic human coronary atherosclerotic plaques
45. Obstructive uropathy in the mouse: role of osteopontin in interstitial fibrosis and apoptosis
46. Osteopontin - a possible anchor of osteoclasts to bone
47. Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro
48. Osteopontin function in pathology: lessons from osteopontin-deficient mice
49. 3 potentiate bone resorption
50. 3 integrin-induced endothelial survival
51. Pathological considerations in replacement cardiac valves
52. Definition of a specific interaction between the early T-lymphocyte activation 1 (eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo
53. 1 integrin
54. CD44 is not an adhesive receptor for osteopontin
55. Identification of two phosphorylation motifs in bovine osteopontin
56. Osteopontin and p53 expression are associated with tumor progression in a case of synchronous, bilateral, invasive mammary carcinoma
57. Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin
58. Receptor-ligand interaction between CD44 and osteopontin (eta-1)
59. 1 binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino terminal fragment of osteopontin
60. Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
61. A functional role for osteopontin in experimental cresenctic glomerulonephritis in the rat