SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells

American Journal of Pathology

Volumn 159, Issue 2, 2001, Pages 609-622

  Yiu, Gary K ^a   Chan, Wood Yee ^b   Ng, Shu Wing ^a   Chan, Pui Suen ^b   Cheung, Kwok Kuen ^b   Berkowitz, Ross S ^a   Mok, Samuel C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEONECTIN; OSTEONECTIN RECEPTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0034879902     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61732-4     Document Type: Article

References (56)

1. Cancer incidence and mortality, 1973-1995, a report card for the U.S
2. Cancer of the ovary
3. The biology of ovarian cancer
4. Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1
5. Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)
6. Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture
7. Osteonectin cDNA sequence reveals potential binding regions for calcium and hydroxyapatite and shows homologies with both a basement membrane protein (SPARC) and a serine proteinase inhibitor (ovomucoid)
8. Structure of human osteonectin based upon analysis of cDNA and genomic sequences
9. Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization
10. Distribution of the calcium-binding protein SPARC in tissues of embryonic and adult mice
11. Distribution of osteonectin mRNA and protein during human embryonic and fetal development
12. The biology of SPARC, a protein that modulates cell-matrix interactions
13. ++-binding protein SPARC (osteonectin) revealed by in situ hybridization
14. SPARC, an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells
15. Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer
16. Distribution of SPARC in normal and neoplastic human tissue
17. Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer
18. Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin
19. +2-dependent binding to the extracellular matrix
20. SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function
21. (2-)-deficient medium
22. Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells in vitro
23. SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
24. SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway
25. Molecular cloning of differentially expressed genes in human epithelial ovarian cancer
26. Characterization of human ovarian surface epithelial cells immortalized by human papilloma viral oncogenes (HPV-E6E7 ORFs)
27. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins
28. The expression of the secreted protein acidic and rich in cysteine (SPARC) is associated with the neoplastic progression of human melanoma
29. Increased expression of osteonectin and osteopontin, two bone matrix proteins, in human breast cancer
30. Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin-3 and BM-40/SPARC genes
31. Osteonectin/SPARC is overexpressed in human hepatocellular carcinoma
32. SPARC: A potential diagnostic marker of invasive meningiomas
33. Differential expression of osteonectin/SPARC during human prostate cancer progression
34. Osteonectin promotes prostate cancer cell migration and invasion: A possible mechanism for metastasis to bone
35. Increased SPARC expression promotes U87 glioblastoma invasion in vitro
36. Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells
37. Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors
38. Osteonectin mRNA: Distribution in normal and transformed cells
39. SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts
40. Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000
41. Down-regulation of SPARC/osteonectin/BM-40 expression in methylcholanthrene-induced fibrosarcomas and in Kirsten-MSV transformed fibroblasts
42. Down-regulation of the extracellular matrix protein SPARC in vSrc- and vJun-transformed chick embryo fibroblasts contributes to tumor formation in vivo
43. Hevin, an antiadhesive extracellular matrix protein, is down-regulated in metastatic prostate adenocarcinoma
44. Characterization of MAST9/Hevin, a SPARC-like protein, that is down-regulated in non-small cell lung cancer
45. Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules
46. 2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells
47. Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts
48. Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation
49. Apoptosis in the pathogenesis and treatment of disease
50. Human ovarian surface epithelial (OSE) cells express LH/hCG receptors, and hCG inhibits apoptosis of OSE cells via up-regulation of insulin-like growth factor-1
51. Expression and actions of both the follicle stimulating hormone receptor and the luteinizing hormone receptor in normal ovarian surface epithelium and ovarian cancer
52. Decreased luteinizing hormone receptor mRNA expression in human ovarian epithelial cancer
53. Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells
54. Human ovarian cancer and cisplatin resistance: Possible role of inhibitor of apoptosis proteins
55. Identification and expression cloning of a leptin receptor, OB-R
56. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III