Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide

Brain Research

Volumn 712, Issue 2, 1996, Pages 349-352

  Oyama, Yasuo ^a   Chikahisa, Lumi ^a,b   Ueha, Toshiko ^a   Kanemaru, Kaori ^a   Noda, Katsuhiko ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b Taiho Pharmaceutical   (Japan)

Author keywords

antioxidant; brain neuron; Ginkgo biloba extract; hydrogen peroxide; oxidative stress

Indexed keywords

FLAVINOID; GINKGO BILOBA EXTRACT; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; FLOW CYTOMETRY; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0029928823     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)01440-3     Document Type: Article

References (16)

1. Choi, D.W., Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage, Trends Neurosci., 11 (1988) 465-469.
2. Flamm, E.S., Demopoulos, H.B., Seligman, M.L., Poser, R.G. and Ransohoff, J. Free radicals in cerebral ischemia, Stroke, 9 (1978) 445-447.
3. Haugland, R.P., Fluorescent dyes for assessing vital cell functions. In: The Handbook of Fluorescent Probes and Research Chemicals, Molecular Probe, 1992, pp. 172-180.
4. Lo, H.M., Lin, F.Y., Tseng, C.D., Chiang, F.T., Hsu, K.L. and Tseng, Y.Z., Effect of EGb 761, a Ginkgo biloba extract, on early arrhythmia induced by coronary occlusion and reperfusion in dogs, J. Formas. Med. Assoc., 93 (1994) 592-597.
5. McCord, J.M., Oxygen-derived free radicals in the post ischemic tissue injury, N. Engl. J. Med., 312 (1985) 159-163.
6. 2 determination, Angiology, 45 (1994) 413-417.
7. Oyama, Y., Chikahisa, L., Ueha, T., Hatakeyama, Y. and Kokubun, T., Change in membrane permeability induced by amyloid β-protein fragment 25-35 in brain neurons dissociated from rats, Jpn. J. Pharmacol., 68 (1995) 77-83.
8. 2+-loaded brain neurons, Brain Res., 635 (1994) 125-129.
9. 2+-induced increase in oxidative metabolism of dissociated mammalian brain neurons: effect of extract of Ginkgo biloba leaves, Jpn. J. Pharmacol., 61 (1993) 367-370.
10. Oyama, Y., Hayashi, A., Ueha, T. and Maekawa, K., Characterization of 2′,7′-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide, Brain Res., 635 (1994) 113-117.
11. Oyama, Y., Ueha, T., Hayashi, A., Chikahisa, L. and Noka, K., Flow cytometric estimation of the effect of Ginkgo biloba extract on the content of hydrogen peroxide in dissociated mammalian brain neurons, Jpn. J. Pharmacol., 58 (1992) 385-388.
12. Pincemail., J., Dupuis, M., Nasr, C., Hans, P., Haag-Berrurier, M., Anton, R. and Deby, C., Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo biloba extract, Experimentia, 45 (1989) 708-712.
13. 2+ induced decrease in synaptosomal membrane fluidity, Free Radic. Res. Commun., 19 (1993) 341-350.
14. Shen, J.G. and Zhou, D.Y., Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury, Biochem. Mol. Biol. Int., 35 (1995) 125-134.
15. 2+) by free radical scavengers in the rat retina, Ophthalmic. Res., 25 (1993) 1-9.
16. Tosaki, A., Engelman, D.T., Pali, T., Engelman, R.M. and Droy-Lefaix, M.T., Ginkgo biloba extract (EGb 761) improves postischemic function in isolated preconditioned working rat hearts, Coron. Artery Dis., 5 (1994) 443-450.